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Novel evaluation method using 3D OCT for safety of drug eluting stent

Research Project

Project/Area Number 23591045
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionYamaguchi University

Principal Investigator

OKAMURA Takayuki  山口大学, 医学部附属病院, 助教 (70380011)

Co-Investigator(Kenkyū-buntansha) MATSUZAKI Masunori  山口大学, その他部局等, 名誉教授 (60116754)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords虚血性心疾患 / 冠動脈ステント / 光干渉断層法 / 動脈硬化 / 画像診断
Research Abstract

We have developed a novel method to evaluate the tissue coverage using 3-dimensional optical coherence tomography. It had a good correlation to the standard quantitative analysis. The tissue coverage after biolimus- and evarolimus-eluting stent were evaluated by this method and good tissue coverage was revealed at 1-year follow-up. Furthermore, it has been reported that a lipid rich plaque with thin-fibrous cap related to occurrence of acute coronary syndrome and stent-related events. We have developed novel software which demonstrates such vulnerable plaque on 3-dimensional vessel model to facilitate understanding its location.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (16 results) (of which Invited: 3 results)

  • [Journal Article] Serial three-dimensional optical coherence tomography assessment of strut coverage and intraluminal structures after drug-eluting stent implantation2014

    • Author(s)
      Maeda T, Okamura T, Yamada J, Nao T, Tateishi H, Yoshimura M, Oda T, Shiraishi K, Nakashima T, Nakamura T, Miura T, Yano M
    • Journal Title

      Cardiovasc Interv Ther

      Volume: 29(1) Issue: 1 Pages: 31-9

    • DOI

      10.1007/s12928-013-0209-5

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequel of Jailed Side Branch2014

    • Author(s)
      Hiroki Tateishi, Takayuki Okamura, Jutaro Yamada, Tomoko Nao, Takao Maeda, Takamasa Oda, Takeshi Nakamura, Toshiro Miura, Masunori Matsuzaki, Masafumi Yano
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 3 Pages: 772-774

    • DOI

      10.1253/circj.CJ-13-0709

    • NAID

      130003382223

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sirolimus eluting stent fracture detection by three-dimensional optical coherence tomography2012

    • Author(s)
      Okamura T, Matsuzaki M.
    • Journal Title

      Catheter Cardiovasc Interv

      Volume: 79 Issue: 4 Pages: 628-32

    • DOI

      10.1002/ccd.23268

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional optical coherence tomography assessment of coronary wire re-crossing position during bifurcation stenting.2011

    • Author(s)
      Okamura T, Yamada J, Nao T, Suetomi T, Maeda T, Shiraishi K, Miura T, Matsuzaki M.
    • Journal Title

      Eurointervention

      Volume: 7 Issue: 7 Pages: 886-887

    • DOI

      10.4244/eijv7i7a138

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Three-dimensional assessment of Everolimus vs Biolimus eluting stent based on serial optical coherence tomography2014

    • Author(s)
      Maeda T, Okamura T, Yamada J, Nao T, Oda T, Mochizuki M, Tateishi H, Shiraishi K, Nakashima T, Nakamura T, Nishimura S, Yano M.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京、東京国際フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] The usefulness of three-dimensional optical tomography quantification of fibrous cap; serial change of thin-cap fibroatheroma by statin therapy2014

    • Author(s)
      Nakamura T, Okamura T, Yamada J, Nao T, Oda T, Mochizuki M, Tateishi H, Shiraishi K, Maeda T, Nakashima T, Nishimura S, Yano M.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京、東京国際フォーラム
    • Related Report
      2013 Final Research Report
  • [Presentation] Three-dimensional Assessment of Everolimus- vs. Biolimus-eluting stent Based on Serial Optical Coherence Tomography2014

    • Author(s)
      Takao Maeda, Takayuki Okamura, Jutaro Yamada, Tomoko Nao, Tetsuro Oda, Mamoru Mochizuki, Hiroki Tateishi, Kozo Shiraishi, Tadamitsu Nakashima, Takeshi Nakamura, Shigehiko Nishimura, Masafumi Yano
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京、東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] The usefulness of three-dimensional optical coherence tomography (3D OCT) quantification of fibrous cap; serial change of thin-cap fibroatheroma(TCFA) by statin therapy2014

    • Author(s)
      Takeshi Nakamura, Takayuki Okamura , Jutaro Yamada, Tomoko Nao ,Tetsuro Oda, Mamoru Mochizuki, Hiroki Tateishi, Kozo Shiraishi, Takao Maeda, Tadamitsu Nakashima, Shigehiko Nishimura, Masafumi Yano
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京、東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Basics of 3-dimensional OCT assessment2013

