Risk Assessment of Cardiovascular Events by Meta-Analysis of Genome-Wide Association Studies for Atrial Fibrillation in Patients With Heart Failure

• Project/Area Number: 23591048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Ehime University
• Principal Investigator: OGIMOTO AKIYOSHI 愛媛大学, 医学部附属病院, 准教授 (00403832)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 心筋症 / 遺伝子解析 / 心血管事故 / リスク層別化 / 心房細動

Research Abstract

A meta-analysis of genome-wide association studies for atrial fibrillation (AF) has successfully identified ten genotypes. We conducted a cross-sectional study to clarify the association between cumulative effects of GWAS-proved single nucleotide polymorphisms (SNPs) and AF in patients with heart failure.
One hundred seventy-two patients with heart failure were enrolled. One hundred twenty-six were diagnosed with AF. We genotyped 10 SNPs validated by meta-analysis of GWAS for AF. Ten SNPs were KCNN3-PMVK(rs6666258), PRRX1(rs3903239), PITX2(rs6817105), WNT8A(rs2040862), CAV1(rs3807989), C9orf3(rs10821415), SYNPO2L(rs10824026), SYNE2(rs1152591), HCN4(rs7164883), and ZFHX3(rs2106261). Cumulative effects were calculated as a genotype risk score (GRS) by adding the risk allele number of 10 SNPs. Mean GRS in patients with AF was significantly higher than that in patients with sinus rhythm. We found that the GRS was significantly associated with AF in patients with heart failure.

Research Products

• [Journal Article] Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade (2014)
  • Author(s): Ohshima K, Mogi M, Nakaoka H, Iwanami J, Min LJ, Kanno H, Tsukuda K, Chisaka T, Bai HY, Wang XL, Ogimoto A, Higaki J, Horiuchi M.
  • Journal Title: Hypertension Volume: 63
  • Peer Reviewed
• [Journal Article] Positron Emission Tomography Computed Tomography for Imaging of Inflammatory Cardiovascular Diseases (2014)
  • Author(s): Miyagawa M, Yokoyama R, Nishiyama Y, Ogimoto A, Higaki J, Mochizuki T.
  • Journal Title: Circ J Volume: May 9(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade (2014)
  • Author(s): Ohshima K, Mogi M(31人中②), et al
  • Journal Title: Hypertension Volume: 63 Issue: 3
  • DOI: 10.1161/hypertensionaha.113.02426
  • Peer Reviewed / Open Access
• [Journal Article] Positron Emission Tomography-Computed Tomography for Imaging of Inflammatory Cardiovascular Diseases ? Sarcoidosis, Large-Vessel Arteritis, and Atherosclerosis ? (2014)
  • Author(s): Miyagawa M, Yokoyama R, Nishiyama Y, Ogimoto A, Higaki J, Mochizuki T.
  • Journal Title: Circ J Volume: Epub ahead of print
  • NAID: 130004427924
  • Peer Reviewed
• [Journal Article] Relationship Between Augmentation Index and Left Ventricular Diastolic Function in Healthy Women and Men (2013)
  • Author(s): Higashi H, Okayama H, Saito M, Morioka H, Aono J, Yoshii T, Hiasa G, Sumimoto T, Nishimura K, Inoue K, Ogimoto A, Higaki J.
  • Journal Title: Am J Hypertens Volume: Jul 17(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Role of transthoracic Doppler echocardiography in patients with a proximal left coronary artery lesion that cannot be diagnosed by computed tomography angiography (2013)
  • Author(s): Higashi H, Okayama H, Saito M, Morioka H, Aono J, Yoshii T, Sumimoto T, Hiasa G, Nishimura K, Inoue K, Ogimoto A, Higaki J.
