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Parity check by gap junctions maintains normal cardiac conduction in sinoatrial node

Research Project

Project/Area Number 23591091
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Women's Medical University

Principal Investigator

NISHII Akiko  東京女子医科大学, 医学部, 助教 (80408608)

Co-Investigator(Renkei-kenkyūsha) NISHII Kiyomasa  防衛医科大学校, 医学部, 助教 (20264020)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsギャップジャンクション / コネキシン45 / 洞結節 / パリティ保証機構 / ノックアウトマウス / 伝導障害 / コネキシン / 刺激伝導系 / パリティ保障機構
Research Abstract

Gap junctions (GJ) are intercellular pathway consisted of protein called connexins (Cx). Cx45 is distributed in whole heart in early embryonic stage and it is restricted in cardiac conduction system in the adult heart. We proposed that parity check by Cx45 is important to maintain normal cardiac conduction. To verify this hypothesis, we built region and time specific Cx45 knockout mice. Both in embryonic and adult heart, Cx45 knockout showed abnormal cardiac conduction. The data are in agreement with the hypothesis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Cardiac connexins, mutations and arrhythmias2012

    • Author(s)
      Delmar M, Makita N
    • Journal Title

      Curr Opin Cardiol

      Volume: (in press) Issue: 1 Pages: 163-172

    • DOI

      10.1161/circep.111.967604

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure2011

    • Author(s)
      Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, Seki A, Murasaki KM, Shimizu T, Okano T, Hagiwara N, Komuro I
    • Journal Title

      PLoS One

      Volume: 6 Issue: 12 Pages: e27901-e27901

    • DOI

      10.1371/journal.pone.0027901

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 網膜電気シナプスはカルシウム依存転写因子NFATの活性化に必要である2014

    • Author(s)
      西井清雅、関明子、David L. Paul、萩原誠久、小林靖
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(下野)(3/27-29)
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Cx knock-outと不整脈. Role of connexins on cardiac arrhythmia(シンポジウム:心筋ギャップ結合機能調節機構とその病態,招待)2014

    • Author(s)
      関明子、西井清雅、柴田洋三郎、小林靖、萩原誠久
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学(鹿児島)(3/16-18)
    • Year and Date
      2014-03-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of connexins on cardiac arrhythmia2014

    • Author(s)
      関 明子、西井 清雅、柴田 洋三郎、小林 靖、萩原 誠久
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学(鹿児島)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 網膜電気シナプスはカルシウム依存転写因子NFATの活性化に必要である2014

    • Author(s)
      西井 清雅、関 明子、David L. Paul、萩原 誠久、小林 靖
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(下野)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Connexin45 conducts essential myocardial functions during heart development2013

    • Author(s)
      西井清雅、関明子、熊井まどか、森本幸生、三輪岳志、萩原誠久、柴田洋三郎、小林靖
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      大阪大学(神戸)(12/3-6)
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Connexin45 conducts essential myocardial functions during heart development.2013

    • Author(s)
      西井 清雅、関 明子、熊井 まどか、森本 幸生、三輪 岳志、萩原 誠久、柴田 洋三郎、小林 靖
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      大阪大学(神戸)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inhibition of Activin A is the Novel Therapeutic Target for Heart Failure.2011

    • Author(s)
      Fukushima N、Matsuura K、Akazawa H、Honda A、Nagai T、Takahashi M、 Seki A、Murasaki K、Shimizu T、Okano M、Hagiwara N、 Komuro I.
    • Organizer
      Scientific sessions 2011. American Heart Association
    • Place of Presentation
      Orland, Florida, USA
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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