Pathophysiology and prognostic factors of classic asthma and cough variant asthma: A comprehensive study

• Project/Area Number: 23591117
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Nagoya City University (2012-2015); Kyoto University (2011)
• Principal Investigator: Niimi Akio 名古屋市立大学, 医学(系)研究科(研究院), 教授 (30252513)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Hisako 京都大学, 医学研究科, 助教 (60359809) ; ITO Isao 京都大学, 医学研究科, 助教 (40447975) ; OGURI Testuya 名古屋市立大学, 大学院医学研究科, 准教授 (60363925)
• Project Period (FY): 2011-04-28 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 咳喘息 / 慢性咳嗽 / 典型的喘息 / 好酸球性炎症 / 気道過敏性 / 咳受容体感受性 / 予後 / 遺伝子多型 / 好酸球 / 好中球

Outline of Final Research Achievements

We aimed to pursue the phenotypic determinants of classis asthma and cough variant asthma. We have reported 1) that the two conditions comprises more that 70% of chronic cough patients in specialist allergy clinics of Japan (J Asthma 2013), 2) that nasal allergy is more prevalent in classis asthma than in cough variant asthma but contributes similarly to pathophysiology of both conditions (Respiration 2014), 3) the utility of cysteinyl leukotriene antagonist (Respiration 2012) and characteristic triggers of cough (Allergol Int 2012) in cough variant asthma patients, and 4) important contribution of eosinophilic inflammation (Lung 2014) and gastroesophageal dysmotility (Allergol Int 2016) in asthmatic cough.

Research Products

• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] King's College(英国)
• [Journal Article] CT-assessed large airway involvement and lung function decline in eosinophilic asthma: The association between induced sputum eosinophil differential counts and airway remodeling. (2016)
  • Author(s): Inoue H, Ito I, Niimi A, Matsumoto H, Matsuoka H, Jinnai M, Takeda T, Oguma T, Otsuka K, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Mishima M.
  • Journal Title: J Asthma Volume: 未定
  • Peer Reviewed
• [Journal Article] Utility of serum periostin and free IgE levels in evaluating responsiveness to omalizumab in patients with severe asthma. (2016)
  • Author(s): Tajiri T, Matsumoto H, Gon Y, Ito R, Hashimoto S, Izuhara K, Suzukawa M, Ohta K, Ono J, Ohta S, Ito I, Oguma T, Inoue H, Iwata T, Kanemitsu Y, Nagasaki T, Niimi A, Mishima M.
  • Journal Title: Allergy Volume: 未定 Issue: 10 Pages: 1472-1479
  • DOI: 10.1111/all.12922
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Gastroesophageal dysmotility is associated with the impairment of cough-specific quality of life in patients with cough variant asthma (2016)
  • Author(s): Kanemitsu Y, Niimi A, Matsumoto H, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Izuhara Y, Petrova G, Birring SS, Mishima M.
  • Journal Title: Allergology International Volume: 65 Issue: 3 Pages: 320-326
  • DOI: 10.1016/j.alit.2016.02.014
  • NAID: 130005165869
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mouth Breathing, another Risk Factor for Asthma: the Nagahama Study. (2016)
  • Author(s): Yumi I, Matsumoto H, Nagasaki T, Kanemitsu Y, Murase K, Ito I, Oguma T, Muro S, Asai K, Tabara Y, Takahashi K, Bessho K, Sekine A, Kosugi S, Yamada R, Nakayama T, Matsuda F, Niimi A, Chin K, Mishima M; Nagahama Study Group.
  • Journal Title: Allergy Volume: 未定 Issue: 7 Pages: 1031-1036
  • DOI: 10.1111/all.12885
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 吸入ステロイド薬の使い分け (2016)
  • Author(s): 新実彰男
  • Journal Title: アレルギー Volume: 未定
  • NAID: 130005166054
  • Open Access
• [Journal Article] 慢性咳嗽の病態、鑑別診断、治療 一咳喘息を中心に一 (2016)
  • Author(s): 新実彰男
  • Journal Title: 日内会誌 Volume: 105（臨時増刊号） Pages: 72-76
  • Acknowledgement Compliant
• [Journal Article] Mechanical Stimulation by Postnasal Drip Evokes Cough. (2015)
  • Author(s): Iwata T, Ito I, Niimi A, Ikegami K, Marumo S, Tanabe N, Nakaji H, Kanemitsu Y, Matsumoto H, Kamei J, Setou M, Mishima M.
