Clinical Significance of BAFF and APRIL in AIP

• Project/Area Number: 23591014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: KUMAGI Teru 愛媛大学, 医学(系)研究科(研究院), 寄附講座准教授 (30594147)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 自己免疫性膵炎 / 膵癌 / BAFF / APRIL / 鑑別診断 / 治療効果判定 / 病態解明

Research Abstract

Although high serum levels of B cell-activating factor (BAFF) are reported in patients with autoimmune pancreatitis (AIP) and some malignant diseases, its role in the pathogenesis remains unclear. In this study, we aimed to understand the role of BAFF in the pathogenesis of AIP and pancreatic cancer (PC). First, using serum and pancreatic tissues from patients with PC, and PC cell line, we showed that BAFF was elevated in patients with metastatic advanced PC and induced alterations in PC cells via regulation of EMT-related genes. Second, using serum and pancreatic tissues from patients with AIP, and mice with various features of AIP, we identified that overexpression of lymphotoxin (LT) beta specifically in acinar cells of mice caused features of AIP.

Research Products

• [Journal Article] Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response. (2014)
  • Author(s): Trivedi P, Bruns T, Cheung AC, Li KK, Kumagi T, Shah H, Corbett C, Al-Harthy N, Acarsu U, Coltescu C, Tripathi D, Neuberger J, Janssen H, Hirschfield GM.
  • Journal Title: J Hepatol Volume: 6 Issue: 6 Pages: 1249-1258
  • DOI: 10.1016/j.jhep.2014.01.029
  • Peer Reviewed
• [Journal Article] Local recurrence of hepatocellular carcinoma in the tumor blood drainage area following radiofrequency ablation. (2014)
  • Author(s): Hirooka M, Ochi H, Koizumi Y, Tokumoto Y, Hiraoka A, Kumagi T, Abe M, Tanaka H, Hiasa Y
  • Journal Title: Mol Clin Oncol Volume: 2 Pages: 182-186
  • Peer Reviewed
• [Journal Article] Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer (2013)
  • Author(s): Koizumi M, Hiasa Y, Kumagi T, et al.
  • Journal Title: PLoS One Volume: Aug 6;8(8)
  • Peer Reviewed
• [Journal Article] as the Ehime Pancreato-Cholangiology (EPOCH) Study Group. Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era : A collaborative retrospective multi- center clinical review of 1,082 patients (2013)
  • Author(s): Kuroda T, Kumagi T, Yokota T, et al.
  • Journal Title: BMC Gastroenterology Volume: 13 Pages: 134-134
  • Peer Reviewed
• [Journal Article] 当科で経過をおえた膵癌stageIVb死亡症例における予後因子の検討 (2013)
  • Author(s): 畔元信明、熊木天児、黒田太良, 他
  • Journal Title: 愛媛医学 Volume: 32 Pages: 15-18
  • Peer Reviewed
• [Journal Article] Improvement of long-term outcomes in pancreatic cancer and its associated factors within the gemcitabine era: A collaborative retrospective multicenter clinical review of 1,082 patients. (2013)
  • Author(s): Kuroda T, Kumagi T, Yokota T, Seike H, Nishiyama M, Imai Y, et al., as the Ehime Pancreato-Cholangiology (EPOCH) Study Group.
  • Journal Title: BMC Gastroenterol Volume: 13 Issue: 1 Pages: 134-134
  • DOI: 10.1186/1471-230x-13-134
  • Peer Reviewed
• [Journal Article] Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer. (2013)
  • Author(s): Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Kobata T, Matsuura B, Abe M, Onji M.
  • Journal Title: PLoS One Volume: 8 Issue: 8 Pages: e71367-e71367
  • DOI: 10.1371/journal.pone.0071367
  • Peer Reviewed
• [Journal Article] Nocturnal intermittent hypoxia as an associated risk factor for microalbuminuria in Japanese patients with type 2 diabetes mellitus. (2013)
  • Author(s): Furukawa S, Saito I, Yamamoto S, Miyake T, Ueda T, Niiya T, Torisu M, Kumagi T, Sakai T, Minami H, Miyaoka H, Sakurai S, Matsuura B, Onji M, Tanigawa T.
