Molecular characterization of IPMN using comprehensive genome analysis

• Project/Area Number: 23591010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: TADA Minoru 東京大学, 医学部附属病院, 講師 (80302719)
• Co-Investigator(Kenkyū-buntansha): TATEISHI Keisuke 東京大学, 医学部附属病院, 講師 (20396948) ; MOHRI Dai 東京大学, 医学部附属病院, 特任臨床医 (20582513)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: IPMN

Research Abstract

We characterized the molecular signature of IPMN in this project. 11 gastric, 11 intestinal, one pancreatobiliary, and two oncocytic types were included in this study. We compared the molecular characteristics of two major subtypes, gastric-type and intestinal-type IPMN. Gastric-type showed a higher incidence of KRAS mutations (9/11, 81.8%) compared with intestinal type (3/11, 27.3%). The intestinal type (9/11, 81.8%) demonstrated more frequent SMAD1/5/8 phosphorylation compared with gastric-type IPMN (3/11, 27.3%).In addition, we identified a molecule that accerelated epithelial- mesenchymal transition in pancreas cancer cells. The gene was amplified in pancreas cancer cells and human pancreatic tumors. We now examine the significance of the molecule in IPMN as well as in pancreatic cancers.

Research Products

• [Journal Article] Disease-Specific Mortality Among Patients With Intraductal Papillary Mucinous Neoplasm of the Pancreas (2014)
  • Author(s): Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Takahara N, Uchino R, Hamada T, Miyabayashi K, Yamamoto K, Mizuno S, Mohri D, Kogure H, Sasaki T, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Koike K
  • Journal Title: Clin Gastroenterol Hepatol Volume: 12(3) (2013 Jul 25) Issue: 3 Pages: 486-91
  • DOI: 10.1016/j.cgh.2013.06.032
  • Peer Reviewed
• [Journal Article] Clinical outcomes of chemotherapy for diabetic and nondiabetic patients with pancreatic cancer : better prognosis with statin use in diabetic patients (2013)
  • Author(s): Nakai Y, Isayama H, Sasaki T, Mizuno S, Sasahira N, Kogure H, Kawakubo K, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K
  • Journal Title: Pancreas Volume: 42(2) Pages: 202-8
• [Journal Article] Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer (2013)
  • Author(s): Takahara N, Nakai Y, Isayama H, Sasaki T, Satoh Y, Takai D, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Mohri D, Kawakubo K, Kogure H, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tada M, Yatomi Y, Koike K
  • Journal Title: Cancer Chemother Pharmacol Volume: 71(1) Pages: 85-92
• [Journal Article] Duodenal metal stent placement is a risk factor for biliary metal stent dysfunction : an analysis using a time-dependent covariate (2013)
  • Author(s): Hamada T, Nakai Y, Isayama H, Sasaki T, Kogure H, Kawakubo K, Sasahira N, Yamamoto N, Togawa O, Mizuno S, Ito Y, Hirano K, Toda N, Tada M, Koike K
  • Journal Title: Surg Endosc Volume: 27(4) Pages: 1243-8
• [Journal Article] The results of the Tokyo trial of prevention of post-ERCP pancreatitis with risperidone (Tokyo P3R): a multicenter, randomized, phase II, non-placebo-controlled trial (2013)
  • Author(s): Tsujino T, Isayama H, Nakai Y, Ito Y, Togawa O, Toda N, Arizumi T, Kogure H, Yamamoto K, Mizuno S, Yashima Y, Yagioka H, Sasaki T, Matsubara S, Yamamoto N, Hirano K, Sasahira N, Tada M, Koike K
  • Journal Title: J Gastroenterol Volume: 48(8) Pages: 982-8
