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Evaluation of spacial heterogeneous distribution of ventricular repolarization and arrhythmic risk by the body surface standard electrocardiogram

Research Project

Project/Area Number 23591032
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionNiigata University

Principal Investigator

IZUMI Daisuke  新潟大学, 医歯学総合病院, 特任助教 (30529699)

Co-Investigator(Kenkyū-buntansha) CHINUSHI Masaomi  新潟大学, 医歯学系, 准教授 (40303151)
Co-Investigator(Renkei-kenkyūsha) FURUSHIMA Hiroshi  新潟大学, 医歯学総合病院, 助教 (10377161)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsQT延長 / T波 / 不整脈 / 再分極 / 多形性心室頻拍 / 多型性心室頻拍
Research Abstract

Fatal ventricular tachyarrhythmias often originate from enlargement of ventricular transmural dispersion of repolarization (TDR). Using canine model which showed spacial heterogeneous distribution of ventricular repolarization, we studied the relationship between the interval of the peak-to-end of the T wave (Tp-e) in ECG and the 3-dimensional repolarization heterogeneity. Tp-e in the limb leads expresses total distribution of repolarization in the left ventricle (LV). The proportion of variance of TDR in each LV region for Tp-e on V2-4 were higher in the anterior rather than in the lateral region, while those on V5-6 were higher in the lateral or midventricular/apical region rather than in the anterior or basal region. The precordial Tp-e seemed to express a certain degree of TDR at near and vertical ventricular wall. These results elucidated the electrophysiological background of the T wave and showed the alternative method of the discrimination of the fatal arrhythmic risk.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Open Access: 1 results) Presentation (10 results)

  • [Journal Article] Augmentation of the J wave by rapid pacing in a patient with vasospastic angina2014

    • Author(s)
      Sato A, Watanabe H, Sonoda K, Chinushi M, Tsuda T, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Int J Cardiol

      Volume: 172(1)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Augmentation of the J wave by rapid pacing in a patient with vasospastic angina.2014

    • Author(s)
      Sato A, Watanabe H, Sonoda K, Chinushi M, Tsuda T, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Int J Cardiol.

      Volume: 172 Issue: 1 Pages: e111-e113

    • DOI

      10.1016/j.ijcard.2013.12.121

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the renal artery2013

    • Author(s)
      Chinushi M, Izumi D, Iijima K, Suzuki K, Furushima H, Saitoh O, Furuta Y, Aizawa Y, Iwafuchi M.
    • Journal Title

      Hypertension

      Volume: 61(2) Pages: 450-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead2013

    • Author(s)
      Sato A, Chinushi M, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Intern Med

      Volume: 52(11) Pages: 1189-93

    • NAID

      130003365633

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead.2013

    • Author(s)
      Sato A, Chinushi M, Izumi D, Furushima H, Minamino T.
    • Journal Title

      Intern Med.

      Volume: 52 Pages: 1189-93

    • NAID

      130003365633

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Benign premature ventricular complexes from the right ventricular outflow tract triggered polymorphic ventricular tachycardia in a latent type 2 LQTS patient2012

    • Author(s)
      Sato A, Chinushi M, Sonoda K, Abe A, Izumi D, Furushima H.
    • Journal Title

      Intern Med

      Volume: 51(23) Pages: 3261-5

    • NAID

      130003308151

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulation defects in Riata implantable cardioverter-defibrillator leads2012

    • Author(s)
      Sato A, Chinushi M, Iijima K, Izumi D, Furushima H.
    • Journal Title

      Intern Med

      Volume: 51(19) Pages: 2689-94

    • NAID

      130002062028

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nifekalant Enlarged the Transmural Activation-Recovery Interval Difference as Well as the Peak-to-End Interval on Surface ECG in a Patient with Short-QT Syndrome2012

