| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
To develop new therapy for pancreatic cancer, it is essential to understand biological features of this disease. Autophagy is one of major protein degradation systems that were reportedly involved in tumorigenesis. To elucidate roles of autophagy in pancreatic cancer development, we deleted Atg5 gene, which is essential for autophagy, in pancreatic cancer mouse models. Our results demonstrated that autophagy has a suppressive role in initiation but a promotive role in progression of pancreatic cancer.
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