| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We here revealed that phosphorylated HSP27 (P-HSP27) played a key role in gemcitabine (GEM)-induced apoptosis in pancreatic cancer derived cell line. Furthermore, the level of P-HSP27 was a factor to determine the sensitivity to GEM from the results of siRNA and inhibitor experiments. In addition, we examine the clinical significance of investigating the expression levels of HSP27 or P-HSP27 in the biopsied specimen of the pancreatic cancer using endoscopic ultrasound -guided fine needle aspiration (EUS-FNA) technique. As a result, the expression level of P-HSP27 was associated with the absence of metastasis and longer survival. These results suggest that the evaluation of the P-HSP27 expression in the biopsy specimen can be a prognostic factor to predict the prognosis. On the other hand, it was failed to proven that the expression level of HSP27 or P-HSP27 was a factor to predict the response to GEM chemotherapy.
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