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Translational research of circulation-regulated peptide using B-type natriuretic peptide and adrenomedullin

Research Project

Project/Area Number 23591041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyoto University

Principal Investigator

NISHIKIMI Toshio  京都大学, 医学(系)研究科(研究院), その他 (80291946)

Co-Investigator(Kenkyū-buntansha) KUWAHARA Koichiro  京都大学, 医学部付属病院医学部付属病院内分泌代謝内科, 講師 (30402887)
NAKAGAWA Yasuaki  京都大学, 内分泌代謝内科, 助教 (70452357)
Co-Investigator(Renkei-kenkyūsha) MINAMINO Naoto  国立循環器病研究センター研究所, 薬理部, 部長 (50124839)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsB 型ナトリウム利尿ペプチド / アドレノメデュリン / 循環ペプチド / 心不全 / ノックアウトマウス / proBNP / 脂肪組織 / BNP / プロセシング / 糖鎖修飾 / 血圧 / 糖鎖 / 脂肪 / processing
Research Abstract

We investigated the translational research of circulation-regulated peptide using B-type natriuretic peptide and adrenomedullin. We newly developed the immunofluorescent assay for proBNP and total BNP(= BNP32 + proBNP). Using this immunofluorescent assay system we found that proBNP is about 70% of total BNP immunoreactivity. ProBNP level increases with age. ProBNP level is increased in heart failure in proportion to its severity. ProBNP/total BNP ratios are greater in chronic renal failure patients than in normal subjects. We successfully produced fat tissue specific deficient AM knockout mouse. The phenotype under normal diet reveals no differences compared with wild type mouse such as body weight, body height, and fat tissue amount.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (72 results)

All 2014 2013 2012 2011 Other

All Journal Article (36 results) (of which Peer Reviewed: 29 results) Presentation (35 results) (of which Invited: 3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis2014

    • Author(s)
      Wetzel-Strong SE, Nishikimi T, 他3名
    • Journal Title

      Dev Dyn

      Volume: 243 Pages: 243-56

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis.2014

    • Author(s)
      Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K
    • Journal Title

      PLoS One

      Volume: 9

    • NAID

      120007100132

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis2014

    • Author(s)
      Wetzel-Strong SE, Li M, Klein KR, Nishikimi T, Caron KM
    • Journal Title

      Dev Dyn

      Volume: 243 Pages: 243-256

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complexity of molecular forms of B-type natriuretic peptide in heart failure2013

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, Minamino N, 他2名
    • Journal Title

      Heart

      Volume: 99 Pages: 677-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure2013

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, Minamino N, 他13名
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005241437

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of HCN channels in the ventricular myocardium contributes to enhanced arrhythmicity in mouse failing hearts2013

    • Author(s)
      Kuwabara Y, Kuwahara K, Nakagawa Y, Nishikimi T, 他13名
    • Journal Title

      J Am Heart Assoc

      Volume: 2

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin in cardiovascular disease : a useful biomarker, its pathological roles and therapeutic application2013

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, 他2名
    • Journal Title

      Curr Protein Pept Sci

      Volume: 14 Pages: 256-67

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy2013

    • Author(s)
      Yasuno S, Kuwahara K, Nakagawa Y, Nishikimi T, 他7名
    • Journal Title

      Br J Pharmacol

      Volume: 170 Pages: 1384-95

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ストローマとナトリウム利尿ペプチド-急性心筋梗塞の病態生理的意義と臨床応用-2013

    • Author(s)
      錦見俊雄
    • Journal Title

      循環器内科

      Volume: 74 Pages: 174-180

    • Related Report
      2013 Final Research Report
  • [Journal Article] Complexity of molecular forms of B-type natriuretic peptide in heart failure2013

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Minamino N, Nakao K
    • Journal Title

      Heart

      Volume: 99 Pages: 677-679

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct immunochemiluminescent assay for proBNP and total BNP in human plasma proBNP and total BNP levels in normal and heart failure.2013

