| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Although high serum levels of B cell-activating factor (BAFF) are reported in patients with autoimmune pancreatitis (AIP) and some malignant diseases, its role in the pathogenesis remains unclear. In this study, we aimed to understand the role of BAFF in the pathogenesis of AIP and pancreatic cancer (PC). First, using serum and pancreatic tissues from patients with PC, and PC cell line, we showed that BAFF was elevated in patients with metastatic advanced PC and induced alterations in PC cells via regulation of EMT-related genes. Second, using serum and pancreatic tissues from patients with AIP, and mice with various features of AIP, we identified that overexpression of lymphotoxin (LT) beta specifically in acinar cells of mice caused features of AIP.
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