| Project/Area Number |
23591080
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
HIRASHIKI Akihiro 名古屋大学, 医学系研究科, 寄附講座助教 (10418741)
CHENG Xianwu 名古屋大学, 医学系研究科, 特任准教授 (30378228)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子心臓病理学 / 糖尿病性心筋症 / 心不全 / バイオマーカー / 糖尿病 / セリンプロテアーゼ / 慢性心不全 / インクレチン |
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| Research Abstract |
Heart failure caused by diabetes has been designated as diabetic cardiomyopathy and the underlying pathophysiology remains uncertain. Our group has focused and clarified the molecular mechanisms underlying diabetic cardiomyopathy both in preclinical and clinical settings and has found the primary role of incretin, particularily glucagon-like peptide (GLP-1), and its proteolytic regulator dipeptidyl peptidase-4 (DPP4) in pathogenesis of microvasculopathy and mitochondrial remodeling observed in diabetic cardiomyopathy. Moreover, we have recently obtained important clues implicating the potent role of incretine-insulin axis in diagnosis, thepeutic intervention, and prevention of heart failure. We thus aimed to establish the comprehensive system for managing heart failure via modulating incretine-insulin axis to reduce mortality and ameliorate quality of life.
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