Novel evaluation method using 3D OCT for safety of drug eluting stent

• Project/Area Number: 23591045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamaguchi University
• Principal Investigator: OKAMURA Takayuki 山口大学, 医学部附属病院, 助教 (70380011)
• Co-Investigator(Kenkyū-buntansha): MATSUZAKI Masunori 山口大学, その他部局等, 名誉教授 (60116754)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 虚血性心疾患 / 冠動脈ステント / 光干渉断層法 / 動脈硬化 / 画像診断

Research Abstract

We have developed a novel method to evaluate the tissue coverage using 3-dimensional optical coherence tomography. It had a good correlation to the standard quantitative analysis. The tissue coverage after biolimus- and evarolimus-eluting stent were evaluated by this method and good tissue coverage was revealed at 1-year follow-up. Furthermore, it has been reported that a lipid rich plaque with thin-fibrous cap related to occurrence of acute coronary syndrome and stent-related events. We have developed novel software which demonstrates such vulnerable plaque on 3-dimensional vessel model to facilitate understanding its location.

Research Products

• [Journal Article] Serial three-dimensional optical coherence tomography assessment of strut coverage and intraluminal structures after drug-eluting stent implantation (2014)
  • Author(s): Maeda T, Okamura T, Yamada J, Nao T, Tateishi H, Yoshimura M, Oda T, Shiraishi K, Nakashima T, Nakamura T, Miura T, Yano M
  • Journal Title: Cardiovasc Interv Ther Volume: 29(1) Issue: 1 Pages: 31-9
  • DOI: 10.1007/s12928-013-0209-5
  • Peer Reviewed
• [Journal Article] Sequel of Jailed Side Branch (2014)
  • Author(s): Hiroki Tateishi, Takayuki Okamura, Jutaro Yamada, Tomoko Nao, Takao Maeda, Takamasa Oda, Takeshi Nakamura, Toshiro Miura, Masunori Matsuzaki, Masafumi Yano
  • Journal Title: Circulation Journal Volume: 78 Issue: 3 Pages: 772-774
  • DOI: 10.1253/circj.CJ-13-0709
  • NAID: 130003382223
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Sirolimus eluting stent fracture detection by three-dimensional optical coherence tomography (2012)
  • Author(s): Okamura T, Matsuzaki M.
  • Journal Title: Catheter Cardiovasc Interv Volume: 79 Issue: 4 Pages: 628-32
  • DOI: 10.1002/ccd.23268
  • Peer Reviewed
• [Journal Article] Three-dimensional optical coherence tomography assessment of coronary wire re-crossing position during bifurcation stenting. (2011)
  • Author(s): Okamura T, Yamada J, Nao T, Suetomi T, Maeda T, Shiraishi K, Miura T, Matsuzaki M.
  • Journal Title: Eurointervention Volume: 7 Issue: 7 Pages: 886-887
  • DOI: 10.4244/eijv7i7a138
  • Peer Reviewed
• [Presentation] Three-dimensional assessment of Everolimus vs Biolimus eluting stent based on serial optical coherence tomography (2014)
  • Author(s): Maeda T, Okamura T, Yamada J, Nao T, Oda T, Mochizuki M, Tateishi H, Shiraishi K, Nakashima T, Nakamura T, Nishimura S, Yano M.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京、東京国際フォーラム
• [Presentation] The usefulness of three-dimensional optical tomography quantification of fibrous cap; serial change of thin-cap fibroatheroma by statin therapy (2014)
  • Author(s): Nakamura T, Okamura T, Yamada J, Nao T, Oda T, Mochizuki M, Tateishi H, Shiraishi K, Maeda T, Nakashima T, Nishimura S, Yano M.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京、東京国際フォーラム
• [Presentation] Three-dimensional Assessment of Everolimus- vs. Biolimus-eluting stent Based on Serial Optical Coherence Tomography (2014)
  • Author(s): Takao Maeda, Takayuki Okamura, Jutaro Yamada, Tomoko Nao, Tetsuro Oda, Mamoru Mochizuki, Hiroki Tateishi, Kozo Shiraishi, Tadamitsu Nakashima, Takeshi Nakamura, Shigehiko Nishimura, Masafumi Yano
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京、東京国際フォーラム
• [Presentation] The usefulness of three-dimensional optical coherence tomography (3D OCT) quantification of fibrous cap; serial change of thin-cap fibroatheroma(TCFA) by statin therapy (2014)