    • Author(s)
      Nishikimi T, Okamoto H, Nakamura M, Ogawa N, Horii K, Nagata K, Nakagawa Y, Kinoshita H, Yamada C, Nakao K, Minami T, Kuwabara Y, Kuwahara K, Masuda I, Kangawa K, Minamino N, Nakao K
    • Journal Title

      PLoS One

      Volume: 8

    • NAID

      120005241437

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application2013

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Nakao K
    • Journal Title

      Curr Protein Pept Sci

      Volume: 14 Pages: 256-267

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure2013

    • Author(s)
      Nishikimi, T., Okamoto, H., Nakamura, M., Ogawa, N., Horii, K., Nagata, K., Nakagawa, Y., Kinoshita, H., Yamada, C., Nakao, K., Minami, T., Kuwabara, Y., Kuwahara, K., Masuda, I., Kangawa, K., Minamino, N., Nakao, K.
    • Journal Title

      PLoS ONE

      Volume: 8(1) Issue: 1 Pages: e53233-e53233

    • DOI

      10.1371/journal.pone.0053233

    • NAID

      120005241437

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Complexity of molecular forms of B-type natriuretic peptide in heart failure.2013

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Minamino N, Nakao K.
    • Journal Title

      HEART

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application.2013

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, Nakao K, Kangawa K
    • Journal Title

      Curr. Protein & Peptide Sci

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] BNPの分子型の最新知見-BNPの生化学、分子生物学、臨床的意義を含めて-2013

    • Author(s)
      錦見俊雄
    • Journal Title

      シーメンスサイエンティフィックインフォメーション

      Volume: 16 Pages: 1-9

    • Related Report
      2012 Research-status Report
  • [Journal Article] The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure2012

    • Author(s)
      Nishikimi T, Kuwahara K, Nakagawa Y, 他7名
    • Journal Title

      Heart

      Volume: 98 Pages: 152-61

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of the fetal cardiac gene program2012

    • Author(s)
      Kuwahara K, Nishikimi T, Nakao K
    • Journal Title

      J Pharmacol Sci

      Volume: 119 Pages: 198-203

    • NAID

      10030986728

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Do plasma levels of brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) increase in diastolic dysfunction as well as in systolic dysfunction?2012

    • Author(s)
      Nishikimi T
    • Journal Title

      Circ J

      Volume: 76 Pages: 2540-1

    • NAID

      10031078464

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice2012

    • Author(s)
      Minami T, Kuwahara K, Nakagawa Y, Nishikimi T, 他18名
    • Journal Title

      EMBO J

      Volume: 31 Pages: 4428-40

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 心疾患のバイオマーカーとしてのBNPの意義ー基礎的・臨床的観点からー2012

    • Author(s)
      錦見俊雄
    • Journal Title

      日本臨床

      Volume: 70 Pages: 774-784

    • Related Report
      2013 Final Research Report
  • [Journal Article] BNP、ANPと高血圧2012

    • Author(s)
      錦見俊雄
    • Journal Title

      血圧

      Volume: 19 Pages: 884-889

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 降圧薬としてのエンドセリン拮抗薬、PDE5阻害薬—治療抵抗性高血圧におけるエンドセリン拮抗薬、PDE5阻害薬の可能性—2012

    • Author(s)
      錦見俊雄
    • Journal Title

      循環器内科

      Volume: 72 Pages: 515-520

    • NAID

      40019499216

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice.2012

    • Author(s)
      Minami T, Nakao K, et al
    • Journal Title

      EMBO J.

