Heat shock protein mediates the cardioprotection induced by ischemic postconditioning

• Project/Area Number: 23591025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Asahikawa Medical College
• Principal Investigator: TAKEUCHI Toshiharu 旭川医科大学, 医学部, 講師 (10372278)
• Co-Investigator(Kenkyū-buntansha): HASEBE Naoyuki 旭川医科大学, 医学部, 教授 (30192272)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 臨床心血管病態学 / 急性心筋梗塞 / 再灌流障害 / ポストコンディショニング / 熱ショック蛋白 / 経皮的冠動脈インターベンション / 再灌流傷害

Research Abstract

Ischemic postconditioning to repeat ischemia and reperfusion of the short time at reperfusion therapy for patient with acute myocardial infarction is effective strategy to reduce reperfusion injury. To elucidate the mechanism of postconditioning, we evaluated HSP72 expression levels in a white blood corpuscle until 48 hours after reperfusion. We compared prodromal angina (+) group with prodromal angina (-) group. There was no significant difference in peak HSP72 level after reperfusion between both groups. However, in prodromal angina (+) group, HSP72 expression level before reperfusion has increased to 3.4 times of prodromal angina (-) group. Interestingly, in subgroup of postconditioning(+) among prodromal angina (-) group, HSP72 expression level showed a marked increase also 14.9 times as compared to before reperfusion. It was shown that the postconditioning induced the cardioprotection effect through increase of HSP72.

