| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Research Abstract |
GATA-3-overexpressing mice exhibited steroid-sensitive eosinophilic inflammation under Th2-biased conditions and RORgammat-overexpressing mice developed steroid-insensitive neutrophilic inflammation under Th17-biased conditions. The levels of KC, MIP-2, IL-6 and other neutrophil chemotaxis-related mediators were significantly elevated in OVA-exposed RORgammat-overexpressing mice, compared with wild-type mice. Interestingly, airway hyperresponsiveness accompanied by neutrophilic airway inflammation in RORgammat-overexpressing mice was effectively suppressed by anti-IL-17 antibody, CXCR2 antagonist or anti-IL-6 receptor antibody administration. In conclusion, our results suggest that the expression levels of GATA-3 and RORgammat may be important for determining the phenotype of asthmatic airway inflammation. Furthermore, blockade of the Th17 signaling pathway may be a treatment option for steroid-insensitive asthma.
|