  • Journal Title: Am J Cardiol Volume: 112 Pages: 938-42
  • Peer Reviewed
• [Journal Article] Qualitative and quantitative assessment of adenosine triphosphate stress whole-heart dynamic myocardial perfusion imaging using 256-slice computed tomography (2013)
  • Author(s): Kurata A, Kawaguchi N, Kido T, Inoue K, Suzuki J, Ogimoto A, Funada J, Higaki J, Miyagawa M, Vembar M, Mochizuki T.
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] 遺伝子から診た特発性心筋症 (2013)
  • Author(s): 藤本香織,大木元明義,大蔵隆文,檜垣實男
  • Journal Title: 愛媛医学 Volume: 32 Pages: 165-70
  • Peer Reviewed
• [Journal Article] 心室中隔中部に憩室様の菲薄化をきたした心サルコイドーシスの1例 (2013)
  • Author(s): 村上千佳,永井啓行,飯尾千春子,藤井昭,西村和久,井上勝次,鈴木純,宮川正男,望月輝一,檜垣實男,大木元明義
  • Journal Title: 心臓 Volume: 45 Pages: 1007-12
  • NAID: 130004691773
  • Peer Reviewed
• [Journal Article] Relationship Between Augmentation Index and Left Ventricular Diastolic Function in Healthy Women and Men. (2013)
  • Author(s): Higashi H, Okayama H, Saito M, Morioka H, Aono J, Yoshii T, Hiasa G, Sumimoto T, Nishimura K, Inoue K, Ogimoto A, Higaki J.
  • Journal Title: Am J Hypertens Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Role of transthoracic Doppler echocardiography in patients with a proximal left coronary artery lesion that cannot be diagnosed by computed tomography angiography. (2013)
  • Author(s): Higashi H, Okayama H, Saito M, Morioka H, Aono J, Yoshii T, Sumimoto T, Hiasa G, Nishimura K, Inoue K, Ogimoto A, Higaki J.
  • Journal Title: Am J Cardiol Volume: 112 (7) Issue: 7 Pages: 938-942
  • DOI: 10.1016/j.amjcard.2013.05.023
  • Peer Reviewed
• [Journal Article] Qualitative and quantitative assessment of adenosine triphosphate stress whole-heart dynamic myocardial perfusion imaging using 256-slice computed tomography. (2013)
  • Author(s): Kurata A, Kawaguchi N, Kido T, Inoue K, Suzuki J, Ogimoto A, Funada J, Higaki J, Miyagawa M, Vembar M, Mochizuki T.
  • Journal Title: PLoS One Volume: 8 (12) Issue: 12 Pages: e83950-e83950
  • DOI: 10.1371/journal.pone.0083950
  • Peer Reviewed
• [Journal Article] 遺伝子から診た特発性心筋症． (2013)
  • Author(s): 藤本香織，大木元明義，大蔵隆文，檜垣實男．
  • Journal Title: 愛媛医学 Volume: 32 (3) Pages: 165-170
  • Peer Reviewed
• [Journal Article] 心室中隔中部に憩室様の菲薄化をきたした心サルコイドーシスの1例． (2013)
  • Author(s): 村上千佳，永井啓行，飯尾千春子，藤井昭，西村和久，井上勝次，鈴木純，宮川正男，望月輝一，檜垣實男，大木元明義．
  • Journal Title: 心臓 Volume: 45 (8) Pages: 1007-1012
  • NAID: 130004691773
  • Peer Reviewed
• [Journal Article] Stress/Rest circumferential strain in non-ischemia, ischemia, and infarction. (2013)
  • Author(s): Kido T, Nagao M, Kido T, Kurata A, Miyagawa M, Ogimoto A, Mochizuki T.
  • Journal Title: Circulation Journal Volume: 77 Pages: 1235-1241
  • Peer Reviewed
• [Journal Article] The Roles of Calcium and Phosphorus in Cardiovascular Diseases. Pleiotropic effects of new generation calcium channel blockers on cardiovascular protections. (2013)
  • Author(s): Ogimoto A, Higaki J.
