Development of the molecular imaging and the therapy of the unstable plaque targeting activated macrophages
| Project/Area Number |
23591105
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
MIYATA MASAAKI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (00347113)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUYAMA Takami 鹿児島大学, 医歯学総合研究科, 教授 (30145479)
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| Co-Investigator(Renkei-kenkyūsha) |
FURUSHO Yuko 鹿児島大学, 医歯学総合研究科, 助教 (00632514)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 動脈硬化 / 葉酸レセプターβ / マクロファージ / 活性化マクロファージ / 分子イメージング |
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| Research Abstract |
The folic acid receptor beta (FR-beta) attracts attention as a marker of activated macrophages. We found that the activated macrophage which expressed FR-beta was present in the arteriosclerosis lesion of the arteriosclerosis model mouse. We administrated the recombinant immunotoxin which coupled Pseudomonas aeruginosa toxin to anti-FR-beta monoclonal antibody into the arteriosclerosis model mice, selectively killed the activated macrophages, and demonstrated that it reduced arteriosclerotic lesion.
In addition, we established a sandwich ELISA assay using anti-FR-beta monoclonal antibody and measured the soluble FR-beta concentration of human serum. The patients with aortic aneurysms showed a higher serum FR-beta level compared with the normal control. The measurement of the soluble FR-beta concentration is suggested to be useful for the diagnosis of atherosclerosis.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.2013
Author(s)
Yoshino S, Yoshikawa A, Hamasaki S, Ishida S, Oketani N, Saihara K, Okui H, Kuwahata S, Fujita S, Ichiki H, Ueya N, Iriki Y, Maenosono R, Miyata M, Tei C
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Journal Title
Int J Cardiol.
Volume: 168
Issue: 2
Pages: 1280-1285
DOI
Related Report
Peer Reviewed
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[Journal Article] The incidence of asymptomatic cerebral microthromboembolism after atrial fibrillation ablation: comparison of warfarin and dabigatran.2013
Author(s)
Ichiki H, Oketani N, Ishida S, Iriki Y, Okui H, Maenosono R, Namino F, Ninomiya Y, Miyata M, Hamasaki S, Tei C.
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Journal Title
Pacing Clin Electrophysiol
Volume: 36
Issue: 11
Pages: 1328-1335
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel therapy for atherosclerosis using recombinant immunotoxin against folate receptor β-expressing macrophages2012
Author(s)
Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
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Journal Title
Journal of American Heart Association
Volume: 1
Issue: 4
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of valsartan on fibrinolysis in hypertensive patients with metabolic syndrome: the KACT-MetS Study2012
Author(s)
Miyata M, Ikeda Y, Nakamura S, Sasaki T, Abe S, Minagoe S, Torii H, Lee S, Tateishi S, Kihara K, Ohba I, Kajiya S, Furusho Y, Hamasaki S, Tei C, et al
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Journal Title
Circulation Journal
Volume: 76
Pages: 843-851
NAID
Related Report
Peer Reviewed
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