• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation by the molecular biological method of the complications for Colorectal endoscopic submucosal dissection.

Research Project

Project/Area Number 23591023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionJuntendo University

Principal Investigator

OSADA Taro  順天堂大学, 医学部, 准教授 (00338336)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Naoto  順天堂大学, 医学部, 准教授 (10420845)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords大腸腫瘍 / 内視鏡治療 / 菌血症 / 合併症 / 大腸内視鏡 / S-O Clip / Loop Clip / 大腸ESD
Research Abstract

We examined the incidence of and factors associated with fever, as well as the frequency of bacteremia, in patients with colorectal ESD. The incidence of post-ESD fever in the entire cohort was 46.7%. Multivariate analysis for post-ESD fever found that age and lesion size were closely associated. Bacteria were not detectable.
We evaluate the efficacy of traction device-assisted ESD. Patients were randomized into two groups. The mean procedure time for the S-O clip-assisted ESD group (n=27) was significantly shorter than for the conventional ESD group (n=23).
We evaluate how long the endoscopic clips exert an effect on closure of mucosal defects after ESD. At one week after ESD (n=7), there were clips that were still attached at the repaired lesions in five patients. The defect area indicated a reduction of about 78.8%. At four weeks after ESD (n=7), only one or two clips were still attached at the repaired lesions in two patients. The defect area showed a reduction of about 99.8%.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (44 results)

All 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 5 results) Presentation (22 results) Book (4 results)

  • [Journal Article] Traction device to remove an adenoma in the appendiceal orifice by endoscopic submucosal dissection2013

    • Author(s)
      Takeda T, Murakami T, Sakamoto N, Goto SP, Ritsuno H, Ueyama H, Mori H, Matsumoto K, Shibuya T, Osada T, Nagahara A, Ogihara T, Watanabe S
    • Journal Title

      Endoscopy

      Volume: 45 Suppl

    • Related Report
      2013 Final Research Report
  • [Journal Article] Process of wound healing of large mucosal defect areas that were sutured by using a loop clip-assisted closure technique after endoscopic submucosal dissection of a colorectal tumor2013

    • Author(s)
      Osada T, Sakamoto N, Ritsuno H, Murakami T, Ueyama H, Shibuya T, Matsumoto K, Nagahara A, Ogihara T, Watanabe S
    • Journal Title

      Gastrointest Endosc

      Volume: 78 Pages: 793-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Development and clinical usability of a new traction device "medical ring" for endoscopic submucosal dissection of early gastric cancer2013

    • Author(s)
      Matsumoto K, Nagahara A, Ueyama H, Konuma H, Morimoto T, Sasaki H, Hayashi T, Shibuya T, Sakamoto N, Osada T, Ogihara T, Yao T, Watanabe S
    • Journal Title

      Surg Endosc

      Volume: 27 Pages: 3444-51

    • Related Report
      2013 Final Research Report
  • [Journal Article] Process of wound healing of mucosal defect areas that were sutured using endoscopic clips after2013

    • Author(s)
      Osada T, Sakamoto N, Ritsuno H, Murakami T, Ueyama H, Shibuya T, Matsumoto K, Nagahara A, Ogihara T, Watanabe S.
    • Journal Title

      Gastrointest Endosc.

      Volume: 78(5) Issue: 5 Pages: 793-8

    • DOI

      10.1016/j.gie.2013.05.035

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and clinical usability of a new traction device "medical ring" for endoscopic submucosal dissection of early gastric cancer.2013

    • Author(s)
      Matsumoto K, Nagahara A, Ueyama H, Konuma H, Morimoto T, Sasaki H, Hayashi T, Shibuya T, Sakamoto N, Osada T, Ogihara T, Yao T, Watanabe S.
    • Journal Title

      Surg Endosc.

      Volume: 27(9):3444-51 Issue: 9 Pages: 3444-51

    • DOI

      10.1007/s00464-013-2887-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Traction device to remove an adenoma in the appendiceal orifice by endoscopic submucosal dissection.2013

    • Author(s)
      Takeda T, Murakami T, Sakamoto N, Goto SP, Ritsuno H, Ueyama H, Mori H,
    • Journal Title

      Endoscopy.