  • Journal Title: PLos One Volume: 10 Issue: 11 Pages: e0141823-e0141823
  • DOI: 10.1371/journal.pone.0141823
  • NAID: 120005749926
  • Peer Reviewed / Open Access
• [Journal Article] Evidence for neuropathic processes in chronic cough. (2015)
  • Author(s): Niimi A, Chung KF.
  • Journal Title: Pulm Pharmacol Ther Volume: 35 Pages: 100-104
  • DOI: 10.1016/j.pupt.2015.10.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Longitudinal shape irregularity of airway lumen assessed by CT in patients with bronchial asthma and COPD. (2015)
  • Author(s): Oguma T, Hirai T, Fukui M, Tanabe N, Marumo S, Nakamura H, Ito H, Sato S, Niimi A, Ito I, Matsumoto
  • Journal Title: Thorax Volume: 70(8) Issue: 8 Pages: 719-24
  • DOI: 10.1136/thoraxjnl-2014-206651
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Small Airways with Computed Tomography: Mosaic Attenuation or Lung Density? (2015)
  • Author(s): Oguma T, Niimi A, Hirai T, Jinnai M, Matsumoto H, Ito I, Yamaguchi M, Matsuoka H, Otsuka K, Takeda T, Nakaji H, Chin K, Mishima M.
  • Journal Title: Respiration Volume: 89 Issue: 6 Pages: 539-549
  • DOI: 10.1159/000381553
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study. (2014)
  • Author(s): Tajiri T, Niimi A, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Izuhara Y, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol Volume: 113 Issue: 4 Pages: 470-475
  • DOI: 10.1016/j.anai.2014.06.004
  • Peer Reviewed
• [Journal Article] Osteopontin and periostin are associated with a 20-year decline of pulmonary function in patients with asthma. (2014)
  • Author(s): Kanemitsu Y, Ito I, Niimi A, Izuhara K, Ohta S, Ono J, Iwata T, Matsumoto H, Mishima M
  • Journal Title: Am J Respir Crit Care Med Volume: 190 Issue: 4 Pages: 472-474
  • DOI: 10.1164/rccm.201403-0562le
  • Peer Reviewed / Open Access
• [Journal Article] Using exhaled nitric oxide and serum periostin as a composite marker to identify severe/steroid-insensitive asthma. (2014)
  • Author(s): Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Tomii K, Fujimura M, Yokoyama A, Nakano Y, Hozawa S, Ito I, Oguma T, Izuhara Y, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M.
  • Journal Title: Am J Respir Crit Care Med Volume: 190 Issue: 12 Pages: 1449-1452
  • DOI: 10.1164/rccm.201407-1290le
  • NAID: 40020962796
  • Peer Reviewed / Open Access
• [Journal Article] Pathophysiological characteristics of asthma in the elderly: a comprehensive study. (2014)
  • Author(s): Inoue H, Niimi A, Takeda T, Matsumoto H, Ito I, Matsuoka H, Jinnai M, Otsuka K, Oguma T, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Chin K, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol Volume: 113 Issue: 5 Pages: 527-533
  • DOI: 10.1016/j.anai.2014.08.002
  • Peer Reviewed / Open Access
• [Journal Article] ABCB1 polymorphism as a predictive biomarker for amrubicin-induced neutropenia. (2014)
  • Author(s): Takakuwa O, Oguri T, Uemura T, Kunii E, Nakao M, Hijikata H, Kawaguchi Y, Ohkubo H, Takemura M, Maeno K, Niimi A.
  • Journal Title: Anticancer Res Volume: 34 Issue: 5 Pages: 3517-3522
  • DOI: 10.1007/s00280-015-2723-x
  • Peer Reviewed / Open Access
• [Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. (2014)
  • Author(s): Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M.