      Volume: 31 Issue: 23 Pages: 4428-4440

    • DOI

      10.1038/emboj.2012.296

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of the fetal cardiac gene program.2012

    • Author(s)
      Kuwahara K, Nishikimi T, Nakao K
    • Journal Title

      J Pharmacol Sci

      Volume: 119 Pages: 198-203

    • NAID

      10030986728

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 降圧薬としてのエンドセリン拮抗薬、PDE5阻害薬―治療抵抗性高血圧におけるエンドセリン拮抗薬、PDE5阻害薬の可能性2012

    • Author(s)
      錦見俊雄
    • Journal Title

      循環器内科

      Volume: 72 Pages: 42-47

    • NAID

      40019499216

    • Related Report
      2012 Research-status Report
  • [Journal Article] The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure2012

    • Author(s)
      Nishikimi T, Nakao K, et al
    • Journal Title

      Heart

      Volume: 98 Issue: 2 Pages: 152-161

    • DOI

      10.1136/heartjnl-2011-300102

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 心疾患のバイオマーカーとしてのBNPの臨床的意義―基礎的臨床的観点からー2012

    • Author(s)
      錦見俊雄
    • Journal Title

      日本臨床

      Volume: 70 Pages: 774-784

    • Related Report
      2011 Research-status Report
  • [Journal Article] Diverse molecular forms of plasma B-type natriuretic peptide in heart failure2011

    • Author(s)
      Nishikimi T, Minamino N, Nakao K
    • Journal Title

      Curr Heart Fail Rep

      Volume: 8 Pages: 140-6

    • NAID

      120003184065

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides2011

    • Author(s)
      Nishikimi T, Kuwahara K, Nakao K
    • Journal Title

      J Cardiol

      Volume: 57 Pages: 131-40

    • NAID

      10031159554

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zinc-finger protein 90 negatively regulates neuron- restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes2011

    • Author(s)
      Hata L, Kuwahara K, Nakagawa Y, Nishikimi T, 他12名
    • Journal Title

      J Mol Cell Cardiol

      Volume: 50 Pages: 972-81

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese-Western consensus meeting on biomarkers2011

    • Author(s)
      Maisel AS, Minamino N, Nishikimi T, 他12名
    • Journal Title

      Int Heart J

      Volume: 52 Pages: 253-65

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diverse molecular forms of plasma B-type natriuretic peptide in heart failure2011

    • Author(s)
      Nishikimi T, Minamino N, Nakao K
    • Journal Title

      Curr Heart Fail Rep 2011;8:140-6

      Volume: 8 Issue: 2 Pages: 140-146

    • DOI

      10.1007/s11897-011-0051-y

    • NAID

      120003184065

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Current biochemistry molecular biology, and clinical relevance of natriuretic peptides2011

    • Author(s)
      Nishikimi T, Kuwahara K, Nakao K
    • Journal Title

      J Cardiol

      Volume: 57 Issue: 2 Pages: 131-140

    • DOI

      10.1016/j.jjcc.2011.01.002

    • NAID

      10031159554

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese-Western consensus meeting on biomarkers2011

    • Author(s)
      Maisel AS, Nakao K, Ponikowski P, Peacock WF, Yoshimura M, Suzuki T, Tsutamoto T, Filippatos GS, Saito Y, Seino Y, Minamino N, Hirata Y, Mukoyama M, Nishikimi T, Nagai R
    • Journal Title

      Int Heart J.

      Volume: 52 Pages: 253-265

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Zinc-finger protein 90 negatively relulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes2011

    • Author(s)
      Hata L, Murakami M, Kuwahara K, Nakagawa Y, Kinoshita H, Usami S, Yasuno S, Fujiwara M, Kuwabara Y, Minami T, Yamada Y, Yamada C, Nakao K, Ueshima K, Nishikimi T, Nakao K
    • Journal Title

      J Mol Cell Cardiol.

