Insulin Resistance as Promoters for Developemnts of Aortic Valve Sclerosis and Coronary Artery Disease

• Project/Area Number: 23591044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Hiroshima University
• Principal Investigator: HIDEYA Yamamoto 広島大学, 大学病院, 講師 (70335678)
• Co-Investigator(Kenkyū-buntansha): KIHARA Yasuki 広島大学, 医歯薬保健学研究院, 教授 (40214853)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: インスリン抵抗性 / 弁膜石灰化 / 冠動脈 / アディポネクチン / CT / シンチグラフィー / 心エコー図 / ストレイン / 大動脈弁石灰化 / 心臓CT / 耐糖能障害 / メタボリック症候群 / 石灰化弁 / 冠動脈ＣＴ / プラーク

Research Abstract

1. We studied patients with aortic valvular calcification (AVC) assessed by echocardiography had higher rates of induced myocardial ischemia, especially in diabetes mellitus (DM) patients. 2. When AVC scores were measured by cardiac CT, higher AVC score was an independent predictor of cardiac mortality in aortic stenosis (AS) patients. 3. Echocardiographic heart calcification score, the sum of the amounts of AVC, mitral annular, and aortic root calcification, has an independent and incremental prognostic value in a high-risk population. 4. Assessed by two-dimensional speckle-tracking echocardiography, insulin resistance is a powerful independent predictor of subclinical left ventricular dysfunction in patients with AVC and thus may be a novel therapeutic target to prevent subsequent heart failure.

Research Products

• [Journal Article] Age- and sex-related differences in coronary plaque high-risk features in patients with acute coronary syndrome assessed by computed tomography angiography (2014)
  • Author(s): Kitagawa T, Yamamoto H, Kihara Y
  • Journal Title: Int J Cardiol Volume: (Epub ahead of print) Issue: 3 Pages: 744-747
  • DOI: 10.1016/j.ijcard.2014.04.089
  • Peer Reviewed
• [Journal Article] Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis (2014)
  • Author(s): Utsunomiya H, Yamamoto H, Kihara Y. (他2名)
  • Journal Title: Cardiovasc Diabetol Volume: 13 Issue: 1 Pages: 86-86
  • DOI: 10.1186/1475-2840-13-86
  • Peer Reviewed
• [Journal Article] Prognostic value of coronary artery calcium and epicardial adipose tissue assessed by non-contrast cardiac computed tomography. Atherosclerosis (2014)
  • Author(s): Kunita E, Yamamoto H, Kitagawa T, Ohashi N, Oka T, Utsunomiya H, Urabe Y, Tsushima H, Awai K, Budoff MJ, Kihara Y
  • Journal Title: Atherosclerosis Volume: 233(2) Issue: 2 Pages: 447-53
  • DOI: 10.1016/j.atherosclerosis.2014.01.038
  • Peer Reviewed
• [Journal Article] Rationale and design of the PREDICT (Plaque Registration and Evaluation Detected In Computed Tomography) registry. J Cardiovasc Comp Tomography (2014)
  • Author(s): Yamamoto Y, Awai K, Kuribayashi S, Kihara Y; on behalf of the PREDICT Investigators.
  • Journal Title: . J Cardiovasc Comput Tomogr Volume: 8(2) Issue: 2 Pages: 90-6
  • DOI: 10.1016/j.jcct.2013.12.004
  • Peer Reviewed
• [Journal Article] Association between heart calcification assessed by echocardiography and future cardiovascular disease mortality and morbidity (2014)
  • Author(s): Utsunomiya H, Yamamoto H, Kihara Y. (他6名)
  • Journal Title: IJ C Heart and Vessel Volume: 2
  • Peer Reviewed
• [Journal Article] Association between heart calcification assessed by echocardiography and future cardiovascular disease mortality and morbidity (2014)
  • Author(s): Utsunomiya H, Yamamoto H, Kitagawa T, Kunita E, Urabe Y, Tsushima H, Hidaka T, Awai K, Kihara Y. )
  • Journal Title: Int J Cardiolo Heart and Vessel. Volume: 2 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Insulin resistance and subclinical abnormalities of global and regional left ventricular function in patients with aortic valve sclerosis (2014)
  • Author(s): Utsunomiya H, Yamamoto H, hidaka T, Kunita E, Kihara Y.