    • Author(s)
      Okamura T.
    • Organizer
      CCT2013
    • Place of Presentation
      神戸、神戸国際会議場
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Impact of characterization of tissue prolapse on neointimal formation after drug eluting stent implantation; a serial optical coherence tomography study2013

    • Author(s)
      Nakamura T, Okamura T, Yamada J, Tateishi H,Maeda T, Oda T, Nao T, Shiraishi K, Yoshimura M, Nakashima T, Yano M.
    • Organizer
      EuroPCR2013
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Three-dimensional optical coherence tomography assessment for strut coverage of sirolimus vs everolimus eluting stent at follow-up2013

    • Author(s)
      Maeda T, Okamura T, Yoshimura M, Oda T, Shiraishi K, Nakashima T, Nakamura T, Miura T, Yano M.
    • Organizer
      EuroPCR2013
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of characterization of tissue prolapse on neointimal formation after drug stent implantation; a serial optical coherence tomography study2013

    • Author(s)
      Takeshi Nakamura, Takayuki Okamura, Jurtaro Yamada, Tomoko Kuwata, Hiroki Tateishi, Takao Maeda, Takamasa Oda, Tomoko Nao, Kouzou Shiraishi, Masayuki Yoshimura, Tadamitsu Nakashima, Masafumi Yano
    • Organizer
      EuroPCR2013
    • Place of Presentation
      フランス、パリ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Three-dimensional optical coherence tomography assessment for strut coverage of biolimus- vs. everolimus-eluting stent at follow-up2013

    • Author(s)
      Takao Maeda, Takayuki Okamura, Masayuki Yoshimura, Takamasa Oda, Kozo Shiraishi, Tadamitsu Nakashima, Takeshi Nakamura, Toshiro Miura, Masafumi Yano
    • Organizer
      EuroPCR2013
    • Place of Presentation
      フランス、パリ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Basics of 3-Dimensional OCT assessment2013

    • Author(s)
      Takayuki Okamura
    • Organizer
      CVIT2013
    • Place of Presentation
      神戸、神戸国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Tissue coverage and extra stent area of everolimus- vs. biolimus-eluting stent at 1-year follow-up using optical coherence tomography2013

    • Author(s)
      前田貴生、岡村誉之
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel Automatic Stent Strut Detection Technique for Rapid Three-dimensional Optical Coherence Tomography to Complex Stenting Procedure2012

    • Author(s)
      Okamura T, Maeda T, Yamada J, Nao T, Suetomi T, Yoshimura M, Hino A, Oda T, Nakashima T, Shiraishi K, Nakashima T, Nakamura T, Nishimura S, Miura T, Matsuzaki M.
    • Organizer
      第76回日本循環器学会
    • Place of Presentation
      福岡、福岡国際会議場
    • Year and Date
      2012-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] OCTの3次元イメージングをPCIに活用する2012

    • Author(s)
      岡村誉之
    • Organizer
      第26回冠疾患学会学術集会
    • Place of Presentation
      東京、ステーションカンファレンス
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Novel Automatic Stent Strut Detection Technique for On-site Three-dimensional Optical Coherence Tomography to Complex Stenting Procedure2012

    • Author(s)
      Takayuki Okamura
    • Organizer
      EuroPCR2012
    • Place of Presentation
      フランス、パリ
    • Related Report
      2012 Research-status Report
  • [Presentation] Novel Automatic Stent Strut Detection Technique for Rapid Three-dimensional Optical Coherence Tomography to Complex Stenting Procedure2012

    • Author(s)
      T Okamura, T Maeda, J Yamada, T Nao, T Suetomi, M Yoshimura, A Hino, T Oda, T Nakashima, K Shiraishi, T Nakashima, T Nakamura, S Nishimura, T Miura, M Matsuzaki
    • Organizer
      日本循環器学会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] Three-Dimensional Optical Coherence Tomography Assessment of Strut Coverage after Everolimus-Eluting Stent Implantation2012

    • Author(s)
      T Maeda, T Okamura, J Yamada, T Nao, M Yoshimura, T Suetomi, A Hino, T Oda, T Nakashima, K Shiraishi, T Nakashima, T Nakamura, S Nishimura, T Miura, M Matsuzaki
    • Organizer
      米国心臓病学会
    • Place of Presentation
      シカゴ(アメリカ)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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