  • Journal Title: Allergy Volume: 69 Issue: 5 Pages: 668-73
  • DOI: 10.1111/all.12400
  • Peer Reviewed / Open Access
• [Journal Article] Esophagitis resulting from treatment with crizotinib for anaplastic lymphoma kinase rearrangement-positive lung adenocarcinoma: A case report. (2014)
  • Author(s): Takakuwa O, Oguri T, Yokoyama M, Hijikata H, Uemura T, Ohkubo H, Maeno K, Niimi A.
  • Journal Title: Mol Clin Oncol Volume: 2 Pages: 121-123
  • Peer Reviewed
• [Journal Article] Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. (2014)
  • Author(s): Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M
  • Journal Title: J Allergy Clin Immunol Volume: 133 Issue: 5 Pages: 1474-1477
  • DOI: 10.1016/j.jaci.2013.12.1084
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and clinical relevance of allergic rhinitis in patients with classic asthma and cough variant asthma. (2014)
  • Author(s): Tajiri T, Niimi A, Matsumoto H, Ito I, Oguma T, Otsuka K, Takeda T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Mishima M.
  • Journal Title: Respiration. Volume: 87 Issue: 3 Pages: 211-8
  • DOI: 10.1159/000355706
  • Peer Reviewed
• [Journal Article] Cough in asthma is due to eosinophilic airway inflammation: a pro/con debate. (2014)
  • Author(s): Niimi A, Brightling CE, Dicpinigaitis PV.
  • Journal Title: Lung Volume: 192 Issue: 1 Pages: 33-38
  • DOI: 10.1007/s00408-013-9543-8
  • Peer Reviewed
• [Journal Article] Transformed lymphoplasmacytic lymphoma involving the main carina: A case report. (2013)
  • Author(s): Nakao M, Oguri T, Miyazaki M, Hijikata H, Yokoyama M, Kunii E, Uemura T, Takakuwa O, Ohkubo H, Maeno K, Niimi A.
  • Journal Title: Oncol Lett. Volume: 6 Pages: 4409-13
  • Peer Reviewed
• [Journal Article] Limitations of airway dimension measurement on images obtained using multi-detector row computed tomography. (2013)
  • Author(s): Oguma T, Hirai T, Niimi A, Matsumoto H, Muro S, Shigematsu M, Nishimura T, Kubo Y, Mishima M.
  • Journal Title: PLoS One Volume: 8 Issue: 10 Pages: e76381-e76381
  • DOI: 10.1371/journal.pone.0076381
  • NAID: 120005347090
  • Peer Reviewed
• [Journal Article] Cough variant and cough-predominant asthma are major causes of persistent cough: a multicenter study in Japan. (2013)
  • Author(s): Niimi A, Ohbayashi H, Sagara H, Yamauchi K, Akiyama K, Takahashi K, Inoue H, Wakayama T, Kobayashi H, Hasegawa M, Kimura G, Yokoe T, Adachi M.
  • Journal Title: J Asthma Volume: 50 Issue: 9 Pages: 932-7
  • DOI: 10.3109/02770903.2013.823444
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids (2013)
  • Author(s): Kanemitsu Y, Mishima M,et al.
  • Journal Title: J Allergy Clin Immunol Volume: 132 Issue: 2 Pages: 305-312
  • DOI: 10.1016/j.jaci.2013.04.050
  • NAID: 120005342661
  • Peer Reviewed
• [Journal Article] Cough, asthma, and cysteinyl-leukotrienes. (2013)
  • Author(s): Niimi A.
  • Journal Title: Pulm Pharmacol Ther Volume: 26 Issue: 5 Pages: 514-9
  • DOI: 10.1016/j.pupt.2013.06.003
  • Peer Reviewed
• [Journal Article] ssociation of eosinophilic inflammation with FKBP51 expression in sputum cells in asthma. (2013)
  • Author(s): Tajiri T, Matsumoto H, Niimi A, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Petrova G, Mishima M.