  • Journal Title: Diabetic Cardiology Volume: 13(1) Epub ahead of print Pages: 86-86
  • Peer Reviewed
• [Journal Article] Impact of aldosterone-producing adenoma on cardiac structures in echocardiography (2013)
  • Author(s): Hidaka T, Yamamoto H, Kihara Y. (他13名)
  • Journal Title: J Echocardiogr Volume: 11 Pages: 123-9
  • Peer Reviewed
• [Journal Article] Incremental prognostic value of cardiac computed tomography angiography in asymptomatic aortic stenosis: significance of aortic valve calcium score. (2013)
  • Author(s): Utsunomiya H, Yamamoto H, Kitagawa T, Kunita E, Urabe Y, Tsushima H, Hidaka T, Awai K, Kihara Y.
  • Journal Title: Int J Cardiol Volume: 168(6) Issue: 6 Pages: 5205-11
  • DOI: 10.1016/j.ijcard.2013.07.235
  • Peer Reviewed
• [Journal Article] Association Between Serum Levels of n-3 Polyunsaturated Fatty Acids and Coronary Plaque Detected by Coronary Computed Tomography Angiography in Patients Receiving Statin Therapy (2013)
  • Author(s): Urabe Y, Yamamoto H, Kihara Y. (他5名)
  • Journal Title: Circ J Volume: 77 Pages: 2578-85
  • NAID: 10031191799
  • Peer Reviewed
• [Journal Article] Noncalcified atherosclerotic lesions with vulnerable characteristics detected by coronary CT angiography and future coronary events. (2013)
  • Author(s): Yamamoto H, Kitagawa T, Ohashi N, Utsunomiya H, Kunita E, Oka T, Urabe Y, Tsushima H, Awai K, Kihara Y.
  • Journal Title: J Cardiovasc Comput Tomogr Volume: 7(3): Issue: 3 Pages: 192-9
  • DOI: 10.1016/j.jcct.2013.05.008
  • Peer Reviewed
• [Journal Article] Dose napkin-ring sign suggest possibility to identify rupture-prone plaque in coronary computed tomography angiography? (2013)
  • Author(s): Yamamoto H, Kitagawa T, Kihara Y.
  • Journal Title: J Cardiol. Volume: 62(5): Issue: 5 Pages: 328-9
  • DOI: 10.1016/j.jjcc.2013.02.020
  • Peer Reviewed
• [Journal Article] Impact of aldosterone-producing adenoma on cardiac structures in echocardiography. (2013)
  • Author(s): Hidaka T, Shiwa T, Fujii Y, Nishioka K, Utsunomiya H, Ishibashi K, Mitsuba N, Dohi Y, Oda N, Noma K, Kurisu S, Nakano Y, Yamamoto H, Iishida T, Higashi Y, Kihara Y.
  • Journal Title: J Echocardiogr. Volume: 11: Pages: 123-129
  • Peer Reviewed
• [Journal Article] Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy. (2013)
  • Author(s): Urabe Y, Yamamoto H, Kitagawa T, Utsunomiya H, Tsushima H, Tatsugami F, Awai K, Kihara Y.
  • Journal Title: Circ J. Volume: 77(10): Pages: 2578-85
  • NAID: 10031191799
  • Peer Reviewed
• [Journal Article] Underestimation of aortic valve area in calcified aortic valve disease : effects of left ventricular outflow tract ellipticity (2012)
  • Author(s): Utsunomiya H, Yamamoto H, Kihara Y. (他5名)
  • Journal Title: Int J Cardiol Volume: 157 Issue: 3 Pages: 347-53
  • DOI: 10.1016/j.ijcard.2010.12.071
  • Peer Reviewed
• [Journal Article] Association between epicardial adipose tissue volume and characteristics of non-calcified plaques assessed by coronary computed tomographic angiography. (2012)
  • Author(s): Oka T, Yamamoto H, Ohashi N, Kitagawa T, Kunita E, Utsunomiya H, Yamazato R, Urabe Y, Horiguchi J, Awai K, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 161(1): Issue: 1 Pages: 45-9
  • DOI: 10.1016/j.ijcard.2011.04.021
  • Peer Reviewed
• [Journal Article] Use of preprocedural multidetector computed tomography to decrease atrial fibrillation recurrence following extensive encircling circumferential pulmonary vein isolation (2012)
  • Author(s): Makita Y, Yamamoto H, Kihara Y
  • Journal Title: J Cardiol Volume: 60 Issue: 3 Pages: 236-41
  • DOI: 10.1016/j.jjcc.2012.03.007
  • Peer Reviewed
• [Journal Article] Association between aortic valve calcification and myocardial ischemia, especially in asymptomatic patients (2012)
  • Author(s): Yamazato R, Yamamoto H, Kihara Y. (他8名)
  • Journal Title: J Nucl Med Volume: 53 Issue: 8 Pages: 1216-21
  • DOI: 10.2967/jnumed.111.099275
  • Peer Reviewed
• [Journal Article] Association between plasma high-molecular-weight adiponectin and coronary plaque characteristics assessed by computed tomography angiography in conditions of visceral adipose accumulation (2012)
  • Author(s): Kunita E, Yamamoto H, Ohashi N, Awai K, Kihara Y.
