Development of new comprehensive heart failure treatment that takes into account the underlying disease and the stage of the heart failure

• Project/Area Number: 23591093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ASANUMA HIROSHI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (20416217)
• Co-Investigator(Kenkyū-buntansha): ASAKURA Masanori 独立行政法人国立循環器病研究センター, 臨床研究企画室, 室長 (80443505) ; KITAKAZE Masafumi 独立行政法人国立循環器病研究センター, 臨床研究部, 部長 (20294069) ; HIRAIDE Atsushi 近畿大学, 医学部, 教授 (20199037)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 心不全 / トランスレーショナルリサーチ / 循環器内科学 / 分子心臓病態学 / 循環器・高血圧

Research Abstract

We examined whether AMPK activation can modulate cardiac remodeling and inhibit the progression of heart failure in the canine myocardial infarction model and pacing induced decompensated heart failure, which is considered to be similar to human dilated cardiomyopathy and can be superimposed on translational study for human heart failure. Neither blood pressure nor heart rate differed between the groups with and without AICAR (AMPK activator) at 6 weeks after the onset of myocardial infarction or pacing-induced heart failure. Left ventricular ejection fraction increased, and mean pulmonary arterial pressure and pulmonary capillary wedge pressure decreased in the AICAR treated group compared with the untreated group. These effects were observed in both models, even after the onset of heart failure. Thus, we conclude that AMPK activation is an important novel therapeutic target in chronic heart failure.

Research Products

• [Journal Article] Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation (2014)
  • Author(s): Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Takafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y, Takashima S
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 111(1) Pages: 273-278
  • Peer Reviewed
• [Journal Article] Dipeptidyl -Peptidase IV Inhibition Improves Pathophysiology of Heart Failure and Increases Survival Rate in Pressure -Overloaded Mice (2013)
  • Author(s): Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 304(10)
  • Peer Reviewed
• [Journal Article] Liposomal Amiodarone Augments Anti-arrhythmic Effects and Reduces Hemodynamic Adverse Effects in an Ischemia/Reperfusion Rat Model (2013)
  • Author(s): Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T
  • Journal Title: Cardiovasc Drugs Ther. Volume: 27(2) Pages: 125-132
  • Peer Reviewed
• [Journal Article] Derivation of a mathematical expression for predicting the time to cardiac events in patients with heart failure : a retrospective clinical study (2013)
  • Author(s): Yoshida A, Asakura M, Asanuma H, Ishii A, Hasegawa T, Minamino T, Takashima S, Kanzaki H, Washio T, Kitakaze M
  • Journal Title: Hypertens Res. Volume: 36(5) Pages: 450-456
  • Peer Reviewed
• [Journal Article] わが国の循環器臨床試験から学ぶJ-WIND試験から学ぶEvidence & Pitfall (2013)
  • Author(s): 北風政史、金智隆、浅沼博司、朝倉正紀
  • Journal Title: 医学のあゆみ Volume: 244(13) Pages: 1311-1316
• [Journal Article] カルシウム拮抗薬 (2013)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: The Lipid(メディカルレビュー社) Volume: 24(2) Pages: 43-50
• [Journal Article] アデノシンと臓器障害 (2013)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: メディカルレビュー社(メディカルレビュー社) Volume: 17(2) Pages: 55-60
• [Journal Article] Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation (2013)
  • Author(s): Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
  • Journal Title: PNAS Volume: 111 Issue: 1 Pages: 273-278
  • DOI: 10.1073/pnas.1318547111
  • Peer Reviewed / Open Access
• [Journal Article] Dipeptidyl-peptidase IV inhibition improves pathophysiology of heart failure and increases survival rate in pressure-overloaded mice. (2013)
  • Author(s): Takahashi A, Asakura M, Ito S, Min KD, Shindo K, Yan Y, Liao Y, Yamazaki S, Sanada S, Asano Y, Ishibashi-Ueda H, Takashima S, Minamino T, Asanuma H, Mochizuki N, Kitakaze M
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 304(10) Issue: 10 Pages: H1361-H1369
  • DOI: 10.1152/ajpheart.00454.2012
  • Peer Reviewed
• [Journal Article] Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model. (2013)
  • Author(s): Takahama H, Shigematsu H, Asai T, Matsuzaki T, Sanada S, Fu HY, Okuda K, Yamato M, Asanuma H, Asano Y, Asakura M, Oku N, Komuro I, Kitakaze M, Minamino T.
