Elucidation of role of fatty acid-binding protein in vascular endothelial function and blood pressure control

• Project/Area Number: 23591106
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: FURUHASHI Masato 札幌医科大学, 医学部, 助教 (20563852)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 脂肪酸結合タンパク / 血管内皮 / 血圧 / 高血圧

Research Abstract

Fatty acid-binding protein 4 is expressed in both adipcoytes and macrophages and plays an important role in many aspects of metabolic syndrome. Here we investigated the role of secreted form and ectopic expression of FABP4 on blood pressure regulation. Serum FABP4 level was significantly higher in essential hypertensives than in normotensives. Serum FABP4 level was positively and independently correlated with blood pressure and insulin resistance. Angiotensin II receptor blockers significantly decreased FABP4 level in hypertensives. FABP4-deficient mice protected from blood pressure elevation. Expression of FABP4 was related to increased inflammatory markers. Further understanding of role of FABP4 on blood pressure and endothelial function will enable the development of new therapeutic strategies for hypertension.

Research Products

• [Journal Article] Small molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. (2014)
  • Author(s): Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS.
  • Journal Title: Diabetes Volume: 63 Issue: 2 Pages: 526-534
  • DOI: 10.2337/db13-1019
  • Peer Reviewed
• [Journal Article] Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension. (2014)
  • Author(s): Koyama M, Furuhashi M, Ishimura S, Fuseya T, Mita T, Okazaki Y, Yoshida H, Tsuchihashi K, Miura T.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: -
  • Peer Reviewed
• [Journal Article] Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker (2014)
  • Author(s): Furuhashi M, Moniwa N, Mita T, Fuseya T, Ishimura S, Ohno K, Shibata S, Tanaka M, Watanabe Y, Akasaka H, Ohnishi H, Yoshida H, Takizawa H, Saitoh S, Ura N, Shimamoto K, Miura T.
  • Journal Title: Am J Hypertens Volume: -
  • Peer Reviewed
• [Journal Article] Emerging issues in radiogenic cataracts and cardiovascular disease. (2014)
  • Author(s): Hamada N, Fujimichi Y, Iwasaki T, Fujii N, Furuhashi M, Kubo E, Minamino T, Nomura T, Sato H.
  • Journal Title: J Radiat Res Volume: -
  • Peer Reviewed
• [Journal Article] 脂肪酸結合タンパク4とインスリン抵抗性. (2014)
  • Author(s): 古橋眞人
  • Journal Title: Diabetes Frontier Volume: 25 Pages: 83-91
• [Journal Article] Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population. (2013)
  • Author(s): Ishimura S, Furuhashi M, Watanabe Y, Hoshina K, Fuseya T, MIta T, Okazaki Y, Koyama M, Tanaka M, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T.
  • Journal Title: PLoS ONE Volume: 8 Issue: 11 Pages: e81318-e81318
  • DOI: 10.1371/journal.pone.0081318
  • Peer Reviewed
• [Journal Article] Adipocyte lipid chaperone aP2 is a secreted adipokine regulating hepatic glucose production. (2013)
  • Author(s): Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS.
  • Journal Title: Cell Metab Volume: 17 Issue: 5 Pages: 768-778
  • DOI: 10.1016/j.cmet.2013.04.012
  • Peer Reviewed
• [Journal Article] 脂肪酸結合タンパクファミリー (2013)
  • Author(s): 古橋眞人
  • Journal Title: 肥満研究 Volume: 19 Pages: 167-174
• [Journal Article] メタボリックシンドロームにおける新規バイオマーカーとしての脂肪酸結合タンパクの可能性 (2013)
  • Author(s): 古橋眞人
  • Journal Title: Ther Res Volume: 34 Pages: 958-962
• [Journal Article] 心血管・代謝疾患における脂質シャペロンおよび小胞体ストレス応答の解明と治療への応用 (2013)
  • Author(s): 古橋眞人
  • Journal Title: 医科学応用研究財団研究報告書 Volume: 30 Pages: 194-197
  • NAID: 40020578285
• [Journal Article] メタボリックシンドロームにおける新規バイオマーカーとしての脂肪酸結合タンパクの可能性. (2013)
  • Author(s): 古橋眞人
  • Journal Title: Ther Res Volume: 34 Pages: 958-962
• [Journal Article] Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation. (2012)
  • Author(s): Ota H, Furuhashi M, Ishimura S, Koyama M, Okazaki Y, Mita T, Fuseya T, Yamashita T, Tanaka M, Yoshida H, Shimamoto K, Miura T.
