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Basic and clinical research for therapeutic angiogenesis of the next generation

Research Project

Project/Area Number 23591035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionShinshu University

Principal Investigator

IKEDA Uichi  信州大学, 医学部, 教授 (30221063)

Co-Investigator(Kenkyū-buntansha) KOYAMA Jun  信州大学, 医学部, 准教授 (10303463)
IZAWA Atsushi  信州大学, 医学部附属病院, 講師 (50464095)
KASHIMA Yuichiro  信州大学, 医学部附属病院, 助教(診療) (70545722)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords糖鎖 / 血管再生 / 循環器内科学 / 幹細胞
Research Abstract

To apply the sugar chain for regenerative medicine of cardiovascular diseases, we administered N-acetyl glucosamine (GlcNAc)-modified liposome intravenously to the vascular injury model of mice, and found that GlcNAc-liposome was accumulated specifically in the vascular injury site. In addition, we started a new therapeutic angiogenesis using adipose tissue-derived stem cells (ADRC), which is less invasive compared to revascularization therapy using bone marrow cells.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (39 results)

All 2013 2012 2011

All Journal Article (22 results) (of which Peer Reviewed: 22 results) Presentation (17 results)

  • [Journal Article] Crucial role of hyaluronan in neointimal formation after vascular injury.2013

    • Author(s)
      Kashima Y, Takahashi M, Shiba Y, Itano N, Izawa A, Koyama J, Nakayama J, Taniguchi S, Kimata K, Ikeda U.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e58760-e58760

    • DOI

      10.1371/journal.pone.0058760

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Presence of diastolic dysfunction in patients with peripheral artery disease2013

    • Author(s)
      Yamasaki S, Izawa A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
    • Journal Title

      Angiology

      Volume: 64(7) Issue: 7 Pages: 540-543

    • DOI

      10.1177/0003319713476135

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostacyclin -a potential new target for endothelial progenitor cell-mediated angiogenesis -2013

    • Author(s)
      Shiba Y, Ikeda U.
    • Journal Title

      Circ J

      Volume: 77(4) Pages: 906-907

    • NAID

      10031138991

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prostacyclin - a potential new target for endothelial progenitor cell-mediated angiogenesis -.2013

    • Author(s)
      Shiba Y, Ikeda U.
    • Journal Title

      Circ J

      Volume: 77(4) Pages: 906-907

    • NAID

      10031138991

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of human cardiac cell sheets using pluripotent stem cells.2012

    • Author(s)
      Matsuura K, Wada M, Shimizu T, Haraguchi Y, Sato F, Sugiyama K, Konishi K, Shiba Y, Ichikawa H, Tachibana A, Ikeda U, Yamato M, Hagiwara N, Okano T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 425(2) Issue: 2 Pages: 321-327

    • DOI

      10.1016/j.bbrc.2012.07.089

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts.2012

    • Author(s)
      Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, 他5名
    • Journal Title

      Nature

      Volume: 489(7415) Issue: 7415 Pages: 322-325

    • DOI

      10.1038/nature11317

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunoadsorption therapy reduces oxidative stress in patients with dilated cardiomyopathy.2012

    • Author(s)
      Kasai H, Kashima Y, Izawa A, Tomita T, Miyashita Y, Koyama J, Takahashi M, Yoshio T, Yazaki Y, Higuchi M, Ikeda U
    • Journal Title

      WJCD

      Volume: 2 Issue: 04 Pages: 305-312

    • DOI

      10.4236/wjcd.2012.24048

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunoadsorption therapy reduces oxidative stress in patients with dilated cardiomyopathy.2012

    • Author(s)
      Kasai H, Kashima Y, Izawa A, Tomita T, Miyashita Y, Koyama J, Takahashi M, Yoshio T, Yazaki Y, Higuchi M, Ikeda U
    • Journal Title

      World Journal of Cardiovascular Diseases

      Volume: 2 Pages: 305-312

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early Intervention with Rosuvastation Decreases the Lipid Components of the Plaque in Acute Coronary Syndrome2011

    • Author(s)
      Otagiri K, Tsutsui H, Kumazaki S, Miyashita Y, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Koyama J, Ikeda U.
    • Journal Title

      Circulation Journal

      Volume: 75(3) Pages: 633-641

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transient pseudorestrictive pattern of transmitral flow velocity curve in patients with paroxysmal atrial fibrillation.2011

    • Author(s)
      Motoki H, Koyama J, Tomita T, Aizawa K, Kasai H, Koshikawa M, Izawa A, Kumazaki S, Takahashi M, Ikeda U.
    • Journal Title

      Echocardiography

      Volume: 28(3) Issue: 3 Pages: 289-297

    • DOI

      10.1111/j.1540-8175.2010.01312.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammasome activation of cardiac fibroblasts is effential for myocardial ischemia/reperfusion injury2011

    • Author(s)
      Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U
    • Journal Title

