The role of HSP27 in the anti-tumor action of gemcitabine for pancreatic cancer

• Project/Area Number: 23591013
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Gifu University
• Principal Investigator: YASUDA Ichiro 岐阜大学, 医学(系)研究科(研究院), 准教授 (00377673)
• Co-Investigator(Kenkyū-buntansha): KOZAWA Osamu 岐阜大学, 大学院医学系研究科, 教授 (90225417) ; ADACHI Seiji 岐阜大学, 大学院医学系研究科, 非常勤 講師 (50467205)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膵癌 / Gemcitabine / HSP27 / EUS-FNA / リン酸化

Research Abstract

We here revealed that phosphorylated HSP27 (P-HSP27) played a key role in gemcitabine (GEM)-induced apoptosis in pancreatic cancer derived cell line. Furthermore, the level of P-HSP27 was a factor to determine the sensitivity to GEM from the results of siRNA and inhibitor experiments. In addition, we examine the clinical significance of investigating the expression levels of HSP27 or P-HSP27 in the biopsied specimen of the pancreatic cancer using endoscopic ultrasound -guided fine needle aspiration (EUS-FNA) technique. As a result, the expression level of P-HSP27 was associated with the absence of metastasis and longer survival. These results suggest that the evaluation of the P-HSP27 expression in the biopsy specimen can be a prognostic factor to predict the prognosis. On the other hand, it was failed to proven that the expression level of HSP27 or P-HSP27 was a factor to predict the response to GEM chemotherapy.

Research Products

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• [Journal Article] Technique of endoscopic ultrasonography-guided pancreatic duct intervention (with videos). (2014)
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  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 21 Issue: 2
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• [Journal Article] Multicenter retrospective study of endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction in Japan. (2014)
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  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 印刷中 Issue: 5 Pages: 328-334
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• [Journal Article] Endoscopic papillary large balloon dilation as a salvage procedure for basket impaction during retrieval of common bile duct stones. (2014)
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  • Peer Reviewed / Open Access
• [Journal Article] Impact of anticancer treatment on recurrent obstruction in covered metallic stents for malignant biliary obstruction (2013)
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• [Journal Article] Two rare cases of a solid pseudopapillary neoplasm of the pancreas (2013)
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  • Journal Title: Oncol Lett Volume: 6 Pages: 871-874
• [Journal Article] Serum level of soluble tumor necrosis factor receptor 2 is associated with the outcome of patients with diffuse large B-cell lymphoma treated with the R-CHOP regimen (2013)
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• [Journal Article] Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation : A propensity score-based cohort analysis (2013)
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  • NAID: 10031201980
• [Journal Article] Endoscopic ultrasound-guided antegrade treatments for biliary disorders in patients with surgically altered anatomy (2013)
  • Author(s): Iwashita T, Yasuda I, et al.
  • Journal Title: Dig Dis Sci Volume: 58 Pages: 2417-22
• [Journal Article] Percutaneous transgallbladder rendezvous for enteroscopic management of choledocholithiasis in patients with surgically altered anatomy (2013)
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• [Journal Article] Japanese multicenter experience of endoscopic necrosectomy for infected walled-off pancreatic necrosis : The JENIPaN study (2013)
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  • Journal Title: Endoscopy Volume: 45 Pages: 627-34
• [Journal Article] Tumor necrosis factor-αpromotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells (2013)
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  • Journal Title: PLoS One Volume: 8 Pages: 65251-65251
• [Journal Article] Recent advances in endoscopic management of difficult bile duct stones (2013)
  • Author(s): Yasuda I, Itoi T
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  • NAID: 130005143613
• [Journal Article] Endoscopic biliary stenting and pancreatitis (2013)
  • Author(s): Yasuda I
  • Journal Title: Clin J Gastroenterol Volume: 6 Pages: 193-7
• [Journal Article] Endoscopic ultrasonography-guided pancreatic duct access : techniques and literature review of pancreatography, transmural drainage and rendezvous techniques (2013)
  • Author(s): Itoi T, Yasuda I, et al.
  • Journal Title: Dig Endosc Volume: 25 Pages: 241-52
• [Journal Article] Endoscopic ultrasound-guided celiac ganglia neurolysis vs. celiac plexus neurolysis : a randomized multicenter trial (2013)
  • Author(s): Doi S, Yasuda I, et al.
  • Journal Title: Endoscopy Volume: 45 Pages: 362-9
• [Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer (2013)
  • Author(s): Osawa Y, Yasuda I, Kozawa O, et al.
  • Journal Title: J Clin Invest Volume: 123 Pages: 834-43
• [Journal Article] The role of peroral video cholangioscopy in patients with IgG4-related sclerosing cholangitis (2013)
  • Author(s): Itoi T, Yasuda I, et al.
  • Journal Title: J Gastroenterol Volume: 48 (with video) Pages: 504-14
  • NAID: 10031169225
• [Journal Article] New fully-covered self-expandable metal stent for endoscopic ultrasonography-guided intervention in infectious walled-off pancreatic necrosis (2013)
  • Author(s): Itoi T, Yasuda I, at al.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 20 Pages: 403-6
• [Journal Article] Preoperative routine evaluation of bilateral adrenal glands by endoscopic ultrasound and fine-needle aspiration in patients with potentially resectable lung cancer (2013)
  • Author(s): Uemura S, Yasuda I, et al.