Research Products

• [Journal Article] Successful percutaneous transluminal angioplasty for the treatment of renovascular hypertension with an atrophic kidney. (2014)
  • Author(s): Maruyama K, Chinda J, Kabara M, Nakagawa N, Fujino T, Takeuchi T, Hasebe N.
  • Journal Title: Heart Vessels. Volume: Epub ahead of print
  • NAID: 120006510210
• [Journal Article] Dipstick proteinuria as a surrogate marker of long-term mortality after acute myocardial infarction. (2013)
  • Author(s): Ota H, Takeuchi T, Sato N, Hasebe N.
  • Journal Title: J Cardiol. Volume: 62(5) Issue: 5 Pages: 277-282
  • DOI: 10.1016/j.jjcc.2013.05.002
  • Peer Reviewed
• [Journal Article] Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes. (2013)
  • Author(s): Sakamoto N, Sato N, Goto M, Kobayashi M, Takehara N, Takeuchi T, Talib AK, Sugiyama E, Minoshima A, Tanabe Y, Akasaka K, Kawabe J, Kawamura Y, Doi A, Hasebe N.
  • Journal Title: Heart Vessels. Volume: Epub ahead of print
  • NAID: 120005567845
• [Journal Article] Combination of antihypertensive therapy in the elderly, multicenter investigation (CAMUI) trial: results after 1 year. (2013)
  • Author(s): Sato N, Saijo Y, Sasagawa Y, Morimoto H, Takeuchi T, Sano H, Koyama S, Takehara N, Morita K, Sumitomo K, Maruyama J, Kikuchi K, Hasebe N; the CAMUI investigators.
  • Journal Title: J Hypertens. Volume: Epub ahead of print Issue: 6 Pages: 1245-55
  • DOI: 10.1097/hjh.0b013e32835fdf60
  • Peer Reviewed
• [Journal Article] Site of Transmural Late Gadolinium Enhancement on the Cardiac MRI Coincides With the ECG Leads Exhibiting Terminal QRS Distortion in Patients With ST-Elevation Myocardial Infarctions (2012)
  • Author(s): Nimura A, Sakamoto N, Nakagawa N, Ota H, Tanabe Y, Takeuchi T, Natori S, Sato N, Hasebe N, Kawamura Y.
  • Journal Title: International Heart Journal Volume: 53 Issue: 5 Pages: 270-275
  • DOI: 10.1536/ihj.53.270
  • NAID: 130001914161
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Recurrent ventricular fibrillation related to hypokalemia in early repolarization syndrome. (2012)
  • Author(s): Myojo T, Sato N, Nimura A, Matsuo A, Taniguchi O, Nakamura H, Karim Talib A, Sakamoto N, Takeuchi T, Kawamura Y, Hasebe N.
  • Journal Title: Pacing Clin Electrophysiol. Volume: 35 Issue: 8 Pages: 234-238
  • DOI: 10.1111/j.1540-8159.2012.03460.x
  • Peer Reviewed
• [Journal Article] Enhanced transmural dispersion of repolarization in patients with J wave syndromes. (2012)
  • Author(s): Karim Talib A, Sato N, Sakamoto N, Tanabe Y, Takeuchi T, Saijo Y, Kawamura Y, Hasebe N.
  • Journal Title: J Cardiovasc Electrophysiol. Volume: 23 Issue: 10 Pages: 1109-1114
  • DOI: 10.1111/j.1540-8167.2012.02363.x
  • Peer Reviewed
• [Journal Article] Impaired Ventricular Repolarization Dynamics in Patients with Early Repolarization Syndrome. (2012)
  • Author(s): Talib AK, Sato N, Asanome A, Myojo T, Nishiura T, Yamaki M, Nakagawa N, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Kawamura Y, Hasebe N.
  • Journal Title: J Cardiovasc Electrophysiol. Volume: Epub ahead of print Issue: 5 Pages: 556-61
  • DOI: 10.1111/jce.12074
  • Peer Reviewed
• [Journal Article] 【高齢者の心不全】 高齢者における心不全再発予防 (2012)
  • Author(s): 竹内利治、長谷部直幸
  • Journal Title: Geriatric Medicine Volume: 50巻 Pages: 43-47
  • NAID: 120004107920
• [Journal Article] Ischemic Preconditioning Effect of Prodromal Angina Is Attenuated in Acute Myocardial Infarction Patients With Hypertensive Left Ventricular Hypertrophy (2011)
  • Author(s): Takeuchi T, Ishii Y, Kikuchi K, Hasebe N.
  • Journal Title: Circulation Journal Volume: 75 Issue: 5 Pages: 1192-1199
  • DOI: 10.1253/circj.CJ-10-0906
  • NAID: 10028147722
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Ischemic preconditioning effect of prodromal angina is attenuated in acute myocardial infarction patients with hypertensive left ventricular hypertrophy. (2011)
  • Author(s): Takeuchi T, Ishii Y, Kikuchi K, Hasebe N.
  • Journal Title: Circ J. Volume: 75(5) Pages: 1192-1199
  • NAID: 10028147722
  • Peer Reviewed
• [Journal Article] A case of idiopathic systemic capillary leak syndrome with high serum levels of G-CSF on exacerbation. (2011)
