Angiogenic mechanism spatio-temporally controlled by Id-Notch signal crosstalk and their therapeutic application
| Project/Area Number |
23591099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NISHIYAMA Koichi 東京大学, 医学(系)研究科(研究院), 助教 (80398221)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 発生・分化 / 血管新生 / ライブイメージング / 転写因子 / 多細胞運動 / モデル化 |
|---|
| Research Abstract |
This study aimed to examine whether or not or how a signal crosstalk between HLH transcriptional factor Id and Notch contributes to the spatio-temporal control of endothelial cell behaviors during angiogenesis. A 4D analysis using an in vitro angiogenesis model suggested that the crosstalk possibly related to the dynamic regulation of moving speed and direction in individual endothelial cells. However, "cell sorting" phenomenon did not seem to explain the regulatory mechanism. Furthermore, we constructed a mathematical model for endothelial cell dynamics driving VEGF-induced vessel elongation, which enables us to further dissect the mechanisms systemically.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Endothelin regulates neural crest deployment and fate to form great vessels through D1x5/D1x6-independent mechanisms.2013
Author(s)
Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, Kurihara H.
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Journal Title
Mechanism of Development
Volume: 130
Issue: 11-12
Pages: 553-566
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Resistin-Like Molecule β Is Abundantly Expressed in Foam Cells and Is Involved in Atherosclerosis Development.2013
Author(s)
Kushiyama A, Sakoda H, Oue N, Okubo M, Nakatsu Y, Ono H, Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T.
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 33
Issue: 8
Pages: 1986-1993
DOI
Related Report
Peer Reviewed / Open Access
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