  • Journal Title: Endoscopy Volume: 45 Pages: 195-201
• [Journal Article] Metallic stents are more efficacious than plastic stents in unresectable malignant hilar biliary strictures : a randomized controlled trial (2013)
  • Author(s): Mukai T, Yasuda I, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 20 Pages: 214-222
  • NAID: 10031168212
• [Journal Article] Endoscopic ultrasound-guided antegrade papillary balloon dilation for treating a common bile duct stone (2013)
  • Author(s): Iwashita T, Yasuda I, et al.
  • Journal Title: Dig Endosc Volume: 25 Pages: 89-90
• [Journal Article] A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer (2013)
  • Author(s): Sasaki T, Yasuda I, et al.
  • Journal Title: Cancer Chemother Pharmacol Volume: 71 Pages: 973-9
• [Journal Article] Two rare cases of a solid pseudopapillary neoplasm of the pancreas. (2013)
  • Author(s): Saigo C, Hirose Y, Asano N, Takamatsu M, Fukushima N, Yasuda I, Goshima S, Ozeki M, Osada S.
  • Journal Title: Oncol Lett. Volume: 6 Pages: 871-874
  • Peer Reviewed
• [Journal Article] Japanese multicenter experience of endoscopic necrosectomy for infected walled-off pancreatic necrosis: The JENIPaN study. (2013)
  • Author(s): Yasuda I, Nakashima M, Iwai T, Isayama H, Itoi T, Hisai H, Inoue H, Kato H, Kanno A, Kubota K, Irisawa A, Igarashi H, Okabe Y, Kitano M, Kawakami H, Hayashi T, Mukai T, Sata N, Kida M, Shimosegawa T
  • Journal Title: Endoscopy. Volume: 45 Issue: 08 Pages: 627-634
  • DOI: 10.1055/s-0033-1344027
  • Peer Reviewed
• [Journal Article] Percutaneous transgallbladder rendezvous for enteroscopic management of choledocholithiasis in patients with surgically altered anatomy. (2013)
  • Author(s): Okuno M, Iwashita T, Yasuda I, Mabuchi M, Uemura S, Nakashima M, Doi S, Adachi S, Mukai T, Moriwaki H.
  • Journal Title: Scand J Gastroenterol. Volume: 48 Issue: 8 Pages: 974-978
  • DOI: 10.3109/00365521.2013.805812
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-α promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells． (2013)
  • Author(s): Osawa Y,Saibara T et.al
  • Journal Title: PloS One Volume: 8（6） Issue: 6 Pages: e65251-e65251
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• [Journal Article] Serum level of soluble tumor necrosis factor receptor 2 is associated with the outcome of patients with diffuse large B-cell lymphoma treated with the R-CHOP regimen. (2013)
  • Author(s): Nakamura N, Goto N, Tsurumi H, Takemura M, Kanemura N, Kasahara S, Hara T, Yasuda I, Shimizu M, Sawada M, Yamada T, Seishima M, Takami T, Moriwaki H.
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  • Journal Title: Dig Endosc. Volume: 25 Issue: 4 Pages: 376-385
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  • Author(s): Yasuda I, Mukai T, Moriwaki H.
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  • Author(s): Doi S, Yasuda I, Kawakami H, Hayashi T, Hisai H, Irisawa A, Mukai T, Katanuma A, Kubota K, Ohnishi T, Ryozawa S, Hara K, Itoi T, Hanada K, Yamao K.
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  • Peer Reviewed
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  • Peer Reviewed
• [Journal Article] Endoscopic ultrasonography-guided pancreatic duct access: techniques and literature review of pancreatography, transmural drainage and rendezvous techniques. (2013)
  • Author(s): Itoi T, Kasuya K, Sofuni A, Itokawa F, Kurihara T, Yasuda I, Nakai Y, Isayama H, Moriyasu F.
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• [Journal Article] A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer. (2013)
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  • Peer Reviewed
• [Journal Article] Impact of anticancer treatment on recurrent obstruction in covered metallic stents for malignant biliary obstruction. (2013)
  • Author(s): Nakai Y, Isayama H, Mukai T, Itoi T, Maetani I, Kawakami H, Yasuda I, Maguchi H, Ryozawa S, Hanada K, Hasebe O, Ito K, Kawamoto H, Mochizuki H, Igarashi Y, Irisawa A, Sasaki T, Togawa O, Hara T, Kamada H, Toda N, Hamada T, Kogure H.
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  • Author(s): Uemura S, Yasuda I, Kato T, Doi S, Kawaguchi J, Yamauchi T, Kaneko Y, Ohnishi R, Suzuki T, Yasuda S, Sano K, Moriwaki H.
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  • DOI: 10.1055/s-0032-1325988
  • Peer Reviewed
• [Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer． (2013)
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  • DOI: 10.1172/jci65188
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• [Journal Article] Endoscopic ultrasound-guided antegrade papillary balloon dilation for treating a common bile duct stone. (2013)
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• [Journal Article] The role of peroral video cholangioscopy in patients with IgG4-related sclerosing cholangitis. (2013)
  • Author(s): Itoi T, Kamisawa T, Igarashi Y, Kawakami H, Yasuda I, Itokawa F, Kishimoto Y, Kuwatani M, Doi S, Hara S, Moriyasu F, Baron TH.