      Volume: 45 Suppl 2 Issue: S 02 Pages: E239-E240

    • DOI

      10.1055/s-0032-1309711

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The origin of hyperamylasemia associated with peroral double-balloon endoscopy2012

    • Author(s)
      Shibuya T, Osada T, Nomura O, Fukuo Y, Watanabe S
    • Journal Title

      J Clin Gastroenterol

      Volume: 46(10) Pages: 888-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] The relationship between physical activity level and completion rate of small bowel examination in patients undergoing capsule endoscopy2012

    • Author(s)
      Shibuya T, Mori H, Takeda T, Konishi M, Fukuo Y, Matsumoto K, Beppu K, Sakamoto N, Osada T, Nagahara A, Otaka M, Ogihara T, Watanabe S
    • Journal Title

      Intern Med

      Volume: 51 Pages: 997-1001

    • NAID

      130002061791

    • Related Report
      2013 Final Research Report
  • [Journal Article] Endoscopic mucosal resection using a cap-fitted panendoscope as a diagnostic procedure in a case of scirrhous gastric carcinoma2012

    • Author(s)
      Kodani T, Osada T, Matsumoto K, Kato J, Higashihara Y, Morimoto T, Ogata C, Taniguchi G, Mizui T, Matsumura Y, Yoshizawa T, Nagahara A, Mitomi H, Yao T, Watanabe S
    • Journal Title

      Dig Endosc

      Volume: 24 Pages: 190-190

    • Related Report
      2013 Final Research Report
  • [Journal Article] Watanabe S. Autofluorescence imaging endoscopy for identification and assessment of inflammatory ulcerative colitis2011

    • Author(s)
      Osada T, Arakawa A, Sakamoto N, Ueyama H, Shibuya T, Ogihara T, Yao T
    • Journal Title

      World J Gastroenterol

      Volume: 14;17 Pages: 5110-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] The 'Loop Clip' is useful for closing large mucosal defects after colorectal endoscopic submucosal dissection : a preliminary clinical study2011

    • Author(s)
      Mori H, Sakamoto N, Osada T, Ritsuno H, Hidaka Y, Nakae K, Matsumoto K, Beppu K, Shibuya T, Yoshizawa T, Nagahara A, Otaka M, Ogihara T, Arai F, Watanabe S
    • Journal Title

      Dig Endosc

      Volume: 23 Pages: 330-1

    • Related Report
      2013 Final Research Report
  • [Journal Article] Advanced colorectal cancer with double-hump camel-like appearance2011

    • Author(s)
      Ritsuno H, Sakamoto N, Mitomi H, Namihisa A, Mori H, Nakae K, Matsumoto K, Beppu K, Shibuya T, Osada T, Nagahara A, Otaka M, Terai T, Ogihara T, Yao T, Watanabe S
    • Journal Title

      Dig Endosc

      Volume: 23 Pages: 329-329

    • Related Report
      2013 Final Research Report
  • [Journal Article] Successful endoscopic mucosal resection of a solitary extramedullary plasmacytoma in the sigmoid colon2011

    • Author(s)
      Kodani T, Osada T, Terai T, Ohkusa T, Shibuya T, Sakamoto N, Beppu K, Kato J, Nagahara A, Watanabe H, Watanabe S
    • Journal Title

      Endoscopy

      Volume: 43 Suppl

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autofluorescence imaging endoscopy for identification and assessment of inflammatory ulcerative colitis.2011

    • Author(s)
      Taro Osada
    • Journal Title

      World J Gastroenterol.

      Volume: 17(46) Issue: 46 Pages: 5110-6

    • DOI

      10.3748/wjg.v17.i46.5110

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful endoscopic mucosal resection of a solitary extramedullary plasmacytoma in the sigmoid colon.2011

    • Author(s)
      Tomohiro Kodani
    • Journal Title

      Endoscopy.

