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Role of natural killer T cells in chronic inflammation of atherogenesis

Research Project

Project/Area Number 23591096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionHokkaido University

Principal Investigator

ISHIMORI Naoki  北海道大学, 大学病院, 准教授 (70399848)

Co-Investigator(Kenkyū-buntansha) TSUTSUI Hiroyuki  北海道大学, 大学院医学研究科, 教授 (70264017)
KINUGAWA Shintaro  北海道大学, 大学院医学研究科, 講師 (60399871)
Research Collaborator TOKUHARA Satoshi  北見赤十字病院, 循環器内科, 副部長
SAITO Akimichi  北海道大学, 大学病院, 医員 (40735502)
NISHIKAWA Mikito  帯広協会病院, 循環器内科, 医長
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords慢性炎症 / 動脈硬化 / マクロファージ / リンパ球 / 免疫調節 / ナチュラルキラーT細胞 / 免疫応答 / 脂質異常症 / ナチュラルキラーT細胞
Outline of Final Research Achievements

The purpose of this study was to elucidate the role of natural killer T (NKT) cells in chronic inflammation elicited by dyslipidemia, which result in atherosclerosis. Splenocytes from apolipoprotein-E deficient mice, including mononuclear phagocytes and NKT cells, were cultured with α-Galactosylceramide (α-GalCer), which specifically activates NKT cells, and significantly reduced in the production of inflammatory cytokines compared to those from wild-type mice, suggesting NKT cell anergy. Splenocytes cultured with Th1 or Th2 cytokines were stimulated with α-GalCer, but did not differ in the production of inflammatory cytokines between apolipoprotein-E deficient mice and wild-type mice. Thus, we could not elucidate the significant role of NKT cells in chronic inflammation in the present study.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2012 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (15 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress.2015

    • Author(s)
      Nishikawa M, Ishimori N, Takada S, Saito A, Kadoguchi T, Furihata T, Fukushima A, Matsushima S, Yokota T, Kinugawa S, Tsutsui H
    • Journal Title

      Nephrol Dial Transplant.

      Volume: in press Issue: 6 Pages: 182-188

    • DOI

      10.1093/ndt/gfv103

    • NAID

      120005743055

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type II NKT cells stimulate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance2012

    • Author(s)
      Satoh, M., Andoh, Y., Clingan, S. C., Ogura, H., Fujii, S., Nakayama, T., Taniguchi, M., Hirata, N., Ishimori, N., Tsutsui, H., Onoe, K. Iwabuchi, K
    • Journal Title

      PLoS ONE

      Volume: 7(2) Issue: 2 Pages: 1-12

    • DOI

      10.1371/journal.pone.0030568

    • NAID

      120004043739

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Circulating invariant natural killer T cells are decreased in patients with chronic heart failure.2014

    • Author(s)
      Saito A, Ishimori N, Nishikawa M, Kinugawa S, Tsutsui H
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      McCormick Place (シカゴ・アメリカ)
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] AST-120 ameliorates lowered exercise capacity and mitochondrial dysfunction of the skeletal muscle in mice with chronic kidney disease via reducing oxidative stress.2014

    • Author(s)
      Nishikawa M, Ishimori N, Takada S, Saito A, Kadoguchi T, Furihata T, Fukushima A, Matsushima S, Yokota T, Kinugawa S, Tsutsui H
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      McCormick Place (シカゴ・アメリカ)
    • Year and Date
      2014-11-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Activation of invariant natural killer T cells ameliorates the development of angiotensin II-mediated abdominal aortic aneurysm formation in obese ob/ob mice.2014

    • Author(s)
      Saito A, Ishimori N, Tokuhara S, Nishikawa M, Tsutsui H
    • Organizer
      European Society of Cardiology Congress 2014
    • Place of Presentation
      Fira Gran Via (バルセロナ・スペイン)
    • Year and Date
      2014-09-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Activation of invariant natural killer T Cells ameliorates the development of angiotensin II-mediated abdominal aortic aneurysm formation in ob/ob mice.2014

