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Predictor of lymph node metastasis using molecular marker for submucosal invasive gastric cancer

Research Project

Project/Area Number 23591021
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionHiroshima University

Principal Investigator

OKA SHIRO  広島大学, 大学病院, 病院助教 (30403538)

Co-Investigator(Kenkyū-buntansha) TANAKA Shinji  広島大学, 病院, 教授 (00260670)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胃SM癌 / リンパ節転移 / 内視鏡的根治判定基準 / 分子病理学的マーカー / 未分化型胃癌 / 早期胃癌 / SM癌 / リンパ節転移予測 / 未分化型癌 / 内視鏡的摘除 / 分子病理マーカー
Research Abstract

We evaluated the expressions of micro satellite instability (BAT26) and mitochondria DNA between the surface and the deeper site of submucosal invasive early gastric cancers, which were indication of non-curative after endoscopic resection. However, there was no significant difference of these molecular markers' expression between these sites (no heterogeneity). These data suggested that it is not clinically usefulness to predict lymph node metastasis from the biopsy specimen of submucosal invasive gastric cancer using molecular marker.
The incidence of lymph node metastasis of submucosal invasive undifferentiated-type early gastric cancers was high regardless of their clinicopathologic factors. The expanded criteria (ulcer-negative, intramucosal cancer 20mm or less without lymphovascular invasion)of endoscopic resection for undifferentiated-type early gastric cancer was pertinent based on long-term outcomes.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Clinical validity of the expanded criteria for endoscopic resection of undifferentiated-type early gastric cancer based on long-term outcome2014

    • Author(s)
      Shiro Oka, Shinji Tanaka, et al.
    • Journal Title

      Surg Endosc

      Volume: 28 Pages: 639-647

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical validity of the expanded criteria for endoscopic resection of undifferentiated-type early gastric cancer based on long-term outcomes2014

    • Author(s)
      Oka S, Tanaka S, Higashiyama M, Numata N, Sanomura Y, Yoshida S, Arihiro K, Chayama K.
    • Journal Title

      Surgical Endoscopy

      Volume: 28 Pages: 639-647

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical validity of endoscopic submucosal dissection for submucosal invasive gastric cancer : a single-center study2012

    • Author(s)
      Yoji Sanomura, Shiro Oka, Shinji Tanaka,et al.
    • Journal Title

      Gastric Cancer

      Volume: 15 Pages: 97-105

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical validity of endoscopic submucosal dissection for submucosal invasive gastric cancer: a single-center study2012

    • Author(s)
      Sanomura Y, Oka S, Tanaka S, Noda I, Higashiyama M, Imagawa H, Shishido T, Yoshida S, Hiyama T, Arihiro K, Chayama K.
    • Journal Title

      Gastric cancer

      Volume: 15 Pages: 97-105

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Endoscopic submucosal dissection for Tib gastric carcinoma2014

    • Author(s)
      Yoji Sanomura, Shiro Oka, Shinji Tanaka, et al.
    • Organizer
      第86回日本胃癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 治療成績と長期予後からみた未分化型早期胃癌に対するESDの妥当性2013

    • Author(s)
      東山真、岡志郎、茶山一彰
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 当科における胃pSM2癌に対するESDの現状2012

    • Author(s)
      佐野村洋次、岡志郎、田中信治、他
    • Organizer
      第84回日本胃癌学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-02-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 胃SM癌に対するESDの有効性と限界2011

    • Author(s)
      佐野村洋次、岡志郎、田中信治、他
    • Organizer
      第81回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-08-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Long-term follow-up investigation of the expanded indications for endoscopic submucosal dissection for submucosal gastric cancer2011

    • Author(s)
      Shiro Oka, Shinji Tanaka, et al.
    • Organizer
      Digestive Disease Week 2011
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-05-10
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/endosc/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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