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Role of oxysterols on pathogenesis of chronic obstructive pulmoanry disease

Research Project

Project/Area Number 23591126
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University (2012-2013)
Wakayama Medical University (2011)

Principal Investigator

SUGIURA HISATOSHI  東北大学, 大学病院, 講師 (20445092)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsオキシステロール / 慢性閉塞性肺疾患 / 肺線維芽細胞 / 組織改変 / 炎症性メディエーター / 酸化ストレス / 活性窒素種 / 幹細胞 / 組織修復 / 細胞老化 / 酸化コレステロール / リモデリング
Research Abstract

We have demonstrated that much oxysterols are produced in the lungs and airways of the patients with COPD and the levels are correlated with their pulmonary function in the current study. We have also shown that oxysterols have potent profibrotic effects of lung tissues, neutrophilic inflammation, and amplification of Toll-like receptor signaling which are pivotal roles on the pathogenesis of COPD. These findings suggest that oxysterols could be involved in the development and/or progression of COPD.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (85 results)

All 2013 2012 2011

All Journal Article (57 results) (of which Peer Reviewed: 36 results) Presentation (25 results) (of which Invited: 3 results) Book (3 results)

  • [Journal Article] 25-Hydroxycholesterol Promotes Fibroblast-Mediated Tissue Remodeling Through NF-kB Dependent Pathway2013

    • Author(s)
      Ichikawa T, Sugiura H, Koarai A, Kikuchi T, Hiramatsu M, Kawabata H, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
    • Journal Title

      Exp Cell Res

      Volume: 319 Pages: 1176-1186

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Difference in time-course of improvement in asthma control measures between budesonide and budesonide/ formoterol2013

    • Author(s)
      Matsunaga K, Kawabata H, Hirano T, Sugiura H, Minakata Y, Ichinose M
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 26 Pages: 189-194

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A review of the long-term safety, efficacy and patient acceptability of the tulobuterol patch2013

    • Author(s)
      Ichikawa T, Sugiura H
    • Journal Title

      Research and Reports in Transdermal Drug Delivery

      Volume: 2 Pages: 9-18

    • URL

      https://www.dovepress.com/research-and-reports-in-transdermal-drug-delivery-i820-j142

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Persistent elevation of exhaled nitric oxide and modification of corticosteroid therapy in asthma2013

    • Author(s)
      Hirano T, Matsunaga K, Sugiura H, Minakata Y, Koarai A, Akamatsu K, Ichikawa T, Furukawa K, Ichinose M
    • Journal Title

      Respir Investig

      Volume: 51 Pages: 84-91

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between alveolar nitric oxide concentration in exhaled air and small airway function in COPD.2013

    • Author(s)
      T. Hirano, H. Sugiura et al.
    • Journal Title

      J Breath Res

      Volume: 7 Issue: 4 Pages: 046002-046002

    • DOI

      10.1088/1752-7155/7/4/046002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【気管支喘息の研究アップデート】気管支喘息のバイオマーカーをめぐって2013

    • Author(s)
      杉浦久敏、一ノ瀬正和
    • Journal Title

      アレルギー・免疫

      Volume: 20 Pages: 972-982

    • Related Report
      2013 Final Research Report
  • [Journal Article] 気管支喘息とCOPDの合併気管支喘息とCOPD合併の診断2013

    • Author(s)
      赤松啓一郎、松永和人、杉浦久敏、小荒井晃、平野綱彦、南方良章、一ノ瀬正和
    • Journal Title

      呼吸

      Volume: 32 Pages: 753-755

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【変貌する肺の生活習慣病COPD-早期診断で併存症にも好影響】疾患理解の変遷炎症とCOPD2013

    • Author(s)
      杉浦久敏
    • Journal Title

      Modern Physician

      Volume: 33 Pages: 1335-1340

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【活性酸素-基礎から病態解明・制御まで】疾患病態・臨床編慢性閉塞性肺疾患と酸化・ニトロ化ストレス2013

    • Author(s)
      杉浦久敏、一ノ瀬正和
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 863-869

    • Related Report
      2013 Final Research Report
  • [Journal Article] Difference in time-course of improvement in asthma control measures between budesonide and budesonide/formoterol2013

    • Author(s)
      Matsunaga K
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 26 Issue: 2 Pages: 189-194

    • DOI

      10.1016/j.pupt.2012.10.006

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 25-Hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway2013

    • Author(s)
      Tomohiro Ichikawa
    • Journal Title

      Experimental Cell Research

      Volume: 319 Issue: 8 Pages: 1176-1186

    • DOI

      10.1016/j.yexcr.2013.02.014

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Persistent elevation of exhaled nitric oxide and modification of corticosteroid therapy in asthma.2013