  • Journal Title: Eur J Endocrinol Volume: 169 Issue: 2 Pages: 239-246
  • DOI: 10.1530/eje-13-0086
  • Peer Reviewed
• [Journal Article] Nonalcoholic fatty liver disease: Factors associated with its presence and onset. (2013)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Tokumoto Y, Hirooka M, Abe M, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: J Gastroenterol Hepatol Volume: Suppl 4 Issue: S4 Pages: 71-78
  • DOI: 10.1111/jgh.12251
  • Peer Reviewed
• [Journal Article] Oral administration of carbonic anhydrase I ameliorates murine experimental colitis induced by Foxp3-CD4+CD25- T cells. (2013)
  • Author(s): Mori K, Yamanishi H, Ikeda Y, Kumagi T, Hiasa Y, Matsuura B, Abe M, Onji M.
  • Journal Title: J Leukoc Biol Volume: 93 Issue: 6 Pages: 963-972
  • DOI: 10.1189/jlb.1212612
  • Peer Reviewed
• [Journal Article] B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease. (2013)
  • Author(s): Miyake T, Abe M, Tokumoto Y, Hirooka M, Furukawa S, Kumagi T, Hamada M, Kawasaki K, Tada F, Ueda T, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: Hepatol Int Volume: 7 Issue: 2 Pages: 539-547
  • DOI: 10.1007/s12072-012-9345-8
  • Peer Reviewed
• [Journal Article] Body Mass Index as the Predictive Factor for the Onset of Nonalcoholic Fatty Liver Disease: A Community-based Retrospective Longitudinal Cohort Study. (2013)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Furukawa S, Koizumi M, Tokumoto Y, Ueda T, Yamamoto S, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: J Gastroenterol Volume: 48 Issue: 3 Pages: 413-422
  • DOI: 10.1007/s00535-012-0650-8
  • Peer Reviewed
• [Journal Article] LymphotoxinβReceptor Signaling Promotes Development of Autoimmune Pancreatitis (2012)
  • Author(s): Seleznik GM, Reding T, Kumagi T, et al.
  • Journal Title: Gastroenterology Volume: 143 Pages: 1361-74
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. (2012)
  • Author(s): Nakamura M
  • Journal Title: Am J Hum Genet. Volume: 91 Issue: 4 Pages: 721-728
  • DOI: 10.1016/j.ajhg.2012.08.010
  • Peer Reviewed
• [Journal Article] Lymphotoxin β Receptor Signaling Promotes Development of Autoimmune Pancreatitis. (2012)
  • Author(s): Seleznik GM, Reding T, Romrig F,…… Kumagi T, et al.
  • Journal Title: Gastroenterology Volume: 143 Issue: 5 Pages: 1361-1374
  • DOI: 10.1053/j.gastro.2012.07.112
  • Peer Reviewed
• [Journal Article] High Serum Palmitic Acid is Associated with Low Antiviral Effects of Interferon-Based Therapy for Hepatitis C Virus. (2012)
  • Author(s): Miyake T, Hiasa Y, Hirooka M, Tokumoto Y, Watanabe T, Furukawa S, Ueda T, Yamamoto S, Kumagi T, Miyaoka H, Abe M, Matsuura B, Onji M.
  • Journal Title: Lipids Volume: 47 Issue: 11 Pages: 1053-1062
  • DOI: 10.1007/s11745-012-3716-8
  • Peer Reviewed
• [Journal Article] Natural history and management of primary biliary cirrhosis. (2012)
  • Author(s): Al-Harthy N, Kumagi T
  • Journal Title: Hepatic Medicine: Evidence and Research Volume: 4 Pages: 61-71
  • DOI: 10.2147/hmer.s25998
  • Peer Reviewed
• [Journal Article] Metabolic Markers and ALT Cutoff Level for Diagnosing Nonalcoholic Fatty Liver Disease: A Community-based Cross-sectional Study. (2012)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Koizumi M, Furukawa S, Ueda T, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: J Gastroenterol Volume: 47 Issue: 6 Pages: 696-703
  • DOI: 10.1007/s00535-012-0534-y
  • NAID: 10030802769
  • Peer Reviewed
• [Journal Article] Long-term Branched-chain Amino Acid Supplementation Improves Glucose Tolerance in Patients with Nonalcoholic Steatohepatitis-related Cirrhosis. (2012)
  • Author(s): Miyake T, Abe M, Furukawa S, Tokumoto Y, Toshimitsu K, Ueda T, Yamamoto S, Hirooka M, Kumagi T, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: Intern Med Volume: 51 Pages: 2151-2155
  • NAID: 130002062298
  • Peer Reviewed
• [Journal Article] A relationship between motilin and growth hormone secretagogue receptors. (2012)
  • Author(s): Nunoi H, Matsuura B, Utsunomiya S, Ueda T, Miyake T, Furukawa S, Kumagi T, Ikeda Y, Abe M, Hiasa Y, Onji M.