  • Journal Title: Am J Hypertens Volume: 25 Issue: 10 Pages: 1124-1130
  • DOI: 10.1038/ajh.2012.88
  • Peer Reviewed
• [Journal Article] Histopathology of the pancreas in fulminant type 1 diabetes after 23-year follow-up : a case report (2012)
  • Author(s): Sato T, Miki T, Murakami N, Hirohashi Y, Kouzu H, Furuhashi M, Tanno M, Yuda T, Saitoh S, Hasegawa T, Miura T
  • Journal Title: Pathology International Volume: 62 Issue: 12 Pages: 827-29
  • DOI: 10.1111/pin.12017
  • Peer Reviewed
• [Journal Article] 代謝および心血管疾患における炎症と小胞体ストレス応答の解明 (2012)
  • Author(s): 古橋眞人
  • Journal Title: 上原記念生命科学財団研究報告書 Volume: 25 Pages: 146-146
• [Journal Article] 心血管・代謝疾患における脂質シャペロンと小胞体ストレス応答の解明 (2012)
  • Author(s): 古橋眞人
  • Journal Title: 持田記念財団年報 Volume: H23 Pages: 245-247
• [Journal Article] 腹部肥満とメタボリックシンドローム発症予防に関する新規分子マーカーを用いた地域住民縦断研究 (端野・壮瞥町研究) (2012)
  • Author(s): 島本和明, 古橋眞人, 赤坂 憲, 石村周太郎, 大西浩文, 斉藤重幸
  • Journal Title: 代謝異常治療研究基金研究業績集 Volume: 38 Pages: 7-16
• [Journal Article] 小胞体ストレスと心血管炎症 (2012)
  • Author(s): 古橋眞人
  • Journal Title: 生体の科学 Volume: 63 Pages: 386-387
• [Journal Article] Angiotensin II receptor activation in youth triggers persistent insulin resistance and hypertension - a legacy effect? (2012)
  • Author(s): Togashi N, Maeda T, Yoshida H, Koyama M, Tanaka M, Furuhashi M, Shimamoto K, Miura T.
  • Journal Title: Hypertens Res Volume: 35 Issue: 3 Pages: 334-340
  • DOI: 10.1038/hr.2011.206
  • NAID: 10030644565
  • Peer Reviewed
• [Journal Article] Lipid chaperones in metabolic inflammation (2011)
  • Author(s): Furuhashi M, et al.
  • Journal Title: Int J Inflam Volume: 2011 Pages: 642612-642612
  • DOI: 10.4061/2011/642612
  • Peer Reviewed
• [Journal Article] Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease (2011)
  • Author(s): Furuhashi M, et al.
  • Journal Title: PLoS ONE Volume: 6 Issue: 11 Pages: e27356-e27356
  • DOI: 10.1371/journal.pone.0027356
  • Peer Reviewed
• [Journal Article] 脂肪酸結合タンパクと小胞体ストレス応答 (2011)
  • Author(s): 古橋眞人
  • Journal Title: Annual Review糖尿病・代謝・内分泌 Pages: 91-97
• [Journal Article] 慢性炎症における脂質シャペロンとリポカイン (2011)
  • Author(s): 古橋眞人
  • Journal Title: 血管医学 Volume: 53 Pages: 51-58
• [Journal Article] マクロファージの脂肪酸結合タンパク (2011)
  • Author(s): 古橋眞人
  • Journal Title: The Lipid Volume: 22 Pages: 36-43
• [Journal Article] 脂肪酸結合タンパク(A-FABP) (2011)
  • Author(s): 古橋眞人
  • Journal Title: 臨床検査 Volume: 55 Pages: 593-598
• [Journal Article] 脂肪酸結合蛋白 (2011)
  • Author(s): 古橋眞人
  • Journal Title: 医学のあゆみ Volume: 239 Pages: 305-306
• [Journal Article] 脂肪酸結合タンパクとメタボリックシンドローム・動脈硬化 (2011)
  • Author(s): 古橋眞人, 他
  • Journal Title: Angiology Frontier Volume: 10 Pages: 287-295
• [Journal Article] Deterioration of renal function by chronic heart failure is associated with congestion and oxidative stress in the tubulointerstitium. (2011)
  • Author(s): Tanaka M, Yoshida H, Furuhashi M, Togashi N, Koyama M, Yamamoto S, Yamashita T, Okazaki Y, Ishimura S, Ota H, Hasegawa T, Miura T.
  • Journal Title: Internal Med Volume: 50 Pages: 2877-2887
  • NAID: 130002062709
  • Peer Reviewed
• [Journal Article] 脂肪酸結合タンパクと小胞体ストレス応答. (2011)
  • Author(s): 古橋眞人
  • Journal Title: Annual Review 糖尿病・代謝・内分泌 Volume: 2011 Pages: 91-97
• [Journal Article] 小胞体ストレスと慢性炎症性疾患. (2011)
  • Author(s): 古橋眞人
  • Journal Title: 医学のあゆみ Volume: 236 Pages: 249-254
• [Journal Article] 慢性炎症における脂質シャペロンとリポカイン. (2011)
  • Author(s): 古橋眞人
  • Journal Title: 血管医学 Volume: 53 Pages: 51-58
• [Journal Article] 治療抵抗性高血圧患者に対する腎交感神経アブレーションの効果. (2011)
  • Author(s): 古橋眞人, 太田英喜, 石村周太郎.