  • NAID: 10031195124
• [Journal Article] False pancreas divisum : a complication of post-endoscopic retrograde pancreatography pancreatitis (2013)
  • Author(s): Gonoi W, Akahane M, Tada M, Ohtomo K
  • Journal Title: Jpn J Radiol Volume: 31(2) Pages: 148-51
  • NAID: 210000168608
• [Journal Article] High alcohol consumption increases the risk of pancreatic stone formation and pancreatic atrophy in autoimmune pancreatitis (2013)
  • Author(s): Hirano K, Tada M, Isayama H, Watanabe T, Saito T, Uchino R, Hamada T, Miyabayashi K, Mizuno S, Mohri D, Sasaki T, Kogure H, Yamamoto N, Sasahira N, Toda N, Takahara N, Yagioka H, Akiyama D, Ito Y, Koike K
  • Journal Title: Pancreas Volume: 42(3) Pages: 502-5
• [Journal Article] Japanese multicenter estimation of WallFlex duodenal stent for unresectable malignant gastric outlet obstruction (2013)
  • Author(s): Sasaki T, Isayama H, Maetani I, Nakai Y, Kogure H, Kawakubo K, Mizuno S, Yagioka H, Matsubara S, Ito Y, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Koike K
  • Journal Title: Dig Endosc Volume: 25(1) Pages: 1-6
  • NAID: 130004555333
• [Journal Article] One-step, simultaneous triple endoscopic nasobiliary drainage for hilar biliary stricture (2013)
  • Author(s): Kawakubo K, Isayama H, Mizuno S, Hirano K, Yamamoto N, Takahara N, Miyabayashi K, Mohri D, Sasaki T, Kogure H, Sasahira N, Tada M, Koike K
  • Journal Title: Dig Endosc Volume: 25(1) Pages: 76-9
• [Journal Article] Risk for mortality from causes other than pancreatic cancer in patients with intraductal papillary mucinous neoplasm of the pancreas (2013)
  • Author(s): Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Takahara N, Miyabayashi K, Yamamoto K, Mizuno S, Mohri D, Kogure H, Sasaki T, Yamamoto N, Tateishi R, Hirano K, Ijichi H, Tateishi K, Koike K
  • Journal Title: Pancreas Volume: 42(4) Pages: 687-91
• [Journal Article] A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer : GECA2 (2013)
  • Author(s): Nakai Y, Isayama H, Ijichi H, Sasaki T, Takahara N, Ito Y, Matsubara S, Uchino R, Yagioka H, Arizumi T, Hamada T, Miyabayashi K, Mizuno S, Yamamoto K, Kogure H, Yamamoto N, Hirano K, Sasahira N, Tateishi K, Tada M, Koike K
  • Journal Title: Invest New Drugs Volume: 31(5) Pages: 1294-9
• [Journal Article] Diabetes is a useful diagnostic clue to improve the prognosis of pancreatic cancer (2013)
  • Author(s): Mizuno S, Nakai Y, Isayama H, Takahara N, Miyabayashi K, Yamamoto K, Kawakubo K, Mohri D, Kogure H, Sasaki T, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Ijichi H, Tateishi K, Tada M, Koike K
  • Journal Title: Pancreatology Volume: 13(3) Pages: 285-9
• [Journal Article] A pilot study of salvage irinotecan monotherapy for advanced biliary tract cancer (2013)
  • Author(s): Sasaki T, Isayama H, Nakai Y, Takahara N, Satoh Y, Takai D, Kogure H, Yamamoto N, Hirano K, Tada M, Yatomi Y, Koike K
  • Journal Title: Anticancer Res Volume: 233(6) Pages: 2619-22
• [Journal Article] Results of the Tokyo trial of prevention of post-ERCP pancreatitis with risperidone-2: a multicenter, randomized, placebo-controlled, double-blind clinical trial (2013)
  • Author(s): Uchino R, Isayama H, Tsujino T, Sasahira N, Ito Y, Matsubara S, Takahara N, Arizumi T, Toda N, Mohri D, Togawa O, Yagioka H, Yanagihara Y, Nakajima K, Akiyama D, Hamada T, Miyabayashi K, Mizuno S, Kawakubo K, Kogure H, Sasaki T, Yamamoto N, Nakai Y, Hirano K, Tada M, Koike K