  • Journal Title: Regul Pept Volume: 176 Issue: 1-3 Pages: 28-35
  • DOI: 10.1016/j.regpep.2012.03.001
  • Peer Reviewed
• [Journal Article] Suicide attempt by an overdose of sitagliptin, an oral hypoglycemic agent: A case report and a review of the literature. (2012)
  • Author(s): Furukawa S, Kumagi T, Miyake T, Ueda T, Niiya T, Nishino K, Murakami S, Murakami M, Matsuura B, Onji M.
  • Journal Title: Endocrine J Volume: 59 Pages: 329-333
  • NAID: 10030749488
  • Peer Reviewed
• [Journal Article] An unusual case of subclinical diffuse glucagonoma coexisting with two nodules in the pancreas: characteristic features on computed tomography. (2012)
  • Author(s): Azemoto N, Kumagi T, Yokota T, Kuroda T, Koizumi M, Yamanishi H, Soga Y, Furukawa S, Abe M, Ikeda Y, Hiasa Y, Matsuura B, Watanabe J, Kushihata F, Onji M.
  • Journal Title: Clin Res Hepatol Gastroenterol Volume: 36 Issue: 3 Pages: 43-47
  • DOI: 10.1016/j.clinre.2011.12.003
  • Peer Reviewed
• [Journal Article] Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8 (2012)
  • Author(s): Tokumoto Y, Hiasa Y, Uesugi K, 他7名、2番目
  • Journal Title: Journal of Infectious Diseases Volume: 205 Issue: 7 Pages: 1121-1130
  • DOI: 10.1093/infdis/jis025
  • Peer Reviewed
• [Journal Article] Regulatory Dendritic Cells Pulsed with Carbonic Anhydrase I Protect Mice from Colitis Induced by CD4+CD25− T Cells. (2012)
  • Author(s): Yamanishi H, Murakami H, Ikeda Y, Kumagi T, Hiasa Y, Abe M, Matsuura B, Onji M.
  • Journal Title: J Immunol Volume: 188 Issue: 5 Pages: 2164-2172
  • DOI: 10.4049/jimmunol.1100559
  • Peer Reviewed
• [Journal Article] Biliary atresia and survival into adulthood without transplantation: a collaborative multi-centre clinic review. (2012)
  • Author(s): Kumagi T, Drenth JPH, Guttman O, Ng V, Lilly L, Therapondos G, Hiasa Y, Michitaka K, Onji M, Watanabe Y, Sen S, Griffiths W, Roberts E, Heathcote EJ, Hirschfield GM.
  • Journal Title: Liver Int Volume: 32 Issue: 3 Pages: 510-518
  • DOI: 10.1111/j.1478-3231.2011.02668.x
  • Peer Reviewed
• [Journal Article] Ulcerative colitis complicated with primary biliary cirrhosis. (2011)
  • Author(s): Tada F, Abe M, Nunoi H, Azemoto N, Mashiba T, Furukawa S, Kumagi T, Murakami H, Ikeda Y, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Intern Med Volume: 50 Pages: 2323-2327
  • NAID: 130001087740
  • Peer Reviewed
• [Journal Article] Epithelial Cyst Arising in an Intrapancreatic Accessory Spleen: A Diagnostic Dilemma. (2011)
  • Author(s): Yamanishi H, Kumagi T*, Yokota T, Koizumi M, Azemoto N, Watanabe J, Mizuno Y, Sugita A, Abe M, Ikeda Y, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Intern Med . Volume: 50 Pages: 1947-1952
  • NAID: 130000969301
  • Peer Reviewed
• [Journal Article] Characteristics of small-bowel tumors detected by double balloon endoscopy. (2011)
  • Author(s): Imaoka H, Higaki N, Kumagi T*, Miyaike J, Ohmoto M, Yamauchi K, Murakami T, Murakami H, Ikeda Y, Yokota T, Shibata N, Ninomiya T, Abe M, Hiasa Y, Matsuura B, Onji M, Umeda M, Horiike N.
