An immunological study of pthogenesis in autoimmune pancreatitis
| Project/Area Number |
23591017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIO Akiyoshi 関西医科大学, 医学部, 准教授 (50362463)
UCHIDA Kazushige 関西医科大学, 医学部, 講師 (40411516)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | IgG4関連疾患 / 自己免疫性膵炎 / IgG4 / 制御性T細胞 / 制御性B細胞 / 自然免疫 / ＩｇＧ４ / 制御性Ｔ細胞 / 制御性Ｂ細胞 |
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| Research Abstract |
(1)In pancreas cancer and obstructive pancreatitis type 1 AIP, infiltration of memory regulatory T cells (Tregs) and IgG4-positive cells were positively correlated, which suggested that increased memory-Tregs may be an inhibitory immune response against inflammation, although decreased naïve Tregs may be pathogenic. (2) We identified two subtypes of regulatory B cells (Bregs), CD19+CD24highCD38high Bregs and CD19+CD24highCD27+ Bregs in type 1 AIP. The increased CD19+CD24highCD38high Bregs may suppress the disease activity of type 1 AIP, whereas the decreased CD19+CD24highCD27+ Bregs might be involved in the development of type 1 AIP. (3) In animal models, activation of TLR3 (polyinosinic:polycytidylic acid) can induce immune-mediated cholangitis, pancreatitis and sialadenitis similar to human autoimmune pancreatitis.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Possible Involvement of Foxp3(+) Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid.2013
Author(s)
Koyabu M, Uchida K, Sakaguchi Y, Fukata N, Kusuda T, Miyoshi H, Yoshida K, Sumimoto K, Mitsuyama T, Fukui T, Nishio A, Okazaki K.
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Journal Title
Int J Rheumatol.
Volume: 2013
Pages: 367325-30
DOI
Related Report
Peer Reviewed
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[Journal Article] A proposal of a diagnostic algorithm with validation of International Consensus Diagnostic Criteria for autoimmune pancreatitis in a Japanese cohort.2013
Author(s)
Sumimoto K, Uchida K, Mitsuyama T, Fukui Y, Kusuda T, Miyoshi H, Tomiyama T, Fukata N, Koyabu M, Sakaguchi Y, Ikeura T, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Okazaki K.
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Journal Title
Pancreatology.
Volume: 13(3)
Issue: 3
Pages: 230-7
DOI
Related Report
Peer Reviewed
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[Journal Article] The similarity of Type 1 autoimmune pancreatitis to pancreatic ductal adenocarcinoma with significant IgG4-positive plasma cell infiltration.2013
Author(s)
Fukui Y, Uchida K, Sumimoto K, Kusuda T, Miyoshi H, Koyabu M, Ikeura T, Sakaguchi Y, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Shikata N, Sakaida N, Uemura Y, Satoi S, Kwon AH, Okazaki K.
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Journal Title
J Gastroenterol.
Volume: 48(6)
Issue: 6
Pages: 751-61
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Regulatory T cells in type 1 autoimmune pancreatitis2012
Author(s)
Uchida K, Kusuda T, Koyabu M, Miyoshi H, Fukata N, Sumimoto K, Fukui Y, Sakaguchi Y, Ikeura T, Shimatani M, Fukui T, Matsushita M, Takaoka M, Nishio A, Okazaki K
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Journal Title
Int J Rheumatol
Volume: 2012 (795026)
Related Report
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[Journal Article] Autoimmune pancreatitis with histologically proven lymphoplasmacytic sclerosing pancreatitis with granulocytic epithelial lesions2012
Author(s)
Ikeura T, Takaoka M, Uchida K, Shimatani M, Miyoshi H, Kusuda T, Kurishima A, Fukui Y, Sumimoto K, Satoi S, Ohe C, Uemura Y, Kwon AH, Okazaki K
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Journal Title
Intern Med
Volume: 51(7)
Pages: 733-7
NAID
Related Report
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[Journal Article] Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 20112012
Author(s)
Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H
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Journal Title
Mod Rheumatol
Volume: 22(1)
Pages: 21-30
NAID
Related Report
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[Presentation] Increased peripheral CD19+CD24hiCD38hi regulatory B Cells may be involved in the pathophysiology of type 1 autoimmune pancreatitis.2013
Author(s)
Kimi Sumimoto, Kazushige Uchida, Yuri Fukui, Takeo Kusuda, Hideaki Miyoshi, Norimasa Fukata, Masanori Koyabu, Yutaku Sakaguchi, Tsukasa Ikeura, Masaaki Shimatani, Toshiro Fukui, Mitsunobu Matsushita, Makoto Takaoka, Akiyoshi Nishio, Kazuichi Okazaki.
Organizer
American Gastroenterology Association
Place of Presentation
Orlando, Florida, USA
Related Report
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[Presentation] Comparison of International Consensus Diagnostic Criteria and Major Diagnostic Criteria for Autoimmune Pancreatitis2012
Author(s)
Sumimoto , Uchida K, Fukui K, Kusuda , Hideaki Miyoshi, Norimasa Fukata, Masanori Koyabu, Yutaku Sakaguchi, Tsukasa Ikeura, Masaaki Shimatani, Toshiro Fukui, Mitsunobu Matsushita, Makoto Takaoka, Akiyoshi Nishio, Okazaki K
Organizer
DDW2012
Place of Presentation
San Diego, California, USA
Year and Date
2012-05-20
Related Report
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[Presentation] Possible role of ICOS positive and IL-10 producing regulatory T cells in patients with autoimmune pancreatitis.2011
Author(s)
K Uchida, T Kusuda, H Miyoshi, T Ikeura, Y Sakaguchi, K Yoshida, T Fukui, M Shimatani, M Matsushita, M Takaoka, A Nishio, K Okazaki
Organizer
Joint Meeting of the International Association of Pancreatology and Indian Pancreas Club
Place of Presentation
Kochi, Kerala, India
Related Report
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