      Circulation

      Volume: 123 Issue: 6 Pages: 594-604

    • DOI

      10.1161/circulationaha.110.982777

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia.2011

    • Author(s)
      Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
    • Journal Title

      Cardiovasc Res

      Volume: 90 Issue: 2 Pages: 362-372

    • DOI

      10.1093/cvr/cvq397

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of circumferential pulmonary vein isolation for atrial fibrillation on ST elevation in patient with Brugada syndrome2011

    • Author(s)
      Tomita T , Aizawa K , Shimada K, Motoki H, Otagiri K, Koshikawa M, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U.
    • Journal Title

      Int J Cardiol

      Volume: 149 Issue: 2 Pages: e82-e84

    • DOI

      10.1016/j.ijcard.2009.04.010

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel microsnare successfully used to remove small debris from the right coronary artery2011

    • Author(s)
      Miyashita Y, Saigusa T, Ikeda U.
    • Journal Title

      J Invasive Cardiol

      Volume: Jul. 23(7)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells2011

    • Author(s)
      Ise M, Ise H, Shiba Y, Kobayashi S, Goto M, Takahashi M, Akaike T, Ikeda U.
    • Journal Title

      J Artif Organs

      Volume: (4) Issue: 4 Pages: 301-309

    • DOI

      10.1007/s10047-011-0595-3

    • NAID

      10030339271

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early intervention with rosuvastation decreases the lipid components of the plaque in acute coronary syndrome.2011

    • Author(s)
      Otagiri K, Tsutsui H, Kumazaki S, Miyashita Y, Aizawa K, Koshikawa M, Kasai H, Izawa A, Tomita T, Koyama J, Ikeda U.
    • Journal Title

      Circulation Journal

      Volume: 75 Pages: 633-641

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient pseudorestrictive pattern of transmitral flow velocity curve in patients with paroxysmal atrial ibrillation.2011

    • Author(s)
      Motoki H, Koyama J, Tomita T, Aizawa K, Kasai H, Koshikawa M, Izawa A, Kumazaki S, Takahashi M, Ikeda U.
    • Journal Title

      Echocardiography

      Volume: 28 Pages: 289-97

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury.2011

    • Author(s)
      Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
    • Journal Title

      Circulation

      Volume: 123 Pages: 594-604

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischaemia.2011

    • Author(s)
      Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U.
    • Journal Title

      Cardiovasc Res

      Volume: 90 Pages: 364-72

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of circumferential pulmonary vein isolation for atrial fibrillation on ST elevation in patient with Brugada syndrome.2011

    • Author(s)
      Tomita T , Aizawa k, Shimada K, Motoki H, Otagiri K, Koshikawa M, Kasai H, Izawa A, Kumazaki S, Tsutsui H, Koyama J, Ikeda U.
    • Journal Title

      Int J Cardiol

      Volume: 149

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel microsnare successfully used to remove small debris from the right coronary artery.2011

    • Author(s)
      Miyashita Y, Saigusa T, Ikeda U.
    • Journal Title

      J Invasive Cardiol

      Volume: 23

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Targeting N-acetylglucosamine-bearing polymer-coated liposomes to vascular smooth muscle cells.2011

    • Author(s)
      Ise M, Ise H, Shiba Y, Kobayashi S, Goto M, Takahashi M, Akaike T, Ikeda U.
    • Journal Title

      J Artif Organs

      Volume: 14 Pages: 301-309

    • NAID

      10030339271

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Crucial role of hyaluronan derived from macrophages in neointimal formation after vascular injury2013

    • Author(s)
      Kashima Y, Takahashi M, Itano N, Taniguchi S, Kimata K, Ikeda U.
    • Organizer
      ESC2013欧州心臓学会議
    • Place of Presentation
      アムステルダム(オランダ)
    • Related Report
      2013 Final Research Report
  • [Presentation] Predictors of long-term outcomes in patients with medical treatment for acute aortic dissection2013

    • Author(s)
      Izawa A, Hirota S, Yamaka K, Takeuchi T, Okada A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
    • Organizer
      ESC2013欧州心臓学会議
    • Place of Presentation
      アムステルダム(オランダ)
    • Related Report
      2013 Final Research Report
  • [Presentation] The successful case of angioplasty on popliteal artery occlusion by using excimer laser atherectomy after balloon angioplasty failure2013

    • Author(s)
      Ebisawa S, Miyashita Y, Hioki H, Karube K, Yaguchi T, Abe N, Saigusa T, Miura T, Ikeda U.
    • Organizer
      第22回日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of prognostic improvement by multidisciplinary therapy on patients with critical limb ischemia2013

    • Author(s)
      Hioki H, Miyashita Y, Yaguchi T, Abe N, Ebisawa S, Miura T, Tomita T, Koyama J, Ikeda U.
    • Organizer
      第22回日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Assessment of prognostic improvement by multidisciplinary therapy on patients with critical limb ischemia.2013