  • Journal Title: Circ J Volume: 76 Pages: 1687-96
  • NAID: 10030503524
  • Peer Reviewed
• [Journal Article] Association between plasma high-molecular-weight adiponectin and coronary plaque characteristics assessed by computed tomography angiography in conditions of visceral adipose accumulation. (2012)
  • Author(s): Kunita E, Yamamoto H, Kitagawa T, Ohashi N, Utsunomiya H, Oka T, Horiguchi J, Awai K, Kihara Y.
  • Journal Title: Circ J Volume: 76(7) Pages: 1687-96
  • NAID: 10030503524
  • Peer Reviewed
• [Journal Article] Association between aortic valve calcification and myocardial ischemia especially in asymptomatic patients. (2012)
  • Author(s): Yamazato R, Yamamoto H, Tadehara F, Teragawa H, Kurisu S, Dohi Y, Ishibashi K, Kunita E, Utsunomiya H, Oka T, Kihara Y.
  • Journal Title: J Nucl Med. Volume: in-press
  • Peer Reviewed
• [Journal Article] Association between plasma high-molecular-weight adiponectin and coronary plaque characteristics assessed by computed tomography angiography in conditions of visceral adipose accumulation (2012)
  • Author(s): Kunita E, Yamamoto H, Kitagawa T, Ohashi N, Utsunomiya H, Oka T, Horiguchi J, Awai K, Kihara Y.
  • Journal Title: Circ J. Volume: in-press
  • NAID: 10030503524
  • Peer Reviewed
• [Journal Article] Coronary calcium score as a predictor for coronary artery disease and cardiac events in Japanese high-risk patients (2011)
  • Author(s): Yamamoto H, Ohashi N, Utsunomiya H, Kunita E, Ishibashi K, Horiguchi J, Kihara Y.
  • Journal Title: Circ J. Volume: 75 Pages: 2424-2431
  • NAID: 10029459594
  • Peer Reviewed
• [Journal Article] Association between epicardial adipose tissue volume and characteristics of non-calcified plaques assessed by coronary computed tomographic angiography (2011)
  • Author(s): Oka T, Yamamoto, Ohashi N, Kitagawa T, Kunita E, Utsunomiya H, Yamazato R, Urabe Y, Horiguchi J, Awai K, Kihara Y.
