Role of intracellular calcium handling on the occurrence and maintenance for atrial fibrillation
| Project/Area Number |
23591038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
UEDA Norihiro 名古屋大学, 環境医学研究所, 助教 (10456709)
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| Co-Investigator(Renkei-kenkyūsha) |
HONJO Haruo 名古屋大学, 環境医学研究所, 准教授 (70262912)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 心房細動 / カルシウム / 心房拡大 / 圧負荷 / カルモジュリン |
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| Research Abstract |
Inducibility of atrial fibrillation (AF) was increased by an elevation of atrial pressure in the pressure changeable preparation. The elevation of atrial pressure caused the shortening of effective refractory period (ERP) of atrium. KN-93, as inhibitor of calmodulin kinase (CAMKII) reduced the inducibility of AF. KN-93 did not affect to the pressure-induced shortening of ERP. Intracellular calcium handling should have an important role in the occurrence and maintenance of AF. Intervention to the intracellular calcium handling may be the key factor for AF treatment.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Inhibition of intercellular coupling stabilizes spiral-wave reentry, whereas enhancement of the coupling destabilizes the reentry in favor of early termination2012
Author(s)
TAKEMOTO Yoshio, TAKANARI Hiroki, HONJO Haruo, UEDA Norihiro, HARADA Masahide, KATO Sara, YAMAZAKI Masatoshi, SAKUMA Ichiro, OPTHOF Tobias, KODAMA Itsuo, KAMIYA Kaichiro
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Journal Title
American Jounal of Physiology Heart and Circulatory Physiology
Volume: 303(5)
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[Presentation] Partial blockade of IK_1 destabilizes the rotation center of spiral wave reentry without enhancement of wavefront-tail interaction in the arm2012
Author(s)
KUSHIYAMA Yasunori, HONJO Haruo, NIWA Ryoko, TAKANARI Hiroki, YAMAZAKI Masatoshi, TAKEMOTO Yoshio, UEDA Norihiro, OKUNO Yusuke, SAKUMA Ichiro, KODAMA Itsuo, KAMIYA Kaichiro
Organizer
European Society of Cardiology Congress
Place of Presentation
Munich
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