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Adaptive servo-ventilation improves cardiac sympathetic nerve activity in patients with heart failure: Evaluation by cardiac 11C-Hydroxyephedrine positron emission tomography

Research Project

Project/Area Number 23591024
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionHokkaido University

Principal Investigator

SAKAKIBARA Mamoru  北海道大学, 大学病院, 助教 (90349366)

Co-Investigator(Kenkyū-buntansha) TSUTSUI Hiroyuki  北海道大学, 大学院医学研究科, 教授 (70264017)
KINUGAWA Shintaro  北海道大学, 大学院医学研究科, 講師 (60399871)
Co-Investigator(Renkei-kenkyūsha) YOSHINAGA Keiichiro  北海道大学, 大学院医学研究科, 特任教授 (30435961)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords交感神経活性 / ASV / 慢性心不全 / 非薬物学的治療 / HED-PET / 陽圧呼吸療 / PET / 交感神経活 / 陽圧呼吸療法 / ASV / PET
Outline of Final Research Achievements

Aims: ASV has been shown to improve cardiac function in patients with heart failure (HF). The sympathetic overactivation is associated with a poor prognosis of HF patients, we investigated whether ASV could improve cardiac sympathetic nerve activity in patients with HF. Methods: Nine HF patients (age: 57.3±17.3 years old, male: 6) We performed echocardiography, polysomnography, and the evaluation of the cardiac sympathetic nerve activity before and after 9weeks of ASV. Cardiac presynaptic innervation was analyzed by 11C-hydroxyephedrine (HED) retention assessed with positron emission tomography (PET).Result: LVEF tended to improve after ASV, although there was no statistical significant difference Global 11C-HED retention index improved from 0.068±0.032 to 0.089±0.045 (p=0.0404). Conclusion: We could evaluate cardiac sympathetic nerve activity by HED-PET, and ASV improved cardiac sympathetic nerve activity in patients with HF.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (7 results) Book (7 results)

  • [Journal Article] PET for the simultaneous assessment of cardiac sympathetic and contractile functions.2014

    • Author(s)
      Keiichi Magota
    • Journal Title

      Ann Nucl Med

      Volume: 28 Issue: 3 Pages: 187-195

    • DOI

      10.1007/s12149-013-0795-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute hemodynamic effects of adaptive servo-ventilation in patients with heart failure.2013

    • Author(s)
      Yamada S, Sakakibara M, Yokota T, Kamiya K, Asakawa N, Iwano H, Oba K, Tsutsui H
    • Journal Title

      Circulation Journal

      Volume: 77 Pages: 1214-1220

    • NAID

      10031151383

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients With Heart Failure.2013

    • Author(s)
      Yamada S, Sakakibara M, Yokota T, Kamiya K, Asakawa N, Iwano H, Yamada S, Oba K, Tsutsui H.
    • Journal Title

      Circ J.

      Volume: 77 Pages: 1214-1220

    • NAID

      10031151383

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 慢性心不全患者に対するAdaptive Servo-ventilation(ASV)導入時のクリニカルパスの有用性.2013

    • Author(s)
      石川幸司,榊原 守,山田史郎,神谷究,浅川直也,高岡勇子,筒井裕之:
    • Journal Title

      心臓病学会誌

      Volume: 未定

    • NAID

      40019745809

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sleep-disordered breathing is an independent risk factor of aborted sudden cardiac arrest in patients with coronary artery spasm.2012

    • Author(s)
      Sakakibara M, Yamada S, Kamiya K, Yokota T, Oba K, Tsutsui H:
    • Journal Title

      Circ J.