  • Journal Title: Gastrointest Endosc Volume: 78(6) Pages: 842-50
• [Journal Article] A retrospective study of S-1 and oxaliplatin combination chemotherapy in patients with refractory pancreatic cancer (2013)
  • Author(s): Takahara N, Isayama H, Nakai Y, Sasaki T, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Kogure H, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K
  • Journal Title: Cancer Chemother Pharmacol Volume: 72(5) Pages: 985-90
• [Journal Article] A retrospective study of gemcitabine and cisplatin combination therapy as second-line treatment for advanced biliary tract cancer (2013)
  • Author(s): Sasaki T, Isayama H, Nakai Y, Takahara N, Akiyama D, Yagioka H, Kogure H, Matsubara S, Ito Y, Yamamoto N, Sasahira N, Hirano K, Toda N, Tada M, Koike K
  • Journal Title: Chemotherapy Volume: 59(2) Pages: 106-11
• [Journal Article] Trimming a covered metal stent during hepaticogastrostomy by using argon plasma coagulation (2013)
  • Author(s): Hamada T, Nakai Y, Isayama H, Saito K, Kogure H, Sasaki T, Yamamoto N, Hirano K, Tada M, Koike K
  • Journal Title: Gastrointest Endosc Volume: 78(6) Pages: 817-817
• [Journal Article] A retrospective analysis of early CA19-9 change in salvage chemotherapy for refractory pancreatic cancer (2013)
  • Author(s): Nakai Y, Isayama H, Sasaki T, Takahara N, Hamada T, Uchino R, Mizuno S, Miyabayashi K, Yamamoto K, Mohri D, Kogure H, Yamamoto N, Hirano K, Ijichi H, Tateishi K, Tada M, Koike K
  • Journal Title: Cancer Chemother Pharmacol Volume: 72(6) Pages: 1291-7
• [Journal Article] A novel, fully covered laser-cut nitinol stent with antimigration properties for nonresectable distal malignant biliary obstruction : a multicenter feasibility study (2013)
  • Author(s): Isayama H, Kawakubo K, Nakai Y, Inoue K, Gon C, Matsubara S, Kogure H, Ito Y, Tsujino T, Mizuno S, Hamada T, Uchino R, Miyabayashi K, Yamamoto K, Sasaki T, Yamamoto N, Hirano K, Sasahira N, Tada M, Koike K
  • Journal Title: Gut Liver Volume: 7(6) Pages: 725-30
• [Journal Article] Risk factors and early signs of pancreatic cancer in diabetes : screening strategy based on diabetes onset age (2013)
  • Author(s): Mizuno S, Nakai Y, Isayama H, Yanai A, Takahara N, Miyabayashi K, Yamamoto K, Kawakubo K, Mohri D, Kogure H, Sasaki T, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Ijichi H, Tateishi K, Akanuma M, Tada M, Koike K
  • Journal Title: J Gastroenterol Volume: 48(2) Pages: 238-46
  • NAID: 10031156309
• [Journal Article] Risk for mortality from causes other than pancreatic cancer in patients with intraductal papillary mucinous neoplasm of the pancreas (2013)
  • Author(s): Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Takahara N, Miyabayashi K, Yamamoto K, Mizuno S, Mohri D, Kogure H, Sasaki T, Yamamoto N, Tateishi R, Hirano K, Ijichi H, Tateishi K, Koike K
  • Journal Title: Pancreas Volume: 42(4) Issue: 4 Pages: 687-91
  • DOI: 10.1097/mpa.0b013e318270ea97
  • Peer Reviewed
• [Journal Article] Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals (2013)
  • Author(s): Miyabayashi K, Ijichi H, Mohri D, Tada M, Yamamoto K, Asaoka Y, Ikenoue T, Tateishi K, Nakai Y, Isayama H, Morishita Y, Omata M, Moses HL, Koike K.