  • Author(s): Takeshi Nakamura, Takayuki Okamura , Jutaro Yamada, Tomoko Nao ,Tetsuro Oda, Mamoru Mochizuki, Hiroki Tateishi, Kozo Shiraishi, Takao Maeda, Tadamitsu Nakashima, Shigehiko Nishimura, Masafumi Yano
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京、東京国際フォーラム
• [Presentation] Basics of 3-dimensional OCT assessment (2013)
  • Author(s): Okamura T.
  • Organizer: CCT2013
  • Place of Presentation: 神戸、神戸国際会議場
  • Invited
• [Presentation] Impact of characterization of tissue prolapse on neointimal formation after drug eluting stent implantation; a serial optical coherence tomography study (2013)
  • Author(s): Nakamura T, Okamura T, Yamada J, Tateishi H,Maeda T, Oda T, Nao T, Shiraishi K, Yoshimura M, Nakashima T, Yano M.
  • Organizer: EuroPCR2013
  • Place of Presentation: Paris, France
• [Presentation] Three-dimensional optical coherence tomography assessment for strut coverage of sirolimus vs everolimus eluting stent at follow-up (2013)
  • Author(s): Maeda T, Okamura T, Yoshimura M, Oda T, Shiraishi K, Nakashima T, Nakamura T, Miura T, Yano M.
  • Organizer: EuroPCR2013
  • Place of Presentation: Paris, France
• [Presentation] Impact of characterization of tissue prolapse on neointimal formation after drug stent implantation; a serial optical coherence tomography study (2013)
  • Author(s): Takeshi Nakamura, Takayuki Okamura, Jurtaro Yamada, Tomoko Kuwata, Hiroki Tateishi, Takao Maeda, Takamasa Oda, Tomoko Nao, Kouzou Shiraishi, Masayuki Yoshimura, Tadamitsu Nakashima, Masafumi Yano
  • Organizer: EuroPCR2013
  • Place of Presentation: フランス、パリ
• [Presentation] Three-dimensional optical coherence tomography assessment for strut coverage of biolimus- vs. everolimus-eluting stent at follow-up (2013)
  • Author(s): Takao Maeda, Takayuki Okamura, Masayuki Yoshimura, Takamasa Oda, Kozo Shiraishi, Tadamitsu Nakashima, Takeshi Nakamura, Toshiro Miura, Masafumi Yano
  • Organizer: EuroPCR2013
  • Place of Presentation: フランス、パリ
• [Presentation] Basics of 3-Dimensional OCT assessment (2013)
  • Author(s): Takayuki Okamura
  • Organizer: CVIT2013
  • Place of Presentation: 神戸、神戸国際会議場
  • Invited
• [Presentation] Tissue coverage and extra stent area of everolimus- vs. biolimus-eluting stent at 1-year follow-up using optical coherence tomography (2013)
  • Author(s): 前田貴生、岡村誉之
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: パシフィコ横浜、横浜
• [Presentation] Novel Automatic Stent Strut Detection Technique for Rapid Three-dimensional Optical Coherence Tomography to Complex Stenting Procedure (2012)
  • Author(s): Okamura T, Maeda T, Yamada J, Nao T, Suetomi T, Yoshimura M, Hino A, Oda T, Nakashima T, Shiraishi K, Nakashima T, Nakamura T, Nishimura S, Miura T, Matsuzaki M.
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡、福岡国際会議場
  • Year and Date: 2012-03-17
• [Presentation] OCTの３次元イメージングをPCIに活用する (2012)
  • Author(s): 岡村誉之
  • Organizer: 第２６回冠疾患学会学術集会
  • Place of Presentation: 東京、ステーションカンファレンス
  • Invited
• [Presentation] Novel Automatic Stent Strut Detection Technique for On-site Three-dimensional Optical Coherence Tomography to Complex Stenting Procedure (2012)
  • Author(s): Takayuki Okamura
  • Organizer: EuroPCR2012
  • Place of Presentation: フランス、パリ
• [Presentation] Novel Automatic Stent Strut Detection Technique for Rapid Three-dimensional Optical Coherence Tomography to Complex Stenting Procedure (2012)
  • Author(s): T Okamura, T Maeda, J Yamada, T Nao, T Suetomi, M Yoshimura, A Hino, T Oda, T Nakashima, K Shiraishi, T Nakashima, T Nakamura, S Nishimura, T Miura, M Matsuzaki
  • Organizer: 日本循環器学会
  • Place of Presentation: 福岡国際会議場（福岡）
• [Presentation] Three-Dimensional Optical Coherence Tomography Assessment of Strut Coverage after Everolimus-Eluting Stent Implantation (2012)
  • Author(s): T Maeda, T Okamura, J Yamada, T Nao, M Yoshimura, T Suetomi, A Hino, T Oda, T Nakashima, K Shiraishi, T Nakashima, T Nakamura, S Nishimura, T Miura, M Matsuzaki
  • Organizer: 米国心臓病学会
  • Place of Presentation: シカゴ（アメリカ）