    • Author(s)
      T. Hirano, H. Sugiura et al.
    • Journal Title

      Respir Invest

      Volume: 51 Issue: 2 Pages: 84-91

    • DOI

      10.1016/j.resinv.2013.01.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【気管支喘息の研究 アップデート】 気管支喘息のバイオマーカーをめぐって2013

    • Author(s)
      杉浦久敏、他
    • Journal Title

      アレルギー・免疫

      Volume: 20 Pages: 972-982

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 気管支喘息とCOPDの合併 気管支喘息とCOPD合併の診断2013

    • Author(s)
      赤松啓一郎、杉浦久敏、他
    • Journal Title

      呼吸

      Volume: 32 Pages: 735-755

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 【変貌する肺の生活習慣病COPD-早期診断で併存症にも好影響】 疾患理解の変遷 炎症とCOPD2013

    • Author(s)
      杉浦久敏
    • Journal Title

      Modern Physician

      Volume: 33 Pages: 1335-1340

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 【活性酸素-基礎から病態解明・制御まで】 疾患病態・臨床編 慢性閉塞性肺疾患と酸化・ニトロ化ストレス2013

    • Author(s)
      杉浦久敏、他
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 863-869

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease2012

    • Author(s)
      Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Yanagisawa S, Furusawa M, Uno Y, Yamasaki M, Satomi Y, Ichinose M
    • Journal Title

      Respirology

      Volume: 17 Pages: 533-540

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts2012

    • Author(s)
      Sugiura H, Kawabata H, Ichikawa T, Koarai A, Yanagisawa S, Kikuchi T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Furukawa K, Ichinose M
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics2012

    • Author(s)
      Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M
    • Journal Title

      Clin Exp Allergy

      Volume: 42 Pages: 775-781

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells2012

    • Author(s)
      Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
    • Journal Title

      Respir Res

      Volume: 13 Issue: 1 Pages: 63-63

    • DOI

      10.1186/1465-9921-13-63

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages2012

    • Author(s)
      Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
    • Journal Title

      Respirology

      Volume: 17 Pages: 1018-1025

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease : possible role of 27-hydroxycholesterol in tissue fibrosis2012

    • Author(s)
      Kikuchi T, Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Yanagisawa S, Furukawa K, Kawabata H, Ichinose M
    • Journal Title

      Chest

      Volume: 142 Pages: 329-337

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of the triaxial accelerometer for the evaluation of physical activity in Japanese patients with COPD2012

    • Author(s)
      Kanda M, Minakata Y, Matsunaga K, Sugiura H, Hirano T, Koarai A, Akamatsu K, Ichikawa T, Ichinose M
    • Journal Title

      Intern Med

      Volume: 51 Pages: 369-75

    • NAID

      130002062007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【呼吸器疾患バイオマーカーの新展開】COPD2012

    • Author(s)
      杉浦久敏
    • Journal Title

      呼吸

      Volume: 11 Pages: 1019-1027

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 【COPD:診断と治療の進歩】治療抗コリン薬2012

    • Author(s)
      杉浦久敏、一ノ瀬正和
    • Journal Title

      日本内科学会雑誌

      Volume: 101 Pages: 1594-1600

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【最近10年間で最も進歩した研究分野を検証する】呼気分析2012

    • Author(s)
      杉浦久敏
    • Journal Title

      呼吸

      Volume: 9 Pages: 822-826

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] 【COPD薬物療法の新展開】薬物の特徴と使用法気管支拡張薬2012

    • Author(s)
      杉浦久敏
    • Journal Title

      Medicinal

      Volume: 2 Pages: 72-82

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【呼吸器病学TOPICS 2012】閉塞性肺疾患気管支喘息とCOPDのバイオマーカー2012

    • Author(s)
      杉浦久敏
    • Journal Title

      分子呼吸器病

      Volume: 16 Pages: 42-46

    • Related Report
      2013 Final Research Report
  • [Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease: possible role of 27-hydroxycholesterol in tissue fibrosis.2012

    • Author(s)
      Kikuchi T, Sugiura H et al.
    • Journal Title

      Chest

      Volume: 142 Pages: 329-337

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts.2012

    • Author(s)
      Sugiura H
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 302 Issue: 8 Pages: 764-774

    • DOI

      10.1152/ajplung.00342.2011

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease.2012

    • Author(s)
      Sugiura H et al.
    • Journal Title

      Respirology

      Volume: 17 Issue: 3 Pages: 533-540

    • DOI

      10.1111/j.1440-1843.2012.02136.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of the triaxial accelerometer for the evaluation of physical activity in Japanese patients with COPD.2012

    • Author(s)
      Kanda M, Minakata Y, Matsunaga K, Sugiura H et al.
    • Journal Title

      Intern Med

      Volume: 51 Pages: 369-375

    • NAID

      130002062007

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics.2012

    • Author(s)
      Matsunaga K
    • Journal Title

      Clin Exp Allergy

      Volume: 42 Issue: 5 Pages: 775-781

    • DOI

      10.1111/j.1365-2222.2011.03945.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages.2012