      Volume: 5 Issue: 6 Pages: 972-981

    • DOI

      10.1016/j.yjmcc.2011.01.017

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Molecular mechanism of lower processing rate in human proBNP : importance of the distance between the O-glycosylation and cleavage sites2014

    • Author(s)
      Toshio Nishikimi, Yasuaki Nakagawa, Naoto Minamino, Koichiro Kuwahara, 他9名
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ナトリウム利尿ペプチドBNP、ANPの最新知見とその臨床応用2013

    • Author(s)
      錦見俊雄
    • Organizer
      日本自動分析学会
    • Place of Presentation
      横浜(ランチョンセミナー)
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] B型ナトリウム利尿ペプチド研究の最前線2013

    • Author(s)
      錦見俊雄
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      大阪(シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] O-glycosylated Pro B-type Natriuretic Peptide is Cleaved intracellularly By Furin in Ventricular Myocytes and Atrial Myocytes : Importance of the Distance Between the O-glycosylation Sites and Cleaved Sites2013

    • Author(s)
      Toshio Nishikimi, Yasuaki Nakagawa, Naoto Minamino, Koichiro Kuwahara, 他9名
    • Organizer
      American Heart Association Annual Meeting
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 心不全におけるBNP前駆体proBNPの病態生理的意義2013

    • Author(s)
      錦見俊雄
    • Organizer
      日本心血管内分泌代謝学会
    • Place of Presentation
      大阪(イブニングセミナー)
    • Related Report
      2013 Final Research Report
  • [Presentation] BNP測定の特徴と値の見方  ーBNP関連ペプチドの最新知見ー2013

    • Author(s)
      錦見俊雄
    • Organizer
      The 77th Annual Scientific Meeting of The Japanese Circulation
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト血漿におけるproBNP、total BNP直接測定法の確立ー健常者、心不全患者での検討ー2012

    • Author(s)
      錦見俊雄、中川靖章、桑原宏一郎、南野直人, 他11名
    • Organizer
      第35回日本高血圧学会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] Direct immunoassay for proBNP and total BNP in human plasma–proBNP and total BNP levels in healthy and heart failure patients2012

    • Author(s)
      Nishikimi T, Nakagawa1 Y, Kuwahara K, Minamino N, 他8名
    • Organizer
      24th International Society of Hypertension
    • Place of Presentation
      Sidney, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] proBNP、total BNP直接化学発光測定法の確立ー心不全患者における検討ー2012

    • Author(s)
      錦見俊雄、中川靖章、桑原宏一郎、南野直人, 他12名
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] BNP revisited2012

    • Author(s)
      錦見俊雄
    • Organizer
      第16回日本心血管内分泌学会
    • Place of Presentation
      東京(ワークショップ)
    • Related Report
      2013 Final Research Report
  • [Presentation] BNP関連ペプチドの最新知見2012

    • Author(s)
      錦見俊雄
    • Organizer
      The76th Annual Scientific Meeting of The Japanese Circulation
    • Place of Presentation
      Fukuoka, Japan(ランチョンセミナー)
    • Related Report
      2013 Final Research Report
  • [Presentation] BNP関連ペプチドの最新知見2012

    • Author(s)
      錦見俊雄
    • Organizer
      The76th Annual Scientific Meeting of The Japanese Circulation
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] proBNP、total BNP直接化学発光測定法の確立ー心不全患者における検討ー2012

    • Author(s)
      錦見俊雄
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      金沢全日空ホテル、金沢
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト血漿におけるproBNP、total BNP直接測定法の確立ー健常者、心不全患者での検討ー2012

    • Author(s)
      錦見俊雄
    • Organizer
      第35回日本高血圧学会
    • Place of Presentation
      ウエスティン名古屋キャッスルホテル、名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] B-type natriuretic peptide: revisited2012

    • Author(s)
      錦見俊雄
    • Organizer
      第16回日本心血管内分泌代謝学会
    • Place of Presentation
      東京大学構内鉄門講堂、東京
    • Related Report
      2012 Research-status Report
  • [Presentation] BNP関連ペプチドの最新知見2012

    • Author(s)
      錦見俊雄
    • Organizer
      The76th Annual Scientific Meeting of The Japanese Circulation Society
    • Place of Presentation
      国際会議場(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] Increased HCN channels in failing hearts possibly contribute to ventricular arrhythmias2012