  • Journal Title: Int J Cardiol Volume: in-press
  • Peer Reviewed
• [Journal Article] Development of new risk score for pre-test probability of obstructive coronary artery disease based on coronary CT angiography
  • Author(s): Fujimoto S, Kondo T, Yamamoto H, Kihara Y. (他10名)
  • Journal Title: Heart Vessels Volume: (Epub ahead of print)
  • Peer Reviewed
• [Presentation] Plenary session; Cardiovascular disease in diabetes mellitus : where are we now? Coronary artery calcium score as a predictor of adverse outcomes in patients with diabetes mellitus (2014)
  • Author(s): Yamamoto H, Kihara Y, 他
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
  • Year and Date: 2014-03-21
• [Presentation] Plenary Session Cardiovascular disease in diabetes mellitus: where are we now?Coronary Artery Calcium Score as a Predictor of Adverse Outcomes in Patients with Diabetes Mellitus (2014)
  • Author(s): 山本 秀也
  • Organizer: 第78回日本循環器学会学術総会
  • Place of Presentation: 東京（東京国際フォーラム他）
• [Presentation] 我が国における大規模前向き試験 (2013)
  • Author(s): 山本秀也,木原康樹
  • Organizer: ビジュアルワークショップ4「冠動脈CT、MRIのトピック」冠動脈CTによる虚血性心疾患の予後評価
  • Place of Presentation: 熊本(JALホテル熊本)
  • Year and Date: 2013-09-22
• [Presentation] 明日へのシンポジウム2画像診断や生理機能検査を実臨床にどう使うか「冠動脈石灰化スコアと臨床応用:日本人でも予後予測に有用か?」 (2013)
  • Author(s): 山本秀也
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 東京(京王プラザホテル)
  • Year and Date: 2013-07-19
• [Presentation] Prognostic Value of Coronary Artery Calcium and Epicardial Adipose Tissue Assessed by Non-contrast Computed Tomography The 8th Scientific Sessions (2013)
  • Author(s): Yamamoto H, Kihara Y, 他
  • Organizer: Society of Cardiovascular Computed Tomography
  • Place of Presentation: Montréal, Canada
  • Year and Date: 2013-07-12
• [Presentation] 明日へのシンポジウム 明日へのシンポジウム2「画像診断や生理機能検査を実臨床にどう使うか」 冠動脈石灰化スコアの臨床応用：日本人の予後予測に有用か？ (2013)
  • Author(s): 山本 秀也
  • Organizer: 第45回日本動脈硬化学会総会
  • Place of Presentation: 東京（京王プラザホテル）
  • Invited
• [Presentation] ビジュアルワークショップ4「冠動脈CT、MRIのトピック」冠動脈CTによる虚血性心疾患の予後評価―我が国における大規模前向き試験― (2013)
  • Author(s): 山本秀也、木原康樹：
  • Organizer: 第61回日本心臓病学会学術総会
  • Place of Presentation: 熊本（JALホテル熊本他）
  • Invited
• [Presentation] Prognostic Value of Coronary Artery Calcium and Epicardial Adipose Tissue Assessed by Non-contrast Computed Tomography (2013)
  • Author(s): Yamamoto H, Kunita E, Toshiro K, Utsunomiya H, Urabe U, Tsushima H, Kihara Y, Budoff MJ.
  • Organizer: The 8th Scientific Sessions, Society of Cardiovascular Computed Tomography,
  • Place of Presentation: Montreal, Canada
• [Presentation] シンポジウム「心臓CTガイドラインを考える:皆さんは現場でどうしていますか?」―4.日本におけるカルシウムスコアリングの活用について― (2012)
  • Author(s): 山本秀也
  • Organizer: 第6回SCCT研究会
  • Place of Presentation: 東京(品川コンベンションセンター)
  • Year and Date: 2012-09-09
• [Presentation] 合同シンポジウム「CTを中心とした心臓マルチモダリティーイメージング」冠動脈CTによる心イベント予知について ―カルシウムスコア、閉塞性病変、非石灰化プラークの観点から― (2012)
  • Author(s): 山本秀也
  • Organizer: 第22回日本心血管画像動態学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-01-28
• [Presentation] Plenary session. Association of Aortic Valve Calcification and Vulnerable Coronary Plaques Assessed by Coronary CT Angiography (2012)
  • Author(s): Utsunomiya H, Yamamoto H, Kihara Y, 他
  • Organizer: 第75回日本循環器学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Relationship between Eicosapentaenoic Acid/ Arachidonic Acid Ratios and Coronary Plaques as Detected by Computed Tomography Angiography in Patients Receiving Statin Therapy (2012)
  • Author(s): Urabe Y, Yamamoto H, Kihara Y, 他
  • Organizer: 第75回日本循環器学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Impact of Plasma High-Molecular-Weight Adiponectin on Left Ventricular Mass and Concentricity in Men (2012)