  • Journal Title: Dig Dis Sci Volume: 50 Pages: 2366-2371
  • Peer Reviewed
• [Journal Article] Biochemical response to ursodeoxycholic acid predicts long-term outcome in Japanese patients with primary biliary cirrhosis. (2011)
  • Author(s): Azemoto N, Kumagi T*, Abe M, Konishi I, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Hepatol Res Volume: 41 Pages: 310-317
  • NAID: 10031144095
  • Peer Reviewed
• [Journal Article] Clinical significance of B Cell-Activating Factor in Autoimmune Pancreatitis. (2011)
  • Author(s): Yamanishi H, Kumagi T, Yokota T, Azemoto N, Koizumi M, Kobayashi Y, Abe M, Murakami H, Hiasa Y, Matsuura B, Kawamoto H, Yamamoto K, Onji M.
  • Journal Title: Pancreas Volume: 40 Pages: 840-845
  • Peer Reviewed
• [Journal Article] Hepatocellular carcinoma in case of Wilson’s disease treated with radiofrequency ablation therapy. (2011)
  • Author(s): Ikegawa S, Hiraoka A, Shimizu Y, Hidaka S, Tazuya N, Ichiryu M, Nakahara H, Tanabe A, Tanihira T, Hasebe A, Miyamoto Y, Ninomiya T, Hirooka M, Kumagi T, Abe M, Hiasa Y, Onji M, Michitaka K.
  • Journal Title: Intern Med Volume: 50 Pages: 1433-1437
  • NAID: 130000770522
  • Peer Reviewed
• [Journal Article] Severe hypoglycemia associated with insulin-like growth factor II-producing liver metastasis from gastric carcinoma treated with overnight total parenteral nutrition via a central vein catheter reserve port. (2011)
  • Author(s): Koizumi Y, Hiraoka A, Michitaka K, Tazuya N, Ichiryu M, Nakahara H, Ochi H, Tanabe A, Hidaka S, Kodama A, Uehara T, Hasebe A, Miyamoto Y, Ninomiya T, Kumagi T, et al.
  • Journal Title: Clin J Gastroenterol Volume: 4 Pages: 68-72
  • Peer Reviewed
• [Journal Article] Trancatheter arterial embolization with fine-powder cisplatin-lipiodol for HCC. (2011)
  • Author(s): Koizumi Y, Hirooka M, Uehara T, Kisaka Y, Uesugi K, Kumagi T, Abe M, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Hepatogastroenterology Volume: 58 Pages: 512-5
  • Peer Reviewed
• [Presentation] 膵癌進展に及ぼすB細胞活性化因子(BAFF)の作用 (2013)
  • Author(s): 小泉光仁,日浅陽一,熊木天児,阿部雅則,松浦文三,恩地森一
  • Organizer: 第44回日本膵臓学会大会
  • Place of Presentation: 仙台
• [Presentation] 新規化学療法時代における愛媛県膵癌診療の現状と展望 (2013)
  • Author(s): 熊木天児,黒田太良,横田智行,清家裕貴,西山麻里,今井祐輔,稲田暢,柴田直純,今峰聡,岡田眞一,小泉光仁,山西浩文,畔元信明,長谷部昌,田中良憲,達川はるか,宇都宮大貴,恩地森一,日浅陽一
  • Organizer: 第99回日本消化器病学会四国支部例会
  • Place of Presentation: 高知
• [Presentation] Changes in the characteristics and prognosis of pancreatic cancer within the gemcitabine era and the issues facing elderly patients (2013)
  • Author(s): Kuroda T,Kumagi T,Yokota T,Seike H,Miyaike J,Nishiyama M,Imai Y,Tatsukawa H,Shibata N,Koizumi M,Yamanishi H,Azemoto N,Abe M,Matsuura B,Hiasa Y,Onji M.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando,USA
• [Presentation] Increased B cell-activating factor promotes epithelial- mesenchymal transition in human pancreatic cancer (2013)
  • Author(s): Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Abe M, Ikeda Y, Matsuura B, Onji M.