  • Journal Title: PLoS One Volume: 8 Issue: 6 Pages: e65284-e65284
  • DOI: 10.1371/journal.pone.0065284
  • Peer Reviewed
• [Journal Article] Smoking attenuates the age-related decrease in IgE levels and maintains eosinophilic inflammation (2013)
  • Author(s): Nagasaki T, Matsumoto H, et al
  • Journal Title: Clin Exp Allergy Volume: 43 Issue: 6 Pages: 608-15
  • DOI: 10.1111/cea.12073
  • Peer Reviewed
• [Journal Article] Thymidylate synthase gene copy number as a predictive marker for response to pemetrexed treatment of lung adenocarcinoma. (2013)
  • Author(s): Kasai D, Ozasa H, Oguri T, Miyazaki M, Uemura T, Takakuwa O, Kunii E, Ohkubo H, Maeno K, Niimi A.
  • Journal Title: Anticancer Res Volume: ３３ Pages: 1935-40
  • Peer Reviewed
• [Journal Article] Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma. (2013)
  • Author(s): Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol. Volume: 110 Issue: 5 Pages: 387-8
  • DOI: 10.1016/j.anai.2013.01.024
  • Peer Reviewed
• [Journal Article] Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma. (2013)
  • Author(s): Nakaji H, Petrova G, Matsumoto H, Iwata T, Ito I, Oguma T, Inoue H, Tajiri T, Nagasaki T, Kanemitsu Y, Niimi A, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol. Volume: 110 Issue: 3 Pages: 198-203
  • DOI: 10.1016/j.anai.2012.12.016
  • NAID: 120005244569
  • Peer Reviewed
• [Journal Article] Analgesic Effect of Switching From Oral Opioids to a Once-a-Day Fentanyl Citrate Transdermal Patch in Patients With Lung Cancer. (2013)
  • Author(s): Takakuwa O, Oguri T, Maeno K, Yokoyama M, Hijikata H, Uemura T, Ozasa H, Ohkubo H, Miyazaki M, Niimi A.
  • Journal Title: Am J Hosp Palliat Care. Volume: -
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids (2013)
  • Author(s): Kanemitsu Y, Matsumoto H, Izuhara K, Niimi A et al.
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: -
  • NAID: 120005342661
  • Peer Reviewed
• [Journal Article] Efficacy of Budesonide in Combination with Formoterol in Patients with Inadequately Controlled Asthma on Fluticasone in Combination with Salmeterol (2012)
  • Author(s): Kanemitsu Y, Kita H, Niimi A, Fuseya Y, Tanimura K, Katayama Y, Takahashi T, Hatachi Y, Nishihara Y, Sado T.
  • Journal Title: Allergology International Volume: 61 Issue: 4 Pages: 625-627
  • DOI: 10.2332/allergolint.12-LE-0430
  • NAID: 130004873056
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Clinical, physiological and anti-inflammatory effect of montelukast in patients with cough (2012)
  • Author(s): Takemura M et al.
  • Journal Title: Respiration Volume: 83 Issue: 4 Pages: 308-315
  • DOI: 10.1159/000332835
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population (2011)
  • Author(s): Hirota, T., et.al.