      Volume: 43 Suppl 2 Issue: S 02 Pages: E298-E299

    • DOI

      10.1055/s-0030-1256451

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The 'Loop Clip' is useful for closing large mucosal defects after colorectal endoscopic submucosal dissection: a preliminary clinical study.2011

    • Author(s)
      Hiroki Mori
    • Journal Title

      Dig Endosc。

      Volume: 23(4): Issue: 4 Pages: 330-1

    • DOI

      10.1111/j.1443-1661.2010.01099.x

    • Related Report
      2011 Research-status Report
  • [Journal Article] Frequent occurrence of fever in patients who have undergone endoscopic submucosal dissection for colorectal tumor but bacteremia is not a significant cause

    • Author(s)
      Izumi K, Osada T, Sakamoto N, Kodani T,Higashihara Y, Ritsuno H, Shibuya T, Nagahara A, Ogihara T, Kikuchi K, Watanabe S
    • Journal Title

      Surg Endosc

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prospective clinical trial of traction device-assisted endoscopic submucosal dissection of large superficial colorectal tumors using the S-O clip

    • Author(s)
      Ritsuno H,Sakamoto N Osada T, Goto S, Murakami T,Ueyama H,Mori H, Matsumoto K, Beppu K,Shibuya T, Nagahara A, Ogihara T, Watanabe S
    • Journal Title

      Surg Endosc

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸内視鏡検査からみた高齢者における大腸腫瘍有病率の10年の変遷と内視鏡治療における合併症とその特徴2013

    • Author(s)
      長田太郎.坂本直人.渡辺純夫
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸ESDにおける偶発症を予防するための施術トラクションデバイスを用いた病変剥離と縫縮デバイスを用いた潰瘍完全縫縮による偶発症予防の可能性2013

    • Author(s)
      長田太郎.坂本直人.渡辺純夫
    • Organizer
      第85回日本消化器内視鏡学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Process of wound healing of mucosal defect areas that were sutured using endoscopic clips after endoscopic submucosal dissection of colorectal tumor2013

    • Author(s)
      Osada T. Sakamoto N. Ritsuno H. Murakami T. Ueyama H. Shibuya T. Matsumoto K. Nagahara A. Ogihara T. Watanabe S
    • Organizer
      Digestive Disease Week2013(DDW2013)
    • Place of Presentation
      アメリカ
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of factors contributing to fever and the frequency of bacteremia in patients after endoscopic submucosal dissection of colorectal tumor2012

    • Author(s)
      Osada T.Sakamoto N.Izumi K.Kodani T.Shibuya T.Matsumoto K.Nagahara A.Ogihara T. Watanabe S
    • Organizer
      Digestive Disease Week 2012 (DDW2012)
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸ESDにおける潰瘍縫縮術の役割について-内視鏡観察症例からの検討-2012

    • Author(s)
      長田太郎.坂本直人.澁谷智義.上山浩也.村上敬.立之英明.森広樹.松本健史.永原章仁.荻原達雄.渡辺純夫
    • Organizer
      第84回日本消化器内視鏡学会総会
    • Place of Presentation
      神戸(JDDW2012(第20回日本消化器関連学会週間))
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸EMR/ESDの現状と適応2012

    • Author(s)
      坂本直人.長田太郎.渡辺純夫
    • Organizer
      第84回日本消化器内視鏡学会総会
    • Place of Presentation
      神戸(JDDW2012(第20回日本消化器関連学会週間))
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸ESDにおける牽引法の有用性に関する検討2012

    • Author(s)
      立之英明.坂本直人.長田太郎.竹田努.村上敬.上山浩也.森広樹.松本健史.別府加寿子.澁谷智義.永原章仁.荻原達雄.渡辺純夫
    • Organizer
      第83回日本消化器内視鏡学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Usefulness of Counter Traction Device During Endoscopic Submucosal Dissection for Large Superficial Colorectal Tumors2012

    • Author(s)
      Ritsuno H.Sakamoto N.Osada T.Goto Shingo P.Ueyama H.Murakami T.Mori H.Matsumoto K.Beppu K.Shibuya T.Nagahara A.Ogihara T.Terai T.Watanabe S.
    • Organizer
      Digestive Disease Week 2012 (DDW2012)
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸ESDにおける術後菌血症の可能性2012

    • Author(s)
      泉健太郎.長田太郎.坂本直人.小谷知弘.東原良恵.別府加寿子.澁谷智義.立之英明.森広樹.松本健史.永原章仁.荻原達雄.菊池賢.渡辺純夫
    • Organizer
      第83回日本消化器内視鏡学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸ESD術後発熱におよぼす因子の検討および菌血症の可能性2011