  • Journal Title: Cancer Res Volume: 73 Issue: 7 Pages: 2221
  • DOI: 10.1158/0008-5472.can-12-1453
  • Peer Reviewed
• [Journal Article] Intraductal papillary mucinous neoplasm was associated with pancreatic carcinogenesis, but not with systemic carcinogenesis (2012)
  • Author(s): Kawakubo K, Tada M, Koike K
  • Journal Title: Surgery Volume: 152(1) Pages: 141-2
• [Journal Article] Meandering main pancreatic duct as a relevant factor to the onset of idiopathic recurrent acute pancreatitis (2012)
  • Author(s): Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Kiryu S, Tada M, Uno K, Ohtsu H, Okura N, Koike K, Ohtomo K
  • Journal Title: PLoS One Volume: 7(5) Pages: 37652-37652
• [Journal Article] One- and two-step self-expandable metal stent placement for distal malignant biliary obstruction : a propensity analysis (2012)
  • Author(s): Hamada T, Nakai Y, Isayama H, Togawa O, Kogure H, Kawakubo K, Tsujino T, Sasahira N, Hirano K, Yamamoto N, Ito Y, Sasaki T, Mizuno S, Toda N, Tada M, Koike K
  • Journal Title: J Gastroenterol Volume: 47(11) Pages: 1248-56
  • NAID: 10031126957
• [Journal Article] Long-term prognosis of autoimmune pancreatitis in terms of glucose tolerance (2012)
  • Author(s): Hirano K, Isogawa A, Tada M, Isayama H, Takahara N, Miyabayashi K, Mizuno S, Mohri D, Kawakubo K, Sasaki T, Kogure H, Yamamoto N, Sasahira N, Toda N, Nagano R, Yagioka H, Yashima Y, Hamada T, Ito Y, Koike K
  • Journal Title: Pancreas Volume: 41(5) Pages: 691-5
• [Journal Article] Autoimmune pancreatitis with low serum immunoglobulin G4 level associated with annular pancreas (2012)
  • Author(s): Hirano K, Matsubara S, Tada M, Isayama H, Sasahira N, Koike K
  • Journal Title: Pancreas Volume: 41(5) Pages: 811-3
• [Journal Article] Lower incidence of biliary carcinoma in patients with primary sclerosing cholangitis and high serum levels of immunoglobulin E (2012)
  • Author(s): Hirano K, Tada M, Mizuno S, Isayama H, Takahara N, Nagano R, Hamada T, Miyabayashi K, Ito Y, Mohri D, Kawakubo K, Sasaki T, Kogure H, Yamamoto N, Sasahira N, Yamashiki N, Sugawara Y, Kokudo N, Toda N, Koike K
  • Journal Title: Clin Gastroenterol Hepatol Volume: 10(1) Pages: 79-83
  • NAID: 40019405097
• [Journal Article] Management of malignant gastric outlet obstruction with a modified triple-layer covered metal stent (2012)
  • Author(s): Isayama H, Sasaki T, Nakai Y, Togawa O, Kogure H, Sasahira N, Yashima Y, Kawakubo K, Ito Y, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • Journal Title: Gastrointest Endosc Volume: 75(4) Pages: 757-63
• [Journal Article] Simultaneous duodenal metal stent placement and EUS-guided choledochoduodenostomy for unresectable pancreatic cancer (2012)
  • Author(s): Kawakubo K, Isayama H, Nakai Y, Sasahira N, Kogure H, Sasaki T, Hirano K, Tada M, Koike K
  • Journal Title: Gut Liver Volume: 6(3) Pages: 399-402
• [Journal Article] Risk factors for pancreatitis following transpapillary self-expandable metal stent placement (2012)
  • Author(s): Kawakubo K, Isayama H, Nakai Y, Togawa O, Sasahira N, Kogure H, Sasaki T, Matsubara S, Yamamoto N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • Journal Title: Surg Endosc Volume: 26(3) Pages: 771-6
• [Journal Article] Mucosal hyperplasia in an uncovered portion of partially covered metal stent (2012)
  • Author(s): Kawakubo K, Isayama H, Sasahira N, Kogure H, Miyabayashi K, Hirano K, Tada M, Koike K
  • Journal Title: World J Gastrointest Endosc Volume: 4(9) Pages: 432-3
• [Journal Article] Clinical utility of single-operator cholangiopancreatoscopy using a SpyGlass probe through an endoscopic retrograde cholangiopancreatography catheter (2012)
  • Author(s): Kawakubo K, Isayama H, Sasahira N, Kogure H, Takahara N, Miyabayashi K, Mizuno S, Yamamoto K, Mohri D, Sasaki T, Yamamoto N, Nakai Y, Hirano K, Tada M, Koike K
  • Journal Title: J Gastroenterol Hepatol Volume: 27(8) Pages: 1371-6
• [Journal Article] Endoscopic removal of a spontaneously fractured biliary uncovered self-expandable metal stent (2012)
  • Author(s): Kawakubo K, Isayama H, Tsujino T, Nakai Y, Sasahira N, Kogure H, Hamada T, Nagano R, Miyabayashi K, Yamamoto K, Mohri D, Sasaki T, Ito Y, Yamamoto N, Hirano K, Tada M, Koike K
  • Journal Title: Dig Endosc Volume: 24(3) Pages: 182-4