    • Author(s)
      Koarai A
    • Journal Title

      Respirology

      Volume: 17 Issue: 6 Pages: 1018-1025

    • DOI

      10.1111/j.1440-1843.2012.02198.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells.2012

    • Author(s)
      Koarai A, Yanagisawa S, Sugiura H et al.
    • Journal Title

      Respir Res

      Volume: 13 Pages: 63-63

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【COPD薬物療法の新展開】 薬物の特徴と使用法 気管支拡張薬2012

    • Author(s)
      杉浦久敏
    • Journal Title

      Medicinal

      Volume: 2 Pages: 72-82

    • Related Report
      2012 Research-status Report
  • [Journal Article] 【呼吸器病学TOPICS 2012】 閉塞性肺疾患 気管支喘息とCOPDのバイオマーカー2012

    • Author(s)
      杉浦久敏
    • Journal Title

      分子呼吸器病

      Volume: 16 Pages: 42-46

    • Related Report
      2012 Research-status Report
  • [Journal Article] 【COPD:診断と治療の進歩】治療 抗コリン薬2012

    • Author(s)
      杉浦久敏、一ノ瀬正和
    • Journal Title

      日本内科学会雑誌

      Volume: 101 Pages: 1594-1600

    • Related Report
      2012 Research-status Report
  • [Journal Article] Ichinose M. Nitrative stress in inflammatory lung diseases2011

    • Author(s)
      Sugiura H
    • Journal Title

      Nitric Oxide

      Volume: 25 Pages: 138-144

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-4 induces differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells2011

    • Author(s)
      Sato T, Liu X, Basma H, Togo S, Sugiura H, Nelson A, Nakanishi M, Kanaji N, Wang X, Kim M, Li Y, Michalski J, Farid M, Sharp JG, Rennard SI
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Pages: 1595-1603

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of embryonic stem cells into fibroblast-like cells in three-dimensional type I collagen gel cultures2011

    • Author(s)
      Togo S, Sato T, Sugiura H, Wang X, Basma H, Nelson A, Liu X, Barger TW, Sharp JP, Rennard SI
    • Journal Title

      In Vitro Cell Dev Biol Anim

      Volume: 47 Pages: 114-124

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of nitrosative stress in patients with eosinophilic pneumonia2011

    • Author(s)
      Furukawa K, Koarai A, et al.
    • Journal Title

      Respir Res

      Volume: 12 Issue: 1 Pages: 81-91

    • DOI

      10.1186/1465-9921-12-81

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exhaled Nitric Oxide Cutoff Values for Asthma Diagnosis According to Rhinitis and Smoking Status in Japanese Subjects2011

    • Author(s)
      Matsunaga K, Hirano T, Akamatsu K, Koarai A, Sugiura H, Minakata Y, Ichinose M
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 331-337

    • NAID

      130004723045

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of Airflow Limitation by Fluticasone Propionate/Salmeterol in Chronic Obstructive Pulmonary Disease : What is the Specific Marker?2011

    • Author(s)
      Akamatsu K, Koarai A, et al.
    • Journal Title

      Front Pharmacol

      Volume: 2 Pages: 36-41

    • DOI

      10.3389/fphar.2011.00036

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of a Compact Motion Sensor for the Measurement of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease2011

    • Author(s)
      Sugino A, Minakata Y, Kanda M, Akamatsu K, Koarai A, Hirano T, Sugiura H, Matsunaga K, Ichinose M
    • Journal Title

      Respiration

      Volume: 83 Pages: 300-307

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 気管支喘息のバイオマーカー2011

    • Author(s)
      平野綱彦、杉浦久敏
    • Journal Title

      救急医学

      Volume: 35 Pages: 572-575

    • Related Report
      2013 Final Research Report
  • [Journal Article] 線維芽細胞分化と呼吸器疾患2011

    • Author(s)
      杉浦久敏
    • Journal Title

      呼吸

      Volume: 30 Pages: 684-691

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] COPDの自然歴をめぐって海外で行われた多施設共同研究の成果から2011

    • Author(s)
      杉浦久敏
    • Journal Title

      呼吸

      Volume: 30 Pages: 827-828

    • Related Report
      2013 Final Research Report
  • [Journal Article] Nitrative stress in inflammatory lung diseases.2011

    • Author(s)
      Sugiura H et al.
    • Journal Title

      Nitric Oxide

      Volume: 25 Pages: 138-144

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differentiation of embryonic stem...2011

    • Author(s)
      Togo S, Sugiura H et al.
    • Journal Title

      In Vitro Cell Dev Biol Anim

      Volume: 47 Pages: 114-124

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-4 induces differentiation of human...2011

    • Author(s)
      Sato T, Sugiura H et al.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 127 Pages: 1595-1603

