CD40 in the development of COPD

• Project/Area Number: 23591114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Chiba University
• Principal Investigator: TADA Yuji 千葉大学, 医学部附属病院, 助教 (50344990)
• Co-Investigator(Kenkyū-buntansha): KASAHARA Yasunori 千葉大学, 医学部附属病院, 講師 (60343092)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 慢性閉塞性肺疾患 / COPD / 慢性閉塞性肺障害 / CD40L / 肺胞構成細胞 / アポトーシス / CD40 / Fas / IFN-γ / apoptosis / 肺気腫

Research Abstract

We have shown the possible role of CD40/CD40ligand interaction in the development of chronic obstructive pulmonary disease in the aspects of airway inflammation and apoptosis of alveolar cells including epithelial cells and endothelial cells using a animal models. Furthermore, we elucidated the positive interaction of serum level of CD40L and the disease severity of COPD patients. These findings possibly indicates that to command CD40/CD40L system is promising for treatment of COPD in future.

Research Products

• [Journal Article] Quantitative assessment of cross-sectional area of small pulmonary vessels in patients with COPD using inspiratory and expiratory MDCT (2013)
  • Author(s): Matsuura Y, Kawata N, Yanagawa N, Sugiura T, Sakurai Y, Sato M, Iesato K, Terada J, Sakao S, Tada Y, Tanabe N, Suzuki Y, and Tatsumi K.
  • Journal Title: Eur J Radiol Volume: 82(10) Pages: 1804-1810
• [Journal Article] Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming (2013)
  • Author(s): M. Fessel JP, Hamid R, Wittmann BM, Robinson LJ, Blackwell T, Tada Y, Tanabe N, Tatsumi K, Hemnes AR, and West JD.
  • Journal Title: Pulm Circ. Volume: 2(2) Pages: 201-13
• [Journal Article] Quantitative assessment of cross-sectional area of small pulmonary vessels in patients with COPD using inspiratory and expiratory MDCT. (2013)
  • Author(s): Matsuura Y, Kawata N, Yanagawa N, Sugiura T, Sakurai Y, Sato M, Iesato K, Terada J, Sakao S, Tada Y, Tanabe N, Suzuki Y, Tatsumi K
  • Journal Title: Eur J Radiol. Volume: 82810) Issue: 10 Pages: 1804-10
  • DOI: 10.1016/j.ejrad.2013.05.022
  • Peer Reviewed
• [Journal Article] CD40 amplifies Fas-mediated apoptosis : a mechanism contributing emphysema (2012)
  • Author(s): Shigeta A, Tada Y, Wang JY, Ishizaki S, Tsuyusaki J, Yamauchi K, Kasahara Y, Iesato K, Tanabe N, Takiguchi Y, Sakamoto A, Tokuhisa T, Shibuya K, Hiroshima K, West J, and Tatsumi
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 303(2)
• [Journal Article] CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema (2012)
  • Author(s): Shigeta, A., Tada, Y., Wang, J.-Y., Ishizaki, S., Tuyusaki, J., Yamauchi, K., Kasahara, Y., Iesato, K., Tanabe, N., Takiguchi, Y., Sakamoto, A., Tokuhisa, T., Shibuya, K., Hiroshima, K., West, J. and Tatsumi, K.
  • Journal Title: American Journal of Physiology Volume: 303 Issue: 2 Pages: 141-151
  • DOI: 10.1152/ajplung.00337.2011
  • Peer Reviewed
• [Presentation] 可溶性CD40リガンド濃度とCOPD重症度の相関 (2013)
  • Author(s): 重田文子、多田裕司、家里憲、笠原靖紀、滝口裕一、田邉信宏、巽浩一郎
  • Organizer: 第53回日本呼吸器学会総会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-21
• [Presentation] 可溶性CD40リガンド濃度とCOPD重症度との相関 (2013)
  • Author(s): 重田文子, 多田裕司, 家里憲, 笠原靖紀,滝口裕一、田邉信宏、巽浩一郎
  • Organizer: 第51回 日本呼吸器学会総会
  • Place of Presentation: 東京
• [Presentation] 可溶性CD40リガンドとCOPD重症度の相関 (2013)
  • Author(s): 重田文子、多田裕司 ほか
  • Organizer: 第53回日本呼吸器学会学術講演会ミニシンポジウム
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 慢性肺気腫症の発症におけるCD40/CD40Lシステムの関与 (2012)
  • Author(s): 多田裕司、重田文子、石崎俊介、露崎淳一、山内圭太、笠原靖紀、田邉信宏、滝口裕一、坂本明美、徳久剛史、渋谷和俊、廣島健三、James West、巽浩一郎
  • Organizer: 第85回閉塞性肺疾患研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-21
• [Presentation] High concentration of plasma soluble CD40 ligand is associated with impaired lung function and alveolar structural destruction (2012)
  • Author(s): Shigeta A, Tada Y et al.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: サンフランシスコ米国
  • Year and Date: 2012-05-18
• [Presentation] High concentration of plasma soluble CD40 ligand is associated with impaired lung function and alveolar structural destruction (2012)
  • Author(s): Shigeta A, Tada Y, et al.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: サンフランシスコ Moscone Center. U.S.A
• [Presentation] IFNγ・Fas抗体反復気管内投与による肺気腫モデルマウスの作成 (2011)
  • Author(s): 重田文子、多田裕司、川田奈緒子、巽浩一郎
  • Organizer: 第34回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 浜松市
  • Year and Date: 2011-06-17
• [Book] Respiratory medical research, 特集日本呼吸器学会COPDガイドライン第4版を読み解く併存症とその対応 (2014)
  • Author(s): 巽浩一郎、川田奈緒子、寺田二郎、坂尾誠一郎、多田裕司
  • Publisher: 先端医学社
• [Book] 内科2014年特集;COPD治療の新時代PEACE研究 (2014)
  • Author(s): 巽浩一郎、川田奈緒子、寺田二郎、坂尾誠一郎、多田裕司
  • Publisher: 南江堂
• [Book] Annual Review 呼吸器 (2014)
  • Author(s): 多田裕司、重田文子、巽浩一郎
  • Total Pages: 3
  • Publisher: 中外製薬医学社
• [Book] Annual Review, 2014年気腫肺形成におけるCD40の関与
  • Author(s): 重田文子、多田裕司
  • Publisher: 呼吸器疾患中外医学社