  • Author(s): Kunita K, Yamamoto H, Kihara Y, 他
  • Organizer: 第75回日本循環器学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Association of Left Ventricular Mass and Coronary Atherosclerosis in Cardiac Computed Tomography Angiography (2012)
  • Author(s): Kunita K, Yamamoto H, Kihara Y, 他
  • Organizer: 第75回日本循環器学会学術総会
  • Place of Presentation: 福岡
• [Presentation] シンポジウム「心臓ＣＴガイドラインを考える：皆さんは現場でどうしていますか？」―4．日本におけるカルシウムスコアリングの活用について― (2012)
  • Author(s): 山本秀也
  • Organizer: 第6回SCCT研究会
  • Place of Presentation: 東京（品川コンベンションセンター）
  • Invited
• [Presentation] 経胸壁心エコーから冠動脈硬化および脆弱性プラークの存在を予測できるか-大動脈基部および心臓弁石灰化所見の意義- (2012)
  • Author(s): 宇都宮裕人
  • Organizer: 第60回日本心臓病学会学術総会
  • Place of Presentation: 金沢市
  • Invited
• [Presentation] Association of Aortic Valve Calcification and Vulnerable Coronary Plaques Assessed by Coronary CT Angiography (2012)
  • Author(s): Utsunomiya H, Yamamoto H, Kunita E, OkaT, Urabe U, Tsushima H, Kihara Y.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society(招待講演)
  • Place of Presentation: Fukuoka, Japan
• [Presentation] Prognostic Value of MDCT Findings for Predicting Symptomatic Deterioration and Major Adverse Cardiac Events in Patients with Aortic Stenosis (2011)
  • Author(s): Utsunomiya H, Yamamoto H, Kihara Y, 他
  • Organizer: The 84th Scientific Sessions of the American Heart Association
  • Place of Presentation: Orlando
  • Year and Date: 2011-11-13
• [Presentation] Diffuse Calcium Deposits in Aortic Valve as a Marker of the extent and Vulnerable Characteristics of Coronary Artery Plaque Assessed by 64-Multidetector Computed Tomography (2011)
  • Author(s): Utsunomiya H, Yamamoto H, Kihara Y, 他
  • Organizer: The 84th Scientific Sessions of the American Heart Association
  • Place of Presentation: Orlando
  • Year and Date: 2011-11-13
• [Presentation] シンポジウム「心臓CTによる冠動脈プラーク診断:心臓病診療における位置づけを巡って」外来診療における冠動脈プラーク診断 ―プラーク評価方法と内臓脂肪蓄積症候群への応用― (2011)
  • Author(s): 山本秀也
  • Organizer: 第5回SCCT研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-10
• [Presentation] Future Coronary Events and Non-calcified Plaque with Vulnerable Characteristics as Detected by Coronary Computed Tomography Angiography (2011)
  • Author(s): Yamamoto H, 他
  • Organizer: The 6^<th> annual meeting of Society of Cardiovascular Computed Tomography
  • Place of Presentation: Denver
  • Year and Date: 2011-07-15
• [Presentation] Calcification on Coronary Artery Atherosclerosis and Ventricular Remodeling in Patients with Preserved LV Ejection Fraction (2011)
  • Author(s): 宇都宮裕人,山本秀也,木原康樹, 他
  • Organizer: 日本超音波医学会第84回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-27
• [Presentation] Subclinical LV Dysfunction in Uncomplicated Patients with Impaired Glucose Tolerance and Type 2 Diabetes Mellitus (2011)
  • Author(s): 宇都宮裕人,山本秀也,木原康樹, 他
  • Organizer: 第22回日本心エコー図学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2011-04-21
• [Presentation] Future Coronary Events and Non-calcified Plaque with Vulnerable Characteristics as Detected by Coronary Computed Tomography Angiography
  • Author(s): Yamamoto H, Utsunomiya H, Kunita E, Yamazato R, Urabe U, Kihara Y.
  • Organizer: The 6th Scientific Sessions, Society of Cardiovascular Computed Tomography
  • Place of Presentation: Denver, Colorado, USA,
• [Book] 非石灰化プラークの診断非石灰化プラーク画像とその臨床的利用の可能性(コンセンサス9.1)粥状硬化病変の評価(コンセンサス9.2)不安定プラーク(コンセンサス9.3)心CT第11号心臓CTの使い方―現在のコンセンサス― (小室一成、栗林幸夫編集) (2011)
  • Author(s): 山本秀也
  • Publisher: 文光堂東京
• [Book] 木原康樹Annual Book「血管糖尿病2001」II検査・診断2. CT, 佐田政隆、下村伊一郎、野出孝一、綿田弘孝編集
  • Author(s): 山本秀也
  • Publisher: フジメディカル出版