Identification of coronary vulnerable plaques and effects of intravenous atrial natriuretic peptide on coronary vasodilation using magnetic resonance imaging

• Project/Area Number: 23591057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Osaka City University
• Principal Investigator: EHARA SHOICHI 大阪市立大学, 医学(系)研究科(研究院), 講師 (90382150)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 急性冠症候群 / 血栓 / 核磁気共鳴画像 / 光干渉断層像 / 不安定プラーク / 冠動脈 / 動脈硬化

Outline of Final Research Achievements

As acute myocardial infarction (AMI) or cerebral infarction (CI) frequently occurs as the first symptom, screening of the patients with unstable plaque is important for prevention of the onset of AMI or CI. We reported that coronary artery hyperintense plaques on magnetic resonance imaging (MRI) are associated with a unstable plaque morphology. Furthermore, we showed using MRI that the effect of atrial natriuretic peptide on the coronary artery vasodilation was not inferior to those of nitroglycerin, with no significant alteration in heart rate.

Research Products

• [Journal Article] Serum n-3 to n-6 polyunsaturated fatty acids ratio correlates with coronary plaque vulnerability: an optical coherence tomography study (2014)
  • Author(s): Hasegawa T, Otsuka K, Iguchi T, Matsumoto K, Ehara S, Nakata S, Nishimura S, Kataoka T, Shimada K, Yoshiyama M
  • Journal Title: Heart Vessels Volume: 29 Issue: 5 Pages: 596-602
  • DOI: 10.1007/s00380-013-0404-4
  • Peer Reviewed
• [Journal Article] The strain pattern, and not Sokolow-Lyon electrocardiographic voltage criteria, is independently associated with anatomic left ventricular hypertrophy (2014)
  • Author(s): Ehara S, Hasegawa T, Matsumoto K, OtsukaY, Yamazaki T, Iguchi T, Izumi Y, Shimada K, Yoshiyama M
  • Journal Title: Heart Vessels Volume: 29 Issue: 5 Pages: 638-644
  • DOI: 10.1007/s00380-013-0408-0
  • Peer Reviewed / Open Access
• [Journal Article] Chronic active Epstein-Barr virus infection complicated with multiple artery aneurysms (2014)
  • Author(s): Nishimura S, Ehara S, Hanatani A, Yoshiyama M
  • Journal Title: Eur Heart J Cardiovsc Imaging Volume: 15 Issue: 11 Pages: 1255-1255
  • DOI: 10.1093/ehjci/jeu119
  • Peer Reviewed
• [Journal Article] Insulin resistance is associated with coronary plaque vulnerability: insight from optical coherence tomography analysis (2014)
  • Author(s): Iguchi T, Hasegawa T, Otsuka K, Matsumoto K, Yamazaki T, Nishimura S, Nakata S, Ehara S, Kataoka T, Shimada K, Yoshiyama M
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 15 Issue: 3 Pages: 284-291
  • DOI: 10.1093/ehjci/jet158
  • Peer Reviewed
• [Journal Article] A case of a lesion containing an intracoronary thrombus detected as hyperintense plaque on T1-weighted cardiovascular magnetic resonance in a patient with silent myocardial ischemia (2013)
  • Author(s): Matsumoto K, Ehara S, Hasegawa T, Otsuka K, Yamazaki T, Iguchi T, Shimada K, Yoshiyama M
  • Journal Title: J Cardiovasc Magn Reson Volume: 15 Issue: 1 Pages: 50-50
  • DOI: 10.1186/1532-429x-15-50
  • Peer Reviewed
• [Journal Article] Effects of intravenous atrial natriuretic peptide and nitroglycerin on coronary vasdilation and flow velocity determined using 3 T magnetic resonance imaging in patients with nonischemic heart failure (2013)
  • Author(s): Shoichi Ehara, Yasuhiro Nakamura, Kenji Matsumoto, Takao Hasegawa, Kenei Shimada, Masahiko Takagi, Akihisa Hanatani, Yasukatsu Izumi, Masahiro Terashima, Minoru Yoshiyama
  • Journal Title: Heart Vessels Volume: 28 Issue: 5 Pages: 596-605
  • DOI: 10.1007/s00380-012-0292-z
  • Peer Reviewed
• [Journal Article] Impact of lesion length on functional significance in intermediate coronary lesions (2013)
  • Author(s): Iguchi T, Hasegawa T, Nishimura S, Nakata S, Kataoka T, Ehara S, Hanatani A, Shimada, K, Yoshiyama M
  • Journal Title: Clin Cardiol Volume: 36 Issue: 3 Pages: 172-177
  • DOI: 10.1002/clc.22076
  • Peer Reviewed
• [Journal Article] Typical coronary appearance of dilated cardiomyopathy versus left ventricular concentric hypertrophy: coronary volumes measured by multislice computed tomography (2013)
  • Author(s): Shoichi Ehara, Kenji Matsumoto, Nobuyuki Shirai, Koki Nakanishi, Kenichiro Otsuka, Tomokazu Iguchi, Takao Hasegawa, Shinji Nakata, Junichi Yoshikawa, Minoru Yoshiyama
  • Journal Title: Heart Vessels Volume: 28 Issue: 2 Pages: 188-198
  • DOI: 10.1007/s00380-011-0230-5
  • Peer Reviewed