  • Organizer: Digestive Disease Week 2013
  • Place of Presentation: Orlando,USA
• [Presentation] 高齢者に対する膵癌診療の実態および問題点 (2013)
  • Author(s): 黒田太良,熊木天児,小泉光仁,畔元信明,山西浩文,恩地森一、横田智行、清家裕貴、長谷部昌、今井祐輔、田中良憲、稲田暢
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] Changes in the characteristics and prognosis of pancreatic cancer within the gemcitabine era and the issues facing elderly patients (2013)
  • Author(s): Kuroda T，Kumagi T，Yokota T，Seike H，Miyaike J，Nishiyama M，Imai Y，Tatsukawa H，Shibata N，Koizumi M，Yamanishi H，Azemoto N，Abe M，Matsuura B，Hiasa Y，Onji M
  • Organizer: Digestive Disease Week
  • Place of Presentation: Orlando, USA
• [Presentation] Increased B cell-activating factor promotes epithelial-mesenchymal transition in human pancreatic cancer (2013)
  • Author(s): Koizumi M, Hiasa Y, Kumagi T, Yamanishi H, Azemoto N, Abe M, Ikeda Y, Matsuura B, Onji M
  • Organizer: Digestive Disease Week
  • Place of Presentation: Orlando, USA
• [Presentation] IgG4 関連疾患診断における肝組織検査の有用性 (2013)
  • Author(s): 徳本良雄，阿部雅則，多田藤政，畔元信明，熊木天児，日浅陽一，恩地森一
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] 新規化学療法時代における愛媛県膵癌診療の現状と展望 (2013)
  • Author(s): 熊木天児，黒田太良，横田智行，清家裕貴，西山麻里，今井祐輔，稲田 暢，柴田直純，今峰 聡，岡田眞一，小泉光仁，山西浩文，畔元信明，長谷部昌，田中良憲，達川はるか，宇都宮大貴，恩地森一，日浅陽一
  • Organizer: 第99回 日本消化器病学会四国支部例会
  • Place of Presentation: 高知
• [Presentation] 愛媛県消化器内科における膵癌診療の実態 (2012)
  • Author(s): 黒田太良,熊木天児,小泉光仁,畔元信明,山西浩文,恩地森一,横田智行,清家裕貴,上原貴秀,今井祐輔,達川はるか,宇都宮大貴,西山麻里,稲田暢,芝田直純,今峰聡,岡田眞一
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸
• [Presentation] 当科における膵癌stageIVb患者の予後を規定する因子の検討 (2012)
  • Author(s): 畔元信明,熊木天児,山西浩文,黒田太良,小泉光仁,阿部雅則,松浦文三,日浅陽一,恩地森一
  • Organizer: 第43回日本膵臓学会大会
  • Place of Presentation: 山形
• [Presentation] 横断調査に基づく超高齢者2型糖尿病の治療実態に関する検討 (2012)
  • Author(s): 松田隼弥，古川慎哉，横本祐希，安部陽介，高木康平，垣生恭佑，熊木天児，日浅陽一，松浦文三，恩地森一
  • Organizer: 第109回日本内科学会講演会
  • Place of Presentation: 京都市
• [Presentation] ペルフルブタンを用いた造影超音波検査による慢性膵炎病期診断の試み (2012)
  • Author(s): 畔元信明，熊木天児，恩地森一
  • Organizer: 第98回日本消化器病学会総会 シンポジウム
  • Place of Presentation: 東京
• [Presentation] ウルソデオキシコール酸に対する治療反応性による原発性胆汁性肝硬変の予後予測 (2012)
  • Author(s): 畔元信明，熊木天児，阿部雅則，眞柴寿枝，日浅陽一，恩地森一
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢市
• [Presentation] 当科における膵癌stage IVb患者の予後を規定する因子の検討 (2012)
  • Author(s): 畔元信明，熊木天児，山西浩文，黒田太良，小泉光仁，阿部雅則，松浦文三，日浅陽一，恩地森一
  • Organizer: 第43回日本膵臓学会大会
  • Place of Presentation: 山形市
• [Presentation] 剖検により診断された胆嚢印環細胞癌の1例 (2012)
  • Author(s): 小田眞由，黒田太良，熊木天児，小泉光仁，山西浩文，畔元信明，廣岡昌史，阿部雅則，池田宜央，松浦文三，恩地森一，曽我美子
  • Organizer: 第97回日本消化器病学会四国支部例会
  • Place of Presentation: 徳島市
• [Presentation] 胆道閉鎖症に対する葛西術後，肝移植を施行されることなく成人に達した3例 (2012)
  • Author(s): 熊木天児，小泉光仁，黒田太良，畔元信明，山西浩文
  • Organizer: 第48回日本胆道学会
  • Place of Presentation: 東京
• [Presentation] 愛媛県消化器内科における膵癌診療の実態 (2012)