  • Journal Title: 臨床高血圧 Volume: 17 Pages: 46-47
• [Journal Article] マクロファージの脂肪酸結合タンパク. (2011)
  • Author(s): 古橋眞人
  • Journal Title: The Lipid Volume: 22 Pages: 36-43
• [Journal Article] 脂肪酸結合タンパク (A-FABP). (2011)
  • Author(s): 古橋眞人
  • Journal Title: 臨床検査 Volume: 55 Pages: 593-598
• [Journal Article] 動脈硬化と小胞体ストレス. (2011)
  • Author(s): 古橋眞人, 石村周太郎, 太田英喜.
  • Journal Title: Bio Clinica Volume: 26 Pages: 33-37
• [Journal Article] 小胞体ストレスによる慢性炎症と心血管病. (2011)
  • Author(s): 古橋眞人, 石村周太郎, 小山雅之.
  • Journal Title: 呼吸と循環 Volume: 59 Pages: 865-871
• [Journal Article] 脂肪酸結合蛋白. (2011)
  • Author(s): 古橋眞人
  • Journal Title: 医学のあゆみ Volume: 239 Pages: 305-306
• [Journal Article] 脂肪酸結合タンパクとメタボリックシンドローム・動脈硬化. (2011)
  • Author(s): 古橋眞人, 美田知宏, 伏屋敬博.
  • Journal Title: Angiology Frontier Volume: 10 Pages: 287-295
• [Journal Article] 脂肪酸結合タンパクaP2と糖尿病・動脈硬化. (2011)
  • Author(s): 12.古橋眞人, 岡崎雄介, 美田知宏.
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 33 Pages: 565-572
• [Presentation] Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population (2014)
  • Author(s): Ishimura S, Furuhashi M, et al.
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京
  • Year and Date: 2014-03-23
• [Presentation] Elevation of Fatty Acid-Binding Protein 4 May Contribute to Left Ventricular Hypertrophy and Diastolic Dysfunction in a General Population (2014)
  • Author(s): Mita T, Furuhashi M, et al.
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京
  • Year and Date: 2014-03-22
• [Presentation] 脂肪酸結合タンパク4の脂肪細胞からの分泌機構の検討 (2013)
  • Author(s): 石村周太郎,古橋眞人, 他
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京
  • Year and Date: 2013-11-11
• [Presentation] 日本高血圧学会学術賞受賞講演:高血圧関連疾患におけるアディポカインの役割解明に関する臨床研究 (2013)
  • Author(s): 古橋眞人
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-25
• [Presentation] 一般住民において血中脂肪酸結合タンパク4濃度の上昇は左室肥大ならびに拡張能障害と関連する (2013)
  • Author(s): 伏屋敬博,古橋眞人, 他
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-24
• [Presentation] Elevation of fatty acid-binding protein 4 is associated with left ventricular hypertrophy and diastolic dysfunction in a general population (2013)
  • Author(s): Mita T, Furuhashi M, et al.
  • Organizer: The 67th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2013-09-12
• [Presentation] 心血管・代謝疾患における脂肪酸結合タンパクの役割 (2013)
  • Author(s): 古橋眞人, 他
  • Organizer: 第31回内分泌代謝学サマーセミナー
  • Place of Presentation: 由布
  • Year and Date: 2013-07-12
• [Presentation] Mini Symposium : Lipid chaperones in metabolic syndrome and atherosclerosis (2013)
  • Author(s): Furuhashi M, Miura T
  • Organizer: The 30th Annual Meeting of the International Society of Heart Research Japanese Section
  • Place of Presentation: San Diego, U.S.A.
  • Year and Date: 2013-06-29
• [Presentation] 糸球体における異所性FABP4発現の意義 (2013)
  • Author(s): 岡崎雄介,田中希尚,古橋眞人、他
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-12
• [Presentation] Local production of fatty acid-binding protein 4 in perivascular fat and macrophage leads to coronary atherosclerosis. Keystone Symposia (2013)
  • Author(s): Furuhashi M, et al.
  • Organizer: Metabolic Control of Inflammation and Immunity
  • Place of Presentation: Breckenridge, CO, U.S.A.
  • Year and Date: 2013-01-22
• [Presentation] Symposium 5: Metabolic Syndrome and Obesity. Lipid Chaperones, Inflammation, and Metabolic Syndrome (2012)
  • Author(s): Furuhashi M, et al.
  • Organizer: 第20回日本血管生物医学会
  • Place of Presentation: 徳島
  • Year and Date: 2012-12-07
• [Presentation] メタボリックシンドロームにおける慢性炎症と脂肪酸結合タンパクの役割解明 (2012)
  • Author(s): 古橋眞人
  • Organizer: 第16回日本心血管内分泌代謝学会
  • Place of Presentation: 東京(高峰譲吉研究奨励賞)
  • Year and Date: 2012-11-23
• [Presentation] Elevation of Fatty Acid-Binding Protein 4 is Predisposed by Family History of Hypertension and Contributes to Blood Pressure Elevation (2012)
  • Author(s): Fuseya T, Furuhashi M, et al.