• [Journal Article] Comparison of CT findings of biliary tract changes with autoimmune pancreatitis and extrahepatic bile duct cholangiocarcinoma (2012)
  • Author(s): Maeda E, Akahane M, Yoshioka N, Takao H, Matsuda I, Kamiya K, Hirano K, Tada M, Ohtsu H, Fukushima N, Ohtomo K
  • Journal Title: Jpn J Radiol Volume: 30(3) Pages: 227-34
  • NAID: 210000163116
• [Journal Article] Incidental pancreatic cysts found by magnetic resonance imaging and their relationship with pancreatic cancer (2012)
  • Author(s): Matsubara S, Tada M, Akahane M, Yagioka H, Kogure H, Sasaki T, Arizumi T, Togawa O, Nakai Y, Sasahira N, Hirano K, Tsujino T, Isayama H, Toda N, Kawabe T, Ohtomo K, Omata M
  • Journal Title: Pancreas Volume: 41(8) Pages: 1241-6
• [Journal Article] Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression (2012)
  • Author(s): Mohri D, Asaoka Y, Ijichi H, Miyabayashi K, Kudo Y, Seto M, Ohta M, Tada M, Tanaka Y, Ikenoue T, Tateishi K, Isayama H, Kanai F, Fukushima N, Tada M, Kawabe T, Omata M, Koike K
  • Journal Title: J Gastroenterol Volume: 47(2) Pages: 203-13
  • NAID: 10030296319
• [Journal Article] Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer : GECA1 (2012)
  • Author(s): Nakai Y, Isayama H, Ijichi H, Sasaki T, Kogure H, Yagioka H, Miyabayashi K, Mizuno S, Yamamoto K, Mouri D, Kawakubo K, Yamamoto N, Hirano K, Sasahira N, Tateishi K, Tada M, Koike K
  • Journal Title: Cancer Sci Volume: 103(8) Pages: 1489-92
• [Journal Article] A multicentre randomised phase II trial of gemcitabine alone vs gemcitabine and S-1 combination therapy in advanced pancreatic cancer : GEMSAP study (2012)
  • Author(s): Nakai Y, Isayama H, Sasaki T, Sasahira N, Tsujino T, Toda N, Kogure H, Matsubara S, Ito Y, Togawa O, Arizumi T, Hirano K, Tada M, Omata M, Koike K
  • Journal Title: Br J Cancer Volume: 106(12) Pages: 1934-9
• [Journal Article] Role of intervention for biliary and gastric/intestinal obstruction in gastric cancer with peritoneal metastasis (2012)
  • Author(s): Nakai Y, Ishigami H, Isayama H, Sasaki T, Kawakubo K, Kogure H, Emoto S, Yamaguchi H, Kitayama J, Yamamoto N, Sasahira N, Hirano K, Tada M, Koike K
  • Journal Title: J Gastroenterol Hepatol Volume: 27(12) Pages: 1796-800
• [Journal Article] Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine (2012)
  • Author(s): Sasaki T, Isayama H, Nakai Y, Mizuno S, Yamamoto K, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Togawa O, Matsubara S, Ito Y, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • Journal Title: Invest New Drugs Volume: 30(2) Pages: 708-13
• [Journal Article] Predictive factors of solid food intake in patients with malignant gastric outlet obstruction receiving self-expandable metallic stents for palliation (2012)
  • Author(s): Sasaki T, Isayama H, Nakai Y, Togawa O, Kogure H, Kawakubo K, Mizuno S, Yashima Y, Ito Y, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • Journal Title: Dig Endosc Volume: 24(4) Pages: 226-30
• [Journal Article] Endoscopic papillary balloon dilation for bile duct stones in patients on hemodialysis (2012)
  • Author(s): Takahara N, Isayama H, Sasaki T, Tsujino T, Toda N, Sasahira N, Mizuno S, Kawakubo K, Kogure H, Yamamoto N, Nakai Y, Hirano K, Tada M, Omata M, Koike K
  • Journal Title: J Gastroenterol Volume: 47(8) Pages: 918-23
  • NAID: 10031051346
• [Journal Article] Acoustic radiation force impulse elastography for noninvasive assessment of chronic pancreatitis (2012)
  • Author(s): Yashima Y, Sasahira N, Isayama H, Kogure H, Ikeda H, Hirano K, Mizuno S, Yagioka H, Kawakubo K, Sasaki T, Nakai Y, Tada M, Yoshida H, Omata M, Koike K
  • Journal Title: J Gastroenterol Volume: 47(4) Pages: 427-32
  • NAID: 10030650116
• [Journal Article] Preliminary report on a new, fully covered, metal stent designed for the treatment of pancreatic fluid collections (2012)
  • Author(s): Yamamoto N, Isayama H, Kawakami H, Sasahira N, Hamada T, Ito Y, Takahara N, Uchino R, Miyabayashi K, Mizuno S, Kogure H, Sasaki T, Nakai Y, Kuwatani M, Hirano K, Tada M M, Koike K
  • Journal Title: Gastrointest Endosc Volume: 77(5) Pages: 809-14
• [Journal Article] Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression. (2012)
  • Author(s): Mohri D, Asaoka Y, Ijichi H, Miyabayashi K, Kudo Y, Seto M, Ohta M, Tada M, Tanaka Y, Ikenoue T, Tateishi K, Isayama H, Kanai F, Fukushima N, Tada M, Kawabe T, Omata M, Koike K.
