| Project/Area Number |
23591066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHODA Toru 東京慈恵会医科大学, 医学科, 助教 (80266634)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | Lp(a)コレステロール / 動脈硬化 / バイオマーカー / MMP-2 / 血管内皮膚細胞 / フラミンガムリスクスコア / non HDLコレステロール / 血管内皮細胞 / ＭＭＰ－２ / マクロファージ |
|---|
| Research Abstract |
HPLC lipoprotein analysis showed that in 212 male subjects without cardiovascular disease Lp(a)-C did not correlate with LDL-C while Lp(a)-C correlated positively with IDL-C, VLDL-C, chylomicron-C, but inversely correlated with HDL-C. Framingham Risk Score for atherosclerosis significantly provided a positive correlation to non-HDL-C but a modest correlation to Lp(a)-C. In the basic experiments to establish the study for Lp(a) effects on secretion of MMP-2, a destabilizing factor of atherosclerosis, from vascular endothelial cells, angiotensin 2 (Ang2) enhanced MMP-2, and the Ang2 receptor blocker cancelled that, and thereby it was found that Ang2 could enhance MMP-2 through Ang2 receptors. Although Lp(a) also may have certain potential to enhance MMP-2, its reproducibility and its mechanisms should be revealed. Therefore, Lp(a)-C and MMP-2 may be expected to play a role in biomarkers of cardiovascular disease.
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