  • Organizer: American Heart Association
  • Place of Presentation: Los Angels, CA, U.S.A.
  • Year and Date: 2012-11-07
• [Presentation] Local Production of Fatty Acid-Binding Protein 4 Leads to Coronary Atherosclerosis (2012)
  • Author(s): Furuhashi M, et al.
  • Organizer: American Heart Association
  • Place of Presentation: Los Angels, CA, U.S.A.
  • Year and Date: 2012-11-06
• [Presentation] Elevation of Serum Fatty Acid-Binding Protein 4 Level in Young Normotensive Men with a Family History of Hypertension (2012)
  • Author(s): Mita T, Furuhashi M, et al.
  • Organizer: The 24th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-10-01
• [Presentation] Elevation of Plasma Fatty Acid-Binding Protein 4 Level Contributes to Blood Pressure Elevation and Insulin Resistance in Essential Hypertension (2012)
  • Author(s): Fuseya T, Furuhashi M, et al.
  • Organizer: The 24th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-10-01
• [Presentation] Serum FABP4 (A-FABP/aP2) and FABP5 (E-FABP/mal1) as Possible Biomarkers of Insulin Resistance and Coronary Atherosclerosis (2012)
  • Author(s): Okazaki Y, Furuhashi M, et al.
  • Organizer: The 24th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2012-10-01
• [Presentation] Symposium : Clinical Features and Treatment of Cardiovascular Disease with Diabetes Mellitus. Lipid chaperones in diabetes mellitus and cardiovascular disease (2012)
  • Author(s): Furuhashi M, et al.
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-17
• [Presentation] Local production of fatty acid-binding protein 4 leads to coronary atherosclerosis. Keystone Symposia (2012)
  • Author(s): Furuhashi M, et al.
  • Organizer: Genetic and Molecular Basis of Obesity and Body Weight Regulation
  • Place of Presentation: Santa Fe, NM, U.S.A.
  • Year and Date: 2012-01-30
• [Presentation] Local production of fatty acid-binding protein 4 leads to coronary atherosclerosis. (2012)
  • Author(s): Furuhashi M, Ishimura S, Ota H, Koyama M, Okazaki Y, Yamashita T, Tanaka M, Mita T, Fuseya T, Yoshida H, Miura T.
  • Organizer: Keystone Symposia. Genetic and Molecular Basis of Obesity and Body Weight Regulation.
  • Place of Presentation: Santa Fe, NM, U.S.A.
• [Presentation] Fatty acid-binding protein 4 is a novel predictor of cardiovascular events in end-stage renal disease (2011)
  • Author(s): Furuhashi M, et al.
  • Organizer: American Heart Association
  • Place of Presentation: Orlando, FL, U.S.A.
  • Year and Date: 2011-11-16
• [Presentation] Adipocyte fatty acid-binding protein (A-FABP/FABP4/aP2) as a possible prognostic predictor (2011)
  • Author(s): Furuhashi M, et al.
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-04
• [Presentation] ミートザエキスパート「慢性炎症と生活習慣病」Lipid chaperones, inflammation, and metabolic disease (2011)
  • Author(s): Furuhashi M, et al.
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-08-03
• [Presentation] シンポジウム18「糖尿病と動脈硬化- From bench to bedside」:糖尿病と動脈硬化における脂質シャペロンの役割 (2011)
  • Author(s): 古橋眞人, 他
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-21
• [Presentation] シンポジウム7「インスリン抵抗性のメカニズムと新しい治療戦略」:脂肪酸結合タンパクとインスリン抵抗性 (2011)
  • Author(s): 古橋眞人, 他
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-20
• [Presentation] シンポジウム3「代謝・循環ホットトピック」:慢性炎症と代謝疾患における脂肪酸結合タンパク (2011)
  • Author(s): 古橋眞人, 他
  • Organizer: 第44回日本心脈管作動物質学会
  • Place of Presentation: 第44回日本心脈管作動物質学会
  • Year and Date: 2011-02-04
• [Presentation] Reducing endoplasmic reticulum stress through a chemical chaperone 4-phenylbutyrate inhibits neointima formation. (2011)
  • Author(s): Ishimura S, Furuhashi M, Ota H, Yamashita T, Okazaki Y, Koyama M, Tanaka M, Togashi N, Hagiwara M, Yoshida H, Shimamoto K, Miura T.
  • Organizer: FASEB Summer Research Conference. From Unfolded Proteins in the Endoplasmic Reticulum to Disease.
  • Place of Presentation: Saxtons River, Vermont, U.S.A.
• [Presentation] Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy. (2011)
  • Author(s): Yamashita T, Fujimiya M, Yamamoto S, Koyama M, Okazaki Y, Ishimura S, Tanaka M, Furuhashi M, Yoshida H, Miura T.
  • Organizer: ASN Kidney Week.
  • Place of Presentation: Philadelphia, PA, U.S.A.
