Elucidation of role of fatty acid-binding protein in vascular endothelial function and blood pressure control
| Project/Area Number |
23591106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 脂肪酸結合タンパク / 血管内皮 / 血圧 / 高血圧 |
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| Research Abstract |
Fatty acid-binding protein 4 is expressed in both adipcoytes and macrophages and plays an important role in many aspects of metabolic syndrome. Here we investigated the role of secreted form and ectopic expression of FABP4 on blood pressure regulation. Serum FABP4 level was significantly higher in essential hypertensives than in normotensives. Serum FABP4 level was positively and independently correlated with blood pressure and insulin resistance. Angiotensin II receptor blockers significantly decreased FABP4 level in hypertensives. FABP4-deficient mice protected from blood pressure elevation. Expression of FABP4 was related to increased inflammatory markers. Further understanding of role of FABP4 on blood pressure and endothelial function will enable the development of new therapeutic strategies for hypertension.
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Report
(4 results)
Research Products
(124 results)
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[Journal Article] Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker2014
Author(s)
Furuhashi M, Moniwa N, Mita T, Fuseya T, Ishimura S, Ohno K, Shibata S, Tanaka M, Watanabe Y, Akasaka H, Ohnishi H, Yoshida H, Takizawa H, Saitoh S, Ura N, Shimamoto K, Miura T.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population.2013
Author(s)
Ishimura S, Furuhashi M, Watanabe Y, Hoshina K, Fuseya T, MIta T, Okazaki Y, Koyama M, Tanaka M, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T.
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Journal Title
PLoS ONE
Volume: 8
Issue: 11
Pages: e81318-e81318
DOI
Related Report
Peer Reviewed
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[Journal Article] Adipocyte lipid chaperone aP2 is a secreted adipokine regulating hepatic glucose production.2013
Author(s)
Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS.
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Journal Title
Cell Metab
Volume: 17
Issue: 5
Pages: 768-778
DOI
Related Report
Peer Reviewed
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[Journal Article] Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation.2012
Author(s)
Ota H, Furuhashi M, Ishimura S, Koyama M, Okazaki Y, Mita T, Fuseya T, Yamashita T, Tanaka M, Yoshida H, Shimamoto K, Miura T.
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Journal Title
Am J Hypertens
Volume: 25
Issue: 10
Pages: 1124-1130
DOI
Related Report
Peer Reviewed
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[Journal Article] Histopathology of the pancreas in fulminant type 1 diabetes after 23-year follow-up : a case report2012
Author(s)
Sato T, Miki T, Murakami N, Hirohashi Y, Kouzu H, Furuhashi M, Tanno M, Yuda T, Saitoh S, Hasegawa T, Miura T
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Journal Title
Pathology International
Volume: 62
Issue: 12
Pages: 827-29
DOI
Related Report
Peer Reviewed
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[Journal Article] Deterioration of renal function by chronic heart failure is associated with congestion and oxidative stress in the tubulointerstitium.2011
Author(s)
Tanaka M, Yoshida H, Furuhashi M, Togashi N, Koyama M, Yamamoto S, Yamashita T, Okazaki Y, Ishimura S, Ota H, Hasegawa T, Miura T.
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Journal Title
Internal Med
Volume: 50
Pages: 2877-2887
NAID
Related Report
Peer Reviewed
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[Presentation] Local production of fatty acid-binding protein 4 leads to coronary atherosclerosis.2012
Author(s)
Furuhashi M, Ishimura S, Ota H, Koyama M, Okazaki Y, Yamashita T, Tanaka M, Mita T, Fuseya T, Yoshida H, Miura T.
Organizer
Keystone Symposia. Genetic and Molecular Basis of Obesity and Body Weight Regulation.
Place of Presentation
Santa Fe, NM, U.S.A.
Related Report
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[Presentation] Reducing endoplasmic reticulum stress through a chemical chaperone 4-phenylbutyrate inhibits neointima formation.2011
Author(s)
Ishimura S, Furuhashi M, Ota H, Yamashita T, Okazaki Y, Koyama M, Tanaka M, Togashi N, Hagiwara M, Yoshida H, Shimamoto K, Miura T.
Organizer
FASEB Summer Research Conference. From Unfolded Proteins in the Endoplasmic Reticulum to Disease.
Place of Presentation
Saxtons River, Vermont, U.S.A.
Related Report
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[Presentation] Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy.2011
Author(s)
Yamashita T, Fujimiya M, Yamamoto S, Koyama M, Okazaki Y, Ishimura S, Tanaka M, Furuhashi M, Yoshida H, Miura T.
Organizer
ASN Kidney Week.
Place of Presentation
Philadelphia, PA, U.S.A.
Related Report
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[Presentation] Fatty acid-binding protein 4 is a novel predictor of cardiovascular events in end-stage renal disease.2011
Author(s)
Furuhashi M, Hayashi M, Nishitani T, Ishimura S, Ota H, Koyama M, Okazaki Y, Tanaka M, Yoshida H, Miura T.
Organizer
American Heart Association.
Place of Presentation
Orlando, FL, U.S.A.
