Genome wide association study for associated gens of autoimmune pancreatitis
| Project/Area Number |
23591012
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Shinshu University |
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Principal Investigator |
KAWA Shigeyuki 信州大学, 総合健康安全センター, 教授 (10177628)
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| Co-Investigator(Kenkyū-buntansha) |
OTA Masao 信州大学, 医学部, 准教授 (50115333)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 自己免疫性膵炎 / IgG4 / 涙腺唾液腺病変 / 全ゲノム関連解析 / GWAS / 涙腺･唾液腺炎 |
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| Research Abstract |
Autoimmune pancreatitis is a specific type of pancreatitis characterized by high serum IgG4 concentration and abundant IgG4 bearing plasma cell infiltration, and complicated with variety of other organ involvements. We performed genome-wide association study (GWAS) to elucidate the genes that associated with the pathogenesis of AIP. We confirmed SNPs that showed significant differences between AIP and control, and these SNPs revealed 13 candidate genes. Among these, we identified that CLNK and PAX5 genes showed significant association with AIP by fine mapping. Functions of CLNK and PAK5 genes may associated with immunological responses. In addition, we revealed 10 candidate genes that were associated with complication of lachrymal and salivary gland lesions, that represent active state of AIP. Among these, KLF gene showed significant association with this complication.
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Report
(4 results)
Research Products
(119 results)
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[Journal Article] Type 1 Autoimmune Pancreatitis Can Transform into Chronic Pancreatitis: A Long-Term Follow-Up Study of 73 Japanese Patients.2013
Author(s)
Maruyama M, Arakura N, Ozaki Y, Watanabe T, Ito T, Yoneda S, Maruyama M, Muraki T, Hamano H, Matsumoto A, Kawa S.
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Journal Title
Int J Rheumatol.
Volume: 2013
Pages: 8-8
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical Features of a New Disease Concept, IgG4-related Thyroiditis.2013
Author(s)
Watanabe T, Maruyama M, Ito T, Fujinaga Y, Ozaki Y, Maruyama M, Kodama R, Muraki T, Hamano H, Arakura N, Kadoya M, Suzuki S, Komatsu M, Shimojo H, Notohara K, Uchida M, Kawa S.
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Journal Title
Scand J Rheumatol
Volume: 42
Issue: 4
Pages: 325-30
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of a Serum IgG4 Cut-off Value for the Differential Diagnosis of IgG4-related Sclerosing Cholangitis- A Japanese Cohort.2013
Author(s)
Ohara H, Nakazawa T, Kawa S, Kamisawa T, Shimosegawa T, Uchida K, Hirano K, Nishino T, Hamano H, Kanno A, Notohara K, Hasebe O, Muraki T, Ishida E, Naitoh I, Okazaki K.
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Journal Title
J Gastroenterol Hepatol
Volume: 28
Issue: 7
Pages: 1247-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk factors for pancreatic stone formation in autoimmune pancreatitis over a long-term course.2012
Author(s)
Maruyama M, Arakura N, Ozaki Y, Watanabe T, Ito T, Yoneda S, Maruyama M, Muraki T, Hamano H, Matsumoto A, Kawa S.
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Journal Title
J Gastroenterol
Volume: 47
Issue: 5
Pages: 553-60
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis.2012
Author(s)
Hart PA, Kamisawa T, Brugge WR, Chung JB, Culver EL, Czakó L, Frulloni L, Go VL, Gress TM, Kim MH, Kawa S
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Journal Title
Gut
Volume: on line
Issue: 12
Pages: 1771-1776
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk factors for pancreatic stone formation in autoimmune pancreatitis over a long-term course.2012
Author(s)
Maruyama M, Arakura N, Ozaki Y, Watanabe T, Ito T, Yoneda S, Maruyama M, Muraki T, Hamano H, Matsumoto A, Kawa S.
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Journal Title
J Gastroenterol.
Volume: 47
NAID
Related Report
Peer Reviewed
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[Journal Article] Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD)2012
Author(s)
Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, et al.
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Journal Title
Mod Rheumatol
Volume: 22
Pages: 21-30
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of immunoglobulin G4-associated autoimmune hepatitis2011
Author(s)
Umemura T, Zen Y, Hamano H, Joshita S, Ichijo T, Yoshizawa K, Kiyosawa K, Ota M, Kawa S, Nakanuma Y, Tanaka E
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Journal Title
J Gastroenterol
Volume: 46 (Suppl 1)
Pages: 48-55
NAID
Related Report
Peer Reviewed
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[Journal Article] International Consensus Diagnostic Criteria for Autoimmune Pancreatitis: Guidelines of the International Association of Pancreatology.2011
Author(s)
Shimosegawa T, Chari ST, Frulloni L, Kamisawa T, Kawa S, Mino-Kenudson M, Kim MH, Klöppel G, Lerch MM, Löhr M, Notohara K, Okazaki K, Schneider A, Zhang L.