  • Journal Title: Nat Genet Volume: 43(9) Issue: 9 Pages: 893-6
  • DOI: 10.1038/ng.887
  • Peer Reviewed
• [Journal Article] Plasma substance P levels in patients with persistent cough (2011)
  • Author(s): Otsuka K, Niimi A, Matsumoto H, et
  • Journal Title: Respiration Volume: 82 Issue: 5 Pages: 431-8
  • DOI: 10.1159/000330419
  • NAID: 120003534358
  • Peer Reviewed
• [Presentation] Clinical and pathological difference between CVA, CPA, classic asthma. (2016)
  • Author(s): Akio Niimi
  • Organizer: the 2nd International Cough Conference
  • Place of Presentation: Shenzhen, China
  • Year and Date: 2016-11-11
  • Int'l Joint Research / Invited
• [Presentation] 咳の病態と治療 (2016)
  • Author(s): 新実彰男
  • Organizer: 第30回日本臨床内科医学会 教育講演
  • Place of Presentation: 京王プラザホテル（東京都、新宿区）
  • Year and Date: 2016-10-09
  • Invited
• [Presentation] 「慢性咳嗽の病態、鑑別診断と治療 一Cough hypersensitivity syndromeの概念を含めて一 (2016)
  • Author(s): 新実彰男
  • Organizer: 第87回日本呼吸器学会近畿地方会 教育講演
  • Place of Presentation: 大阪国際交流センター（大阪府、大阪市）
  • Year and Date: 2016-07-09
  • Invited
• [Presentation] Studies of GORD and cough in Japan (2016)
  • Author(s): Akio Niimi
  • Organizer: 9th International Symposium on Cough
  • Place of Presentation: London, UK
  • Year and Date: 2016-06-29
  • Int'l Joint Research / Invited
• [Presentation] 呼吸器内科からみたOne airway one disease：喘息での呼気・鼻腔NO測定を中心に (2016)
  • Author(s): 竹村昌也、浅野貴光、金光禎寛、新実彰男
  • Organizer: 第65回日本アレルギー学会学術大会シンポジウム One Airway, One Diseaseの病態と臨床
  • Place of Presentation: 東京国際フォーラム（東京都、千代田区）
  • Year and Date: 2016-06-17
  • Invited
• [Presentation] 慢性咳嗽の病態、鑑別診断、治療 一咳喘息を中心に一 (2016)
  • Author(s): 新実彰男
  • Organizer: 第113回日本内科学会講演会 招請講演
  • Place of Presentation: 東京国際フォーラム（東京都、千代田区）
  • Year and Date: 2016-04-15
  • Invited
• [Presentation] 喘息の長期予後・寛解：小児期喘息から成人喘息への移行を中心に (2015)
  • Author(s): 新実彰男
  • Organizer: 第52回日本小児アレルギー学会 教育セミナー
  • Place of Presentation: なら百年会館、他（奈良県、奈良市）
  • Year and Date: 2015-11-21
  • Invited
• [Presentation] 慢性咳嗽の診断と治療 一GERDの関与を中心に一 (2015)
  • Author(s): 新実彰男
  • Organizer: 第67回日本気管食道科学会学術講演会 教育講演
  • Place of Presentation: ザ・セレクトン福島他（福島県、福島市）
  • Year and Date: 2015-11-19
  • Invited
• [Presentation] Novel Imaging Approach For Asthma (2015)
  • Author(s): Akio Niimi
  • Organizer: XXIV World Allergy Congress 2015
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2015-10-14
  • Int'l Joint Research / Invited
• [Presentation] The Diagnosis and Clinical Burden of Chronic Cough (2015)
  • Author(s): Akio Niimi
  • Organizer: ERS International Congress 2015 Symposium: : Cough: a Major Problem in Lung Disease
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2015-09-26
  • Int'l Joint Research / Invited
• [Presentation] Refractory Cough in Adult Asthma (2015)
  • Author(s): Akio Niimi
  • Organizer: The 25th Congress of Interasma Japan / North Asia シンポジウム
  • Place of Presentation: ホテルニューグランド（神奈川県、横浜市）
  • Year and Date: 2015-09-03
  • Int'l Joint Research / Invited
• [Presentation] 喘息の難治化をめぐる最新の話題：難治化のメカニズム (2015)
  • Author(s): 新実彰男