  • Journal Title: Cardiovasc Drugs Ther. Volume: 27 Issue: 2 Pages: 125-132
  • DOI: 10.1007/s10557-012-6437-6
  • Peer Reviewed
• [Journal Article] Derivation of a mathematical expression for predicting the time to cardiac events in patients with heart failure: a retrospective clinical study. (2013)
  • Author(s): Yoshida A, Asakura M, Asanuma H, Ishii A, Hasegawa T, Minamino T, Takashima S, Kanzaki H, Washio T, Kitakaze M.
  • Journal Title: Hypertens Res. Volume: 36 Issue: 5 Pages: 450-456
  • DOI: 10.1038/hr.2012.200
  • Peer Reviewed
• [Journal Article] J-WIND試験から学ぶ (2013)
  • Author(s): 北風政史、金智隆、浅沼博司、朝倉正紀
  • Journal Title: 医学のあゆみ Volume: 244 Pages: 1311-1316
• [Journal Article] カルシウム拮抗薬 (2013)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: The Lipid Volume: 24 Pages: 43-50
• [Journal Article] Serum Blood Urea Nitrogen and Plasma Brain Natriuretic Peptide and Low Diastolic Blood Pressure Predict Cardiovascular Morbidity and Mortality Following Discharge in Acute Decompensated Heart Failure Patients (2012)
  • Author(s): Chen CY, Yoshida A, Asakura M, Hasegawa T, Takahama H, Amaki M, Funada A, Asanuma H, Yokoyama H, Kim J, Kanzaki H, Kitakaze M
  • Journal Title: Circ J. Volume: 76(10) Pages: 2372-2379
  • NAID: 10030874757
  • Peer Reviewed
• [Journal Article] H(2) Mediates Cardioprotection Via Involvements of K(ATP) Channels and Permeability Transition Pores of Mitochondria in Dogs (2012)
  • Author(s): Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M
  • Journal Title: Cardiovasc Drugs Ther. Volume: 26(3) Pages: 217-226
  • Peer Reviewed
• [Journal Article] Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan : the importance of the plasma adiponectin levels (2012)
  • Author(s): Chen CY, Asakura M, Asanuma H, Hasegawa T, Tanaka J, Toh N, Min KD, Kanzaki H, Takahama H, Amaki M, Itoh Y, Ichien G, Okumoto Y, Funahashi T, Kim J, Kitakaze M
  • Journal Title: Hypertens Res. Volume: 35(8) Pages: 843-848
  • Peer Reviewed
• [Journal Article] 近畿大学医学部付属病院救急診療部(ER)における低血糖症例の特徴 (2012)
  • Author(s): 松田外志朗、栗原敏修、浅沼博司、中江晴彦、冨吉浩雅、森田正則、嶋津岳士、平出敦
  • Journal Title: 近畿大学医学雑誌 Volume: 37 Pages: 71-79
  • Peer Reviewed
• [Journal Article] 耐糖能異常は心不全と連関するか? (2012)
  • Author(s): 浅沼博司、朝倉正紀、金智隆、北風政史
  • Journal Title: 日本冠疾患学会雑誌 Volume: 18(3) Pages: 245-251
  • NAID: 130001928893
• [Journal Article] 疫学研究・大規模臨床試験より得られたEBM PROactive、最新臨床糖尿病学上―糖尿病学の最新動向― (2012)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: 日本臨床(日本臨床社) Volume: 70(増刊3) Pages: 301-308
• [Journal Article] 心血管リスク症例における海外での報告特集:メトホルミンの現況と新たな展開 (2012)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: Diabetes Frontier(メディカルレビュー社) Volume: 23(1) Pages: 53-58
• [Journal Article] Cardioprotective effects of low-dose combination therapy with a statin and an angiotensin receptor blocker in a rat myocardial infarction model (2012)
  • Author(s): Sohma R, Inoue T, Abe S, Taguchi I, Kikuchi M, Toyoda S, Arikawa T, Hikichi Y, Sanada S, Asanuma H, Kitakaze M, Node K
  • Journal Title: J Cardiol. Volume: 59(1) Pages: 91-96
  • Peer Reviewed
• [Journal Article] H(2) mediates cardioprotection via involvements of K(ATP) channels and permeability transition pores of mitochondria in dogs (2012)
  • Author(s): Yoshida A, Asanuma H, Sasaki H, Sanada S, Yamazaki S, Asano Y, Shinozaki Y, Mori H, Shimouchi A, Sano M, Asakura M, Minamino T, Takashima S, Sugimachi M, Mochizuki N, Kitakaze M.