  • Journal Title: Clin Calcium Volume: 23 Pages: 569-574
• [Journal Article] Frequent urination caused by a giant iliac artery aneurysm. (2013)
  • Author(s): Higashi H, Saito M, Aono J, Yoshii T, Ogimoto A, Higaki J.
  • Journal Title: J Am Coll Cardiol Volume: 61 Issue: 10 Pages: e151-e151
  • DOI: 10.1016/j.jacc.2012.08.1037
  • Peer Reviewed
• [Journal Article] Impact of synergistic polymorphisms in adrenergic receptor-related genes and cardiovascular events in patients with dilated cardiomyopathy. (2012)
  • Author(s): Ogimoto A, Okayama H, Nagai T, Suzuki J, Inoue K, Nishimura K, Shigematsu Y, Tabara Y, Miki T, Higaki J.
  • Journal Title: Circulation Journal Volume: 76 Pages: 2003-2008
  • NAID: 10030505036
  • Peer Reviewed
• [Journal Article] Deletion of the Angiotensin II Type 1a Receptor Prevents Atherosclerotic Plaque Rupture in Apolipoprotein E-/- Mice. (2012)
  • Author(s): Aono J, Suzuki J, Iwai M, Horiuchi M, Nagai T, Nishimura K, Inoue K, Ogimoto A, Okayama H, Higaki J.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Issue: 6 Pages: 1453-1459
  • DOI: 10.1161/atvbaha.112.249516
  • Peer Reviewed
• [Journal Article] Impact of type 2 diabetes on serial changes in tissue characteristics of coronary plaques: an integrated backscatter intravascular ultrasound analysis. (2012)
  • Author(s): Inaba S, Okayama H, Funada JI, Higashi H, Saito M, Yoshii T, Hiasa G, Sumimoto T, Takata Y, Nishimura K, Inoue K, Ogimoto A, Higaki J.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 13 Issue: 9 Pages: 717-723
  • DOI: 10.1093/ehjci/jes033
  • Peer Reviewed
• [Journal Article] Carotid arterial circumferential strain by two-dimensional speckle tracking: a novel parameter of arterial elasticity. (2012)
  • Author(s): Saito M, Okayama H, Inoue K, Yoshii T, Hiasa G, Sumimoto T, Nishimura K, Ogimoto A, Higaki J.
  • Journal Title: Hypertension Research Volume: 35 Issue: 9 Pages: 897-902
  • DOI: 10.1038/hr.2012.39
  • Peer Reviewed
• [Journal Article] Clinical significance of global two-dimensional strain as a surrogate parameter of myocardial fibrosis and cardiac events in patients with hypertrophic cardiomyopathy. (2012)
  • Author(s): Saito M, Okayama H, Yoshii T, Higashi H, Morioka H, Hiasa G, Sumimoto T, Inaba S, Nishimura K, Inoue K, Ogimoto A, Shigematsu Y, Hamada M, Higaki J.
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 13 Issue: 7 Pages: 617-623
  • DOI: 10.1093/ejechocard/jer318
  • Peer Reviewed
• [Journal Article] Impact of Septal Curvature on Regional Strain in Patients With Hypertrophic Cardiomyopathy. (2012)
  • Author(s): Inoue K, Okayama H, Nishimura K, Nagai T, Suzuki J, Ogimoto A, Saito M, Yoshii T, Hiasa G, Sumimoto T, Funada JI, Shigematsu Y, Hamada M, Higaki J.
  • Journal Title: Circulation Journal Volume: E-pub ahead of print Pages: 1040-1045
  • NAID: 10031139009
  • Peer Reviewed
• [Journal Article] Direct angiotensin II type 2 receptor stimulation ameliorates insulin resistance in type 2 diabetes mice with PPARγ activation. (2012)
  • Author(s): Ohshima K, Mogi M, Jing F, Iwanami J, Tsukuda K, Min LJ, Ogimoto A, Dahlöf B, Steckelings UM, Unger T, Higaki J, Horiuchi M.
