A study of the effect that deoxyribonucrease I induces apotosis in cardiac diseases

• Project/Area Number: 23591067
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kanazawa Medical University
• Principal Investigator: KAWAI Yasuyuki 金沢医科大学, 医学部, 准教授 (40324157)
• Co-Investigator(Renkei-kenkyūsha): YASUDA Toshihiro 福井大学, 医学部, 教授 (80175645)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
• Keywords: 酸化ストレス / 冠れん縮 / 一過性心筋虚血 / ニトロチロシン / デオキシリボ核酸分解酵素I / 冠れん縮性狭心症 / DNase I / アポトーシス / 心筋症 / 心筋梗塞 / リモデリング / 心不全

Research Abstract

We could not find out that deoxyribonuclease I induce apoptosis in cardiac diseases. Then, we evaluated whether nitrotyrosin (NT), a marker of oxidative stress, would elevate after vasospasm induced achtylcholine provocation test in patinets with vasospastic angina pectoris (VSAP). The serum NT levels significantly increased after coronary vasospasm induced by the test, suggensting that serum NT could be a biomarker of transient myocardial ischemia and could contribute to the development of VSAP.

Research Products

• [Journal Article] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm (2014)
  • Author(s): Tanabe K, Kawai Y, Kitayama M, Akao H, Ishida R, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Watanabe M, Tsuchiya T, Kimura H, Yoshida K, Kajinami K
  • Journal Title: Journal of Cardiology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm. (2014)
  • Author(s): Tanabe K, Kawai Y, Kitayama M, Akao H, Ishida R, Motoyama A, Wakasa M, Saito R, Aoki H, Fujibayashi K, Watanabe M, Tsuchiya T, Kimura H, Yoshida K, Kajinami K.
  • Journal Title: Journal of Cardiology Volume: 印刷中 Issue: 2 Pages: 86-90
  • DOI: 10.1016/j.jjcc.2013.11.017
  • Peer Reviewed
• [Presentation] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm (2013)
  • Author(s): Tanabe K. Kawai Y. Kitayama M, Akao H, Ishida R, Motoyama A, Watanabe M, Kojima K, Kajinami K.
  • Organizer: The 73^<rd> annual scientific meeting of the Japanese Circulation Society
  • Place of Presentation: Yokohama
  • Year and Date: 2013-03-15
• [Presentation] Increased levels of the oxidative stress marker, nitrotyrosine in patients with provocation test-induced coronary vasospasm (2013)
  • Author(s): Tanabe K
  • Organizer: The 78th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: パシフィコ横浜（横浜市）