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• [Journal Article] A multicenter, prospective, randomized study of selective bile duct cannulation performed by multiple endoscopists : the BIDMEN study (2012)
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  • Author(s): Yasuda I, Mukai T, Doi S, Tomita E, Moriwaki H.
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  • NAID: 120006341951
• [Journal Article] Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells (2011)
  • Author(s): Yamauchi T, Adachi S, Yasuda I, Kozawa O, et al.
  • Journal Title: Int J Oncol Volume: 39 Pages: 1375-1380
  • NAID: 120006341977
• [Journal Article] Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine by activation of 5' AMP-activated protein kinase (2011)
  • Author(s): Adachi S, Yasuda I, Kozawa O, et al.
  • Journal Title: Biochem Biophys Res Commun. Volume: 414 Pages: 53-59
• [Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells (2011)
  • Author(s): Nakashima M, Adachi S, Yasuda I, Kozawa O, et al.
  • Journal Title: Cancer Lett Volume: 313 Pages: 218-225
• [Journal Article] Carbon dioxide insufflation vs. conventional saline irrigation for peroral video cholangioscopy (2011)
  • Author(s): Doi S, Yasuda I, et al.
  • Journal Title: Endoscopy Volume: 43 Pages: 1070-5
• [Journal Article] Combined endobronchial and endoscopic ultrasound-guided fine needle aspiration for mediastinal nodal staging of lung cancer (2011)
  • Author(s): Ohnishi R, Yasuda I, et al.
  • Journal Title: Endoscopy Volume: 43 Pages: 1082-9
• [Journal Article] Combined adenomatoid tumor and well differentiated papillary mesothelioma of the omentum (2011)
  • Author(s): Hatano Y, Yasuda I, et al.
  • Journal Title: Pathology International Volume: 61 Pages: 681-685
  • NAID: 10031185141
• [Journal Article] Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells. (2011)
  • Author(s): Adachi S, Yasuda I, Nakashima M, Yamauchi T, Yoshioka T, Okano Y, Moriwaki H, Kozawa O.
  • Journal Title: Eur J Pharmacol Volume: 650 Pages: 145-150
  • Peer Reviewed
• [Journal Article] EUS-FNA of Lesions near the Aortoiliac Bifurcation via an Upper Gastrointestinal Approach. (2011)
  • Author(s): Doi S, Yasuda I, Nakashima M, Kawaguchi J, Yamauchi T, Iwashita T, Toda K, Adachi S, Shimizu M, Tsurumi H, Moriwaki H
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 1717-1720
  • Peer Reviewed
• [Journal Article] Inhibition of Rho-associated coiled-coil containing protein kinase enhances the activation of epidermal growth factor receptor in pancreatic cancer cells. (2011)
  • Author(s): Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H.
  • Journal Title: Mol Cancer Volume: 10 Pages: 79-79
  • NAID: 120006341951
  • Peer Reviewed
• [Journal Article] UV-C irradiation induces downregulation of EGF receptor via phosphorylation at serine 1046/1047 in human pancreatic cancer cells. (2011)
  • Author(s): Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Nishii Y, Yoshioka T, Okano Y, Hirose Y, Kozawa O, Moriwaki H.
  • Journal Title: Radiation Res Volume: 176 Pages: 565-574
  • Peer Reviewed
• [Journal Article] Ultraviolet irradiation can induce evasion of colon cancer cells from stimulation of epidermal growth factor. (2011)
  • Author(s): Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, Itani M, Nakamura M, Nishii Y, Yoshioka T, Hirose Y, Okano Y, Moriwaki H, Kozawa O.
  • Journal Title: J Biol Chem Volume: 286 Pages: 26178-26187
  • Peer Reviewed
• [Journal Article] Ultra-violet irradiation induces apoptosis via mitochondrial pathway in pancreatic cancer cells. (2011)
  • Author(s): Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Yoshioka T, Hirose Y, Kozawa O, Moriwaki H.
  • Journal Title: Int J Oncol Volume: 39 Pages: 1375-1380
  • NAID: 120006341977
  • Peer Reviewed
• [Journal Article] Ultraviolet enhances the sensitivity of pancreatic cancer cells to gemcitabine by activation of 5' AMP-activated protein kinase (2011)
  • Author(s): Adachi S, Yasuda I, Kawaguchi J, Yamauchi T, Nakashima M, Itani M, Nakamura M, Yoshioka T, Moriwaki H, Kozawa O
  • Journal Title: Biochem Biophys Res Commun Volume: 414 Pages: 53-59
  • Peer Reviewed
• [Journal Article] Phosphorylation status of heat shock protein 27 plays a key role in gemcitabine-induced apoptosis of pancreatic cancer cells. (2011)
  • Author(s): Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Itani M, Yoshioka T, Matsushima-Nishiwaki R, Hirose Y, Kozawa O, Moriwaki H.
  • Journal Title: Cancer Lett Volume: 313 Pages: 218-225
  • Peer Reviewed
• [Journal Article] Role of EUS in early detection of small pancreatic cancer. (2011)
  • Author(s): Yasuda I, Iwashita T, Doi S, Nakashima M, Moriwaki H.
