Establishment of the comprehensive medical treatment strategy of chronic obstructive pulmonary disease based on the concept of cardio-pulmonary connection
Project/Area Number |
23591123
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Osaka City University |
Principal Investigator |
KANAZAWA HIROSHI 大阪市立大学, 医学(系)研究科(研究院), 准教授 (90332957)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 閉塞性肺疾患 / 肺血管リモデリング / 左室拡張障害 / 肺過膨張 / 慢性閉塞性肺疾患 / 血管弾性能 |
Research Abstract |
We comprehensively examined the physiologic lung function and right and left ventricular function in patients with chronic obstructive pulmonary disease (COPD), and established the rationale of the concept of cardio-pulmonary connection. Subsequently, we identified the selective biomarker which can be sensitively reflected this concept. Furthermore, we determined the candidate gene which specifies the dynamics of pulmonary circulation in patients with COPD. And the drug selection in consideration of the improvement of right and left ventricular function was introduced on medical treatment strategy based on the concept of heart-and-lung connection. We newly demonstrated the theory for realizing improvement in the exercise capacity resulting from the efficient oxygen transport ability to the peripheral muscles.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] 気管支喘息患者における喀痰中ペントラキシン3(PTX3)の検討
Author(s)
今橋由美子, 浅井一久, 井尻尚樹, 武田倫子, 玉垣学也, 吉井直子, 一丸之寿, 栩野吉弘, 鴨井 博, 金澤 博, 平田一人
Organizer
第62回日本アレルギー学会秋季学術大会
Place of Presentation
大阪国際会議場
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