| Project/Area Number |
23591024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUI Hiroyuki 北海道大学, 大学院医学研究科, 教授 (70264017)
KINUGAWA Shintaro 北海道大学, 大学院医学研究科, 講師 (60399871)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINAGA Keiichiro 北海道大学, 大学院医学研究科, 特任教授 (30435961)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 交感神経活性 / ASV / 慢性心不全 / 非薬物学的治療 / HED-PET / 陽圧呼吸療 / PET / 交感神経活 / 陽圧呼吸療法 / ＡＳＶ / ＰＥＴ |
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| Outline of Final Research Achievements |
Aims: ASV has been shown to improve cardiac function in patients with heart failure (HF). The sympathetic overactivation is associated with a poor prognosis of HF patients, we investigated whether ASV could improve cardiac sympathetic nerve activity in patients with HF. Methods: Nine HF patients (age: 57.3±17.3 years old, male: 6) We performed echocardiography, polysomnography, and the evaluation of the cardiac sympathetic nerve activity before and after 9weeks of ASV. Cardiac presynaptic innervation was analyzed by 11C-hydroxyephedrine (HED) retention assessed with positron emission tomography (PET).Result: LVEF tended to improve after ASV, although there was no statistical significant difference Global 11C-HED retention index improved from 0.068±0.032 to 0.089±0.045 (p=0.0404). Conclusion: We could evaluate cardiac sympathetic nerve activity by HED-PET, and ASV improved cardiac sympathetic nerve activity in patients with HF.
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