  • Journal Title: Dig Endosc Volume: 23 Pages: 22-25
  • Peer Reviewed
• [Journal Article] Cholangioscopic view of IgG4-related sclerosing cholangitis. (2011)
  • Author(s): Yasuda I, Nakashima M, Moriwaki H.
  • Journal Title: J Hepatobiliary Pancreat Volume: 18 Pages: 122-124
  • NAID: 10028173307
  • Peer Reviewed
• [Journal Article] Comparison of axial force and cell width of self-expandable metallic stents: which type of stent is better suited for hilar biliary strictures? (2011)
  • Author(s): Mukai T, Yasuda I, Isayama H, Nakashima M, Doi S, Iwashita T, Iwata K, Kato T, Tomita E, Moriwaki H.
  • Journal Title: J Hepatobiliary Pancreat Volume: 18 Pages: 646-652
  • NAID: 10029688323
  • Peer Reviewed
• [Journal Article] EUS-FNA for suspected malignant biliary strictures after negative endoscopic transpapillary brush cytology and forceps biopsy. (2011)
  • Author(s): Ohshima Y, Yasuda I, Kawakami H, Kuwatani M, Mukai T, Iwashita T, Doi S, Nakashima M, Hirose Y, Asaka M, Moriwaki H.
  • Journal Title: J Gastroenterol Volume: 46 Pages: 921-928
  • NAID: 10029313333
  • Peer Reviewed
• [Journal Article] Serum interleukin-18 level is associated with the outcome of patients with diffuse large B-cell lymphoma treated with CHOP or R-CHOP regimens. (2011)
  • Author(s): Goto N, Tsurumi H, Kasahara S, Kanemura N, Hara T, Yasuda I, Shimizu M, Murakami N, Sawada M, Yamada T, Takemura M, Seishima M, Kito Y, Takami T, Moriwaki H.
  • Journal Title: Eur J Haematol Volume: 87 Pages: 217-227
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasound-guided fine-needle aspiration of lesions near the aortoiliac bifurcation via an upper gastrointestinal approach. (2011)
  • Author(s): Doi S, Yasuda I, Nakashima M, Kawaguchi J, Yamauchi T, Iwashita T, Toda K, Adachi S, Shimizu M, Tsurumi H, Moriwaki H.
  • Journal Title: J Gastroenterol Hepatol Volume: 26 Pages: 1717-1720
  • Peer Reviewed
• [Journal Article] Combined endobronchial and endoscopic ultrasound-guided fine needle aspiration for mediastinal nodal staging of lung cancer. (2011)
  • Author(s): Ohnishi R, Yasuda I, Kato T, Tanaka T, Kaneko Y, Suzuki T, Yasuda S, Sano K, Doi S, Nakashima M, Hara T, Tsurumi H, Murakami N, Moriwaki H.
  • Journal Title: Endoscopy Volume: 43 Pages: 1082-1089
  • Peer Reviewed
• [Journal Article] Combined adenomatoid tumor and well differentiated papillary mesothelioma of the omentum. (2011)
  • Author(s): Hatano Y, Hirose Y, Matsunaga K, Kito Y, Yasuda I, Moriwaki H, Osada S, Yoshida K, Hara A.
  • Journal Title: Pathology International Volume: 61 Pages: 681-685
  • NAID: 10031185141
  • Peer Reviewed
• [Journal Article] Results of a Japanese multicenter randomized trial of endoscopic stenting for non-resectable pancreatic head cancer (JM-TEST): Covered Wallstent versus Double layer stent. (2011)
  • Author(s): Isayama H, Yasuda I, Ryozawa S, Maguchi H, Igarashi Y, Matsuyama Y, Katanuma A, Hasebe O, Irisawa A, Itoi T, Mukai H, Arisaka Y, Okushima K, Uno K, Kida M, Tamada K.
  • Journal Title: Dig Endosc Volume: 23 Pages: 310-315
  • Peer Reviewed
• [Journal Article] Endoscopic hemostasis using covered metallic stent placement for uncontrolled post-endoscopic sphincterotomy bleeding. (2011)
  • Author(s): Itoi T, Yasuda I, Doi S, Mukai T, Kurihara T, Sofuni A.
  • Journal Title: Endoscopy Volume: 43 Pages: 369-372
  • Peer Reviewed
• [Journal Article] Unilateral versus bilateral endoscopic biliary stenting for malignant hilar biliary strictures
  • Author(s): Yasuda I, et al.
  • Journal Title: Dig Endosc Volume: (25 Suppl 2:81-5.)
• [Journal Article] Role of EUS in early detection of small pancreatic cancer
  • Author(s): Yasuda I, et al.
  • Journal Title: Dig Endosc Volume: 23 (Suppl 1)
• [Presentation] following endoscopic ultrasound-guided celiac plexus neurolysis (2013)
  • Author(s): Doi S, Yasuda I, et al.
  • Organizer: UEGW2013
  • Place of Presentation: Berlin Long-term outcomes
  • Year and Date: 2013-10-15
• [Presentation] 局所進行膵癌に対する術前化学放射線療法(TS-1+Radiation)の成績 (2013)
  • Author(s): 土井晋平、安田一朗ら
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2013-07-25
• [Presentation] International Symposium"Endoscopic therapy of pancreatic and biliary diseases"Interventional EUS for pancreatic diseases (2013)
  • Author(s): Yasuda I.