  • Journal Title: J Gastroenterol Volume: 47 Pages: 203-13
  • NAID: 10030296319
  • Peer Reviewed
• [Journal Article] Carcinogenesis of IPMN (2012)
  • Author(s): Tada M, Koike K.
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi Volume: 109 Pages: 178-82
  • NAID: 10030310304
  • Peer Reviewed
• [Journal Article] Intraductal papillary mucinous neoplasm was associated with pancreatic carcinogenesis, but not with systemic carcinogenesis. (2012)
  • Author(s): Kawakubo K, Tada M, Koike K.
  • Journal Title: Surgery Volume: 152 Pages: 141-2
  • Peer Reviewed
• [Journal Article] Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers (2011)
  • Author(s): Tada M , Nakai Y, Sasaki T, Hamada T, Nagano R, Mohri D, Miyabayashi K, Yamamoto K, Kogure H, Kawakubo K, Ito Y, Yamamoto N, Sasahira N, Hirano K, Ijichi H, Tateishi K, Isayama H, Omata M, Koike K
  • Journal Title: World J Clin Oncol Volume: 2(3) Pages: 158-63
• [Journal Article] Increased liver elasticity in patients with biliary obstruction (2011)
  • Author(s): Yashima Y, Tsujino T, Masuzaki R, Nakai Y, Hirano K, Tateishi R, Sasahira N, Isayama H, Tada M, Yoshida H, Kawabe T, Omata M
  • Journal Title: J Gastroenterol Volume: 46 Pages: 86-91
  • NAID: 10029026715
• [Journal Article] Pancreas divisum as a predisposing factor for chronic and recurrent idiopathic pancreatitis: initial in vivo survey (2011)
  • Author(s): Gonoi W, Akai H, Hagiwara K, Akahane M, Hayashi N, Maeda E, Yoshikawa T, Tada M, Uno K, Ohtsu H, Koike K, Ohtomo K
  • Journal Title: Gut Volume: 60(8) Pages: 1103-8
• [Journal Article] Duodenal invasion is a risk factor for the early dysfunction of biliary metal stents in unresectable pancreatic cancer (2011)
  • Author(s): Hamada T, Isayama H, Nakai Y, Togawa O, Kogure H, Kawakubo K, Tsujino T, Sasahira N, Hirano K, Yamamoto N, Arizumi T, Ito Y, Matsubara S, Sasaki T, Yagioka H, Yashima Y, Mohri D, Miyabayashi K, Mizuno S, Nagano R, Takahara N, Toda N, Tada M, Omata M, Koike K
  • Journal Title: Gastrointest Endosc Volume: 74(3) Pages: 548-55
• [Journal Article] Significance of measuring IgG and IgG4 during follow-up of autoimmune pancreatitis (2011)
  • Author(s): Hirano K, Tada M, Isayama H, Sasahira N, Koike K
  • Journal Title: Pancreas Volume: 40(5) Pages: 788-91
• [Journal Article] Covered metallic stenting for malignant distal biliary obstruction : clinical results according to stent type (2011)
  • Author(s): Isayama H, Nakai Y, Kawakubo K, Kogure H, Togawa O, Hamada T, Ito Y, Sasaki T, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Tada M, Koike K
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 18(5) Pages: 673-7
  • NAID: 10029688409
• [Journal Article] Gemcitabine and oxaliplatin combination chemotherapy for patients with refractory pancreatic cancer (2011)
  • Author(s): Isayama H, Nakai Y, Yamamoto K, Sasaki T, Mizuno S, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Arizumi T, Togawa O, Ito Y, Matsubara S, Yamamoto N, Sasahira N, Hirano K, Tsujino T, Tada M, Omata M, Koike K