Related Report
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[Presentation] Reduction of endoplasmic reticulum stress prevents neointima formation after vascular injury.2011
Author(s)
Ishimura S, Furuhashi M, Ota H, Yamashita T, Koyama M, Okazaki Y, Tanaka M, Mita T, Fuseya T, Yoshida H, Miura T.
Organizer
American Heart Association.
Place of Presentation
Orlando, FL, U.S.A.
Related Report
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[Presentation] Reducing endoplasmic reticulum stress through a chemical chaperone 4-phenylbutyrate inhibits neointima formation2011
Author(s)
Ishimura S, Furuhashi M, Ota H, Yamashita T, Okazaki Y, Koyama M, Tanaka M, Togashi N, Hagiwara M, Yoshida H, Shimamoto K, Miura T.
Organizer
第43回日本動脈硬化学会
Place of Presentation
札幌
Related Report
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[Presentation] Elevation of fatty acid-binding protein 4 is associated with left ventricular hypertrophy and diastolic dysfunction in a general population.
Author(s)
Mita T, Furuhashi M, Yuda S, Muranaka A, Akasaka H, Ishimura S, Fuseya T, Yoshida H, Shigeyuki S, Miura T.
Organizer
The 67th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. 2013
Place of Presentation
New Orleans, U.S.A.
Related Report
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[Presentation] Renin independent Ang-(1-12) Production in both the systemic and coronary circulation.
Author(s)
Moniwa N, Varagic J, Nagata S, Ahmad S, Simington SW, VonCannon JL, Shimamura Y, Hasegawa K, Takizawa H, Ura N, Tanaka S, Furuhashi M, Yoshida H, Miura T, Ferrario CM.
Organizer
The 67th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research. 2013
Place of Presentation
New Orleans, U.S.A.
Related Report
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[Presentation] Endoplasmic reticulum stress in pulmonary artery smooth muscle cells contributes to the development of pulmonary hypertension induced by chronic hypoxia.
Author(s)
Koyama M, Furuhashi M, Ishimura S, Mita T, Fuseya T, Ono K, Tanaka M, Yoshida H, Tsuchihashi K, Miura T.
Organizer
American Heart Association. 2013
Place of Presentation
Dallas, U.S.A.
Related Report
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[Presentation] Elevation of Serum Fatty Acid-Binding Protein 4 Level in Young Normotensive Men with a Family History of Hypertension.
Author(s)
Mita T, Furuhashi M, Ota H, Ishimura S, Koyama M, Fuseya T, Tanaka M, Yoshida H, Shimamoto K, Miura T.
Organizer
The 24th Scientific Meeting of the International Society of Hypertension
Place of Presentation
Sydney, Australia
Related Report
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[Presentation] Elevation of Plasma Fatty Acid-Binding Protein 4 Level Contributes to Blood Pressure Elevation and Insulin Resistance in Essential Hypertension.
Author(s)
Fuseya T, Furuhashi M, Ota H, Ishimura S, Okazaki Y, Mita T, Yamashita T, Yoshida H, Shimamoto K, Miura T.
Organizer
The 24th Scientific Meeting of the International Society of Hypertension
Place of Presentation
Sydney, Australia
Related Report
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[Presentation] Serum FABP4 (A-FABP/aP2) and FABP5 (E-FABP/mal1) as Possible Biomarkers of Insulin Resistance and Coronary Atherosclerosis.
Author(s)
Okazaki Y, Furuhashi M, Ota H, Ishimura S, Koyama M, Yamashita T, Tanaka M, Yoshida H, Shimamoto K, Miura T.
Organizer
The 24th Scientific Meeting of the International Society of Hypertension
Place of Presentation
Sydney, Australia
Related Report
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[Presentation] Appropriate intensity anticoagulation with warfarin reduces risk of mortality in hemodialysis patients with atrial fibrillation.
Author(s)
Koyama M, Yamashita T, Okazaki Y, Ishimura S, Tanaka M, Togashi N, Furuhashi M, Yoshida H, Tsuchihashi K, Miura T.
Organizer
American Society of Nephrology 2012
Place of Presentation
Chicago, U.S.A.
Related Report
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[Presentation] Local Production of Fatty Acid-Binding Protein 4 Leads to Coronary Atherosclerosis.
Author(s)
Furuhashi M, Ishimura S, Ota H, Okazaki Y, Koyama M, Fuseya T, Mita T, Tanaka M, Yoshida H, Miura T. Local Production of Fatty Acid-Binding Protein 4 Leads to Coronary Atherosclerosis.
Organizer
American Heart Association 2012
Place of Presentation
Los Angels, U.S.A.
Related Report
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[Presentation] Elevation of Fatty Acid-Binding Protein 4 is Predisposed by Family History of Hypertension and Contributes to Blood Pressure Elevation.
Author(s)
Fuseya T, Furuhashi M, Ota H, Ishimura S, Mita T, Akasaka H, Ohnishi H, Yoshida H, Saitoh S, Miura T.
Organizer
American Heart Association 2012
Place of Presentation
Los Angels, U.S.A.
Related Report
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