  • Organizer: 第85回日本消化器内視鏡学会総会 The 4^<th> ESGE-JGES Joint Symposium
  • Place of Presentation: 京都
  • Year and Date: 2013-05-10
• [Presentation] シンポジウム17「Role of oncologists and endoscopists in the management of biliary tract and pancreatic diseases」Chemotherapy and endoscopic management for patients with unresectable advanced pancreatic cancer (2012)
  • Author(s): Mukai T, Yasuda I, Tomita E.
  • Organizer: JDDW2012
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-12
• [Presentation] 膵がん治療におけるgemcitabineと紫外線(UV-C)の併用効果について (2012)
  • Author(s): 足立政治、安田一朗ら
  • Organizer: JDDW2012
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-10
• [Presentation] ゲムシタビン作用機序におけるHSP27リン酸化の役割 (2012)
  • Author(s): 中島賢憲、足立政治、安田一朗、小澤修ら
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-21
• [Presentation] 膵がん細胞に対する短波長紫外線(UV-C)とゲムシタビン併用による腫瘍増殖抑制およびアポトーシス誘導効果 (2012)
  • Author(s): 山内貴裕、足立政治、安田一朗、小澤修ら
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-19
• [Presentation] 膵がんの細胞増殖能におけるRho- kinaseの役割 (2011)
  • Author(s): 足立政治、安田一朗、小澤修ら
  • Organizer: 第42回日本膵臓学会大会
  • Place of Presentation: 弘前
  • Year and Date: 2011-07-30
• [Presentation] シンポジウム1-5「新規診断技術の有効性評価：得られたエビデンスと今後の展望 5. EUS-FNA」 リンパ腫診断におけるEUS-FNA (2011)
  • Author(s): 安田一朗、高見 剛、森脇久隆
  • Organizer: 第81回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋
• [Presentation] VTR Symposium 3「Latest advances of Interventional EUS」 EUS-CPN and EUS-CGN for pancreatobiliary cancer pain (2011)
  • Author(s): Doi S, Yasuda I, Moriwaki H
  • Organizer: 第81回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋
• [Presentation] パネルディスカッション7 「EUS-FNA関連の手技と工夫（ビデオ）」 Convex型EUSによる腹腔神経節描出のコツと腹腔神経節ブロックの治療成績 (2011)
  • Author(s): 土井晋平、安田一朗、森脇久隆
  • Organizer: JDDW2010（第53回日本消化器病学会大会・第82回日本消化器内視鏡学会総会・第9回日本消化器外科学会合同）
  • Place of Presentation: 福岡
• [Presentation] Clinical impact of endoscopic ultrasound-guided fine needle aspiration biopsy in the diagnosis of lymphoma. (2011)
  • Author(s): Yasuda I, Goto N, Tsurumi H, Adachi S, Iwashita T, Toda K, Doi S, Yamauchi T, Nakashima M, Kawaguchi J, Takami T, Moriwaki H.
  • Organizer: Digestive Disease Week (DDW) 2011
  • Place of Presentation: Chicago
• [Presentation] Endoscopic ultrasound-guided core needle biopsy for diagnosis of lymphoma: feasibility of immunophenotypic and cytogenetic assessments. (2011)
  • Author(s): Yasuda I, Goto N, Tsurumi H, Nakashima M, Doi S, Iwashita T, Takami T, Moriwaki H.
  • Organizer: Asian Pacific Digestive Disease Week 2011(APDW 2011)
  • Place of Presentation: Singapore
• [Presentation] Endoscopic ultrasound-guided direct celiac ganglia versus celiac plexus neurolysis : a randomized multi- center trial
  • Author(s): Doi S, Yasuda I, et al.