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Journal Title
Pancreas
Volume: 40
Pages: 352-358
NAID
Related Report
Peer Reviewed
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[Journal Article] IgG4-related pleural disease diagnosed by a re-evaluation of chronic bilateral pleuritis in a patient who experienced occasional acute left bacterial pleuritis.2011
Author(s)
Yamamoto H, Suzuki T, Yasuo M, Kobayashi O, Tsushima K, Ito M, Urushihata K, Yamazaki Y, Hanaoka M, Koizumi T, Uehara T, Kawakami S, Hamano H, Kawa S, Kubo K.
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Journal Title
Intern Med
Volume: 50
Pages: 893-7
NAID
Related Report
Peer Reviewed
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[Journal Article] A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details.2011
Author(s)
Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, et.al.
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Journal Title
Mod Rheumatol.
Volume: 22
Pages: 1-14
NAID
Related Report
Peer Reviewed
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[Presentation] Long Term Outcomes of Type 1 Autoimmune Pancreatitis: Development to Pancreatic Stone Formation and Chronic Pancreatitis2014
Author(s)
Maruyama M, Watanabe T, Kanai K, Oguchi T, Asano J, Ito T, Ozaki Y, Muraki T, Hamano H, Arakura N, Matsumoto A, Kawa S.
Organizer
International Symposium on IgG4-RD & Associated Conditions
Place of Presentation
Honolulu（アメリカ）
Related Report
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[Presentation] Clinical Features of a New Disease Concept, IgG4-related Thyroiditis2014
Author(s)
Watanabe T, Maruyama M, Ito T, Fujinaga Y, Ozaki Y, Maruyama M, Kodama R, Muraki T, Hamano H, Arakura N, Kadoya M, Suzuki S, Komatsu M, Shimojo H, Notohara K, Uchida M,Kawa S.
Organizer
International Symposium on IgG4-RD & Associated Conditions
Place of Presentation
Honolulu（アメリカ）
Related Report
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[Presentation] Two siblings with type 1 autoimmune pancreatitis.2014
Author(s)
Kanai K, Watanabe T, Maruyama M, Oguchi T, Asano J, Ito T, Ozaki Y, Muraki T, Hamano H, Arakura N, Ota M, Kawa S
Organizer
International Symposium on IgG4-RD & Associated Conditions
Place of Presentation
Honolulu（アメリカ）
Related Report
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[Presentation] How frequently does AIP relapse and how can it be prevented? Japanese experience.2011
Author(s)
Kawa S. Ito T, Maruyama M, Watanabe T, Ozaki Y, Maruyama M, Yoneda K, Kodama R, Muraki T, Hamano H, Arakura N.
Organizer
4th AOPA & KPBA
Place of Presentation
Jeju, Korea
Related Report
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[Presentation] Clinical Features of IgG4 Negative Autoimmune Pancreaｔitis.2011
Author(s)
Ito T, Maruyama M, Watanabe T, Maruyama M, Yoneda S, Kodama R, Ozaki Y, Muraki T, Hamano H, Arakura N, Kawa S
Organizer
4th AOPA & KPBA
Place of Presentation
Jeju, Korea.
Related Report
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[Presentation] Thyroiditis: an IgG4-related disease.2011
Author(s)
Watanabe T, Maruyama M, Ito T, Fujinaga Y, Maruyama M, Yoneda S, Ozaki Y, Muraki T, Hamano H, Arakura N, Kawa S.
Organizer
4th AOPA & KPBA
Place of Presentation
Jeju, Korea.
Related Report
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[Presentation] Mechanism of Pancreatic Stone Formation in Patients with Autoimmune Pancreatitis.2011
Author(s)
Maruyama M, Ozaki Y, Arakura N, Watanabe T, Ito T, Yoneda S, Maruyama M, Muraki T, Hamano H, Kawa S.
Organizer
4th AOPA & KPBA
Place of Presentation
Jeju, Korea.
Related Report
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[Presentation] Frequency and Prevention of Autoimmune Pancreatitis Relapse in a Japanese Population.2011
Author(s)
Ito T, Maruyama M, Watanabe T, Maruyama M, Yoneda S, Kodama R, Ozaki Y, Muraki T, Hamano H, Arakura N, Kawa S,
Organizer
Pancreas Research Forum (IPRF) 2011
Place of Presentation
OSAKA Japan
Related Report
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[Presentation] The Mechanism of Lower Bile Duct Stricture seen in IgG4-related Sclerosing Cholangitis.2011
Author(s)
Watanabe T, Maruyama M, Ito T, Fujinaga Y, Maruyama M, Yoneda S, Ozaki Y, Muraki T, Hamano H, Arakura N, Kawa S.
Organizer
Pancreas Research Forum (IPRF) 2011
Place of Presentation
OSAKA Japan
Related Report
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[Book] IgG4-related Disease2013
Author(s)
Kawa S, Watanabe T, Ito T, Maruyama M, Ozaki Y, Muraki T, Hamano H, Arakura N.
Total Pages
237
Publisher
Springer Japan
Related Report
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