  • Author(s): Nakagawa N, Ota H, Tanabe Y, Kabara M, Matsuki M, Chinda J, Sakamoto N, Fujino T, Takehara N, Takeuchi T, Kawabe J, Sato N, Kawamura Y, Fukuhara T, Ikuta K, Kikuchi K, Hasebe N.
  • Journal Title: Intern Med. Volume: 50(6) Pages: 597-600
  • NAID: 130000649892
  • Peer Reviewed
• [Journal Article] Recovery of advanced atrioventricular block by cilostazol. (2011)
  • Author(s): Nimura A, Sato N, Sakuragi H, Koyama S, Maruyama J, Talib AK, Nakagawa N, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Kawamura Y, Hasebe N.
  • Journal Title: Intern Med. Volume: 50(18) Pages: 1957-1961
  • NAID: 130000969303
  • Peer Reviewed
• [Journal Article] Clinical and genetic investigation of a Japanese family with cardiac fabry disease. Identification of a novel α-galactosidase A missense mutation (G195V). (2011)
  • Author(s): Nakagawa N, Maruyama H, Ishihara T, Seino U, Kawabe J, Takahashi F, Kobayashi M, Yamauchi A, Sasaki Y, Sakamoto N, Ota H, Tanabe Y, Takeuchi T, Takenaka T, Kikuchi K, Hasebe N.
  • Journal Title: Int Heart J. Volume: 52(5) Pages: 308-311
  • Peer Reviewed
• [Journal Article] 【心血管病予防からみた高血圧の最新治療戦略】 冠動脈疾患予防と合併時の高血圧治療 (2011)
  • Author(s): 竹内利治、長谷部直幸
  • Journal Title: Circulation Volume: 1巻 Pages: 61-70
• [Journal Article] 【冠動脈疾患(下)-診断と治療の進歩-】 急性冠症候群(ST上昇型心筋梗塞を除く)の臨床 プラーク退縮のエビデンス JAPAN-ACS試験 (2011)
  • Author(s): 竹内利治、太田久宣、長谷部直幸
  • Journal Title: 日本臨床 Volume: 69巻 Pages: 336-340
• [Presentation] Clinical significance of diastolic pulmonary vascular pressure gradient for patients with out-of-proportion pulmonary hypertension (2014)
  • Author(s): 竹内利治、長谷部直幸
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Micro- circulatory dysfunction determines the long-term prognosis in asymptomatic patients with non-obstructive hyper- trophic cardiomyopathy (2013)
  • Author(s): Aita M, Takeuchi T, Hasebe N.
  • Organizer: The American College of Cardiology 62nd Annual Scientific Session
  • Place of Presentation: San Francisco, USA
• [Presentation] 急性心筋梗塞患者における睡眠時無呼吸の心筋障害に及ぼす影響 (2013)
  • Author(s): 竹内利治、長谷部直幸
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Presentation] 左心系疾患に伴うOut of proportion肺高血圧患者の核医学的検討 (2013)
  • Author(s): 竹内利治、長谷部直幸
  • Organizer: 第1回日本肺高血圧学会学術集会
  • Place of Presentation: 横浜
• [Presentation] Microcirculatory Dysfunction Determines the Long-term Prognosis in Asymptomatic Patients with Non-obstructive Hypertrophic Cardiomyopathy (2013)
  • Author(s): Aita M, Takeuchi T, Sakamoto N, Ota H, Sato N, Hasebe N
  • Organizer: The American College of Cardiology 62nd Annual Scientific Session.
  • Place of Presentation: San Francisco, USA
• [Presentation] Micro- albuminuria Associated with Functionally Impaired Endothelial Progenitor Cells Predicts In-Stent Late Loss via Cellular Senescence after Myocardial Infarction (2012)
  • Author(s): Ota H, Takeuchi T, Hasebe N.
  • Organizer: American Heart Association Scientific Session 2012
  • Place of Presentation: Los Angeles, USA
• [Presentation] Postconditioning as More Effective Strategy for Reduction of Reperfusion Injury in Acute Myocardial Infarction (2012)
  • Author(s): Takeuchi T, Ota H, Ishii Y, Hasebe N.
  • Organizer: European Society of Cardiology Congress 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Functional disorder of endothelial progenitor cells enhance microalbuminuria predicting in-stent late loss in acute myocardial infarction (2012)
  • Author(s): Ota H, Takeuchi T, Hasebe N.
  • Organizer: European Society of Cardiology Congress 2012
  • Place of Presentation: Munich, Germany
• [Presentation] Out of proportion pulmonary hypertensionを呈する左心不全患者の臨床像に対する核医学的検討 (2012)
  • Author(s): 竹内利治, 曾田誠, 河端奈穂子, 伊達歩, 杉山英太郎, 蓑島暁帆, 島村浩平, 坂本央, 太田久宣, 竹原有史, 佐藤伸之, 長谷部直幸
  • Organizer: 第60回日本心臓病学会学術集会
  • Place of Presentation: 金沢, 日本
• [Presentation] Microalbuminuria Associated with Functionally Impaired Endothelial Progenitor Cells Predicts In-Stent Late Loss via Cellular Senescence after Myocardial Infarction (2012)
  • Author(s): Ota H, Takehara N, Nakagawa N, Takeuchi T, Kawabe J, Hasebe N
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angeles, USA
• [Presentation] 梗塞前狭心症を有する急性心筋梗塞患者でのポストコンディショニングの上乗せ効果 (2011)
  • Author(s): 竹内利治
  • Organizer: 第59回日本心臓病学会
  • Place of Presentation: 神戸