  • Organizer: 第46回日本職業・環境アレルギー学会総会・学術大会 イブニングセミナー
  • Place of Presentation: 東京大学伊藤国際学術研究センター（東京都、文京区）
  • Year and Date: 2015-07-03
  • Invited
• [Presentation] 吸入ステロイド薬の使い分け (2015)
  • Author(s): 新実彰男
  • Organizer: 第64回日本アレルギー学会学術大会 教育講演
  • Place of Presentation: グランドプリンスホテル新高輪（東京都、港区）
  • Year and Date: 2015-05-27
  • Invited
• [Presentation] 高齢者喘息の病態と治療―COPD合併喘息 (ACOS) への対応を含めてー (2015)
  • Author(s): 新実彰男
  • Organizer: 第55回日本呼吸器学会学術講演会 教育セミナー
  • Place of Presentation: 東京国際フォーラム（東京都、千代田区）
  • Year and Date: 2015-04-17
  • Invited
• [Presentation] 咳の病態と治療：Anatomic diagnostic paradigmからCough hypersensitivity syndromeへ (2015)
  • Author(s): 新実彰男
  • Organizer: 第55回日本呼吸器学会学術講演会 教育講演
  • Place of Presentation: 東京国際フォーラム（東京都、千代田区）
  • Year and Date: 2015-04-17
  • Invited
• [Presentation] 喘息長期管理における長時間作用性気管支拡張薬の現状と展望 (2015)
  • Author(s): 新実彰男
  • Organizer: 第29回日本医学会総会 2015関西 教育セミナー
  • Place of Presentation: 国立京都国際会館他（京都府、京都市）
  • Year and Date: 2015-04-10
  • Invited
• [Presentation] Recognizing Small Airway Dysfunction by Impulse Oscillometry and Exhaled Nitric Oxide in Asthmatics (2014)
  • Author(s): Akio Niimi
  • Organizer: WAO International Scientific Conference 2014
  • Place of Presentation: Rio de Janeiro (Brazil)
  • Year and Date: 2014-12-06 – 2014-12-09
  • Invited
• [Presentation] Chronic Cough in Adults: Anatomic Diagnostic Protocol and Beyond (2014)
  • Author(s): Akio Niimi
  • Organizer: 2014小児アレルギー学会
  • Place of Presentation: 四日市都ホテル（三重県四日市市）
  • Year and Date: 2014-11-08 – 2014-11-09
  • Invited
• [Presentation] Novel Advances in Cough Variant Asthma (2014)
  • Author(s): Akio Niimi
  • Organizer: The 24th Congress of Interasma Japan / North Asia
  • Place of Presentation: ウィンク愛知（愛知県名古屋市）
  • Year and Date: 2014-07-18 – 2014-07-19
  • Invited
• [Presentation] Evidence for Neuropathic Process in Chronic Cough (2014)
  • Author(s): Akio Niimi
  • Organizer: 8th London International Cough Symposium 2014
  • Place of Presentation: London (UK)
  • Year and Date: 2014-06-26 – 2014-06-28
  • Invited
• [Presentation] 抗体療法の役割と抗IgE療法の位置付け (2014)
  • Author(s): 新実彰男
  • Organizer: 第54回日本呼吸器学会
  • Place of Presentation: 大阪国際会議場（大阪市、大阪府）
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] 抗体療法の役割と抗IgE療法の位置づけ (2014)
  • Author(s): 新実彰男
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場、大阪市
  • Invited
• [Presentation] 成人喘息とOne Airway, One Disease (2013)
  • Author(s): 新実彰男
  • Organizer: 第63回日本アレルギー学会秋季学術大会
  • Place of Presentation: ホテルニューオータニ、東京都
  • Invited
• [Presentation] Asthma/Eosinophilic Bronchitis and Atopic Cough:Overlap Syndromes or Distinct Disease? (2013)
  • Author(s): Akio Niimi
  • Organizer: 1st International cough conference
  • Place of Presentation: Dong Fang Hotel, Guangzhou, China
  • Invited
• [Presentation] Cough, Asthma, and Cysteinyl-Leukotrienes (2013)
  • Author(s): Akio Niimi
  • Organizer: The 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: パシフィコ横浜、横浜市
  • Invited
