The mechanism of cardio-renal interaction in heart failure-the approach from functional renal reserve-

• Project/Area Number: 23591042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka University
• Principal Investigator: MANO Toshiaki 大阪大学, 医学部附属病院, 講師 (90379165)
• Co-Investigator(Kenkyū-buntansha): SAKATA Yasushi 大阪大学, 医学系研究科, 教授 (00397671) ; YAMAMOTO Kazuhiro 鳥取大学, 医学系研究科, 教授 (90303966)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 心腎連関 / 腎予備力 / 心不全 / 機能的腎予備力 / 腎血流ドプラ

Research Abstract

Decreased renal function is an independent risk for cardiovascular adverse outcomes in patients with heart failure. However, the impact of renal function, especially functional renal reserve on the pathophysiology of heart failure remains unknown. This study clarified that intrarenal vascular resistance as a physiological parameter of functional renal reserve plays an important role in the development of heart failure with preserved ejection fraction (HFpEF) and the existence of a cytokine specific for HFpEF and diastolic dysfunction from comprehensive screening.

Research Products

• [Journal Article] Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction. (2013)
  • Author(s): Tamaki S, Komuro I (19人中19番目）
  • Journal Title: PLoS One Volume: 8 Issue: 7 Pages: e68893-e68893
  • DOI: 10.1371/journal.pone.0068893
  • Peer Reviewed
• [Journal Article] A Novel Heart Failure Mice Model of Hypertensive Heart Disease by Angiotensin II Infusion, Nephrectomy, and Salt Loading (2013)
  • Author(s): Tsukamoto Y, Komuro I（15人中15番目）
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 305 Issue: 11 Pages: 1658-1667
  • DOI: 10.1152/ajpheart.00349.2013
  • Peer Reviewed
• [Journal Article] L-Carnitine prevents the development of ventricular fibrosis and heart failure with preserved ejection fraction in hypertensive heart disease (2012)
  • Author(s): Omori Y, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Tsukamoto Y, Kamimura D, Aizawa Y, Miwa T, Komuro I, Soga T, Yamamoto K.
  • Journal Title: J Hypertens Volume: 30 Issue: 9 Pages: 1834-44
  • DOI: 10.1097/hjh.0b013e3283569c5a
  • Peer Reviewed
• [Presentation] Interleukin-16 is associated with diastolic dysfunction, promotes cardiac fibrosis and accelerates myocardial stiffening in heart failure with preserved ejection fraction (2013)
  • Author(s): 真野敏昭、玉置俊介
  • Organizer: 日本心不全学会学術集会
  • Place of Presentation: 大宮
• [Patent(Industrial Property Rights)] 拡張性心不全を治療、診断するため の組成物およびその利用 (2014)
  • Inventor(s): 真野敏昭 坂田泰史 玉置俊介 萩 原圭祐
  • Industrial Property Rights Holder: 真野敏昭 坂田泰史 玉置俊介 萩 原圭祐
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-01-17
  • Overseas