Genetic background of ventricular tachyarrhythmias associated with acute myocardial ischemia
| Project/Area Number |
23591030
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURABAYASHI Masahiko 群馬大学, 医学系研究科, 教授 (00215047)
KANEKO Yoshiaki 群馬大学, 医学系研究科, 准教授 (60302478)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 遺伝子多型 / 虚血性心疾患 / 致死性不整脈 / イオンチャネル |
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| Research Abstract |
We tried to elucidate the genetic background of ventricular tachyarrhythmias (VTAs) associated with acute coronary ischemia in Japanese patients. We analyzed KCNQ1, KCNH2, KCNE1, KCNE2 and SCN5A in four patients with post myocardial infarction/ischemia-associated torsades de pointes (ACS-TdP), and identified KCNQ1 G643S variant in two patients. The allele frequency of this variant is more common in Asian (about 6 %) than other ethnic groups (white: 0 %). However, it was reported to be associated with secondary long QT syndrome. In contrast, KCNH2 K897T variant, which is prevalent in Caucasian, was reported to be identified in 9 out of 13 Caucasian ACS-TdP patients. Moreover, we analyzed above genes in 8 patients who experienced VTAs associated with vasospastic angina, and identified SCN5A R1193Q, SCN5A L1988R/SCN5A H558R, KCNH2 P10S/SCN5A H558R in three patients. Our data suggest that there may be an ethnic-specific genetic background in VTAs associated with acute coronary ischemia.
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Report
(4 results)
Research Products
(26 results)
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[Presentation] Mechanisms of fever-induced QT prolongation in a patient with a KCNH2 G584S mutation2014
Author(s)
Kenshi Hayashi, Tadashi Nakajima, Shoichi Tange, Hidekazu Ino, Noboru Fujino, Tetsuo Konno, Toyonobu Tsuda, Yoshihiro Tanaka, Masa-aki Kawashiri, Yoshiaki Kaneko, Masahiko Kurabayashi, Masakazu Yamagishi.
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム(東京)
Related Report
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[Presentation] Mechanisms of fever-induced QT prolongation in a patient with a KCNH2 G584S mutation2014
Author(s)
Kenshi Hayashi, Tadashi Nakajima, Shoichi Tange, Hidekazu Ino, Noboru Fujino, Tetsuo Konno, Toyonobu Tsuda, Yoshihiro Tanaka, Masa-aki Kawashiri, Yoshiaki Kaneko, Masahiko Kurabayashi, Masakazu Yamagishi
Organizer
第78回日本循環器学会学術集会
Place of Presentation
東京国際フォーラム（東京）
Related Report
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[Presentation] Genetic heterogeneity of Brugada syndrome in Japanese patients: Implications for genotype-based risk stratification and management2012
Author(s)
Tadashi Nakajima, Yoshiaki Kaneko, Tadanobu Irie, Wu Jie, Seiko Ohno, Megumi Fukuyama, Toshimitsu Kato, Takafumi Iijima, Shoichi Tange, Minoru Horie, Masahiko Kurabayashi
Organizer
第27回日本不整脈学会学術大会（シンポジウム）
Place of Presentation
パシフィコ横浜（横浜）
Related Report
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