| Project/Area Number |
23591048
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 心筋症 / 遺伝子解析 / 心血管事故 / リスク層別化 / 心房細動 |
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| Research Abstract |
A meta-analysis of genome-wide association studies for atrial fibrillation (AF) has successfully identified ten genotypes. We conducted a cross-sectional study to clarify the association between cumulative effects of GWAS-proved single nucleotide polymorphisms (SNPs) and AF in patients with heart failure.
One hundred seventy-two patients with heart failure were enrolled. One hundred twenty-six were diagnosed with AF. We genotyped 10 SNPs validated by meta-analysis of GWAS for AF. Ten SNPs were KCNN3-PMVK(rs6666258), PRRX1(rs3903239), PITX2(rs6817105), WNT8A(rs2040862), CAV1(rs3807989), C9orf3(rs10821415), SYNPO2L(rs10824026), SYNE2(rs1152591), HCN4(rs7164883), and ZFHX3(rs2106261). Cumulative effects were calculated as a genotype risk score (GRS) by adding the risk allele number of 10 SNPs. Mean GRS in patients with AF was significantly higher than that in patients with sinus rhythm. We found that the GRS was significantly associated with AF in patients with heart failure.
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