• [Presentation] Pro-Con session: Cough in asthma is due to eosinophilic airway inflammation.” (2013)
  • Author(s): Akio Niimi
  • Organizer: 4th American Cough Conference
  • Place of Presentation: Affinia Manhattan Hotel, New York, USA
  • Invited
• [Presentation] Pathogenesis and Pathophysiologic Roles of Airway Remodeling in Asthma (2013)
  • Author(s): Akio Niimi
  • Organizer: Asia Pacific Congress of Asthma, Allergy and Clinical Immunology 2013
  • Place of Presentation: Taipei International Convention Center, Taipei, Taiwan
  • Invited
• [Presentation] 成人喘息のフェノタイプ：炎症部位、サブタイプを中心に (2013)
  • Author(s): 新実彰男
  • Organizer: 第25回日本アレルギー学会春期臨床大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Invited
• [Presentation] 喘息の多様性に応じた 治療戦略 (2013)
  • Author(s): 新実彰男
  • Organizer: 第53回日本呼吸器学会総会
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Invited
• [Presentation] 難治性喘息の治療戦略 (2013)
  • Author(s): 新実彰男
  • Organizer: 第53回日本呼吸器学会総会
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Invited
• [Presentation] 咳喘息 (2013)
  • Author(s): 新実彰男
  • Organizer: 第53回日本呼吸器学会総会
  • Place of Presentation: 東京国際フォーラム（東京都）
  • Invited
• [Presentation] Pathogenesis and pathophysiologic relevance of airway remodeling in asthma (2013)
  • Author(s): Akio Niimi
  • Organizer: 2013 Asia Pacific Congress of Allergy, Asthma and Clinical Immunology (APCAACI 2013)
  • Place of Presentation: 台北（台湾）
  • Invited
• [Presentation] 喘息における気道リモデリングの 成因と病態生理学的意義 (2012)
  • Author(s): 新実彰男
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫県）
  • Invited
• [Presentation] 喘息における気道リモデリングの成因と 病態生理学的意義 (2011)
  • Author(s): 新実彰男
  • Organizer: 第48回日本小児アレルギー学会(招待講演)
  • Place of Presentation: 福岡国際会議場
• [Book] 医学書院 (2017)
  • Author(s): 新実彰男（分担執筆）
  • Publisher: 「今日の治療指針」2017年版
• [Book] 内科学 第11版 (2016)
  • Author(s): 新実彰男（分担執筆）
  • Publisher: 朝倉書店
• [Book] 新呼吸器専門医テキスト (2015)
  • Author(s): 新実彰男（分担執筆）
  • Total Pages: 598
  • Publisher: 南江堂
• [Book] 喘息予防・管理ガイドライン2015 (2015)
  • Author(s): 新実彰男（分担執筆）
  • Total Pages: 317
  • Publisher: 協和企画
• [Book] 診療ガイドラインUP-TO-DATE 2014-2015 (2014)
  • Author(s): 新実彰男
  • Total Pages: 935
  • Publisher: メディカルレビュー社
• [Book] わかりやすい内科学 (2014)
  • Author(s): 新実彰男
  • Total Pages: 992
  • Publisher: 文光堂
• [Book] わかりやすい内科学 第4版 (2014)
  • Author(s): 新実彰男
  • Total Pages: 992
  • Publisher: 文光堂
• [Book] 診療ガイドラインUP-TO-DATE 2014-2015. (2014)
  • Author(s): 新実彰男
  • Total Pages: 935
  • Publisher: メディカルレビュー社
• [Book] 長引く咳の治療指針 (2013)
  • Author(s): 新実彰男
  • Total Pages: 201
  • Publisher: 総合医学社
• [Book] 咳嗽に関するガイドライン第2版 (2012)
  • Author(s): 日本呼吸器学会「咳嗽に関するガイドライン第2版」作成委員会（河野茂 (委員長)、岡田 賢司、新実 彰男ほか
  • Total Pages: 104
  • Publisher: メディカルレビュー社
• [Book] 「今日の治療指針 2011版」 (2011)
  • Author(s): 新実彰男
  • Total Pages: 1978
  • Publisher: 医学書院
• [Remarks] 名古屋市立大学大学院医学研究科 呼吸器・免疫アレルギー内科学
  • URL: http://ncu-intern2.jp/
• [Remarks] 呼吸器・アレルギー内科グループ ＞ 研究
  • URL: http://ncu-intern2.jp/group/respirology/research.html
• [Remarks] 名古屋市立大学大学院医学研究科 呼吸器・免疫アレルギー内科学 呼吸器グループ業績集
  • URL: http://ncu-intern2.jp/group/respirology/performance_2010.html