• [Presentation] Fatty acid-binding protein 4 is a novel predictor of cardiovascular events in end-stage renal disease. (2011)
  • Author(s): Furuhashi M, Hayashi M, Nishitani T, Ishimura S, Ota H, Koyama M, Okazaki Y, Tanaka M, Yoshida H, Miura T.
  • Organizer: American Heart Association.
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] Reduction of endoplasmic reticulum stress prevents neointima formation after vascular injury. (2011)
  • Author(s): Ishimura S, Furuhashi M, Ota H, Yamashita T, Koyama M, Okazaki Y, Tanaka M, Mita T, Fuseya T, Yoshida H, Miura T.
  • Organizer: American Heart Association.
  • Place of Presentation: Orlando, FL, U.S.A.
• [Presentation] 慢性炎症と代謝疾患における脂肪酸結合タンパク (2011)
  • Author(s): 古橋眞人、三浦哲嗣
  • Organizer: 第44回日本心脈管作動物質学会(招待講演)
  • Place of Presentation: 高松
• [Presentation] 血管内皮損傷後新生内膜形成に小胞体ストレスが関与する (2011)
  • Author(s): 石村周太郎、古橋眞人、太田英喜、吉田英昭、三浦哲嗣
  • Organizer: 第44回日本心脈管作動物質学会
  • Place of Presentation: 高松
• [Presentation] Lipid chaperones, inflammation, and metabolic diseases (2011)
  • Author(s): Furuhashi M, Miura T.
  • Organizer: 第75回日本循環器学会(招待講演)
  • Place of Presentation: 横浜
• [Presentation] Angiotensin (1-7) Prevents Insulin Resistance and Hypertension Triggered by Chronic Angiotensin II Infusion (2011)
  • Author(s): Togashi N, Yamashita T, Okazaki Y, Ohta H, Ishimura S, Furuhashi M, Yoshida H, Miura T.
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
• [Presentation] SACI testが診断および局在診断に有用であったインスリノーマの一例 (2011)
  • Author(s): 山本 諭、古橋眞人、田中希尚、小山雅之、山下智久、赤坂 憲、下重晋也、橋本暁佳、吉田英昭、三浦哲嗣、木村康利、今村将史、平田公一
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸
• [Presentation] 脂肪酸結合タンパクとインスリン抵抗性 (2011)
  • Author(s): 古橋眞人、三浦哲嗣
  • Organizer: 第54回日本糖尿病学会(招待講演)
  • Place of Presentation: 札幌
• [Presentation] 糖尿病と動脈硬化における脂質シャペロンの役割 (2011)
  • Author(s): 古橋眞人、三浦哲嗣
  • Organizer: 第54回日本糖尿病学会(招待講演)
  • Place of Presentation: 札幌
• [Presentation] 骨髄由来細胞は腎尿細管細胞と細胞融合をきたし糖尿病腎症を進展させる (2011)
  • Author(s): 山下智久、吉田英昭、山本 諭、小山雅之、石村周太郎、太田英喜、田中希尚、富樫信彦、萩原 誠、古橋眞人、藤宮峯子、三浦哲嗣
  • Organizer: 第54回日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] 心房細動を合併する血液透析患者の観察研究 (2011)
  • Author(s): 小山雅之、山下智久、吉田英昭、岡崎雄介、石村周太郎、太田英喜、田中希尚、富樫信彦、古橋眞人、伊藤洋輔、土橋和文、三浦哲嗣
  • Organizer: 第56回日本透析医学会
  • Place of Presentation: 横浜
• [Presentation] Reducing endoplasmic reticulum stress through a chemical chaperone 4-phenylbutyrate inhibits neointima formation (2011)
  • Author(s): Ishimura S, Furuhashi M, Ota H, Yamashita T, Okazaki Y, Koyama M, Tanaka M, Togashi N, Hagiwara M, Yoshida H, Shimamoto K, Miura T.
