| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We have identified a novel gene termed ARIA that regulates angiogenic functions in endothelial cells. Here, we further characterized its function by using ARIA-deficient mice. ARIA-deficient mice demonstrated substantially enhanced neovessel formation comparing to WT mice assessed by hindlimb ischemia model. Moreover, we revealed that enhanced PI3K/Akt signaling in both endothelial cells and endothelial progenitor cells is attributable to the increased neovessel formation in ARIA-deficient mice. Also, we fond a small compound that potentially inhibit ARIA function by in silico screening. Inhibition of ARIA is a new therapeutic approach to treat ischemic diseases.
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