| Project/Area Number |
23591065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHINA Akira 東京医科大学, 医学部, 教授 (60317831)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 高血圧 / 中心血圧 / cystatinC / シスタチンＣ / arterial stiffness / central bloood pressure / renal function |
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| Research Abstract |
We examined the following; 1. Whether the estimated glomerular filtration rate calculated from the serum cystatin C (eGFRcys) and the second peak of the radial pressure waveform (SP2) might be independent predictors of the development of hypertension, without any interaction; 2. whether the SP2 may be directly associated with the development of hypertension without the mediation of renal functional decline. In 1229 middle-aged normotensive Japanese men with preserved renal function, the SP2 and eGFRcys were measured in 3 years interval. Hypertension was detected at the end of the 3-year study period in 127 men. The SP2 and eGFRcys had significant independent odds ratios for the presence of hypertension at the end of the 3-year study period, without any interaction. The SP2 measured at the baseline was not related to the renal function assessed at the end of the 3-year study period. Thus, eGFRcys and SP2 might be independent predictors of the development of hypertension.
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