  • Organizer: 18th International Symposium on Endoscopic Ultrasonography (EUS 2012)
  • Place of Presentation: St. Petersburg
• [Presentation] The 4th ESGE-JGES Joint Symposium International Symposium 1 “Endoscopic therapy of pancreatic and biliary diseases” Interventional EUS for pancreatic diseases
  • Author(s): Ichiro Yasuda
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 京都
• [Presentation] The 4th ESGE-JGES Joint Symposium International Symposium 1 “Endoscopic therapy of pancreatic and biliary diseases” A Japanese multicenter retrospective study of endoscopic ultrasound-guided biliary drainage (EUS-BD) for malignant biliary obstruction
  • Author(s): Hiroyuki Isayama, Kazumichi Kawakubo, Hironari Kato, Takao Itoi, Hiroshi Kawakami, Keiji Hanada, Hirotoshi Ishiwatari, Ichiro Yasuda, Hirofumi Kawamoto, Fumihide Itokawa, Masaki Kuwatani, Tomohiro Iiboshi, Tsuyoshi Hayashi, Shinpei Doi, Yousuke Nakai
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 京都
• [Presentation] プレナリーセッション1 「ERCP・胆道ステント」 胆道疾患に対する超音波内視鏡下順行性アプローチ
  • Author(s): 岩下拓司、安田一朗、森脇久隆
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 京都
• [Presentation] プレナリーセッション1 「ERCP・胆道ステント」 胆道病変に対するEUS-FNA
  • Author(s): 大島靖広、安田一朗、山内貴裕、安藤暢洋、岩田圭介、杉原潤一、馬淵正敏、上村真也、土井晋平、岩下拓司、中島賢憲、向井 強、廣瀬善信、冨田栄一、森脇久隆
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 京都
• [Presentation] プレナリーセッション11 「胃SMT/EUS-FNA」 胃粘膜下腫瘍に対する19-gauge針を用いたEUS-FNAの診断能
  • Author(s): 馬淵正敏、安田一朗、森脇久隆、岩下拓司、土井晋平、上村真也、廣瀬善信、向井 強、中島賢憲、冨田栄一
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 京都
• [Presentation] VTRシンポジウム2 「Interventional EUSの進歩」 膵癌性疼痛に対するEUS下腹腔神経叢/神経節ブロックに関する検討
  • Author(s): 岩田圭介、安田一朗、向井 強
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 京都
• [Presentation] プレナリーセッション21 「膵EUS-FNA・ステント」 副腎病変に対するEUS-FNAの有用性
  • Author(s): 上村真也、安田一朗、馬淵正敏、土井晋平、岩下拓司、後藤尚絵、廣瀬善信、高見 剛、森脇久隆
  • Organizer: 第85回日本消化器内視鏡学会総会
  • Place of Presentation: 京都
• [Presentation] EUS-guided 19-gauge fine needle aspiration biopsy for the diagnosis of both left and right adrenal lesions
  • Author(s): Shinya Uemura, Ichiro Yasuda, Takuji Iwashita, Masatoshi Mabuchi, Shinpei Doi, Hisataka Moriwaki
  • Organizer: Digestive Disease Week 2013 (DDW2013)
  • Place of Presentation: 米国
• [Presentation] Endoscopic ultrasound-guided antegrade treatments for biliary disorders in patients with surgically altered anatomy
  • Author(s): Takuji Iwashita, Ichiro Yasuda, Shinpei Doi, Shinya Uemura, Masatoshi Mabuchi, Tsuyoshi Mukai, Hisataka Moriwaki.
  • Organizer: Digestive Disease Week 2013 (DDW2013)
  • Place of Presentation: 米国
• [Presentation] A multicenter retrospective study of endoscopic ultrasound-guided biliary drainage (EUS-BD) for malignant biliary obstruction in Japan
  • Author(s): Hiroyuki Isayama, Kazumichi Kawakubo, Hironari Kato, Takao Itoi, Hiroshi Kawakami, Keiji Hanada, Hirotoshi Ishiwatari, Ichiro Yasuda, Hirofumi Kawamoto, Fumihide Itokawa, Masaki Kuwatani, Tomohiro Iiboshi, Tsuyoshi Hayashi, Shinpei Doi, Yousuke Nakai.,
  • Organizer: Digestive Disease Week 2013 (DDW2013)
  • Place of Presentation: 米国
• [Presentation] Japanese multicenter experience of endoscopic necrosectomy for infected walled-off pancreatic necrosis: The JENIPaN study
  • Author(s): Ichiro Yasuda, Masanori Nakashima, Tomohisa Iwai, Hiroyuki Isayama, Takao Itoi, Hiroyuki Hisai, Hiroyuki Inoue, Hironari Kato, Atsushi Kanno, Kensuke Kubota, Atsushi Irisawa, Hisato Igarashi, Yoshinobu Okabe, Masayuki Kitano, Hiroshi Kawakami, Tsuyoshi Hayashi, Tsuyoshi Mukai, Mitsuhiro Kida, Tooru Shimosegawa.
  • Organizer: Digestive Disease Week 2013 (DDW2013)
  • Place of Presentation: 米国
• [Presentation] 局所進行膵癌に対する術前化学放射線療法(TS-1+Radiation)の成績