      Volume: 76 Pages: 2204-2210

    • NAID

      10030696838

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful termination of recurrent ventricular arrhythmias by adaptive servo-ventilation in a patient with heart failure.2011

    • Author(s)
      Yamada S, Sakakibara M, Matsushima S, Saito A, Homma T, Fukushima A, Masaki Y, Watanabe M, Mitsuyama H, Yokoshiki H, Tsutsui H
    • Journal Title

      Journal of Cardiology Cases

      Volume: 3 Pages: 57-61

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Adaptive Servo-Ventilation Improves Cardiac Sympathetic Nerve Activity in Patients with Heart Failure by Evaluation of 11C-Hydroxyephedrine Positron Emission Tomography.2014

    • Author(s)
      Takashi Yoshitani, Mamoru Sakakibara, Shiro Yamada, Naoya Asakawa, Kiwamu Kamiya, Satoshi Yamada, Keiichiro Yoshinaga , Hiroyuki Tsutsui
    • Organizer
      American College of Cardiology 63th Annual Scientific Session
    • Place of Presentation
      Washington Convention Center (Washington, America)
    • Related Report
      2013 Research-status Report
  • [Presentation] Acute hemodynamic effects of adaptive servo-ventilation in patients with heart failure2012

    • Author(s)
      Yamada S, Sakakibara M, Yokota T, Kamiya K, Iwano H, Yamada S, Tsutsui H
    • Organizer
      The 76th Annual Scientic Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Sleep Disordered Breathing in Patients with Coronary Artery Spasmv2012

    • Author(s)
      Sakakibara M, Yamada S, Kamiya K, Yokota T, Tsutsui1a H, Yokota T, Tsutsui H
    • Organizer
      The 76th Annual Scientic Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Adaptive servo-ventilation could improve functional mitral regurgitation and left ventricular morphology in patients with severe heart failure2012

    • Author(s)
      Sakakibara M, Yamada S, Kamiya K, Iwano H, Yamada S, Yokota T, Tsutsui H
    • Organizer
      The 76th Annual Scientic Meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 致死的不整脈を引き起こす冠攣縮と睡眠時無呼吸障害の関連について2011

    • Author(s)
      榊原守、山田史郎、神谷究、筒井裕之
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性心不全患者におけるASV(Adaptive Servo-Ventilation)による急性期の血行動態の評価2011

    • Author(s)
      山田史郎、神谷究、横田卓、榊原守、筒井裕之
    • Organizer
      第59回日本心臓病学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性心不全患者におけるAdaptive Servo-Ventilation :ASVとContinuous Positive Airway Pressure:CPAPによる 急性期血行動態の比較

    • Author(s)
      山田史郎、榊原守、神谷究、浅川直也、岩野弘幸、山田聡、筒井裕之:
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      ANAクラウンプラザホテル金沢(金沢)
    • Related Report
      2012 Research-status Report
  • [Book] CIRCULATION Up-to-Date Art&Technique2号2013

    • Author(s)
      榊原 守
    • Publisher
      メディカ出版
    • Related Report
      2012 Research-status Report
  • [Book] SHDインターベンション コンプリートテキスト2013

    • Author(s)
      榊原 守
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 循環器内科 ゴールデンハンドブック 改訂第3版2013

    • Author(s)
      .榊原守,神谷究:
    • Total Pages
      586
    • Publisher
      南江堂
    • Related Report
      2012 Research-status Report
  • [Book] 糖尿病合併症-鑑別ポイントとベスト管理法2011

    • Author(s)
      西川武志
    • Total Pages
      328
    • Publisher
      中山書店
    • Related Report
      2011 Research-status Report
  • [Book] 冠動脈疾患(上)-診断と治療の進歩-2011

    • Author(s)
      榊原守、筒井裕之
    • Total Pages
      661
    • Publisher
      日本臨牀社
    • Related Report
      2011 Research-status Report
  • [Book] 虚血性心疾患2011

    • Author(s)
      榊原守、筒井裕之
    • Total Pages
      216
    • Publisher
      文光堂
    • Related Report
      2011 Research-status Report
  • [Book] そこが知りたい抗血栓療法2011

    • Author(s)
      榊原守
    • Total Pages
      259
    • Publisher
      メジカルビュー社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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