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The establishment of the predictor for lethal ischemia-related arrhythmia and the elucidation of pathological mechanism and new treatment by identification of responsible genes.

Research Project

Project/Area Number 23591031
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNiigata University

Principal Investigator

SATO Akinori  新潟大学, 医歯学総合病院, 助教 (40600044)

Co-Investigator(Kenkyū-buntansha) CHINUSHI Masaomi  新潟大学, 医歯学系, 教授 (40303151)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords虚血性不整脈 / 心室細動 / 心筋梗塞 / 冠攣縮狭心症 / J波 / 遺伝子
Outline of Final Research Achievements

The ischemic heart disease such as the myocardial infarction would be lethal. In fact, the majority of those deaths would happen suddenly, resulting from the ischemia-induced cardiac arrhythmia. We studied the electrocardiographic findings, J wave, as a predictor for lethal arrhythmia. We showed the frequency of a J wave in general population. And we reviewed frequencies and morphologies of J wave in patients with and without ischemic ventricular fibrillation during induction of coronary spasm. As a result, we reported that the presense of J wave and the dynamic changes of J wave contributed to ischemic ventricular fibrillation, and that the J wave can be the predictive factor for occurrences of ischemic ventricular fibrillation. Also, we accumulated clinical features and genetic information of over 70 cases that had suffered from ischemic ventricular fibrillation, and presented analysis results including a treatment method for ischemia-induced arrhythmia at academic meetings.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (30 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (20 results) (of which Peer Reviewed: 18 results,  Open Access: 2 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Augmentation of the J wave by rapid pacing in a patient with vasospastic angina.2014

    • Author(s)
      Sato A, Watanabe H, Sonoda K, Chinushi M, Tsuda T, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Int J Cardiol.

      Volume: 172 Issue: 1 Pages: e111-e113

    • DOI

      10.1016/j.ijcard.2013.12.121

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short QT syndrome in a boy diagnosed on screening for heart disease.2014

    • Author(s)
      Suzuki H, Hoshina S, Ozawa J, Sato A, Minamino T, Aizawa Y, Saitoh A.
    • Journal Title

      Pediatr Int.

      Volume: 56 Issue: 5 Pages: 774-774

    • DOI

      10.1111/ped.12308

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead.2013

    • Author(s)
      Sato A, Chinushi M, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Intern Med.

      Volume: 52 Pages: 1189-93

    • NAID

      130003365633

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arrhythmia and genetic background2013

    • Author(s)
      Chinushi M, Sato A
    • Journal Title

      Rinsho Byori.

      Volume: 61 Pages: 150-8

    • NAID

      10031165633

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short-coupling premature ventricular complexes from the left ventricle triggered isoproterenol-resistant electrical storm in a patient with Brugada syndrome.2013

    • Author(s)
      Chinushi Masaomi, Sato Akinori
    • Journal Title

      Heart Rhythm

      Volume: - Issue: 6 Pages: 916-920

    • DOI

      10.1016/j.hrthm.2013.01.020

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Incessant Ventricular Tachyarrhythmia at Emergency Room2013

    • Author(s)
      Chinushi Masaomi, Sato Akinori
    • Journal Title

      Journal of Cardiology Cases

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel disease gene for Brugada syndrome: sarcolemmal membrane-associated protein gene mutations impair intracellular trafficking of hNav1.52012

    • Author(s)
      Ishikawa T
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 5 Issue: 6 Pages: 1098-1107

    • DOI

      10.1161/circep.111.969972

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamicity of the J wave in idiopathic ventricular fibrillation with a special reference to pause-dependent augmentation of the J wave.2012

    • Author(s)
      Aizawa Y
    • Journal Title

      Journal of American College of Cardiology

      Volume: 59 Issue: 22 Pages: 1948-53

    • DOI

      10.1016/j.jacc.2012.02.028

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Benign premature ventricular complexes from the right ventricular outflow tract triggered polymorphic ventricular tachycardia in a latent type 2 lqts patient.2012

    • Author(s)
      Sato Akinori, Chinushi Masaomi
    • Journal Title

      Internal medicine

      Volume: 51 Pages: 3261-3265

    • NAID

      130003308151

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long qt syndrome with nocturnal cardiac events caused by a kcnh2 missense mutation (g604s)2012

    • Author(s)
      Sato Akinori, Chinushi Masaomi
    • Journal Title

      Internal medicine

      Volume: 51 Pages: 1857-1860

    • NAID

      130002062243

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nifekalant enlarged the transmural activation-recovery interval difference as well as the peak-to-end interval on surface ECG in a patient with short-QT syndrome.2012

    • Author(s)
      Chinushi Masaomi, Sato Akinori
    • Journal Title

      J Cardiovasc Electrophysiol.

      Volume: 8 Issue: 8 Pages: 877-80

    • DOI

      10.1111/j.1540-8167.2012.02292.x

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization.2012

    • Author(s)
      Watanabe H
    • Journal Title

      Int J Cardiol.

      Volume: 159 Issue: 3 Pages: 238-40

    • DOI

      10.1016/j.ijcard.2012.05.091

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics of electrocardiographic repolarization in acute myocardial infarction complicated by ventricular fibrillation.2012

    • Author(s)
      Aizawa Yoshifusa, Chinushi Masaomi
    • Journal Title

      J Electrocardiol.

