Elucidation of roles of proteinase-activated receptor in pulmonary hypertension and development of new therapeutic strategies
| Project/Area Number |
23591104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
HIRANO Katsuya 九州大学, 医学(系)研究科(研究院), 准教授 (80291516)
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Mayumi 九州大学, 大学院医学研究院, 助教 (80336031)
ABE Kohtaro 九州大学, 大学院医学研究院, 助教 (20588107)
ODA Yoshinao 九州大学, 大学院医学研究院, 教授 (70291515)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肺高血圧 / 血管内皮細胞 / 血管平滑筋細胞 / トロンビン / 受容体 / モデル動物 / 受容体拮抗薬 / 肺高血圧症 |
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| Research Abstract |
The present study yielded a new mechanism for endothelial barrier dysfunction. By using an animal model of pulmonary hypertension, a thrombin receptor antagonist was found to effectively prevent the development of pulmonary hypertension and prolonged the survival. The contractile responsiveness of pulmonary artery was found to be enhanced in pulmonary hypretension. As a result, thrombin receptor antagonist is suggested to be potentially useful as a new strategy for treatment of pulmonary hypertension. Proposals of Japanese and international patent for the invention of new treatment for pulmonary hypertension has been submitted.
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Report
(4 results)
Research Products
(50 results)
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[Presentation] A novel endothelin receptor antagonist, macitentan markedly improved severe pulmonary arterial hypertension in rats by a nearly complete blockade of endothelin receptors2013
Author(s)
Kunita M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K
Organizer
American Heart Association Scientific Session
Place of Presentation
Dallas, TX, USA(Circulation 128: A11237, 2013)
Year and Date
2013-11-17
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