  • Journal Title: Cardiovasc Drugs Ther. Volume: 26 Issue: 3 Pages: 217-226
  • DOI: 10.1007/s10557-012-6381-5
  • Peer Reviewed
• [Journal Article] Serum blood urea nitrogen and plasma brain natriuretic Peptide and low diastolic blood pressure predict cardiovascular morbidity and mortality following discharge in acute decompensated heart failure patients. (2012)
  • Author(s): Chen CY, Yoshida A, Asakura M, Hasegawa T, Takahama H, Amaki M, Funada A, Asanuma H, Yokoyama H, Kim J, Kanzaki H, Kitakaze M.
  • Journal Title: Circ J. Volume: 76 Pages: 2372-2379
  • NAID: 10030874757
  • Peer Reviewed
• [Journal Article] Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels. (2012)
  • Author(s): Chen CY, Asakura M, Asanuma H, Hasegawa T, Tanaka J, Toh N, Min KD, Kanzaki H, Takahama H, Amaki M, Itoh Y, Ichien G, Okumoto Y, Funahashi T, Kim J, Kitakaze M.
  • Journal Title: Hypertens Res. Volume: 35 Issue: 8 Pages: 843-848
  • DOI: 10.1038/hr.2012.42
  • Peer Reviewed
• [Journal Article] 耐糖能異常は心不全と連関するか？ (2012)
  • Author(s): 浅沼博司、朝倉正紀、金智隆、北風政史
  • Journal Title: 日本冠疾患学会雑誌 Volume: 18 Pages: 245-251
  • NAID: 130001928893
  • Peer Reviewed
• [Journal Article] PROactive (2012)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: 日本臨床 Volume: 70 Pages: 301-308
• [Journal Article] メトホルミンの現況と新たな展開 (2012)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: Diabetes Frontier Volume: 23 Pages: 53-58
• [Journal Article] Cardioprotective effects of low-dose combination therapy with a statin and an angiotensin receptor blocker in a rat myocardial infarction model. (2012)
  • Author(s): Sohma R, Inoue T, Abe S, Taguchi I, Kikuchi M, Toyoda S, Arikawa T, Hikichi Y, Sanada S, Asanuma H, Kitakaze M, Node K.
  • Journal Title: J Cardiol. Volume: 59 Pages: 91-96
  • Peer Reviewed
• [Journal Article] Does the treatment of both hypertension and cardiac hypertrophy not only prevent but also treat acute myocardial infarction? (2011)
  • Author(s): Asanuma H, Kitakaze M
  • Journal Title: Circ J. Volume: 75(5) Pages: 1061-1062
  • NAID: 10028147243
  • Peer Reviewed
• [Journal Article] The largest cohort study opens a new era for the management of heart failure in Japan (2011)
  • Author(s): Asanuma H, Kitakaze M
  • Journal Title: Circ J. Volume: 75(4) Pages: 775-776
  • NAID: 10028102835
  • Peer Reviewed
• [Journal Article] 虚血性心筋症の分類と特徴、冠動脈疾患(下)-診断と治療の進歩- (2011)
  • Author(s): 浅沼博司、北風政史
  • Journal Title: 日本臨床(日本臨床社) Volume: 69 Pages: 352-357
• [Journal Article] 冠循環と心機能、冠動脈疾患(上)-診断と治療の進歩- (2011)
  • Author(s): 朝倉正紀、浅沼博司、北風政史
  • Journal Title: 日本臨床(日本臨床社) Volume: 69 Pages: 69-73
• [Journal Article] Does the treatment of both hypertension and cardiac hypertrophy not only prevent but also treat acute myocardial infarction? (2011)
  • Author(s): Asanuma H, Kitakaze M.