  • Author(s): 土井晋平、安田一朗、森脇久隆、岩下拓司、上村真也、馬淵正敏、長田真二、佐々木義之、今井 寿、 向井 強、中島賢憲、冨田栄一、岩田圭介、安藤暢洋、山内貴裕
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台
• [Presentation] 特別企画2 「急性膵炎・慢性膵炎に対する内視鏡・腹腔鏡治療の最前線」 Walled-off pancreatic necrosisに対する内視鏡的ネクロセクトミー
  • Author(s): 安田一朗、中島賢憲、岩井知久、伊佐山浩通、糸井隆夫、久居弘幸、井上宏之、加藤博也、菅野 敦、窪田賢輔、入澤篤志、五十嵐久人、岡部義信、北野雅之、河上 洋、林 毅、向井 強、佐田尚宏、木田光弘、下瀬川徹
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台
• [Presentation] 局所進行膵癌に対するS1併用術前化学放射線療法の成績
  • Author(s): 土井 晋平, 安田 一朗, 森脇 久隆, 岩下 拓司, 上村 真也, 馬淵 正敏, 長田 真二, 佐々木 義之, 今井 寿, 向井 強, 中島 賢憲, 冨田 栄一, 岩田 圭介, 安藤 暢洋, 山内 貴裕
  • Organizer: JDDW2013（第55回日本消化器病学会大会）
  • Place of Presentation: 東京
• [Presentation] International Session 3 「IgG4-related disease and endoscopy」 EUS-FNA using a standard 19-gauge needle for the diagnosis of autoimmune pancreatitis
  • Author(s): Iwashita T, Yasuda I, Moriwaki H
  • Organizer: JDDW2013（第55回日本消化器病学会大会・第86回日本消化器内視鏡学会総会合同）
  • Place of Presentation: 東京
• [Presentation] International Session 8 「Recent advances in Interventional EUS」 Endoscopic ultrasound-guided direct celiac ganglia versus celiac plexus neurolysis: A randomized multicenter trial
  • Author(s): Doi S, Yasuda I, Kawakami H
  • Organizer: JDDW2013（第55回日本消化器病学会大会・第86回日本消化器内視鏡学会総会合同）
  • Place of Presentation: 東京
• [Presentation] シンポジウム 4 「IgG4関連膵胆道疾患の診断と治療」 自己免疫性膵炎診断におけるEUS-FNAの有用性
  • Author(s): 奥野 充、岩下 拓司、安田 一朗
  • Organizer: JDDW2013（第55回日本消化器病学会大会・第86回日本消化器内視鏡学会総会・第17回日本肝臓学会大会合同）
  • Place of Presentation: 東京
• [Presentation] シンポジウム 16 「Endoscopic oncology」 EUS-FNAによるリンパ腫の診断
  • Author(s): 丸田 明範、安田 一朗、森脇久隆
  • Organizer: JDDW2013（第55回日本消化器病学会大会・第86回日本消化器内視鏡学会総会合同）
  • Place of Presentation: 東京
• [Presentation] ワークショップ 23 「胆膵内視鏡のトラブルシューティング」 ERCP困難な術後変更解剖症例の胆道病変に対するEUS下順行性治療
  • Author(s): 岩下 拓司、安田一朗、森脇久隆
  • Organizer: JDDW2013（第86回日本消化器内視鏡学会総会）
  • Place of Presentation: 東京
• [Presentation] EUS-FNAによってGISTのリスク分類診断は可能か？
  • Author(s): 馬淵 正敏, 安田 一朗, 岩下 拓司, 土井 晋平, 上村 真也, 高松 学, 広瀬 善信, 森脇 久隆
  • Organizer: JDDW2013（第86回日本消化器内視鏡学会総会）
  • Place of Presentation: 東京
• [Presentation] 縦隔・肺門近傍の末梢型肺癌に対するEUS-FNA
  • Author(s): 馬淵 正敏, 安田 一朗, 加藤 達雄, 大西 涼子, 上村 真也, 土井 晋平, 岩下 拓司, 森脇 久隆
  • Organizer: JDDW2013（第86回日本消化器内視鏡学会総会）
  • Place of Presentation: 東京
• [Presentation] 副腎腫瘤に対するEUS-FNAによる病理組織診断
  • Author(s): 上村 真也, 安田 一朗, 馬淵 正敏, 土井 晋平, 岩下 拓司, 廣瀬 善信, 高見 剛, 森脇 久隆
  • Organizer: JDDW2013（第86回日本消化器内視鏡学会総会）
  • Place of Presentation: 東京
• [Presentation] Oral session “Advances in biliopancreatic imaging” SINGLE-OPERATOR CHOLANGIOPANCREATOSCOPY (SOCPS) IN PATIENTS REQUIRING DIAGNOSIS AND THERAPY FOR BILIARY AND PANCREATIC DISEASES: PROSPECTIVE MULTI-CENTER STUDY IN JAPAN
  • Author(s): Kurihara T, Itoi T, Yasuda I, Tsuyuguchi T, Isayama H.
  • Organizer: UEGW2013
  • Place of Presentation: ドイツ
• [Presentation] HISTOPATHOLOGICAL DIAGNOSIS OF BOTH LEFT AND RIGHT LESIONS BY ENDOSCOPIC ULTRASOUND-GUIDED ASPIRATION BIOPSY WITH A LARGE CALIBRE NEEDLE
  • Author(s): Yasuda I, Uemura S, Mabuchi M, Doi S, Iwashita T, Moriwaki H.
  • Organizer: UEGW2013
  • Place of Presentation: ドイツ
• [Presentation] LONG-TERM OUTCOMES FOLLOWING ENDOSCOPIC ULTRASOUND-GUIDED CELIAC PLEXUS NEUROLYSIS
  • Author(s): Doi S, Yasuda I, Mabuchi M, Uemura S, Iwashita T, Nakashima M, Mukai T, Tomita E, Moriwaki H.
  • Organizer: UEGW2013
  • Place of Presentation: ドイツ
• [Presentation] A PROSPECTIVE MULTICENTER STUDY OF A FULLYCOVERED METAL STENT IN PATIENTS WITH DISTAL MALIGNANT BILIARY OBSTRUCTION: WATCH-2 STUDY.
  • Author(s): Kogure H, Ryozawa S, Isayama H, Maetani I, Nakai Y, Kawakami H, Yasuda I, Mochizuki H, Iwano H, Maguchi H, Kida M, Kubota K, Mukai T, Hasebe O, Igarashi Y, Hanada K, Irisawa A, Itoi T, Ito K.