  • Journal Title: PLoS One Volume: 7 Issue: 11 Pages: e48387-e48387
  • DOI: 10.1371/journal.pone.0048387
  • Peer Reviewed
• [Journal Article] Inhibition of MCP-1/CCR2 signaling pathway is involved in synergistic inhibitory effects of irbesartan with rosuvastatin on vascular remodeling. (2012)
  • Author(s): Ohshima K, Mogi M, Nakaoka H, Jing F, Iwanami J, Min LJ, Tsukuda K, Kanno H, Ogimoto A, Higaki J, Horiuchi M.
  • Journal Title: J Am Soc Hypertens Volume: 6 Issue: 6 Pages: 375-384
  • DOI: 10.1016/j.jash.2012.10.002
  • Peer Reviewed
• [Journal Article] Impact of Synergistic Polymorphisms in Adrenergic Receptor-Related Genes and Cardiovascular Events in Patients with Dilated Cardiomyopathy. (2012)
  • Author(s): Akiyoshi Ogimoto, Hideki Okayama, Takayuki Nagai , Jun Suzuki, Katsuji Inoue, Kazuhisa Nishimura, Yuji Shigematsu, Yasuharu Tabara, Tetsuro Miki, Jitsuo Higaki.
  • Journal Title: Circulation Journal Volume: in press
  • NAID: 10030505036
  • Peer Reviewed
• [Presentation] Impact of SCN10A Gene Polymorphism for Cardiac Conduction Abnormality in Patients with Hypertrophic Cardiomyopathy (2014)
  • Author(s): Ogimoto A, Iio C, Kono T, Fujii A, Uetani T, Nagai T, Nishimura K, Inoue K, Suzuki J, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63^<rd> Annual Scientific Session
  • Place of Presentation: Washington DC, USA
• [Presentation] The Impact of Adaptive-Servo Ventilator on Coronary Flow Velocity Reserve in Patients With Non-ischemic Dilated Cardiomyopathy (2014)
  • Author(s): Nishimura K, Inoue K, Uetani T, Nagai T, Suzuki J, Ogimoto A, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63^<rd> Annual Scientific Session
  • Place of Presentation: Washington DC, USA
• [Presentation] Diagnostic Accuracy of ATP-Stress Dynamic CT Perfusion Imaging as Compared with ATP-Stress Cardiac MR Perfusion Imaging for the Assessment of Myocardial Ischemia (2014)
  • Author(s): Uetani T, Ogimoto A, Kono T, Fujii A, Nagai T, Nishimura K, Inoue K, Suzuki J, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63^<rd> Annual Scientific Session
  • Place of Presentation: Washington DC, USA
• [Presentation] Cumulative Genetic Risk of Single Nucleotide Polymorphisms by Meta-Analysis of Genome-Wide Association Studies for Atrial Fibrillation (2014)
  • Author(s): Fujii A, Ogimoto A, Nagai T, Suzuki J, Inoue K, Nishimura K, Uetani T, Tabara Y, Miki T, Okura T, Higaki J.
  • Organizer: The 78^<th> Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo
• [Presentation] Impact of SCN10A Gene Polymorphism for Cardiac Conduction Abnormality in Patients with Hypertrophic Cardiomyopathy. (2014)
  • Author(s): Ogimoto A, io C, Kono T, Fujii A, Uetani T, Nagai T, Nishimura K, Inoue K, Suzuki J, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63rd Annual Scientific Session
  • Place of Presentation: Washington DC, USA
• [Presentation] Cumulative Genetic Risk of Single Nucleotide Polymorphisms by Meta-Analysis of Genome-Wide Association Studies for Atrial Fibrillation. (2014)
  • Author(s): Fujii A, Ogimoto A, Nagai T, Suzuki J, Inoue K, Nishimura K, Uetani T, Tabara Y, Miki T, Okura T, Higaki J.