  • Journal Title: Circ J. Volume: 75 Pages: 1061-1062
  • NAID: 10028147243
  • Peer Reviewed
• [Journal Article] The largest cohort study opens a new era for the management of heart failure in Japan. (2011)
  • Author(s): Asanuma H, Kitakaze M.
  • Journal Title: Circ J. Volume: 75 Pages: 775-776
  • NAID: 10028102835
  • Peer Reviewed
• [Presentation] The E3 Ligase Asb2 Regulates Cardiac Development Through Targeting Smad9 for Proteasomal Degradation. (2014)
  • Author(s): Min KD, Asakura M, Ito S, Shirai M, Nakano A, Tsukamoto O, Inoue H, Yamazaki S, Asanuma H, Takashima S, Minamino T, Mochizuki N, Schneider M, Kitakaze M.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Does the Treatment of Impaired Glucose Tolerance Provide Cardiovascular Benefits in patients with Previous Myocardial Infarction. (2014)
  • Author(s): Kitakaze M, Asakura M, Asanuma H, J-Wind Investigators.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Exploratory Reserch on Potential Diagnostic as Well as Therapeutic Targets for Heart Failure Using Omics Data Analysis . (2014)
  • Author(s): Asakura M, Asanuma H, Ito S, Min KD, Seguchi O, Takahashi A, Nishigori M, Shindoh K, Imazu M, Nakatani T, Tomonaga T, Minamino N, Kitakaze M.
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Serum Fibroblast Growth Factor 23 as a Surrogate Marker in Patients with Heart Failure. (2013)
  • Author(s): 高濱博幸, 今津美樹, 浅沼博司, 舟田晃, 菅野康夫, 大原貴裕, 長谷川拓也, 朝倉正紀, 神崎秀明,安斉俊久, 北風政史
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Presentation] 次世代シーケンサーを用いた新規心不全関連遺伝子の探索 (2013)
  • Author(s): 進藤一紘, 朝倉正紀, 閔庚徳, 伊藤慎, 高橋彩子, 今津美樹, 浅沼博司, 北風政史
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Presentation] BNPは冠動脈疾患発症リスクの代用マーカーとなりうるか (2013)
  • Author(s): 長谷川拓也, 朝倉正紀, 江口和男, 浅沼博司, 天木誠, 高濱博幸, 舟田晃, 菅野康夫, 大原貴裕, 神崎秀明, 橋村一彦, 友池仁遙暢, 金智隆, 安斉俊久, 北風政史
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Presentation] Concept and Consideration for the Clinical Assessment that an Alpha-GI Blocks Cardiac Events in Patients with MI and IGT (ABC Study) (2012)
  • Author(s): Asanuma H, Asakura M, Kim J, Kitakaze M and the ABC Study Investigators.
  • Organizer: The 33rd Annual Meeting of The Japanese Society of Clinical Pharmacology and Therapeutics
  • Place of Presentation: 沖縄
  • Invited
• [Presentation] Novel synthesized radical-containing nanoparticles augment cardioprotection after ischemia-reperfusion injury via nitric oxide in canine hearts. (2012)
  • Author(s): Yoshida A, Sanada S, Asanuma H, Sasaki H, Takahama H, Asakura M, Yoshitomi T, Nagasaki Y, Kitakaze M.
  • Organizer: European Society of Cardiology Congress 2012
  • Place of Presentation: ドイツ・ミュンヘン
• [Presentation] Alteration of gene expression profiling of the murine intestine suffering from heart failure. (2012)
  • Author(s): Takahashi A, Asakura M, Min K, Ito S, Shindo K, Yan Y, Liu H, Asanuma H, Mochizuki N, Kitakaze M.
  • Organizer: European Society of Cardiology Congress 2012
  • Place of Presentation: ドイツ・ミュンヘン
• [Presentation] Inhaled hydrogen gas therapy reduced infarct size via mitochondrial KATP channels and mitochondrial permeability transition pore in a dog model of myocardial ischemia reperfusion injury. (2011)
  • Author(s): Yoshida A, Asanuma H, Sanada S, Yamazaki S, Takashima S, Minamino T, Asakura M, Mochizuki N, Kitakaze M.