    • Author(s)
      Hioki H, Miyashita Y, Yaguchi T, Abe N, Ebisawa S, Miura T, Tomita T, Koyama J, Ikeda U.
    • Organizer
      日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      神戸国際展示場
    • Related Report
      2013 Annual Research Report
  • [Presentation] The successful case of angioplasty on popliteal artery occlusion by using excimer laser atherectomy after balloon angioplasty failure.2013

    • Author(s)
      Ebisawa S, Miyashita Y, Hioki H, Karube K, Yaguchi T, Abe N, Saigusa T, Miura T, Ikeda U.
    • Organizer
      日本心血管インターベンション治療学会学術集会
    • Place of Presentation
      神戸国際展示場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Predictors of long-term outcomes in patients with medical treatment for acute aortic dissection.2013

    • Author(s)
      Izawa A, Hirota S, Yamaka K, Takeuchi T, Okada A, Shiba Y, Tomita T, Miyashita Y, Koyama J, Ikeda U.
    • Organizer
      欧州心臓学会議
    • Place of Presentation
      アムステルダム(オランダ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Crucial role of hyaluronan derived from macrophages in neointimal formation after vascular injury.2013

    • Author(s)
      Kashima Y, Takahashi M, Itano N, Taniguchi S, Kimata K, Ikeda U.
    • Organizer
      欧州心臓学会議
    • Place of Presentation
      アムステルダム(オランダ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of spontaneous myocarditis in Nuclear Factor kappa B(NFκB)p50-deficient mice : the emerging role of NFκB p65 in its pathogenesis2012

    • Author(s)
      Gautam M, Izawa A, Shiba Y, Kashima Y, Koyama J, Hongo M, Sano K, Hayashi T, Ichikawa M, Ikeda U.
    • Organizer
      AHA2012アメリカ心臓協会
    • Place of Presentation
      ロサンゼルス(アメリカ)
    • Related Report
      2013 Final Research Report
  • [Presentation] Critical role of hyaluronan in neointimal formation after vascular injury in mice2012

    • Author(s)
      Kashima Y, Takahashi M, Shiba Y, Itano N, Kimata K, Izawa A, Ikeda U.
    • Organizer
      AHA2012アメリカ心臓協会
    • Place of Presentation
      ロサンゼルス(アメリカ)
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of spontaneous myocarditis in Nuclear Factor kappa B(NFκB)p50-deficient mice:the emerging role of NFκB p65 in its pathogenesis.2012

    • Author(s)
      Gautam Milan, Izawa A, Shiba Y, Kashima Y, Koyama J, Hongo M, Sano K, Hayashi T, Ichikawa M, Ikeda U
    • Organizer
      米国心臓病学会議
    • Place of Presentation
      ロサンゼルス
    • Related Report
      2012 Research-status Report
  • [Presentation] Critical role of hyaluronan in neointimal formation after vascular injury in mice.2012

    • Author(s)
      Kashima Y, Takahashi M, Shiba Y, Itano N, Kimata K, Izawa A, Ikeda U
    • Organizer
      米国心臓病学会議
    • Place of Presentation
      ロサンゼルス
    • Related Report
      2012 Research-status Report
  • [Presentation] Targeted Disruption of p50 Subunit of Nuclear Factor kappa B (NFB) Leads to Spontaneous Myocarditis in Mice2011

    • Author(s)
      Gotam M, Izawa A, Shiba Y, Kashima Y, Koyama J, Hongo M, Sano K, Hayashi T, Agematsu K, Ichikawa M, Ikeda U.
    • Organizer
      AHA2011アメリカ心臓協会
    • Place of Presentation
      オーランド(アメリカ)
    • Related Report
      2013 Final Research Report
  • [Presentation] Specific Overexpression of Hyaluronan in Vascular Smooth Muscle Cells Augments Neointimal Formation after Vascular Injury in Mice2011

    • Author(s)
      Kashima Y, Takahashi M, Hata T, Kawaguchi M, Izawa A, Itano N, Kimata K, Ikeda U.
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Specific Overexpression of Hyaluronan in Vascular Smooth Muscle Cells Augments Neointimal Formation after Vascular Injury in Mice.2011

    • Author(s)
      Kashima Y, Takahashi M, Hata T, Kawaguchi M, Izawa A, Itano N, Kimata K, Ikeda U.
    • Organizer
      第75回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Targeted disruption of p50 subunit of nuclear factor kappa B (NFkB) leads to spontaneous myocarditis in mice.2011

    • Author(s)
      Gotam M, Izawa A, Shiba Y, Kashima Y, Koyama J, Hongo M, Sano K, Hayashi T, Agematsu K, Ichikawa M, Ikeda U.
    • Organizer
      AHA scientific sessions 2011
    • Place of Presentation
      Orlando(USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] Critical role of hyaluronan derived from vascular smooth muscle cells in neointimal formation after vascular injury.2011

    • Author(s)
      Kashima Y, Takahashi M, Hata T, Kawaguchi M, Izawa A, Itano N, Taniguchi S, Ikeda U.
    • Organizer
      AHA scientific sessions 2011
    • Place of Presentation
      Orlando(USA)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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