  • Organizer: 第43回日本動脈硬化学会
  • Place of Presentation: 札幌
• [Presentation] メタボリックマーカーとしての血中脂肪酸結合タンパク1, 3, 4の比較検討 (2011)
  • Author(s): 古橋眞人、太田英喜、石村周太郎、小山雅之、山下智久、岡崎雄介、美田知宏、伏屋敬博、田中希尚、吉田英昭、三浦哲嗣
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路
• [Presentation] Posttransplantation Thrombotic Microangiopathyの一例 (2011)
  • Author(s): 田中希尚、山下智久、岡崎雄介、小山雅之、古橋眞人、吉田英昭、三浦哲嗣、安井 寛、池田 博、林 敏昭、石田禎夫、千原伸也
  • Organizer: 第41回日本腎臓学会東部会
  • Place of Presentation: 東京
• [Presentation] 本態性高血圧症における血清脂肪酸結合タンパク4濃度とインスリン抵抗性 (2011)
  • Author(s): 太田英喜、古橋眞人、石村周太郎、小山雅之、田中希尚、山下智久、岡崎雄介、美田知宏、伏屋敬博、吉田英昭、三浦哲嗣
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
• [Presentation] 小胞体ストレス軽減により血管内皮傷害後の申請内膜増生を抑制する (2011)
  • Author(s): 石村周太郎、古橋眞人、太田英喜、小山雅之、田中希尚、山下智久、岡崎雄介、美田知宏、伏屋敬博、吉田英昭、三浦哲嗣
  • Organizer: 第34回日本高血圧学会
  • Place of Presentation: 宇都宮
• [Presentation] メタボリックマーカーとしての血中脂肪酸結合タンパクFABP4 (A-FABP/aP2)とFABP5 (E-FABP/mal1)の有用性に関する検討 (2011)
  • Author(s): 石村周太郎、古橋眞人、太田英喜、小山雅之、山下智久、岡崎雄介、美田知宏、伏屋敬博、田中希尚、吉田英昭、三浦哲嗣
  • Organizer: 第15回日本心血管内分泌代謝学会
  • Place of Presentation: 大阪
• [Presentation] Lipid Chaperones in Diabetes Mellitus and Cardiovascular Disease (2011)
  • Author(s): Furuhashi M, Miura T.
  • Organizer: 第76回日本循環器学会(招待講演)
  • Place of Presentation: 福岡
• [Presentation] Mini Symposium: Lipid chaperones in metabolic syndrome and atherosclerosis.
  • Author(s): Furuhashi M, Miura T.
  • Organizer: The 30th Annual Meeting of the International Society of Heart Research Japanese Section.
  • Place of Presentation: San Diego, U.S.A.
  • Invited
• [Presentation] Elevation of fatty acid-binding protein 4 is associated with left ventricular hypertrophy and diastolic dysfunction in a general population.
  • Author(s): Mita T, Furuhashi M, Yuda S, Muranaka A, Akasaka H, Ishimura S, Fuseya T, Yoshida H, Shigeyuki S, Miura T.
  • Organizer: The 67th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. 2013
  • Place of Presentation: New Orleans, U.S.A.
• [Presentation] Renin independent Ang-(1-12) Production in both the systemic and coronary circulation.
  • Author(s): Moniwa N, Varagic J, Nagata S, Ahmad S, Simington SW, VonCannon JL, Shimamura Y, Hasegawa K, Takizawa H, Ura N, Tanaka S, Furuhashi M, Yoshida H, Miura T, Ferrario CM.
  • Organizer: The 67th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. 2013
  • Place of Presentation: New Orleans, U.S.A.
• [Presentation] Endoplasmic reticulum stress in pulmonary artery smooth muscle cells contributes to the development of pulmonary hypertension induced by chronic hypoxia.
  • Author(s): Koyama M, Furuhashi M, Ishimura S, Mita T, Fuseya T, Ono K, Tanaka M, Yoshida H, Tsuchihashi K, Miura T.
  • Organizer: American Heart Association. 2013
  • Place of Presentation: Dallas, U.S.A.
• [Presentation] 糸球体における異所性FABP4発現の意義
  • Author(s): 岡崎雄介、田中希尚、古橋眞人、美田知宏、伏屋敬博、小山雅之、石村周太郎、吉田英昭、三浦哲嗣
  • Organizer: 第56回日本腎臓学会
  • Place of Presentation: 東京
• [Presentation] 小胞体ストレスセンサーPERKとインスリン抵抗性
  • Author(s): 古橋眞人、石村周太郎、三浦哲嗣、Gokhan S. Hotamisligil
  • Organizer: 第56回日本糖尿病学会
  • Place of Presentation: 熊本
• [Presentation] シンポジウム: 細胞ストレス応答の破綻と病態. 肥満および糖尿病における小胞体ストレス
  • Author(s): 古橋眞人、三浦哲嗣、Gokhan S. Hotamisligil
  • Organizer: 第102回日本病理学会
  • Place of Presentation: 札幌
• [Presentation] 心血管・代謝疾患における 脂肪酸結合タンパクの役割
  • Author(s): 古橋眞人、石村周太郎、三浦哲嗣
  • Organizer: 第31回内分泌代謝学サマーセミナー
  • Place of Presentation: 由布
  • Invited
• [Presentation] メサンギウム増殖性糸球体腎炎における糸球体脂肪酸結合タンパク4発現の意義
  • Author(s): 田中希尚、古橋眞人、岡崎雄介、大野紘平、美田知宏、伏屋敬博、石村周太郎、吉田英昭、三浦哲嗣
  • Organizer: 第43回日本腎臓学会東部大会
  • Place of Presentation: 東京
• [Presentation] 脂肪酸結合タンパク4の脂肪細胞からの分泌機構の検討
  • Author(s): 石村周太郎、古橋眞人、美田知宏、伏屋敬博、大野紘平、田中希尚、赤坂 憲、吉田英昭、平光伸也、石井潤一、三浦哲嗣
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京
• [Presentation] 日本高血圧学会学術賞受賞講演: 高血圧関連疾患におけるアディポカインの役割解明に関する臨床研究
  • Author(s): 古橋眞人
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Wistar Kyotoラットおよび高血圧自然発症ラットにおいて血中angiotensin-(1-12)はアンジオテンシン変換酵素によりangiotensin Iへ変換される
  • Author(s): 茂庭仁人、嶋村昌之介、長谷川浩一、滝沢英毅、浦信行、田中繁道、古橋眞人、吉田英昭、Jasmina Varagic、Carlos M. Ferrario、三浦哲嗣
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
• [Presentation] 一般住民において血中脂肪酸結合タンパク4濃度の上昇は左室肥大ならびに拡張能障害と関連する
  • Author(s): 伏屋敬博、古橋眞人、湯田 聡、村中敦子、石村周太郎、美田知宏、大野紘平、田中希尚、赤坂 憲、大西浩文、吉田英昭、齋藤重幸、三浦哲嗣
  • Organizer: 第36回日本高血圧学会
  • Place of Presentation: 大阪
• [Presentation] Elevation of Serum Fatty Acid-Binding Protein 4 Level in Young Normotensive Men with a Family History of Hypertension.
  • Author(s): Mita T, Furuhashi M, Ota H, Ishimura S, Koyama M, Fuseya T, Tanaka M, Yoshida H, Shimamoto K, Miura T.
  • Organizer: The 24th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney, Australia
• [Presentation] Elevation of Plasma Fatty Acid-Binding Protein 4 Level Contributes to Blood Pressure Elevation and Insulin Resistance in Essential Hypertension.
  • Author(s): Fuseya T, Furuhashi M, Ota H, Ishimura S, Okazaki Y, Mita T, Yamashita T, Yoshida H, Shimamoto K, Miura T.
  • Organizer: The 24th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney, Australia
• [Presentation] Serum FABP4 (A-FABP/aP2) and FABP5 (E-FABP/mal1) as Possible Biomarkers of Insulin Resistance and Coronary Atherosclerosis.
  • Author(s): Okazaki Y, Furuhashi M, Ota H, Ishimura S, Koyama M, Yamashita T, Tanaka M, Yoshida H, Shimamoto K, Miura T.
  • Organizer: The 24th Scientific Meeting of the International Society of Hypertension
  • Place of Presentation: Sydney, Australia
• [Presentation] Appropriate intensity anticoagulation with warfarin reduces risk of mortality in hemodialysis patients with atrial fibrillation.
  • Author(s): Koyama M, Yamashita T, Okazaki Y, Ishimura S, Tanaka M, Togashi N, Furuhashi M, Yoshida H, Tsuchihashi K, Miura T.
  • Organizer: American Society of Nephrology 2012
  • Place of Presentation: Chicago, U.S.A.
• [Presentation] Fusion of bone marrow-derived cells with podocytes increases in diabetic nephropathy.
  • Author(s): Yamashita T, Fujimiya M, Koyama M, Okazaki Y, Tanaka M, Furuhashi M, Yoshida H, Miura T.
  • Organizer: American Society of Nephrology 2012
  • Place of Presentation: Chicago, U.S.A.
• [Presentation] Local Production of Fatty Acid-Binding Protein 4 Leads to Coronary Atherosclerosis.
  • Author(s): Furuhashi M, Ishimura S, Ota H, Okazaki Y, Koyama M, Fuseya T, Mita T, Tanaka M, Yoshida H, Miura T. Local Production of Fatty Acid-Binding Protein 4 Leads to Coronary Atherosclerosis.
  • Organizer: American Heart Association 2012
  • Place of Presentation: Los Angels, U.S.A.
• [Presentation] Endoplasmic Reticulum Stress Promotes Neointima Formation After Vascular Injury.
  • Author(s): Ishimura S, Furuhashi M, Okazaki Y, Koyama M, Tanaka M, Mita T, Fuseya T, Yoshida H, Miura T.
  • Organizer: American Heart Association 2012
  • Place of Presentation: Los Angels, U.S.A.
• [Presentation] Elevation of Fatty Acid-Binding Protein 4 is Predisposed by Family History of Hypertension and Contributes to Blood Pressure Elevation.
  • Author(s): Fuseya T, Furuhashi M, Ota H, Ishimura S, Mita T, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T.
  • Organizer: American Heart Association 2012
  • Place of Presentation: Los Angels, U.S.A.
• [Presentation] シンポジウム7: 小胞体ストレスと内分泌代謝疾患. 小胞体ストレスセンサーとインスリン抵抗性
  • Author(s): 古橋眞人、三浦哲嗣、Gokhan S. Hotamisligil
  • Organizer: 第85回日本内分泌学会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 糖尿病性腎症では骨髄由来細胞とポドサイトの細胞融合が増加する
  • Author(s): 山下智久、吉田英昭、大野紘平、伏屋敬博、美田知宏、山本 諭、岡崎雄介、石村周太郎、田中希尚、古橋眞人、三浦哲嗣、安宅弘司、藤宮峯子
  • Organizer: 第55回日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] 心房細動合併の有無による血液透析患者の予後
  • Author(s): 伏屋敬博、小山雅之、美田知宏、岡崎雄介、山下智久、石村周太郎、田中希尚、富樫信彦、伊藤洋輔、古橋眞人、吉田英昭、土橋和文、三浦哲嗣
  • Organizer: 第57回日本透析医学会
  • Place of Presentation: 札幌
• [Presentation] 本態性高血圧症の家族歴を有する若年正常血圧者における脂肪酸結合タンパク4とインスリン抵抗性の関連
  • Author(s): 美田知宏、古橋眞人、太田英喜、石村周太郎、伏屋敬博、岡崎雄介、小山雅之、山下智久、田中希尚、吉田英昭、三浦哲嗣
  • Organizer: 第35回日本高血圧学会
  • Place of Presentation: 名古屋
• [Presentation] 血管傷害後の新生内膜形成における小胞体ストレスの関与
  • Author(s): 石村周太郎、古橋眞人、小山雅之、岡崎雄介、太田英喜、美田知宏、伏屋敬博、山下智久、田中希尚、吉田英昭、三浦哲嗣
  • Organizer: 第35回日本高血圧学会
  • Place of Presentation: 名古屋
• [Presentation] バイオマーカーとしての血中脂肪酸結合タンパクファミリーの比較検討
  • Author(s): 伏屋敬博、古橋眞人、石村周太郎、太田英喜、小山雅之、岡崎雄介、美田知宏、田中希尚、吉田英昭、三浦哲嗣
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都
• [Presentation] 高峰譲吉研究奨励賞受賞講演：メタボリックシンドロームにおける慢性炎症と脂肪酸結合タンパクの役割解明
  • Author(s): 古橋眞人
  • Organizer: 第16回日本心血管内分泌代謝学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 高血圧および動脈硬化における脂肪酸結合タンパク4 (FABP4/A-FABP/aP2)の臨床的役割の検討
  • Author(s): 石村周太郎、古橋眞人、太田英喜、吉田英昭、島本和明、三浦哲嗣
  • Organizer: 第16回日本心血管内分泌代謝学会
  • Place of Presentation: 東京
• [Presentation] Symposium 5: Metabolic Syndrome and Obesity. Lipid Chaperones, Inflammation, and Metabolic Syndrome
  • Author(s): Furuhashi M, Ishimura S, Miura T
  • Organizer: 第20回日本血管生物医学会
  • Place of Presentation: 徳島
  • Invited
• [Presentation] 小胞体ストレスセンサーPERKとインスリン抵抗性
  • Author(s): 古橋眞人、石村周太郎、美田知宏、伏屋敬博、三浦哲嗣、Gokahan S. Hotamisligil
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] Local Production of Fatty Acid-Binding Protein 4 Contributes to Development of Coronary Stenosis
  • Author(s): Ishimura S, Furuhashi M, Fuseya T, Mita T, Okazaki Y, Koyama M, Tanaka M, Yoshida H, Miura T.
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜
• [Presentation] Fatty Acid-Binding Protein 4 Contributes to Obesity- and Insulin Resistance-Related Blood Pressure Elevation in the General Population
  • Author(s): Mita T, Furuhashi M, Ishimura S, Fuseya T, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T.
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜
• [Book] 疾患モデルの作成と利用 – 脂質異常代謝と関連疾患. FABP4 (2014)
  • Author(s): 古橋眞人
  • Publisher: エル・アイ・シー
• [Book] メタボ時代の心血管疾患予防と管理. 3)脂肪酸結合蛋白. a脂肪酸結合蛋白ファミリーとその機能(島本和明編集) (2013)
  • Author(s): 古橋眞人
  • Publisher: 診断と治療社
• [Book] メタボ時代の心血管疾患予防と管理. 3)脂肪酸結合蛋白. b脂肪酸結合蛋白とメタボリックシンドローム(島本和明編集) (2013)
  • Author(s): 石村周太郎,古橋眞人
  • Publisher: 診断と治療社
• [Book] メタボ時代の心血管疾患予防と管理. 3) 脂肪酸結合蛋白. a 脂肪酸結合蛋白ファミリーとその機能 (2013)
  • Author(s): 古橋眞人
  • Publisher: 診断と治療社
• [Book] メタボ時代の心血管疾患予防と管理. 3) 脂肪酸結合蛋白. b 脂肪酸結合蛋白とメタボリックシンドローム (2013)
  • Author(s): 石村周太郎, 古橋眞人
  • Publisher: 診断と治療社
• [Book] メタボ時代の心血管疾患予防と管理. 4) 小胞体ストレス. a 小胞体ストレス (2013)
  • Author(s): 古橋眞人
  • Publisher: 診断と治療社
• [Book] メタボ時代の心血管疾患予防と管理. 4) 小胞体ストレス. b 小胞体ストレスとメタボリックシンドローム (2013)
  • Author(s): 古橋眞人
  • Publisher: 診断と治療社