    • Author(s)
      Saito A, Ishimori N, Tokuhara S, Nishikawa M, Tsutsui H
    • Organizer
      The 18th International Vascular Biology Meeting
    • Place of Presentation
      京都市勧業館みやこめっせ(京都市)
    • Year and Date
      2014-04-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] Natural killer T (NKT) cells are involved in the development of metabolic disorders and atherosclerosis.2011

    • Author(s)
      Ishimori N, Tokuhara S, Nozawa A, Saito A, Tsutsui H
    • Organizer
      The 43rd Annual Scientific Meeting of the Japan Atherosclerosis Society
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T cells are involved in aortic valvular calcification in uremic apolipoprotein-E deficient mice.2011

    • Author(s)
      Nozawa A, Ishimori N, Ohmura Y, Tokuhara S, Horii S, Saito A, Tsutsui H
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T cells are differentially involved in the development of experimental aortic aneurysm in mice according to their subtypes.2011

    • Author(s)
      Tokuhara S, Ishimori N, Nozawa A, Saito A, Tsutsui H
    • Organizer
      The 75th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T cells are involved in atherosclerotic plaque instability in apolipoprotein-E knockout mice.2011

    • Author(s)
      Ishimori N, Ohmura Y, Horii S, Tokuhara S, Nozawa A, Saito A, Tsutsui H
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Parc des Expositions de Paris Nord Villepinte(France)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T Cells are involved in aortic valvular calcification in uremic apolipoprotein-E deficient mice.2011

    • Author(s)
      Nozawa A, Ishimori N, Ohmura Y, Tokuhara S, Saito A, Tsutsui H
    • Organizer
      European Society of Cardiology Congress
    • Place of Presentation
      Parc des Expositions de Paris Nord Villepinte(France)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T cells are involved in aortic valvular calcification via inhibiting osteoclastic differentiation in uremic apolipoprotein-E deficient mice.2011

    • Author(s)
      Ishimori N, Nozawa A, Tokuhara S, Saito A, Iwabuchi K, Tsutsui H
    • Organizer
      The 6th International Symposium on CD1 and NKT Cells
    • Place of Presentation
      University of Chicago Gleacher Center(America)
    • Related Report
      2011 Research-status Report
  • [Presentation] Type II NKT cells operate diet-induced obesity by mediating adipose tissue inflammation, steatohepatitis and insulin resistance.2011

    • Author(s)
      Satoh M, Andoh Y, Clingan CS, Ogura H, Fujii S, Nakayama T, Taniguchi M, Ishimori N, Tsutsui H, Kaer LV, Onoé K, Iwabuchi K
    • Organizer
      The 6th International Symposium on CD1 and NKT Cells
    • Place of Presentation
      University of Chicago Gleacher Center(America)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T cells are involved in the development of experimental aortic aneurysm and dissection in apolipoprotein-E deficient mice.2011

    • Author(s)
      Tokuhara S, Ishimori N, Nozawa A, Saito A, Tsutsui H
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orange County Convention Centre(America)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T cells are involved in aortic valvular calcification via inhibiting osteoclastic differentiation in uremic apolipoprotein-E deficient mice.2011

    • Author(s)
      Nozawa A, Ishimori N, Tokuhara S, Saito A, Tsutsui H
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Orange County Convention Centre(America)
    • Related Report
      2011 Research-status Report
  • [Presentation] Type II NKT cells operate diet-induced obesity by mediating adipose tissue inflammation and steatohepatitis.2011

    • Author(s)
      Satoh M, Eshima K, Nakayama T, Taniguchi M, Ishimori N, Iwabuchi K
    • Organizer
      The 40th Annual Scientific Meeting of the Japanese Society for Immunology
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer T (NKT) cells are involved in the development of metabolic disorders and atherosclerotic diseases.2011

    • Author(s)
      Ishimori N, Tokuhara S, Nozawa A, Saito A, Tsutsui H
    • Organizer
      The 28th Annual Meeting of the International Society for Heart Research Japanese Section
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 樹状細胞を含有する医薬およびその製造方法2015

    • Inventor(s)
      筒井裕之・石森直樹・絹川真太郎・斎藤晶理
    • Industrial Property Rights Holder
      筒井裕之・石森直樹・絹川真太郎・斎藤晶理
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-02-26
    • Related Report
      2014 Annual Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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