Molecular mechanisms of suppression of macrophage foam cell formation by an erythropoietin receptor agonist
Project/Area Number |
23591108
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Jichi Medical University |
Principal Investigator |
UEBA HIROTO 自治医科大学, 医学部, 講師 (80316546)
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Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Masanobu 自治医科大学, 医学部, 名誉教授 (40161286)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 動脈硬化 / erythropoietin / マクロファージ / シグナル伝達 |
Research Abstract |
Erythropoietin (EPO) has been shown to have nonerythropoietic, tissue-protective effects although prothrombotic effects of EPO hamper its clinical use. Recently, we demonstrated that an EPO receptor agonist (HBSP) that does not have prothrombotic effects suppresses coronary atherosclerosis in Watanabe heritable hyperlipidemic spontaneous myocardial infarction (WHHLMI) rabbits. In the present study, we examined the effects of pyroglutamate HBSP (ARA290) on macrophage foam cell formation. ARA290 significantly inhibited it by up-regulating the expression of ABCA1 that plays a pivotal role in reverse cholesterol transport and reduced aortic plaque area in apo E deficient mice. Because ARA290 is chemically more stable than HBSP, it may be a promising drug for treating atherosclerosis.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Suppression of coronary atherosclerosis by helix B surface peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin.2013
Author(s)
Ueba H, Shiomi M, Brines M, Yamin M, Kobayashi T, Ako J, Momomura SI, Cerami A, Kawakami M
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Journal Title
Molecular Medicine
Volume: 19
Issue: 1
Pages: 195-202
DOI
Related Report
Peer Reviewed
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[Presentation] Helix B surface peptide, a nonerythropoietic erythropoietin derivative, modifies macrophage polarization and prevents progression of coronary atherosclerotic lesions2014
Author(s)
Ueba, H., Shiomi, M., Brines, M., Yamin M., Cerami, A., Momomura, S.
Organizer
The 78th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Tokyo
Year and Date
2014-03-22
Related Report
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[Presentation] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue- protective compound derived from erythro- poietin2013
Author(s)
Ueba, H., Shiomi, M., Brines, M., Yamin, M., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
Organizer
The 77th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Year and Date
2013-03-15
Related Report
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[Presentation] Suppression of coronary atherosclerosis by a helix B surface peptide, a nonerythropoietic tissue-protective compound derived from erythropoietin2013
Author(s)
Ueba, H., Shiomi, M., Brines, M., Yamin, M., Ako, J., Momomura, S., Cerami, A., Kawakami
Organizer
The 77th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
横浜市
Related Report
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[Presentation] Cardioprotective Prop- erties of Helix B Surface Peptide, a Nonerythropoietic Derivative Mimicking the 3D Structure of Erythropoietin2011
Author(s)
Ueba, H., Brines, M., Yamin, M., Umemoto, T., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
Organizer
The 75th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Year and Date
2011-08-03
Related Report
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[Presentation] Cardioprotective Properties of Helix B Surface Peptide, a Nonerythropoietic Derivative Mimicking the 3D Structure of Erythropoietin2011
Author(s)
Ueba, H., Brines, M., Yamin, M., Umemoto, T., Ako, J., Momomura, S., Cerami, A., Kawakami, M.
Organizer
The 75th Annual Scientific Meeting of the Japanese Circulation Society
Place of Presentation
Yokohama
Related Report