    • Author(s)
      長田太郎.小谷知弘.東原良恵.坂本直人.別府加寿子.澁谷智義.立之英明.森広樹.松本健史.永原章仁.荻原達雄.渡辺純夫
    • Organizer
      JDDW2011(第19回日本消化器関連学会週間)
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] ESD困難例の克服-Traction deviceを用いた大腸ESDの工夫-2011

    • Author(s)
      坂本直人.長田太郎.渡辺純夫
    • Organizer
      第81回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Double traction法を用いた新たな大腸内視鏡的粘膜剥離術の試み2011

    • Author(s)
      立之英明.坂本直人.長田太郎.中江弘三郎.森広樹.別府加寿子.澁谷智義.松本健史.永原章仁.大高道郎.荻原達雄.渡辺純夫
    • Organizer
      第81回日本消化器内視鏡学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 大腸ESD術後発熱におよぼす因子の検討および菌血症の可能性2011

    • Author(s)
      長田太郎
    • Organizer
      JDDW2011
    • Place of Presentation
      福岡国際センター
    • Related Report
      2011 Research-status Report
  • [Presentation] Process of wound healing of mucosal defect areas that were sutured using endoscopic clips after

    • Author(s)
      Taro osada
    • Organizer
      DDW2013
    • Place of Presentation
      Orland convention center
    • Related Report
      2013 Annual Research Report
  • [Presentation] “S-Oクリップ”を用いた病変剥離と“Loop クリップ”を用いた潰瘍完全縫縮による偶発症予防の可能性

    • Author(s)
      長田太郎、坂本直人、渡辺純夫
    • Organizer
      日本内視鏡学会総会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Presentation] Increasing use of colonoscopy and endoscopic treatment over a decade associated with increased

    • Author(s)
      Taro Osada
    • Organizer
      DDW2013
    • Place of Presentation
      Orland convention center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Predictive ability of relapse in patients with resolved ulcerative colitis using autofluorescence imaging endoscopy

    • Author(s)
      Osamu Nomura,Taro Osada
    • Organizer
      DDW2014
    • Place of Presentation
      McCormick Place
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cytapheresis as remission induction therapy in 154 ulcerative colitis patients: A five year experience.

    • Author(s)
      Osamu Nomura, Tomoyoshi Shibuya,Taro Osada
    • Organizer
      ECCO2014
    • Place of Presentation
      Bella Center Copenhagen
    • Related Report
      2013 Annual Research Report
  • [Presentation] Process of wound healing of mucosal defect areas that were sutured using endoscopic clips after endoscopic submucosal dissection of colorectal tumor

    • Author(s)
      Taro Osada
    • Organizer
      DDW2013
    • Place of Presentation
      Orland convention center
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸内視鏡検査からみた高齢者における大腸腫瘍有病率の10年の変遷と内視鏡治療における合併症とその特徴

    • Author(s)
      長田太郎、坂本直人、渡辺純夫
    • Organizer
      第99回日本消化器病学会
    • Place of Presentation
      鹿児島県民交流センター
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of factors contributing to fever and the frequency of bacteremia in patients after endoscopic submucosal dissection of colorectal tumor

    • Author(s)
      Taro Osada
    • Organizer
      DDW2012
    • Place of Presentation
      San Diego convention center
    • Related Report
      2012 Research-status Report
  • [Presentation] Increasing use of colonoscopy and endoscopic treatment over a decade associated with increased prevalence of colorectal tumors and complications in the elderly

    • Author(s)
      Taro Osada
    • Organizer
      DDW2013
    • Place of Presentation
      Orland convention center
    • Related Report
      2012 Research-status Report
  • [Book] 消化管疾患診療マニュアル消化管画像検査腹部単純X線検査2014

    • Total Pages
      482
    • Publisher
      日本医学館
    • Related Report
      2013 Final Research Report
  • [Book] 消化管疾患 診療マニュアル2014

    • Author(s)
      長田太郎
    • Total Pages
      692
    • Publisher
      日本医学館
    • Related Report
      2013 Annual Research Report
  • [Book] 消化管疾患診療マニュアル消化管画像検査小腸内視鏡検査

    • Total Pages
      528
    • Publisher
      日本医学館
    • Related Report
      2013 Final Research Report
  • [Book] 消化管疾患診療マニュアル消化管画像検査消化管狭窄に対するステント留置

    • Total Pages
      555
    • Publisher
      日本医学館
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi