Role of intracellular calcium handling on the occurrence and maintenance for atrial fibrillation

• Project/Area Number: 23591038
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Nagoya University
• Principal Investigator: UEDA Norihiro 名古屋大学, 環境医学研究所, 助教 (10456709)
• Co-Investigator(Renkei-kenkyūsha): HONJO Haruo 名古屋大学, 環境医学研究所, 准教授 (70262912)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 心房細動 / カルシウム / 心房拡大 / 圧負荷 / カルモジュリン

Research Abstract

Inducibility of atrial fibrillation (AF) was increased by an elevation of atrial pressure in the pressure changeable preparation. The elevation of atrial pressure caused the shortening of effective refractory period (ERP) of atrium. KN-93, as inhibitor of calmodulin kinase (CAMKII) reduced the inducibility of AF. KN-93 did not affect to the pressure-induced shortening of ERP. Intracellular calcium handling should have an important role in the occurrence and maintenance of AF. Intervention to the intracellular calcium handling may be the key factor for AF treatment.

Research Products

• [Journal Article] Atrial selectivity in Na^+ channel blockade by acute amiodarone (2013)
  • Author(s): SUZUKI Tomoyuki, MORISHIMA Mikio, KATO Sara, UEDA Norihiro, HONJO Haruo, KAMIYA Kaichiro
  • Journal Title: Cardiovascular Research Volume: 98 (1) Pages: 136-144
• [Journal Article] Detection of QT prolongation through approximation of the T wave on Gaussian mixture modeling (2013)
  • Author(s): HIBINO Shin, UEDA Norihiro, HORIBA Mitsuru, YASUI Kenji, KAGAMIHARA Yusuke, FUNAHASHI Shuji, KAMIYA Kaichiro, HONDA Hiroyuki
  • Journal Title: Circulation Jounal Volume: 77(11) Pages: 2728-2735
  • NAID: 10031196824
• [Journal Article] Inhibition of intercellular coupling stabilizes spiral-wave reentry, whereas enhancement of the coupling destabilizes the reentry in favor of early termination (2012)
  • Author(s): TAKEMOTO Yoshio, TAKANARI Hiroki, HONJO Haruo, UEDA Norihiro, HARADA Masahide, KATO Sara, YAMAZAKI Masatoshi, SAKUMA Ichiro, OPTHOF Tobias, KODAMA Itsuo, KAMIYA Kaichiro
  • Journal Title: American Jounal of Physiology Heart and Circulatory Physiology Volume: 303(5)
• [Presentation] Atrial selectivity in sodium channel block by amiodarone (2013)
  • Author(s): SUZUKI Tomoyuki, MORISHIMA Mikio, KATO Sara, TAKEMOTO Yoshio, TAKANARI Hiroki, UEDA Norihiro, TSUJI Yukiomi, HONJO Haruo, KAMIYA Kaichiro
  • Organizer: Biophysical Society 57^<th> Annual Meeting
  • Place of Presentation: Philadelphia
• [Presentation] Atrial fibrillation in sheep hearts with regional atrial ischemia is maintained by reentrant activities in the ischemic border zone (2013)
  • Author(s): YAMAZAKI Masatoshi, HONJO Haruo, KUSHIYAMA Yasunori, OGAWA Takashi, NIWA Ryoko, UEDA Norihiro, KODAMA Itsuo, KAMIYA Kaichiro, KALIFA Jerome
  • Organizer: The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama
• [Presentation] Approximation of ECG T-wave by using Gaussian mixture models and accurate automated QT measurement (2013)