    • Author(s)
      Y Kuwabara, K Kuwahara, M Takano, H Kinoshita, Y Nakagawa, S Usami, S Yasuno, K Nakao, T Minami, Y Yamada, J Shibata, T Nishikimi, K Ueshima and K Nakao
    • Organizer
      The76th Annual Scientific Meeting of The Japanese Circulation Society
    • Place of Presentation
      国際会議場(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] MRTF-A, a rho-dependent co-activator of SRF, plays a critical role in vascular remodeling by regulating smooth muscle cell migration2012

    • Author(s)
      T Minami, K Kuwahara, J Shibata, C Yamada, Y Kuwabara, K Nakao, H Kinoshita, S Usami, S Yasuno, Y Nakagawa, K Ueshima, T Nishikimi, M Takaoka, M Sata, R Nagai, K Nakao
    • Organizer
      The76th Annual Scientific Meeting of The Japanese Circulation Society
    • Place of Presentation
      国際会議場(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] TRPC3/6 Ion Channels as Potentially Novel Therapeutic Targets against Pulmonary Arterial Hypertension2012

    • Author(s)
      H Kinoshita, K Kuwahara, S Kiyonaka, Y Mori, J Shibata, C Yamada, T Minami, K Nakao, Y Kuwabara, S Yasuno, S Usami, Y Nakagawa, T Nishikimi, K Ueshima, K Nakao
    • Organizer
      The76th Annual Scientific Meeting of The Japanese Circulation Society
    • Place of Presentation
      国際会議場(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of circulating glycosylated N-terminal proBNP and nonglycosylated N-terminal proBNP in patients with heart failure (HF) and chronic renal failure (CRF) on hemodialysis2011

    • Author(s)
      Nishikimi T, Minamino N, Kuwahara1 K, Nakagawa Y, 他5名
    • Organizer
      European Society of Cardiology 33rd Annual Congress
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Final Research Report
  • [Presentation] 高血圧性左室肥大・潜在性心機能低下のサロゲートマーカーとしての血漿BNP測定の意義と問題点2011

    • Author(s)
      錦見俊雄
    • Organizer
      第34回日本日本高血圧学会総会
    • Place of Presentation
      宇都宮市(Up to Date)
    • Related Report
      2013 Final Research Report
  • [Presentation] 高血圧性左室肥大・潜在性心機能低下のサロゲートマーカーとしての血漿BNP測定の意義と問題点2011

    • Author(s)
      錦見俊雄
    • Organizer
      第34回日本日本高血圧学会総会
    • Place of Presentation
      栃木文化センター(栃木)
    • Related Report
      2011 Research-status Report
  • [Presentation] 拡張型心筋症・不整脈死モデルマウスにおけるN型Ca2+チャネル阻害の有用性の検討2011

    • Author(s)
      山田優子、桑原宏一郎、木下秀之、桑原佳宏、中川靖章、柴田純子、山田千夏、南丈也、保野慎治、宇佐美覚、中尾一泰、錦見俊雄、上嶋健治、森泰生、中尾一和
    • Organizer
      第34回日本日本高血圧学会総会
    • Place of Presentation
      栃木文化センター(栃木)
    • Related Report
      2011 Research-status Report
  • [Presentation] BNP遺伝子発現調節領域におけるserum response factor応答領域の新たなる同定とその心筋細胞肥大反応における意義2011

    • Author(s)
      桑原宏一郎・木下秀之・桒原佳宏・中川靖章・南 丈也・山田千夏・柴田純子・宇佐美覚・錦見俊雄・中尾一和
    • Organizer
      第15回日本心血管内分泌学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Research-status Report
  • [Presentation] 病的血管リモデリングでみられる血管平滑筋細胞形質転換におけるRho依存性転写共役因子MRTF-Aの意義2011

    • Author(s)
      南 丈也・桑原宏一郎・中川靖章・木下秀之・中尾一泰・桒原佳宏・山田千夏・柴田純子・宇佐美覚・錦見俊雄・中尾一和
    • Organizer
      第15回日本心血管内分泌学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Research-status Report
  • [Presentation] ANP・BNP遺伝子発現調節因子NRSFにより制御されるHCNチャネルの心不全モデルマウスにおける突然死発症への関与2011