  • Author(s): 黒田太良，熊木天児，小泉光仁，畔元信明，山西浩文，恩地森一，横田智行，清家裕貴，上原貴秀，今井祐輔，達川はるか，宇都宮大貴，西山麻里，稲田 暢，芝田直純，今峰 聡，岡田眞一
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸市
• [Presentation] ダブルバルーン内視鏡にて診断された小腸腫瘍性病変の臨床的検討 (2012)
  • Author(s): 池田宜央，布井弘明，壷内栄治，川﨑敬太郎，有光英治，竹治 智，渡辺崇夫，森健一郎，山本安則，小泉光仁，畔元信明，山西浩文，熊木天児，阿部雅則，日浅陽一，松浦文三，恩地森一
  • Organizer: 第84回日本消化器内視鏡学会総会
  • Place of Presentation: 神戸市
• [Presentation] 造影超音波検査による慢性膵炎病期診断の試み (2012)
  • Author(s): 畔元信明，熊木天児，黒田太良，小泉光仁，山西浩文，池田宜央，松浦文三，日浅陽一，恩地森一
  • Organizer: 第98回日本消化器病学会四国支部例会
  • Place of Presentation: 松山市
• [Presentation] ERCPにて膵管狭窄像を認めなかったIgG４関連硬化性胆管炎の一例 (2012)
  • Author(s): 小川泰司，長谷部昌，兼光 梢，村上貴俊，上原貴秀，中西征司，宮池次郎，大本昌樹，熊木天児，堀池典生，梅田政吉
  • Organizer: 第98回日本消化器病学会四国支部例会
  • Place of Presentation: 松山市
• [Presentation] 超音波内視鏡検査にて詳細に観察し得た膵サルコイドーシスの1例 (2012)
  • Author(s): 岩村文貴，畔元信明，熊木天児，黒田太良，小泉光仁，山西浩文，池田宜央，松浦文三，日浅陽一，恩地森一
  • Organizer: 第98回日本消化器病学会四国支部例会
  • Place of Presentation: 松山市
• [Presentation] Sleep-disordered breathing as a modifiable risk factor for microvascular complications in Japanese type 2 diabetes mellitus． (2012)
  • Author(s): Furukawa S，Saito I，Miyake T，Ueda T，Niiya T，Kumagi T，Sakai T，Minami H，Miyaoka H，Matsuura B，Tanigawa T，Onji M
  • Organizer: 72nd America Diabetes Association
  • Place of Presentation: Philadelphia, USA
• [Presentation] Therapeutic treatment of experimental colitis with regulatory dendritic cells pulsed with carbonic anhydrase I (2012)
  • Author(s): Yamanishi H，Ikeda Y，Abe M，Kumagi T，Hiasa Y，Matsuura B，Onji M
  • Organizer: 12th International Symposium on Dendritic Cells
  • Place of Presentation: Tegu, Korea
• [Presentation] Correlation between pancreatic blood flow on contrast-enhanced ultrasonography and fibrosis in chronic pancreatitis (2012)
  • Author(s): Azemoto N，Kumagi T，Yokota T，Hirooka M，Kuroda T，Koizumi M，Yamanishi H，Abe M，Ikeda Y，Hiasa Y，Matsuura B，Onji M
  • Organizer: 20th United European Gastroentelorogy Week (EUGW 2012)
  • Place of Presentation: Amsterdam，The Netherlands
• [Presentation] There was a negative relationship between motilin and growth hormone secretagogue receptors. (2012)
  • Author(s): Nunoi H，Matsuura B，Utsunomiya S，Ueda T，Miyake T，Furukawa S，Kumagi T，Ikeda Y，Abe M，Hiasa Y，Onji M
  • Organizer: 20th United European Gastroentelorogy Week (EUGW 2012)
  • Place of Presentation: Amsterdam，The Netherlands
• [Presentation] Carbonic anhydrase I –specific therapeutic approach protect mice from CD4+CD25− T cell induced colitis. (2012)
  • Author(s): Yamanishi H，Ikeda Y，Abe M，Kumagi T，Hiasa Y，Matsuura B，Onji M
  • Organizer: 20th United European Gastroentelorogy Week (EUGW 2012)
  • Place of Presentation: Amsterdam，The Netherlands
• [Presentation] The predictive factor for the onset of nonalcoholic fatty liver disease (2012)