    • Author(s)
      Chinushi M, Sato A, Izumi D, Furushima H.
    • Journal Title

      J Cardiovasc Electrophysiol. J Cardiovasc Electrophysiol

      Volume: 23(8) Pages: 877-80

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exercise-Related QT Interval Shortening with a Peaked T Wave in a Healthy Boy with a Family History of Sudden Cardiac Death2012

    • Author(s)
      Chinushi M, Sato A, Iijima K, Suzuki K, Hiroshi F, Izumi D, Watanabe H, Kanae H, Aizawa Y.
    • Journal Title

      Pacing Clin Electrophysiol

      Volume: 35(8)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is the coexistence of sustained ST-segment elevation and abnormal Q waves a risk factor for electrical storm in implanted cardioverter defibrillator patients with structural heart diseases?2012

    • Author(s)
      Furushima H, Chinushi M, Iijima K, Hasegawa K, Sato A, Izumi D, Watanabe H, Aizawa Y.
    • Journal Title

      Europace

      Volume: 14(5) Pages: 675-81

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval2012

    • Author(s)
      Izumi D, Chinushi M, Iijima K, Furushima H, Hosaka Y, Hasegawa K, Aizawa Y.
    • Journal Title

      Heart Rhythm

      Volume: 9(5) Pages: 796-803

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of J waves during myocardial ischaemia2012

    • Author(s)
      Sato A, Tanabe Y, Chinushi M, Hayashi Y, Yoshida T, Ito E, Izumi D, Iijima K, Yagihara N, Watanabe H, Furushima H, Aizawa Y.
    • Journal Title

      Europace

      Volume: 14(5) Pages: 715-23

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between electroanatomical voltage mapping characteristics and breakout site of ventricular activation in idiopathic ventricular tachyarrhythmia originating from the right ventricular outflow tract septum2012

    • Author(s)
      Furushima H, Chinushi M, Iijima K, Izumi D, Hosaka Y, Aizawa Y.
    • Journal Title

      J Interv Card Electrophysiol

      Volume: 32(2) Pages: 135-41

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence of early repolarization in Wolff-Parkinson-White syndrome with a special reference to J waves and the effects of catheter ablation2012

    • Author(s)
      Yagihara N, Sato A, Iijima K, Izumi D, Furushima H, Watanabe H, Irie T, Kaneko Y, Kurabayashi M, Chinushi M, Satou M, Aizawa Y.
    • Journal Title

      J Electrocardiol

      Volume: 45(1) Pages: 36-42

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epicardial scar in a patient with no apparent heart disease2012

    • Author(s)
      Chinushi M, Izumi D, Furushima H, Sato A, Iijima K, Hasegawa K, Aizawa Y.
    • Journal Title

      Pacing Clin Electrophysiol

      Volume: 35(5)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The peak-to-end of the T wave in the limb ECG leads reflects total spatial rather than transmural dispersion of ventricular repolarization in an anthopleurin-A model of prolonged QT interval.2012

    • Author(s)
      Izumi D
    • Journal Title

      Heart Rhythm.

      Volume: Volume 9 Issue: 5 Pages: 796-803

    • DOI

      10.1016/j.hrthm.2011.11.046

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] An appropriate defibrillation threshold obtained by the combined connection between two shock leads and ICD generator2011

    • Author(s)
      Sato A, Chinushi M, Iijima K, Watanabe H, Izumi D, Furushima H, Sonoda K, Hasegawa K, Yagihara N, Aizawa Y.
    • Journal Title

      Intern Med

      Volume: 50(22) Pages: 2815-8

    • NAID

      130002130066

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inappropriate pacing inhibition triggered by QT prolongation due to T wave oversensing in an ICD recipient presenting with long QT syndrome2011

    • Author(s)
      Iijima K, Chinushi M, Hasegawa K, Izumi D, Hosaka Y, Furushima H, Aizawa Y.
    • Journal Title

      Intern Med

      Volume: 50(9) Pages: 1021-4

    • NAID

      130000650105

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Electrical storm due to reentrant ventricular tachycardia after cardiac resynchronization therapy in a patient with idiopathic dilated cardiomyopathy2013