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Tokyo, Japan
• [Presentation] The Impact of Adaptive-Servo Ventilator on Coronary Flow Velocity Reserve in Patients With Non-ischemic Dilated Cardiomyopathy (2014)
  • Author(s): Nishimura K, Inoue K, Uetani T, Nagai T, Suzuki J, Ogimoto A, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63rd Annual Scientific Session
  • Place of Presentation: Washington DC, USA
• [Presentation] Diagnostic Accuracy of ATP-Stress Dynamic CT Perfusion Imaging as Compared with ATP-Stress Cardiac MR Perfusion Imaging for the Assessment of Myocardial Ischemia (2014)
  • Author(s): Uetani T, Ogimoto A, Kono T, Fujii A, Nagai T, Nishimura K, Inoue K, Suzuki J, Okura T, Higaki J.
  • Organizer: The American College of Cardiology 63rd Annual Scientific Session
  • Place of Presentation: Washington DC, USA
• [Presentation] Symposium. Illness specific issues. Smoking and Heart Diseases. (2013)
  • Author(s): Ogimoto A, Higaki J.
  • Organizer: The 10th APACT Conference 2013
  • Place of Presentation: Chiba, Japan.
  • Invited
• [Presentation] Association between Genetic Variation in SCN10A Gene and Abnormality of Cardiac Conduction in Patients with Hypertrophic Cardiomyopathy (2013)
  • Author(s): Iio C, Ogimoto A, Suzuki J, Inoue K, Nishimura K, Nagai T, Uetani T, Kohno T, Fujii A, Higashi H, Okura T, Okayama H, Shigematsu Y, Hamada M, Tabara Y, Miki T, Higaki J.
  • Organizer: The 77th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama
• [Presentation] Interaction Between Polymorphisms in Inflammation-Related Genes and Atrial fibrillation in Patients with Dilated Cardiomyopathy. (2011)
  • Author(s): Akiyoshi Ogimoto, Jun Suzuki, Katsuji Inoue, Kazuhisa Nishimura, Takayuki Nagai, Yuji Shigematsu, Hideki Okayama, Jitsuo Higaki.
  • Organizer: American Heart Association Scientific Session 2011
  • Place of Presentation: Orlando Florida, USA.
• [Book] 第4章治療薬総論禁煙補助薬禁煙補助薬 (2013)
  • Author(s): 分担執筆大木元明義,檜垣實男, 今日の循環器疾患治療指針第3版編集井上博,許俊鋭,檜垣實男,代田浩之,筒井裕之
  • Publisher: 医学書院
• [Book] 今日の循環器疾患治療指針第3版 （第4章 治療薬総論 禁煙補助薬禁煙補助薬） (2013)
  • Author(s): （分担）大木元明義，檜垣實男．
  • Total Pages: 938
  • Publisher: 医学書院
• [Book] 今日の循環器疾患治療指針第3版 (2013)
  • Author(s): 大木元明義，檜垣實男（分担執筆）
  • Publisher: 医学書院
• [Book] Heart View (2012)
  • Author(s): 大木元明義，檜垣實男（分担執筆）
  • Publisher: メディカルビュー社
• [Book] 高血圧ナビゲーター第3版 (2011)
  • Author(s): 大木元明義，檜垣實男．（分担執筆）
  • Publisher: メディカルレビュー社
• [Remarks]
  • URL: http://www.m.ehime-u.ac.jp/school/int.med2/index.html
• [Remarks] 愛媛大学大学院 循環器・呼吸器・腎高血圧内科ホームページ
  • URL: http://www.m.ehime-u.ac.jp/school/int.med2/index.html
• [Remarks] 愛媛大学教育研究者要覧 大木元明義
  • URL: http://kenqweb.office.ehime-u.ac.jp/Profiles/0004/0001051/profile.html
• [Remarks] Ehime University Academic Staff OGIMOTO-AKIYOSHI
  • URL: http://kenqweb.office.ehime-u.ac.jp/Profiles/0004/0001051/prof_e.html