  • Author(s): Miyake T，Kumagi T，Furukawa S，Hirooka M，Koizumi M，Tokumoto Y，Yamamoto S，Abe M，Hiasa Y，Matsuura B，Onji M
  • Organizer: 3rd Asian-Pacific Topic Conference
  • Place of Presentation: Tokyo, Japan
• [Presentation] B cell activating factor is associated with the histological severity of nonalcoholic fatty liver disease (2012)
  • Author(s): Miyake T，Furukawa S，Abe M，Kawasaki K，Tada F，Yamamoto S，Kumagi T，Hiasa Y，Matsuura B，Onji M
  • Organizer: 9th IDF-WPR Congress and 4th AASD Meeting
  • Place of Presentation: Kyoto, Japan
• [Presentation] Clinical characteristics of diabetic patients beyond age of 85 in Japanese population (2012)
  • Author(s): Matsuda T，Furukawa S，Yamamoto S，miyake T，Ueda T，Kumagi T，Niiya T，Minami H，Sakai T，Miyaoka H，Matsuura B，Onji M
  • Organizer: 9th IDF-WPR Congress and 4th AASD Meeting
  • Place of Presentation: Kyoto, Japan
• [Presentation] Metabolic Markers and ALT Cutoff Level for Diagnosing Nonalcoholic Fatty Liver Disease in Japanese: A Community-based Cross-sectional Study (2012)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Koizumi M, Furukawa S, Ueda T, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Hiasa Y, Matsuura B, Onji M
  • Organizer: Digestive Disease Week 2012
  • Place of Presentation: San Diego, USA
• [Presentation] 自己免疫性膵炎における新規マーカーとしての血清中BAFF濃度の臨床的意義 (2011)
  • Author(s): 熊木天児、山西浩文、河本博文
  • Organizer: 第97回日本消化器病学会総会（パネルディスカッション：自己免疫性肝胆膵疾患～病態解明から治療へ～）
  • Place of Presentation: 東京
• [Presentation] 胆管近接病変に対するGd-EOB-MRIによる仮想超音波支援下RFA (2011)
  • Author(s): 広岡昌史，越智裕紀，小泉洋平，畔元信明，木阪吉保，古川慎哉，阿部雅則，熊木天児，日浅陽一，恩地森一
  • Organizer: 第84回日本超音波医学会学術集会（特別演題企画：消化器インターベンションと超音波）
  • Place of Presentation: 東京
• [Presentation] 当科における非B非C型肝癌の臨床的特徴の検討 (2011)
  • Author(s): 廣岡昌史，平岡淳，日浅陽一，越智裕紀，小泉洋平，木阪吉保，阿部雅則，熊木天児，松浦文三，道堯浩二郎，恩地森一
  • Organizer: 第47回日本肝臓学会総会（ワークショップ：NBNC型肝細胞癌－最近の動向と予後）
  • Place of Presentation: 東京
• [Presentation] C型肝炎ウイルスに対する細胞傷害性T細胞エピトープワクチン (2011)
  • Author(s): 眞柴寿枝，日浅陽一，徳本良雄，上杉和寛，重松秀一郎，多田藤政，廣岡昌史，阿部雅則，熊木天児，池田宜央，松浦文三，恩地森一
  • Organizer: 第95回日本消化器病学会四国支部例会（合同シンポジウム3）
  • Place of Presentation: 高松
• [Presentation] 繰り返す肝性脳症に対して門脈大循環分流術が有用であった1例 (2011)
  • Author(s): 石原暢，木阪吉保，徳本良雄，越智裕紀，小泉洋平，廣岡昌史，眞柴寿枝，阿部雅則，熊木天児，古川慎哉，松浦文三，日浅陽一，恩地森一
  • Organizer: 第95回日本消化器病学会四国支部例会（一般演題）
  • Place of Presentation: 高松
• [Presentation] 経皮的内視鏡的ネクロセクトミーにより救命し得た重症急性膵炎の1例 (2011)
  • Author(s): 八鹿 潤，畔元信明，熊木天児，小泉光仁，山西浩文，阿部雅則，日浅陽一，恩地森一，横田智行
  • Organizer: 第42回日本膵臓学会大会（ポスター：膵内分泌・急性膵炎）
  • Place of Presentation: 青森
• [Presentation] 原発性胆汁性肝硬変において治療反応性および肝線維化の進行に寄与する因子 (2011)
  • Author(s): 熊木天児、畔元信明、阿部雅則
  • Organizer: 第15回日本肝臓学会大会（ワークショップ：自己免疫性肝障害・薬物性肝障害のup-to-date）
  • Place of Presentation: 福岡
• [Presentation] 膵仮性嚢胞内の炎症が胃壁へ波及し穿破をきたした慢性膵炎の1例 (2011)