    • Author(s)
      Sou Otsuki, Daisuke Izumi, Kenichi Iijima, Nobue Yagihara, Akinori Sato, Hiroshi Watanabe, Hiroshi Furushima, Masaomi Chinushi, Tohru Minamino.
    • Organizer
      The 28th Annual Meeting of the Japanese Heart Rhythm Society 2013
    • Place of Presentation
      Minato-ku, Tokyo
    • Year and Date
      2013-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlation between the T Peak-to-End Interval (Tp-e) on the Surface Precordial Leads ECG and the Intracardiac Spacial LV Repolarization Distribution2013

    • Author(s)
      Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Akinori Sato, Hiroshi Furushima, Tohru Minamino.
    • Organizer
      The 77th Annual Scientific Meeting of the Japanese Circulation Society 2013
    • Place of Presentation
      Yokohama
    • Year and Date
      2013-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 左側相同型心房内臓錯位症候群による下大静脈欠損を合併した心房中隔欠損症の修復術後に切開線関連心房頻拍を認めた1例2013

    • Author(s)
      和泉 大輔, 大槻 総, 勝海 吾郎, 長尾 智美, 飯嶋 賢一, 佐藤 光希, 渡部 裕, 古嶋 博司, 池主 雅臣, 南野 徹
    • Organizer
      カテーテルアブレーション関連秋季大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Electrical storm due to reentrant ventricular tachycardia after cardiac resynchronization therapy in a patient with idiopathic dilated cardiomyopathy2013

    • Author(s)
      Sou Otsuki, Daisuke Izumi, Kenichi Iijima, Nobue Yagihara, Akinori Sato, Hiroshi Watanabe, Hiroshi Furushima, Masaomi Chinushi, Tohru Minamino
    • Organizer
      The 28th Annual Meeting of the Japanese Heart Rhythm Society
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 拡張型心筋症例の長期経過におけるICD適切作動の予測因子の検討2012

    • Author(s)
      和泉大輔,池主雅臣,飯嶋賢一,佐藤光希,渡部裕,古嶋博司,南野徹
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of primary prevention ICD therapy for sudden cardiac death in patients with old myocardial infarction or idiopathic dilated cardiomyopathy2012

    • Author(s)
      Daisuke Izumi, Masaomi Chinushi, Hiroshi Furushima, Kenichi Iijima, Akinori Sato, Hiroshi Watanabe, Tohru Minamino
    • Organizer
      The 5th Asia-Pacific Heart Rhythm Society Scientific Sessions 2012
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2012-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 不整脈源性右室心筋症(ARVC)と心機能正常例における心室単極電位の検討2012

    • Author(s)
      和泉大輔,古嶋博司,佐藤光希,飯嶋賢一,八木原伸江,園田桂子,渡部裕,池主雅臣
    • Organizer
      第27回日本不整脈学会学術大会2012年
    • Place of Presentation
      横浜
    • Year and Date
      2012-07-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlation between Spatial Repolarization and Peak-to-end of the T Wave on Transmural Left Ventricular and Body Surface ECG2011

    • Author(s)
      Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Kanae Hasegawa, Akinori Sato, Hiroshi Furushima, Yoshifusa Aizawa
    • Organizer
      American Heart Association Scientific Sessions 2011
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2011-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Correlation between Spatial Repolarization and Peak-to-end of the T Wave on Transmural Left Ventricular and Body Surface ECG2011

    • Author(s)
      Daisuke Izumi
    • Organizer
      American Heart Association Scientific Sessions Conference 2011
    • Place of Presentation
      Orlando, Florida
    • Related Report
      2011 Research-status Report
  • [Presentation] Correlation between the T Peak-to-End Interval (Tp-e) on the Surface Precordial Leads ECG and the Intracardiac Spacial LV Repolarization Distribution

    • Author(s)
      Daisuke Izumi
    • Organizer
      The 77th Annual Scientific Meeting of the japanese Circulation Society 2013
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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