  • Organizer: European Society of Cardiology Congress 2011
  • Place of Presentation: フランス・パリ
• [Presentation] Heterogeneity of global gene expression profiles between endocardial and epicardial normal myocardium diminishes in canine failing hearts. (2011)
  • Author(s): Min KD, Asakura M, Asanuma H, Ito S, Takahashi A, Sasaki H, Takahama H, Yamazaki S, Mochizuki N, Kitakaze M.
  • Organizer: European Society of Cardiology Congress 2011
  • Place of Presentation: フランス・パリ
• [Presentation] A novel approach using exon array technique identifies Mtus1 as a new heart failure-related gene. (2011)
  • Author(s): Ito S, Asakura M, Min KD, Takahashi A, Yamazaki S, Asanuma H, Mochizuki N, Takashima S, Kitakaze M.
  • Organizer: European Society of Cardiology Congress 2011
  • Place of Presentation: フランス・パリ
• [Presentation] The E3 Ligase Asb2 Regulates Cardiac Development Through Targeting Smad9 for Proteasomal Degradation
  • Author(s): Min KD, Asakura M, Ito S, Shirai M, Nakano A, Tsukamoto O, Inoue H, Yamazaki S, Asanuma H, Takashima S, Minamino T, Mochizuki N, Schneider M, Kitakaze M
  • Organizer: 第78回日本循環器学会学術集会2014
• [Presentation] Does the Treatment of Impaired Glucose Tolerance Provide Cardiovascular Benefits in patients with Previous Myocardial Infarction
  • Author(s): Kitakaze M, Asakura M, Asanuma H, J-Wind Investigators
  • Organizer: 第78回日本循環器学会学術集会2014
• [Presentation] Exploratory Reserch on Potential Diagnostic as Well as Therapeutic Targets for Heart Failure Using Omics Data Analysis
  • Author(s): Asakura M, Asanuma H, Ito S, Min KD, Seguchi O, Takahashi A, Nishigori M, Shindoh K, Imazu M, Nakatani T, Tomonaga T, Minamino N, Kitakaze M
  • Organizer: 第78回日本循環器学会学術集会2014
• [Presentation] Serum Fibroblast Growth Factor 23 as a Surrogate Marker in Patients with Heart Failure
  • Author(s): 高濱博幸,今津美樹,浅沼博司,舟田晃,菅野康夫,大原貴裕,長谷川拓也,朝倉正紀,神崎秀明,安斉俊久,北風政史
  • Organizer: 第61回日本心臓病学会学術集会2013
• [Presentation] 次世代シーケンサーを用いた新規心不全関連遺伝子の探索
  • Author(s): 進藤一紘,朝倉正紀,閔庚徳,伊藤慎,高橋彩子,今津美樹,浅沼博司,北風政史
  • Organizer: 第61回日本心臓病学会学術集会2013
• [Presentation] BNPは冠動脈疾患発症リスクの代用マーカーとなりうるか
  • Author(s): 長谷川拓也,朝倉正紀,江口和男,浅沼博司,天木誠,高濱博幸,舟田晃,菅野康夫,大原貴裕,神崎秀明,橋村一彦,友池仁遙暢,金智隆,安斉俊久,北風政史
  • Organizer: 第61回日本心臓病学会学術集会2013
• [Presentation] Concept and Consideration for the Clinical Assessment that an Alpha-GI Blocks Cardiac Events in Patients with MI and IGT (ABC Study)
  • Author(s): Asanuma H, Asakura M, Kim J, Kitakaze M and the ABC Study Investigators
  • Organizer: 第33回日本臨床薬理学会学術総会2012
• [Presentation] Novel synthesized radical-containing nanoparticles augment cardioprotection after ischemia-reperfusion injury via nitric oxide in canine hearts
  • Author(s): Yoshida A, Sanada S, Asanuma H, Sasaki H, Takahama H, Asakura M, Yoshitomi T, Nagasaki Y, Kitakaze M