  • Organizer: UEGW2013
  • Place of Presentation: ドイツ
• [Presentation] INTERIM ANALYSIS OF A PILOT STUDY OF NEW COVERED METALLIC STENTS WITH A LARGE BORE SIZE (NITI-S SUPREMO-12 STENT) FOR UNRESECTABLE DISTAL BILIARY MALIGNANCIES
  • Author(s): Mukai T, Yasuda I, Isayama H, Kawakami H, Itoi T, Nakai Y, Kogure H.
  • Organizer: UEGW2013
  • Place of Presentation: ドイツ
• [Presentation] International Symposium I「EUS-FNA: Current status and new developments」 Combined approach of transesophageal and transbronchial EUS for mediastinal nodal staging of lung cancer.
  • Author(s): Yasuda I, Ohnishi R, Moriwaki H.
  • Organizer: 第83回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
• [Presentation] シンポジウム4「EUSガイド下治療の適応と限界」 Peripancreatic fluid collectionに対するEUS下ドレナージの適応と限界
  • Author(s): 岩田圭介、安田一朗、向井 強
  • Organizer: 第83回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
• [Presentation] バーチャルライブIV「EUS-FNA関連手技」 EUS下腹腔神経叢ブロック・神経節ブロック(EUS-CPN/-CGN)
  • Author(s): 安田一朗、土井晋平、上村真也、山内貴裕、森脇久隆
  • Organizer: 第83回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
• [Presentation] パネルディスカッション5「慢性膵炎の内視鏡診断と治療」 自己免疫性膵炎診断におけるEUS-FNAの有用性と限界
  • Author(s): 岩下拓司、安田一朗、森脇久隆
  • Organizer: 第83回日本消化器内視鏡学会総会
  • Place of Presentation: 東京
• [Presentation] Preoperative routine evaluation of bilateral adrenal glands by EUS/EUS-FNA in patients with potentially resectable lung cancer.
  • Author(s): Yasuda I, Uemura S, Doi S, Kawaguchi J, Yamauchi T, Iwashita T, Moriwaki H.
  • Organizer: 18th International Symposium on Endoscopic Ultrasonography (EUS2012)
  • Place of Presentation: St. Petersburg
• [Presentation] Endoscopic ultrasound-guided direct celiac ganglia versus celiac plexus neurolysis: a randomized multicenter trial.
  • Author(s): Doi S, Yasuda I, Kawakami H, Hayashi T, Hisai H, Irisawa A, Mukai T, Katanuma A, Kubota K, Ohnishi T, Ryozawa S, Hara K, Itoi T, Hanada K, Yamao K, Moriwaki H.
  • Organizer: 18th International Symposium on Endoscopic Ultrasonography (EUS2012)
  • Place of Presentation: St. Petersburg
• [Presentation] EUS-FNA for splenic lesions
  • Author(s): Uemura S, Yasuda I, Iwashita T, Doi S, Yamauchi T, Moriwaki H.
  • Organizer: 18th International Symposium on Endoscopic Ultrasonography (EUS2012)
  • Place of Presentation: St. Petersburg
• [Presentation] Session XI “Bilio-pancreatic Drainage in Difficult Situations” Invited Lecture（招待講演）「EUS-guided bilio-pancreatic drainage: when and how?」
  • Author(s): Yasuda I.
  • Organizer: SGI2012 (The 6th Meeting of the Society of Gastrointestinal Intervention)
  • Place of Presentation: Seoul
  • Invited
• [Presentation] シンポジウム17「Role of oncologists and endoscopists in the management of biliary tract and pancreatic diseases」 Chemotherapy and endoscopic management for patients with unresectable advanced pancreatic cancer.
  • Author(s): Mukai T, Yasuda I, Tomita E
  • Organizer: JDDW2012（第54回日本消化器病学会大会・第84回日本消化器内視鏡学会総会合同）
  • Place of Presentation: 神戸
• [Presentation] シンポジウム16「胆膵疾患に対するtherapeutic EUSの現状」 Peripanceratic fluid collectionに対するEUSガイド下治療の現状
  • Author(s): 岩田圭介、安田一朗、向井 強
  • Organizer: JDDW2012（第54回日本消化器病学会大会・第84回日本消化器内視鏡学会総会合同）
  • Place of Presentation: 神戸
• [Presentation] ワークショップ16「消化器癌に対する緩和医療」 超音波内視鏡ガイド下腹腔神経叢ブロックの長期成績
  • Author(s): 土井晋平、安田一朗、森脇久隆
  • Organizer: JDDW2012（第54回日本消化器病学会大会・第10回日本消化器外科学会大会合同）
  • Place of Presentation: 神戸
• [Book] 胆膵内視鏡治療―手技の極意とトラブルシューティング (2012)
  • Author(s): 安田一朗
  • Total Pages: 286
  • Publisher: 羊土社
• [Book] ＥＵＳ下穿刺術―Interventional EUSの基礎と実践テクニック (2011)
  • Author(s): 安田一朗．
  • Total Pages: 236
  • Publisher: 南江堂
• [Book] 消化器BOOK 05『症状・画像から見抜く！膵胆道系の鑑別診断』 (2011)
  • Author(s): 安田一朗．
  • Total Pages: 227
  • Publisher: 羊土社