  • Author(s): 宮本裕也，畔元信明，熊木天児，黒田太良，小泉光仁，山西浩文，池田宜央，松浦文三，日浅陽一，恩地森一
  • Organizer: 第107回日本消化器内視鏡学会四国支部例会（一般演題：膵）
  • Place of Presentation: 松山
• [Presentation] SNMCとグリチルリチン錠投与による偽性アルドステロン症および横紋筋融解症の (2011)
  • Author(s): 増田香奈，小泉洋平，石原 暢，越智裕紀，徳本良雄，眞柴寿枝，廣岡昌史，古川慎哉，熊木天児，阿部雅則，松浦文三，日浅陽一，恩地森一
  • Organizer: 第96回日本消化器病学会四国支部例会（一般演題）
  • Place of Presentation: 松山
• [Presentation] Characteristics of small-bowel tumors detected by double balloon endoscopy (2011)
  • Author(s): Imaoka H, Higaki N, Kumagi T, Miyaike J, Ohmoto M, Yamauchi K, Murakami T, Murakami H, Ninomiya T, Ikeda Y, Yokota T, Shibata N, Abe M, Hiasa Y, Matsuura B, Onji M, Umeda M, Horiike N
  • Organizer: Digestive Disease Week 2011 (Poster)
  • Place of Presentation: Chicago, USA
• [Presentation] B cell-activating factor as a novel marker in autoimmune pancreatitis. (2011)
  • Author(s): Kumagi T, Yamanishi H, Yokota T, Azemoto N, Koizumi M, Abe M, Murakami H, Ikeda Y, Hiasa Y, Matsuura B, Kawamoto H, Yamamoto K, Onji M
  • Organizer: Digestive Disease Week 2011 (Distinguished plenary)
  • Place of Presentation: Chicago, USA
• [Presentation] Mutational analysis of predicted extracellular domains of human growth hormone secretagogue receptor 1a (2011)
  • Author(s): Ueda T, Matsuura B, Miyake T, Furukawa S, Kumagi T, Abe M, Hiasa Y, Onji M
  • Organizer: Digestive Disease Week 2011 (Poster)
  • Place of Presentation: Chicago, USA
• [Presentation] Biochemical response to ursodeoxycholic acid predicts long-term outcome in Japanese patients with primary biliary cirrhosis: a validation study (2011)
  • Author(s): Azemoto N, Kumagi T, Abe M, Konishi I, Matsuura B, Hiasa Y, Onji M
  • Organizer: Digestive Disease Week 2011 (Poster)
  • Place of Presentation: Chicago, USA
• [Presentation] Regulatory dendritic cells pulsed with carbonic anhydrase I protect mice from colitis induced by CD4+CD25- T cells (2011)
  • Author(s): Yamanishi H, Murakami H, Ikeda Y, Kumagi T, Hiasa Y, Abe M, Matsuura B, Onji M
  • Organizer: Digestive Disease Week 2011 (Poster)
  • Place of Presentation: Chicago, USA
• [Presentation] B Cell-Activating Factor as a novel marker in Autoimmune Pancreatitis (2011)
  • Author(s): Kumagi T,Yamanishi I,Yokota T,Azemoto N,Koizumi M,Kuroda T,Abe M,Ikeda Y,Hiasa Y, Matsuura B,Kawamoto H,Yamamoto K,Onji M.
  • Organizer: International Pancreas Research Forum 2011
  • Place of Presentation: Osaka
• [Presentation] 高齢者原発性胆汁性肝硬変における肝細胞癌合併に関する臨床背景の検討
  • Author(s): 阿部雅則，畔元信明，熊木天児，多田藤政，徳本良雄，眞柴寿枝，廣岡昌史，日浅陽一，恩地森一
  • Organizer: 第23回日本老年医学会四国地方会
  • Place of Presentation: 愛媛県東温市
• [Presentation] カラードプラ超音波が有用であった右肝動脈仮性動脈瘤の一例
  • Author(s): 黒田太良，畔元信明，小泉光仁，山西浩文，熊木天児，廣岡昌史，阿部雅則，池田宜央，松浦文三，恩地森一
  • Organizer: 第22回日本超音波医学会四国地方会学術集会
  • Place of Presentation: 松山市