  • Journal Title: Oncology Volume: 80(1-2) Pages: 97-101
• [Journal Article] Efficacy and safety of covered self-expandable metal stents for management of distal malignant biliary obstruction due to lymph node metastases (2011)
  • Author(s): Kawakubo K, Isayama H, Nakai Y, Togawa O, Sasahira N, Kogure H, Sasaki T, Matsubara S, Yamamoto N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • Journal Title: Surg Endosc Volume: 25(9) Pages: 3094-100
• [Journal Article] Endoscopic transpapillary gallbladder drainage with replacement of a covered self-expandable metal stent (2011)
  • Author(s): Kawakubo K, Isayama H, Sasahira N, Nakai Y, Kogure H, Sasaki T, Hirano K, Tada M, Koike K
  • Journal Title: World J Gastrointest Endosc Volume: 3(2) Pages: 46-8
• [Journal Article] Incidence of extrapancreatic malignancies in patients with intraductal papillary mucinous neoplasms of the pancreas (2011)
  • Author(s): Kawakubo K, Tada M, Isayama H, Sasahira N, Nakai Y, Yamamoto K, Kogure H, Sasaki T, Hirano K, Ijichi H, Tateishi K, Yoshida H, Koike K
  • Journal Title: Gut Volume: 60(9) Pages: 1249-53
• [Journal Article] Endoscopic bilateral metallic stenting for malignant hilar obstruction using newly designed stents (2011)
  • Author(s): Kogure H, Isayama H, Kawakubo K, Sasaki T, Yamamoto N, Hirano K, Sasahira N, Tsujino T, Tada M, Koike K
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 18(5) Pages: 653-7
  • NAID: 10029688346
• [Journal Article] Newly designed large cell Niti-S stent for malignant hilar biliary obstruction : a pilot study (2011)
  • Author(s): Kogure H, Isayama H, Nakai Y, Tsujino T, Ito Y, Yamamoto K, Mizuno S, Yagioka H, Kawakubo K, Sasaki T, Hirano K, Sasahira N, Tada M, Omata M, Koike K
  • Journal Title: Surg Endosc Volume: 25(2) Pages: 463-7
• [Journal Article] Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage (2011)
  • Author(s): Kogure H, Tsujino T, Yamamoto K, Mizuno S, Yashima Y, Yagioka H, Kawakubo K, Sasaki T, Nakai Y, Hirano K, Sasahira N, Isayama H, Tada M, Kawabe T, Omata M, Harada S, Ota Y, Koike K
  • Journal Title: J Gastroenterol Volume: 46(12) Pages: 1411-7
  • NAID: 10030295328
• [Journal Article] Specific increase in serum autotaxin activity in patients with pancreatic cancer (2011)
  • Author(s): Nakai Y, Ikeda H, Nakamura K, Kume Y, Fujishiro M, Sasahira N, Hirano K, Isayama H, Tada M, Kawabe T, Komatsu Y, Omata M, Aoki J, Koike K, Yatomi Y
  • Journal Title: Clin Biochem Volume: 44(8-9) Pages: 576-81
• [Journal Article] Comorbidity, not age, is prognostic in patients with advanced pancreatic cancer receiving gemcitabine-based chemotherapy (2011)
  • Author(s): Nakai Y, Isayama H, Sasaki T, Sasahira N, Tsujino T, Kogure H, Yagioka H, Yashima Y, Togawa O, Arizumi T, Matsubara S, Hirano K, Tada M, Omata M, Koike K
  • Journal Title: Crit Rev Oncol Hematol Volume: 78(3) Pages: 252-9
• [Journal Article] New method of covered wallstents for distal malignant biliary obstruction to reduce early stent-related complications based on characteristics (2011)
