| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
Despite the adverse cardiovascular consequences of sleep disordered breathing (SDB), the majority of patients remain undiagnosed. To establish an effective ECG-based screening tool for SDB, we developed an automated algorithm (ACAT) that detects cyclic variation of heart rate accompanying SDB episodes. Among 862 patients undergoing polysomnographic examination, the ACAT detected moderate-to-severe SDB with 83% sensitivity and 88% specificity. The ACAT also detected SDB patients among 165 apparently healthy track drivers in a transportation company. Furthermore, we applied the ACAT algorithm to Holter ECG recordings in 716 patients after an acute myocardial infarction and found that depression and SDB are interactively associated with increased mortality risk during a median follow-up of 25 months.
|
