| Project/Area Number |
23591042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
MANO Toshiaki 大阪大学, 医学部附属病院, 講師 (90379165)
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| Co-Investigator(Kenkyū-buntansha) |
SAKATA Yasushi 大阪大学, 医学系研究科, 教授 (00397671)
YAMAMOTO Kazuhiro 鳥取大学, 医学系研究科, 教授 (90303966)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 心腎連関 / 腎予備力 / 心不全 / 機能的腎予備力 / 腎血流ドプラ |
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| Research Abstract |
Decreased renal function is an independent risk for cardiovascular adverse outcomes in patients with heart failure. However, the impact of renal function, especially functional renal reserve on the pathophysiology of heart failure remains unknown. This study clarified that intrarenal vascular resistance as a physiological parameter of functional renal reserve plays an important role in the development of heart failure with preserved ejection fraction (HFpEF) and the existence of a cytokine specific for HFpEF and diastolic dysfunction from comprehensive screening.
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