      Volume: 45 Issue: 3 Pages: 252-9

    • DOI

      10.1016/j.jelectrocard.2011.11.007

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The prevalence of early repolarization in Wolff-Parkinson-White syndrome with a special reference to J waves and the effects of catheter ablation.2012

    • Author(s)
      Yagihara Nobue, Sato Akinori, Chinushi Masaomi, Aizawa Yoshifusa
    • Journal Title

      Journal of Electrocardiology

      Volume: 45 Pages: 36-42

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early Repolarization and Its Modification by Preexcitation in Two Patients with Intermittent Wolff-Parkinson-White Syndrome.2012

    • Author(s)
      Hasegawa Kanae, Sato Akinori, Chinushi Masaomi, Aizawa Yoshifusa
    • Journal Title

      Pacing Clinical Electrophysiology

      Volume: - Issue: 8

    • DOI

      10.1111/j.1540-8159.2012.03360.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of J waves during myocardial ischaemia.2012

    • Author(s)
      Sato Akinori, Masaomi Chinushi
    • Journal Title

      Europace

      Volume: - Issue: 5 Pages: 715-723

    • DOI

      10.1093/europace/eur323

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics and Prevalence of J Wave in Our Outpatient Clinic2012

    • Author(s)
      Sato Akinori, Chinushi Masaomi
    • Journal Title

      Japanese Journal of Electrocardiology

      Volume: 32, Suppl. 1 Pages: 19-25

    • Related Report
      2011 Research-status Report
  • [Journal Article] Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization.2011

    • Author(s)
      Watanabe Hiroshi, Sato Akinori, Chinushi Masaomi
    • Journal Title

      Circulation Arrhythmia and Electrophysiology

      Volume: 4 Pages: 847-881

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endocardial arrhythmogenic mechanisms of torsades de pointes in patients with the congenital long QT syndrome.2011

    • Author(s)
      Chinushi Masaomi, Sato Akinori
    • Journal Title

      Internal Medicine

      Volume: 50 Pages: 1695-702

    • NAID

      130000969371

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 心筋虚血におけるJ波と心室細動の関連2011

    • Author(s)
      佐藤光希、池主雅臣
    • Journal Title

      新潟県医師会報

      Volume: 741 Pages: 1-3

    • Related Report
      2011 Research-status Report
  • [Presentation] 経静脈的左室リードの留置後、直下の冠動脈会穿刺に狭窄をきたし心室頻拍の増悪を生じた左室低心機能の1例2015

    • Author(s)
      佐藤 光希, 長谷川 祐紀, 小澤 拓也, 柳川 貴央, 石田 尚子, 早川 貴人,岡田隆, 長谷川 進, 大槻 総, 八木原 伸江, 和泉 大輔, 渡部 裕, 南野 徹
    • Organizer
      第7 回 植え込みデバイス関連冬季大会
    • Place of Presentation
      東京 東京プリンスホテル
    • Year and Date
      2015-02-20 – 2015-02-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] J-wave augmentation related to shortening of the RR interval in a patient with vasospastic angina and ventricular fibrillation2014

    • Author(s)
      Akinori Sato, Hiroshi Watanabe, Keiko Sonoda, Masaomi Chinushi, Takashi Tsuda, Daisuke Izumi, Nobue Yagihara, So Ohtsuki, Yuki Hasegawa, Hiroshi Furushima and Tohru Minamino
    • Organizer
      第29回 日本不整脈学会、第31回 日本心電学会 合同学術大会
    • Place of Presentation
      東京 東京プリンスホテル
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 低侵襲血行動態モニタリングを用いたCRT設定の最適化とその効果2014

    • Author(s)
      佐藤光希、池主雅臣
    • Organizer
      第6回 植え込みデバイス関連冬季大会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] Failure of Cardiac Resynchronization Therapy Associated with Left Ventricular Lead Fractuere2013

    • Author(s)
      佐藤光希、池主雅臣
    • Organizer
      第28回 日本不整脈学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] J波と虚血性心室細動の関係 -冠攣性狭心症における検討-2013

    • Author(s)
      佐藤光希、池主雅臣
    • Organizer
      第30回 日本心電学会
    • Place of Presentation
      青森
    • Related Report
      2013 Research-status Report
  • [Presentation] Beta-blocker therapy in patients with genetically defined congenital long QT syndrome: relationship to their Schwartz score2013

    • Author(s)
      Sato Akinori, Chinushi Masaomi
    • Organizer
      第77回 日本循環器学会・学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 睡眠中のtorsade de pointesが記録されたKCNH2変異(G604S)を保有するtype2 QT延長症候群の一例2012

    • Author(s)
      佐藤光希、池主雅臣
    • Organizer
      第29回日本心電図学会・学術集会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Presentation] Association of J Wave with Cardiac Vulnerability for Ventricular Fibrillation During Coronary Spasm Provocation Test

    • Author(s)
      Sato Akinori, Chinushi Masaomi
    • Organizer
      第75回 日本循環器学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Book] 不整脈症候群2015

    • Author(s)
      佐藤光希、南野徹
    • Total Pages
      204
    • Publisher
      南江堂
    • Related Report
      2014 Annual Research Report
  • [Book] 不整脈の診断と治療2013

    • Author(s)
      Sato Akinori
    • Total Pages
      15
    • Publisher
      科学評論社「循環器内科」
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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