| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Cardiac resynchronization therapy (CRT) has been shown to improve clinical function of heart failure. However, clinical trials show that up to 30% of patients receiving CRT may not benefit from this therapy. Body-surface QRS integral mapping has been shown to be a useful noninvasive method to assess the ventricular depolarization. In this study, we evaluated whether QRS integral mapping is useful to identify patients who may benefit from CRT.
Body-surface QRS integral mapping was obtained after CRT from twenty five patients.11 patients had normal dipolar map pattern whereas 14 patients had an abnormal dipolar map pattern. No patient of normal dipolar map pattern developed HF. Five patients of 14 patients who had an abnormal dipolar map pattern were hospitalized for worsening HF. Thus, abnormal dipolar map pattern was associated with a higher incidence of worsening HF after CRT(p<0.05).Body-surface QRS integral mapping may be a useful diagnostic tool to identify response to CRT.
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