• [Journal Article] Prognostic value of aortic valve area index in asymptomatic patients with severe aortic stenosis (2012)
  • Author(s): Toshio Saito, Takashi Muro, Hisateru Takeda, Eiichi Hyodo, Shoichi Ehara, Yasuhiro Nakamura, Akihisa Hanatani, Kenei Shimada, Minoru Yoshiyama
  • Journal Title: Am J Cardiol Volume: 110 Issue: 1 Pages: 93-97
  • DOI: 10.1016/j.amjcard.2012.02.056
  • Peer Reviewed
• [Journal Article] Detailed observation of arterial healing after stent implantation in swine arteries by using optical coherence tomography (2012)
  • Author(s): Satoshi Nishimura, Toru Kataoka, Takao Hasegawa, Yoshiki Kobayashi, Koichiro Asawa, Shinji Nakata, Shoichi Ehara, Akihisa Hanatani, Kenei Shimada, Takashi Muro, Minoru Yoshiyama
  • Journal Title: Osaka City Med J Volume: 58 Pages: 1-11
  • NAID: 110009418504
  • Peer Reviewed
• [Journal Article] Hyperintense plaque identified by magnetic resonance imaging relates to intracoronary thrombus as detected by optical coherence tomography in patients with angina pectoris (2012)
  • Author(s): Shoichi Ehara, Takao Hasegawa, Shinji Nakata, Kenji Matsumoto, Satoshi Nishimura, Tomokazu Iguchi, Toru Kataoka, Junichi Yoshikawa, Minoru Yoshiyama
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 13 Issue: 5 Pages: 394-399
  • DOI: 10.1093/ehjci/jer305
  • Peer Reviewed
• [Journal Article] Hyperintense plaque identified by magnetic resonance imaging relates to intracoroanry thrombus as detected by optical coherence tomography in patients with angina pectoris (2012)
  • Author(s): Ehara S, Hasegawa T, Nakata S, Matsumoto K, Nishimura S, Iguchi T, Kataoka T, Yosikawa J, Yoshiyama M
  • Journal Title: Eur Heart J Cardiovasc Imaging Volume: 13 Pages: 394-399
  • Peer Reviewed
• [Presentation] 非造影T1強調 black blood MR imagingにおける冠動脈高信号にせまる (2014)
  • Author(s): 江原省一、松本健嗣、長谷川隆生、島田健永、葭山稔
  • Organizer: 第62回日本心臓病学会
  • Place of Presentation: 仙台国際センター （宮城県、仙台市）
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] 冠動脈完全閉塞病変においてWhole Heart Coronary T1強調Black Blood MRIで描出される閉塞区間体部の高信号の有無は閉塞期間と相関する (2014)
  • Author(s): 松本健嗣、江原省一、長谷川隆生、坂口海雲、稲波整、大塚憲一郎、山崎貴紀、島田健永、葭山稔
  • Organizer: 第62回日本心臓病学会
  • Place of Presentation: 仙台国際センター （宮城県、仙台市）
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Localization of Coronary Hyperintense Plaques Identified by Noncontrast T1-weighted MRI: Correlate to Plaque Morphology and Clinical Severity of Angina Pectoris (2014)
  • Author(s): Matsumoto K, Ehara S, Hasegawa T, Sakaguchi M, Inanami H, Otsuka K, Yamazaki T, Iguchi T, Shimada K, Yoshiyama M
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京 (東京国際フォーラム)
• [Presentation] マルチスライスCTを用いた全冠動脈枝における石灰化の分布に関する検討 (2013)
  • Author(s): 江原省一、松本健嗣、長谷川隆生、井口朋和、山崎貴紀、大塚憲一郎、稲波整、坂口海雲、島田健永、葭山稔
  • Organizer: 第61回日本心臓病学会
  • Place of Presentation: 熊本 (ホテル日航熊本)
• [Presentation] Whole Heart Coronary T1-weighted Black Blood MRIで描出される冠動脈プラーク高信号の局在に関する検討：OCT所見との比較検討 (2013)
  • Author(s): 松本健嗣、江原省一、長谷川隆生、坂口海雲、稲波整、大塚憲一郎、山崎貴紀、井口朋和、島田健永、葭山稔
  • Organizer: 第61回日本心臓病学会
  • Place of Presentation: 熊本 (ホテル日航熊本)
• [Presentation] Intraluminal and Intrawall Hyperintense Plaques Identified by Noncontrast T1-weighted Magnetic Resonance Imaging Showed Different Vulnerable Plaque Morphology Assessed by Optical Coherence Tomography (2013)
  • Author(s): Matsumoto K, Ehara S, Hasegawa T, Sakaguchi M, Inanami H, Otsuka K, Yamazaki T, Iguchi T, Shimada K, Yoshiyama M
  • Organizer: American Heart Association
  • Place of Presentation: Dallas, USA
• [Presentation] Prediction of filter no-reflow phenomenon during stent implantation in patients with angina pectoris by using magnetic resonance imaging and optical coherence tomography (2013)
  • Author(s): Kenji Matsumoto, Shoichi Ehara, Kenichirou Otsuka, Takao Hasegawa, Tomokazu Iguchi, Masahiko Takagi, Akihisa Hanatani, Kenei Shimada, Minoru Yoshiyama
  • Organizer: 第77回日本循環器病学会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Whole Heart Coronary T1-weighted Black Blood MRIを用いた冠動脈不安定プラーク描出の試み (2012)
  • Author(s): 江原省一、長谷川隆生、中田真司、松本健嗣、井口朋和、大塚憲一郎、島田建永、葭山稔
  • Organizer: 第60回日本心臓病学会
  • Place of Presentation: 石川県金沢市
• [Presentation] Hyperintense Plaque Detected by Magnetic Resonance T1-weighted Imaging Relates to Intracoronary Thrombus Visualized by Optical Coherence tomography in Patients With Angina Pectoris (2012)
  • Author(s): Kenji Matsumoto, Shoichi Ehara, Takao Hasegawa, Kenichiro Otsuka, Tomokazu Iguchi, Kenei Shimada, Minoru Yoshiyama
  • Organizer: American Heart Association
  • Place of Presentation: Los Angeles, USA