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The role of Dok adaptors in pulmonary disorders

Research Project

Project/Area Number 23591115
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKeio University (2013)
Akita University (2012)
The University of Tokyo (2011)

Principal Investigator

MASHIMA Ryuichi  慶應義塾大学, 医学部, 特任講師 (00401365)

Co-Investigator(Renkei-kenkyūsha) NAKAE Susumu  東京大学, 医科学研究所, 准教授 (60450409)
YAMANASHI Yuji  東京大学, 医科学研究所, 教授 (40202387)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords喘息 / チロシンキナーゼ / アダプター分子 / 疾患モデルマウス / 閉塞性肺疾患 / アダプタータンパク質
Research Abstract

Dok adaptor proteins play important roles on the proper regulation of tyrosine kinase-mediated signaling pathways. In this study, I particularly investigated the role of Dok adaptors in pulmonary disorders such as asthma. Although many causative factors of asthma have been suggested, dysfunction of immune cells is one of the major reason of this disease. In these immune cells, three Dok adaptors can be detected, therefore, the role of them in asthma was investigated using knockout mice.
As expected, mice lacking three Dok adaptors exhibited an abnormal increase in airway hyperreactivity, a biological measure of asthma. Consistent with previous findings, the levels of Th2 cytokines in bronchoalveolar lavage fluids were also elevated in these mice. Furthermore, histological examination revealed hyperplasia of airway epithelial cells and accumulation of goblet cells. These results proved that Dok adaptor proteins play a key role on the regulation of asthma.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2013 2011

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Dok adaptors play anti-inflammatory roles in pulmonary homeostasis.2013

    • Author(s)
      Mashima R, Arimura S, Kajikawa S, Oda H, Nakae S, Yamanashi Y.
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 1 Pages: 56-65

    • DOI

      10.1111/gtc.12016

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dok-1 and Dok-2 deficiency induces osteopenia via regulation of osteoclasts2011

    • Author(s)
      Aya Kawamata
    • Journal Title

      J. Cell. Physiol.

      Volume: 226 Issue: 12 Pages: 3087-3093

    • DOI

      10.1002/jcp.22909

    • Related Report
      2011 Research-status Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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