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Rho-kinase activity in circulating neutrophils as a useful biomarker for diagnosis and disease activity assessment of vasospastic angina

Research Project

Project/Area Number 23591026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNational Cardiovascular Center Research Institute (2012-2013)
Tohoku University (2011)

Principal Investigator

YASUDA Satoshi  独立行政法人国立循環器病研究センター, 病院, 部門長 (00431578)

Co-Investigator(Kenkyū-buntansha) SHIMOKAWA Hiroaki  東北大学, 大学院医学系研究科, 教授 (00235681)
TAKAHASHI Jun  東北大学, 大学院医学系研究科, 講師 (00375081)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsストレス / 循環器・高血圧 / トランスレーショナルリサーチ
Research Abstract

We examined whether Rho-kinase activity is systemically enhanced in vasospastic angina (VSA) patients. The Rho-kinase activity was significantly higher in the VSA group than in the non-VSA group. We also found that Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress and that Rho-kinase activity exhibits distinct circadian variation associated with alterations in coronary vasomotor responses. These results indicate that Rho-kinase activity in circulating neutrophils may be a useful biomarker for diagnosis and disease activity assessment of the vasospastic disorder.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (24 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (9 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Circadian Variation of Rho-Kinase Activity in Circulating Leukocytes of Patients With Vasospastic Angina2014

    • Author(s)
      Nihei T, Takahashi J, Tsuburaya R, Ito Y, Shiroto T, Hao K, Takagi Y, Matsumoto Y, Nakayama M, Miyata S, Sakata Y, Ito K, Shimokawa H.
    • Journal Title

      Circ J

      Volume: Mar 27(Epub ahead of print)

    • NAID

      130003391088

    • Related Report
      2013 Final Research Report
  • [Journal Article] Contemporary crossing techniques for infrapopliteal chronic total occlusions2014

    • Author(s)
      Kawarada O, Sakamoto S, Harada K, Ishihara M, Yasuda S, Ogawa H.
    • Journal Title

      J Endovasc Ther

      Volume: 21 Pages: 266-80

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vasospastic limb ischemia presenting acute and chronic limb ischemia2014

    • Author(s)
      Kaneyama J, Kawarada O, Sakamoto S, Harada K, Ishihara M, Yasuda S, Hisao O.
    • Journal Title

      Ann Vasc Dis

      Volume: (in press)

    • NAID

      130004488034

    • Related Report
      2013 Final Research Report
  • [Journal Article] Circadian Variation of Rho-Kinase Activity in Circulating Leukocytes of Patients With Vasospastic Angina.2014

    • Author(s)
      Nihei T, Takahashi J, Tsuburaya R, Ito Y, Shiroto T, Hao K, Takagi Y, Matsumoto Y, Nakayama M, Miyata S, Sakata Y, Ito K, Shimokawa H.
    • Journal Title

      Circ J.

      Volume: in press

    • NAID

      130003391088

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contemporary crossing techniques for infrapopliteal chronic total occlusions.2014

    • Author(s)
      Kawarada O, Sakamoto S, Harada K, Ishihara M, Yasuda S, Ogawa H.
    • Journal Title

      J Endovasc Ther

      Volume: 21 Pages: 266-80

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vasospastic limb ischemia presenting acute and chronic limb ischemia.2014

    • Author(s)
      Kaneyama J, Kawarada O, Sakamoto S, Harada K, Ishihara M, Yasuda S, Ogawa H.
    • Journal Title

      Ann Vasc Dis

      Volume: in press

    • NAID

      130004488034

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake2012

    • Author(s)
      Nihei T, Takahashi J, Kikuchi Y, Takagi Y, Hao K, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
    • Journal Title

      Circ J

      Volume: 76 Pages: 2892-4

    • NAID

      10031126063

    • Related Report
      2013 Final Research Report
  • [Journal Article] Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake.2012

    • Author(s)
      Nihei T, Takahashi J, Kikuchi Y, Takagi Y, Hao K, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
    • Journal Title

      Circ J

      Volume: 76 Pages: 2892-4

    • NAID

      10031126063

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina : a possible biomarker for diagnosis and disease activity assessment2011

    • Author(s)
      Kikuchi Y, Yasuda S, Aizawa K, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H.
    • Journal Title

      J Am Coll Cardiol

      Volume: 58 Pages: 1231-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment.2011

