| Project/Area Number |
23591110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
|
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| Research Institution | Hokkaido University |
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Principal Investigator |
KONNO Satoshi 北海道大学, 大学病院, 講師 (20399835)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISADA Akira 北海道大学, 北海道大学病院, 特任助教 (80374289)
NASUHARA Yasuyuki 北海道大学, 北海道大学病院, 准教授 (30322811)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
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| Keywords | 閉塞性肺疾患 / 気管支喘息 / COPD / 凝固系 |
|---|
| Research Abstract |
Levels of tissue factor(TF) and factor7 in BALF were signnificantly increased after OVA challenge in two murine models of asthma (acute and chronic models). Intraperitoneal administration of TF-factor7 inhibitor significantly decreased the number of eosinophils in BALF, OVA-IgE levels in serum and bronchial hyperresponsiveness in these moedels, suggesting the potential of TF-factor7 as a novel therapeutic target for asthma treatment. In genetic studies, we conducted case (asthma)-control studies for several genes related with coagulation cascade, including TF,F2R,CC16 and CAT and significant associations of several SNPs in these genes and asthma were identified.
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