  • Author(s): Nakai Y, Isayama H, Togawa O, Kogure H, Tsujino T, Yagioka H, Yashima Y, Sasaki T, Ito Y, Matsubara S, Hirano K, Sasahira N, Toda N, Tada M, Kawabe T, Omata M, Koike K
  • Journal Title: Dig Endosc Volume: 23(1) Pages: 49-55
  • NAID: 10028188306
• [Journal Article] Impact of introduction of wire-guided cannulation in therapeutic biliary endoscopic retrograde cholangiopancreatography (2011)
  • Author(s): Nakai Y, Isayama H, Tsujino T, Sasahira N, Hirano K, Kogure H, Sasaki T, Kawakubo K, Yagioka H, Yashima Y, Mizuno S, Yamamto K, Arizumi T, Togawa O, Matsubara S, Yamamoto N, Tada M, Omata M, Koike K
  • Journal Title: J Gastroenterol Hepatol Volume: 26(10) Pages: 1552-8
• [Journal Article] Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer (2011)
  • Author(s): Sasaki T, Isayama H, Nakai Y, Mizuno S, Yamamoto K, Yagioka H, Yashima Y, Kawakubo K, Kogure H, Togawa O, Matsubara S, Sasahira N, Hirano K, Tsujino T, Tada M, Omata M, Koike K
  • Journal Title: Invest New Drugs Volume: 29(6) Pages: 1488-93
• [Journal Article] Prognostic factors in patients with advanced biliary tract cancer receiving chemotherapy (2011)
  • Author(s): Sasaki T, Isayama H, Nakai Y, Togawa O, Kogure H, Ito Y, Yamamoto K, Mizuno S, Yagioka H, Yashima Y, Kawakubo K, Arizumi T, Matsubara S, Sasahira N, Hirano K, Tsujino T, Toda N, Tada M, Omata M, Koike K
  • Journal Title: Cancer Chemother Pharmacol Volume: 67(4) Pages: 847-53
• [Journal Article] Clinical significance of bile cytology via an endoscopic nasobiliary drainage tube for pathological diagnosis of malignant biliary strictures (2011)
  • Author(s): Yagioka H, Hirano K, Isayama H, Tsujino T, Sasahira N, Nagano R, Hamada T, Miyabayashi K, Ito Y, Mohri D, Kawakubo K, Kogure H, Sasaki T, Tada M, Koike K
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 18(2) Pages: 211-5
  • NAID: 10029286323
• [Presentation] 膵嚢胞および10mm未満のIPMNの発癌リスクの検討 (2013)
  • Author(s): 高木馨, 多田稔, 川畑修平, 斎藤友隆, 渡邉健雄, 内野里枝, 濱田毅, 水野卓, 宮林弘至, 木暮宏史, 佐々木隆, 山本夏代, 中井陽介, 平野賢二, 伊佐山浩通, 小池和彦
  • Organizer: 第44回日本膵臓学会大会特別企画ディベート
  • Place of Presentation: 仙台
• [Presentation] IPMN経過観察における膵発癌リスクファクターの検討 (2012)
  • Author(s): 川久保和道,多田稔,小池和彦
  • Organizer: 第98回日本消化器病学会総会ワークショップ
  • Place of Presentation: 東京
• [Presentation] 分枝型IPMN経過観察中に発生した通常型膵癌診断の現状 (2012)
  • Author(s): 川久保和道,多田稔,小池和彦
  • Organizer: 第83回日本消化器内視鏡病学会総会ワークショップ
  • Place of Presentation: 東京
• [Presentation] IPMNにおける膵発癌危険因子の検討 (2012)
  • Author(s): 川久保和道,多田稔,伊佐山浩通,笹平直樹,平野賢二,高原楠昊,宮林弘至,水野卓,毛利大,佐々木隆,木暮宏史,山本夏代,小池和彦
  • Organizer: 第43回日本膵臓学会シンポジウム
  • Place of Presentation: 山形
• [Presentation] Risk of mortality other than pancreatic cancer in patients with intraductal papillary mucinous neoplasm of the pancreas (2012)
  • Author(s): Kawakubo K, Tada M, Isayama H, Koike K
  • Organizer: United European Gastroenterology Week 2012
  • Place of Presentation: Amsterdam
• [Book] 内科学 (2012)
  • Author(s): 多田稔
  • Publisher: 膵管内乳頭粘液性腫瘍、膵嚢胞