    • Author(s)
      Kikuchi Y, Yasuda S, Aizawa K, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 58 Pages: 1231-7

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Circadian Variation of Rho-kinase Activity in Circulating Leukocytes in Patients with Vasospastic Angina Circulation Journal 2014, 78(Suppl. I) : I-5972014

    • Author(s)
      Taro Nihei, Jun Takahashi, Yoku Kikuchi, Kiyotaka Hao, Yusuke Takagi, Ryuji Tsuburaya, Takashi Shirato, Yoshitaka Itoh, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Hiroaki Shimokawa
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Circadian Variation of Rho-kinase Activity in Circulating Leukocytes in Patients with Vasospastic Angina2014

    • Author(s)
      Taro Nihei,Jun Takahashi, Yoku Kikuchi, Kiyotaka Hao, Yusuke Takagi, Ryuji Tsuburaya, Takashi Shirato, Yoshitaka Itoh, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Hiroaki Shimokawa
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京、日本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Circadian variation of Rho-kinase activity associated with enhanced coronary reactivity in patients with vasospastic angina2013

    • Author(s)
      Nihei T, Takahashi J, Kikuchi Y, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama Y, Ito K, Shimokawa H.
    • Organizer
      European Society of Cardiology 2013
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Final Research Report
  • [Presentation] Circadian variation of Rho-kinase activity associated with enhanced coronary reactivity in patients with vasospastic angina2013

    • Author(s)
      .Nihei T, Takahashi J, Kikuchi Y, Tsuburaya R, Shiroto T, Ito Y, Matsumoto Y, Nakayama Y, Ito K, Shimokawa H.
    • Organizer
      uropean Society of Cardiology 2013
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2013 Annual Research Report
  • [Presentation] Enhanced rho-kinase activity in circulating neutrophils of patients with vasospasticangina after the Great East Japan Earthquake. (#9574)2012

    • Author(s)
      Nihei T, Takahashi J, Kikuchi Y, Hao K, Takagi Y, Tsuburaya R, Shiroto T, ItoY, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Increased Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake disaster2012

    • Author(s)
      Nihei T, Takahashi J, Kikuchi Y, Ito Y, Tsuburaya R, Takagi Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
    • Organizer
      European Society of Cardiology Congress 2012
    • Place of Presentation
      Munich, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Enhanced rho-kinase activity in circulating neutrophils of patients with vasospasticangina after the Great East Japan Earthquake.2012

    • Author(s)
      Nihei T, Takahashi J, Kikuchi Y, Hao K, Takagi Y, Tsuburaya R, Shiroto T, ItoY, Matsumoto Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
    • Organizer
      American Heart Association
    • Place of Presentation
      Los Angeles, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Increased Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake disaster.2012

    • Author(s)
      Nihei T, Takahashi J, Kikuchi Y, Ito Y, Tsuburaya R, Takagi Y, Nakayama M, Ito K, Yasuda S, Shimokawa H.
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Munich, Germany
    • Related Report
      2012 Research-status Report
  • [Presentation] Usefulness of Rho-kinase activity in circulating neutrophils for disease activity assessment of vasospastic angina.2011

    • Author(s)
      9.Kikuchi Y, Aizawa K, Yasuda S, Tsuburaya R, Ito Y, Takeda M, Nakayama M, Ito K, Takahashi J, Shimokawa H.
    • Organizer
      American Heart Association (AHA) Scientific Sessions
    • Place of Presentation
      Chicago, USA
    • Related Report
      2011 Research-status Report
  • [Book] The Pathogenesis of Vasospastic Angina. In : Kaski JC, Eslick GD, Bairey Merz CN (eds.), Chest Pain with Normal Coronary Arteries2013

    • Author(s)
      Yasuda S, Shimokawa H.
    • Publisher
      Springer-Verlag
    • Related Report
      2013 Final Research Report
  • [Book] The Pathogenesis of Vasospastic Angina. In: Kaski JC, Eslick GD, Bairey Merz CN (eds.)2013

    • Author(s)
      2.Yasuda S, Shimokawa H.
    • Total Pages
      12
    • Publisher
      Springer-Verlag, London, UK
    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学循環器内科

    • URL

      http://www.cardio.med.tohoku.ac.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 国立循環器病研究センター病院

    • URL

      http://hospital.ncvc.go.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.cardio.med.tohoku.ac.jp/class/achievements/index.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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