| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Autoimmune pancreatitis is a specific type of pancreatitis characterized by high serum IgG4 concentration and abundant IgG4 bearing plasma cell infiltration, and complicated with variety of other organ involvements. We performed genome-wide association study (GWAS) to elucidate the genes that associated with the pathogenesis of AIP. We confirmed SNPs that showed significant differences between AIP and control, and these SNPs revealed 13 candidate genes. Among these, we identified that CLNK and PAX5 genes showed significant association with AIP by fine mapping. Functions of CLNK and PAK5 genes may associated with immunological responses. In addition, we revealed 10 candidate genes that were associated with complication of lachrymal and salivary gland lesions, that represent active state of AIP. Among these, KLF gene showed significant association with this complication.
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