  • Author(s): UEDA Norihiro, HIBINO Shin, HONJO Haruo, KAGAMIHARA Yusuke, FUNAHASHI Shuji, KODAMA Itsuo, KAMIYA Kaichiro
  • Organizer: The 77^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama
• [Presentation] 心房伸展による心房細動発生のメカニズムとカルモジュリン依存性蛋白キナーゼの関与 (2013)
  • Author(s): 宋顕信,植田典浩,小川貴史,丹羽良子,山﨑正俊,本荘晴朗,神谷香一郎
  • Organizer: 第141回日本循環器学会東海地方会
  • Place of Presentation: 名古屋
• [Presentation] 心房伸展により誘発される心房細動におけるギャップ結合の割合について (2013)
  • Author(s): 植田典浩,本荘晴朗,神谷香一郎
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Presentation] The role of gap junction in atrial fibrillation caused by atrial stretch (2013)
  • Author(s): UEDA Norihiro
  • Organizer: 6^<th> Asia Pacific Heart Rhythm Society and CardioRhythm Meeting 2013
  • Place of Presentation: Hong Kong
• [Presentation] 心房伸展による心房細動発生のメカニズムとカルモジュリン依存性蛋白キナーゼの関与について (2013)
  • Author(s): 植田典浩,宋顕信,小川貴史,丹羽良子,山﨑正俊,本荘晴朗,神谷香一郎
  • Organizer: 第30回日本心電学会学術集会
  • Place of Presentation: 青森
• [Presentation] Approximation of ECG T-wave by using Gaussian mixture models and measurement of QT interval (2012)
  • Author(s): UEDA Norihiro
  • Organizer: The 39^<th> International Congress on Electrocardiology
  • Place of Presentation: Beijing
• [Presentation] Partial blockade of IK_1 destabilizes the rotation center of spiral wave reentry without enhancement of wavefront-tail interaction in the arm (2012)
  • Author(s): KUSHIYAMA Yasunori, HONJO Haruo, NIWA Ryoko, TAKANARI Hiroki, YAMAZAKI Masatoshi, TAKEMOTO Yoshio, UEDA Norihiro, OKUNO Yusuke, SAKUMA Ichiro, KODAMA Itsuo, KAMIYA Kaichiro
  • Organizer: European Society of Cardiology Congress
  • Place of Presentation: Munich
• [Presentation] IK_1遮断が心室筋の活動電位とスパイラル・リエントリーに及ぼす作用 (2012)
  • Author(s): 丹羽良子,櫛山泰規,本荘晴朗,山﨑正俊,鈴木智之,植田典浩,神谷香一郎
  • Organizer: 第139回日本循環器学会東海地方会
  • Place of Presentation: 浜松
• [Presentation] 混合正規分布モデルによる心電図T波の近似とQT延長の検出精度評価 (2012)
  • Author(s): 植田典浩,日比野新,本荘晴朗,鏡原有祐,舟橋修司,本田裕之,児玉逸雄,神谷香一郎
  • Organizer: 第29回日本心電学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 心房細動におけるギャップ結合の役割について (2012)
  • Author(s): 植田典浩,山本充,本荘晴朗,小川貴史,櫛山泰規,山﨑正俊,丹羽良子,児玉逸雄,神谷香一郎
  • Organizer: 第29回日本心電学会学術集会
  • Place of Presentation: 千葉
• [Presentation] 心房細動におけるギャップ結合の役割について (2012)
  • Author(s): 植田典浩、山本 充、小川貴史、櫛山泰規、山崎正俊、丹羽良子、本荘晴朗、児玉逸雄、神谷香一郎
  • Organizer: 日本循環器学会第140回東海・第125回北陸合同地方会
  • Place of Presentation: 名古屋
• [Presentation] 心房伸展により誘発される心房細動におけるギャップ結合の割合について
  • Author(s): 植田典浩, 本荘晴朗, 神谷香一郎
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Presentation] 心房伸展による心房細動発生のメカニズムとカルモジュリン依存性蛋白キナーゼの関与について
  • Author(s): 植田典浩, 宋 顕信, 小川貴史, 丹羽良子, 山﨑正俊, 本荘晴朗, 神谷香一郎
  • Organizer: 第30回日本心電学会学術集会
  • Place of Presentation: 青森
• [Presentation] The role of gap junction in atrial fibrillation caused by atraial stretch
  • Author(s): UEDA Norihiro
  • Organizer: 6th Asia Pacific Heart Rhythm Society and CardioRhythm Meeting 2013
  • Place of Presentation: Hong Kong
• [Book] J波を示す例の予後.森博愛,丸山徹(編): J波症候群 (2013)
  • Author(s): 植田典浩
  • Publisher: 医学出版社