    • Author(s)
      桒原佳宏,桑原宏一郎,木下秀之,鷹野誠,中川靖章,宇佐美覚,柴田純子,山田千夏,南丈也,山田優子,藤原正隆,保野慎治,錦見俊雄,上嶋健治,中尾一和
    • Organizer
      第15回日本心血管内分泌学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of circulating glycosylated N-terminal-proBNP and nonglycosylated N-terminal proBNP in patients with heart failure (HF) and chronic renal failure (CRF) on hemodialysis2011

    • Author(s)
      T Nishikimi, M. Ikeda, Y Takeda, T Ishimitsu, N Minamino, K Kuwahara, H Kinoshita, Y Nakagawa, K Nakao
    • Organizer
      ESC Congress 2011
    • Place of Presentation
      Convention Center(Paris, France)
    • Related Report
      2011 Research-status Report
  • [Presentation] Inhibition of HCN overexpression in failing heart of dilated cardiomyopathy mouse model by ivabradine prevents sudden arrhythmic death2011

    • Author(s)
      Y Kuwabara, K Kuwahara, H Kinoshita, M Takano, Y Nakagawa, S Usami, K Nakao, T Minami, Y Yamada, C Yamada, J Shibata, T Nishikimi1, K Ueshima and K Nakao
    • Organizer
      American Heart Association Scientific Session 2011
    • Place of Presentation
      Convention Center(Orlando, USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] N-Type Ca2+ Channel Blocker is Effective to Prevent Sudden Cardiac Death in Mice with Heart Failure2011

    • Author(s)
      Y Yamada, K Kuwahara, H Kinoshita, Y Kuwabara, Y Nakagawa, J Shibata, C Yamada, T Minami, S Yasuno, S Usami, K Nakao, T Nishikimi, K Ueshima,
    • Organizer
      American Heart Association Scientific Session 2011
    • Place of Presentation
      Convention Center(Orlando, USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] Induction of Myocardin-Related Transcription Factor-A Contributes to the Phenotypic Alteration of Vascular Smooth Muscle Cells and Plays a Pivotal Role in Vascular Remodeling2011

    • Author(s)
      T Minami, K Kuwahara, Y Nakagawa, H Kinoshita, K Nakao, Y Kuwabara, Y Yamada, C Yamada, J Shibata, S Usami, T Nishikimi, K Nakao
    • Organizer
      American Heart Association Scientific Session 2011
    • Place of Presentation
      Convention Center(Orlando, USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] ナトリウム利尿ペプチドBNP、ANPの最新知見とその臨床応用

    • Author(s)
      錦見俊雄
    • Organizer
      日本自動分析学会
    • Place of Presentation
      横浜パシフィコ、横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] B型ナトリウム利尿ペプチド研究の最前線

    • Author(s)
      錦見俊雄
    • Organizer
      日本高血圧学会総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] O-glycosylated Pro B-type Natriuretic Peptide is Cleaved intracellularly By Furin in Ventricular Myocytes and Atrial Myocytes : Importance of the Distance Between the O-glycosylation Sites and Cleaved Sites

    • Author(s)
      Nishikimi Toshio 他12名
    • Organizer
      American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 心不全におけるBNP前駆体 proBNPの病態生理的意義

    • Author(s)
      錦見俊雄
    • Organizer
      日本心血管内分泌代謝学会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism of lower processing rate in human proBNP: importance of the distance between the O-glycosylation and cleavage sites

    • Author(s)
      Nishikimi Toshio 他12名
    • Organizer
      日本循環器学会総会
    • Place of Presentation
      東京フォーラム
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] proBNP-108の新規用途2013

    • Inventor(s)
      錦見俊雄、他1名
    • Industrial Property Rights Holder
      錦見俊雄、他2名
    • Acquisition Date
      2013-09-13
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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