  • Organizer: 欧州心臓病学会学術集会2012
• [Presentation] Alteration of gene expression profiling of the murine intestine suffering from heart failure
  • Author(s): Takahashi A, Asakura M, Min K, Ito S, Shindo K, Yan Y, Liu H, Asanuma H, Mochizuki N, Kitakaze M
  • Organizer: 欧州心臓病学会学術集会2012
• [Presentation] Inhaled hydrogen gas therapy reduced infarct size via mitochondrial KATP channels and mitochondrial permeability transition pore in a dog model of myocardial ischemia reperfusion injury
  • Author(s): Yoshida A, Asanuma H, Sanada S, Yamazaki S, Takashima S, Minamino T, Asakura M, Mochizuki N, Kitakaze M
  • Organizer: 欧州心臓病学会学術集会2011
• [Presentation] Heterogeneity of global gene expression profiles between endocardial and epicardial normal myocardium diminishes in canine failing hearts
  • Author(s): Min KD, Asakura M, Asanuma H, Ito S, Takahashi A, Sasaki H, Takahama H, Yamazaki S, Mochizuki N, Kitakaze M
  • Organizer: 欧州心臓病学会学術集会2011
• [Presentation] A novel approach using exon array technique identifies Mtus1 as a new heart failure-related gene
  • Author(s): Ito S, Asakura M, Min KD, Takahashi A, Yamazaki S, Asanuma H, Mochizuki N, Takashima S, Kitakaze M
  • Organizer: 欧州心臓病学会学術集会2011
• [Book] 冠血流調節と心筋虚血、内科学第10版 (2013)
  • Author(s): 浅沼博司、北風政史
  • Publisher: 朝倉書店
• [Book] 心原性ショック、経静脈治療オーダーマニュアル (2013)
  • Author(s): 浅沼博司、平出敦
  • Publisher: メディカルレビュー社
• [Book] 心不全、経静脈治療オーダーマニュアル (2013)
  • Author(s): 浅沼博司、北風政史
  • Publisher: メディカルレビュー社
• [Book] カルディオバージョン、今日の治療指針 (2013)
  • Author(s): 浅沼博司
  • Total Pages: 83
  • Publisher: 医学書院
• [Book] 内科学第10版 (2013)
  • Author(s): 浅沼博司、北風政史
  • Total Pages: 2548
  • Publisher: 朝倉書店
• [Book] 今日の治療指針 (2013)
  • Author(s): 浅沼博司
  • Total Pages: 2064
  • Publisher: 医学書院
• [Book] 心不全に伴う低ナトリウム血症の補正は必要ですか。またどのように行うべきですか?、心不全診療Q&Aエキスパート106人からの回答 (2012)
  • Author(s): 浅沼博司、北風政史
  • Publisher: 中外医学社
• [Book] 抗アルドステロン薬の有用性を教えてください。スピロノラクトンとエプレレノンの使い分けはありますか?、心不全診療Q&Aエキスパート106人からの回答 (2012)
  • Author(s): 浅沼博司、北風政史
  • Publisher: 中外医学社
• [Book] 貧血の治療法と目標ヘモグロビン値について教えてください。ネスプの使い方についても教えてください。、心不全診療Q&Aエキスパート106人からの回答 (2012)
  • Author(s): 浅沼博司、北風政史
  • Publisher: 中外医学社
• [Book] 急性心不全患者におけるアデノシンA1受容体拮抗薬rolofyllineの効果は?、2012-2013 EBM循環器疾患の治療 (2012)
  • Author(s): 浅沼博司、北風政史
  • Publisher: 中外医学社
• [Book] 経静脈治療オーダーマニュアル (2012)
  • Author(s): 浅沼博司、平出敦
  • Total Pages: 764
  • Publisher: メディカルレビュー社
• [Book] 経静脈治療オーダーマニュアル (2012)
  • Author(s): 浅沼博司、北風政史
  • Total Pages: 764
  • Publisher: メディカルレビュー社
• [Book] 2012-2013 EBM循環器疾患の治療 (2012)
  • Author(s): 浅沼博司、北風政史
  • Total Pages: 424
  • Publisher: 中外医学社
• [Book] 冠動脈疾患(下)-診断と治療の進歩- (2011)
  • Author(s): 浅沼博司, 北風政史.
  • Total Pages: 627
  • Publisher: 日本臨床社
• [Book] 冠動脈疾患(上)-診断と治療の進歩- (2011)
  • Author(s): 朝倉正紀, 浅沼博司, 北風政史.
  • Total Pages: 670
  • Publisher: 日本臨床社