Improvement of therapeutic methods for cardiomyopathy/heart failure based on the functional analysis of stretch-activated ion channel
Project/Area Number |
23591095
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
IWATA Yuko 独立行政法人国立循環器病研究センター, 研究所, 室長 (80171908)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 心筋症 / 拡張型心筋症 |
Research Abstract |
Dilated cardiomyopathy (DCM) is a severe disorder defined by ventricular dilation and cardiac dysfunction. A subset of familial DCM is caused by mutations of the genes encoding cytoskeleton. Here, we show that transient receptor potential vanilloid 2 (TRPV2) is highly concentrated in the ventricular sarcolemma of patients with idiopathic DCM and animal models of cardiomyopathy. We found some tools to inhibit the surface expression of and Ca2+ influx via TRPV2. In the animal models, blockade of TRPV2 ameliorated cardiac dysfunction, and prevented DCM progression; Therefore, we propose that sarcolemmal accumulation or activation of TRPV2 initiated by membrane instability resulting from cytoskeleton abnormalities contributes to cardiac dysfunction in DCM, and TRPV2 may be a promising therapeutic target for advanced heart failure.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy.2013
Author(s)
Maekawa K, Hirayama A, Iwata Y, Tajima Y, Nishimaki-Mogami T, Sugawara S, Ueno N, Abe H, Ishikawa M, Murayama M, Matsuzawa Y, Nakanishi H, Ikeda K, Arita M, Taguchi R, Minamino N, Wakabayashi S, Soga T, Saito Y.
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Journal Title
J Mol Cell Cardiol
Volume: 59
Pages: 76-85
DOI
Related Report
Peer Reviewed
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[Presentation] Lipidomic analysis of heart tissues from a hamster model for dilated cardiomyopathy2013
Author(s)
Maekawa K, Iwata Y, Tajima Y, Ueno N, Nishimaki-Mogam T, Ishikawa M, Murayama M, Nakanishi H, Ikeda K, Arita M, Taguchi R, Minamino N, Wakabayashi S, Saito Y
Organizer
9^<th> Annual Conference of the Metabolomics Society
Place of Presentation
SECC Glasgow/Scotland
Related Report
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[Presentation] Lipidomic analysis of heart tissues from a hamster model for dilated cardiomyopathy.2013
Author(s)
Maekawa, K., Iwata, Y., Tajima, Y., Ueno, N., Nishimaki-Mogami, T., Ishikawa, M., Murayama, M., Nakanishi, H., Ikeda, K., Arita, M., Taguchi, R., Minamino, N., Wakabayashi, S. Saito, Y.
Organizer
9th Annual Conference of the Metabolomics Society
Place of Presentation
SECC Glasgow/Scotland
Related Report
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[Presentation] A metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy using capillary electrophoresis-mass spectrometry.2013
Author(s)
Hirayama, A., Sugawara, S., Abe, H., Iwata, Y., Maekawa, K., Tomita, M., Minamino, N., Saito, Y., Wakabayashi, S., Soga, T.
Organizer
9th Annual Conference of the Metabolomics Society
Place of Presentation
SECC Glasgow/Scotland
Related Report
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[Presentation] Lipidomic analysis of heart tissues in a hamster model for dilated cardiomyopathy2012
Author(s)
Maekawa K, Tajima Y, Ueno N, Ishikawa M, Murayama M, Nishimaki-Mogami T, Nakanishi H, Ikeda K, Arita M, Taguchi R, Iwata Y, Minamino N, Wakabayashi S, Saito Y
Organizer
53^<rd> International Conference on the Bioscience of Lipids
Place of Presentation
Banff, Canada
Related Report
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