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increase of nitrosative stress in...2011

    • Author(s)
      Furukawa K, Sugiura H et al.
    • Journal Title

      Respir Res

      Volume: 12 Pages: 81-81

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Exhaled nitric oxide cutoff values for...2011

    • Author(s)
      Matsunaga K, Sugiura H et al.
    • Journal Title

      Allergol Int

      Volume: 60 Pages: 331-337

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of airflow limitation by...2011

    • Author(s)
      Akamatsu K, Sugiura H et al.
    • Journal Title

      Front Pharmacol

      Volume: 2 Pages: 36-36

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of a Compact Motion Sensor for...2011

    • Author(s)
      Sugino A, Sugiura H et al.
    • Journal Title

      Respiration

      Volume: 83 Pages: 300-307

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 高齢者で合併率が高いCOPDと喘息を鑑別する鍵とは2011

    • Author(s)
      杉浦久敏
    • Journal Title

      Medical Tribune

      Volume: 44 Pages: 14-14

    • Related Report
      2011 Research-status Report
  • [Journal Article] 第60回日本アレルギー学会秋季学術大会より トピックス2011

    • Author(s)
      杉浦久敏
    • Journal Title

      日経メディカル特別編集版

      Volume: 2 Pages: 33-34

    • Related Report
      2011 Research-status Report
  • [Presentation] 閉塞性肺疾患の多様性とフェノタイプバイオマーカー2013

    • Author(s)
      杉浦久敏
    • Organizer
      第53回日本呼吸器学会総会
    • Place of Presentation
      東京(シンポジウム)
    • Year and Date
      2013-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 閉塞性肺疾患の多様性とフェノタイプ バイオマーカー2013

    • Author(s)
      杉浦久敏
    • Organizer
      第53回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Theophylline inhibits peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts2012

    • Author(s)
      H. Sugiura, H. Kawabata, et al.
    • Organizer
      107^<th> American Thoracic Society International Conference
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2012-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢者喘息とCOPDの類似点・相違点疫学2012

    • Author(s)
      杉浦久敏
    • Organizer
      第24回日本アレルギー学会総会春季臨床大会
    • Place of Presentation
      大阪(ワークショップ)
    • Year and Date
      2012-05-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Theophyllineによるmatrix metalloproteinase(MMP)の抑制作用について2012

    • Author(s)
      杉浦久敏,川端宏樹,市川朋宏,小荒井晃,菊池崇史,南方良章,松永和人,中西正典,平野綱彦,赤松啓一郎,一ノ瀬正和
    • Organizer
      第52回日本呼吸器学会総会
    • Place of Presentation
      神戸(一般演題)
    • Year and Date
      2012-04-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 加齢と呼吸器疾患、機能と構造から加齢とCOPD・喘息Overlapping症候群2012

    • Author(s)
      杉浦久敏
    • Organizer
      第52回日本呼吸器学会総会
    • Place of Presentation
      神戸(シンポジウム)
    • Year and Date
      2012-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 加齢と呼吸器疾患、機能と構造から 加齢とCOPD・喘息Overlapping症候群、機能と構造2012

    • Author(s)
      杉浦久敏
    • Organizer
      第52回日本呼吸器学会総会(シンポジウム)
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Theophyllineによるmatrix metalloproteinase(MMP)の抑制作用について2012

    • Author(s)
      杉浦久敏
    • Organizer
      第52回日本呼吸器学会総会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 高齢者喘息とCOPDの類似点・相違点 疫学2012

    • Author(s)
      杉浦久敏
    • Organizer
      第24回日本アレルギー学会総会春季臨床大会(ワークショップ)
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Theophylline Inhibits Peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts.2012

    • Author(s)
      Sugiura H et al.
    • Organizer
      107th American Thoracic Society International Conference
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 活性窒素種によるリモデリングに対するテオフィリンの効果について2011

    • Author(s)
      杉浦久敏,市川朋宏,小荒井晃,一ノ瀬正和
    • Organizer
      第61回日本アレルギー学会総会秋季学術大会
    • Place of Presentation
      東京(一般演題)
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 喘息コントロールの向上のための課題と対策気道炎症をどうモニタリングするか2011

    • Author(s)
      杉浦久敏
    • Organizer
      第61回日本アレルギー学会総会秋季学術大会
    • Place of Presentation
      東京(シンポジウム)
    • Year and Date
      2011-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Ichinose. Nitrative stress in refractory asthma2011

    • Author(s)
      H. Sugiura, A. Koarai, M
    • Organizer
      2011 AAAS and AP Airway Disease Summit
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Possible role of 25-hydroxycholesterol in the pathogenesis of chronic obstructive pulmonary disease2011

    • Author(s)
      H. Sugiura, A. Koarai, et al.
    • Organizer
      2011 The 22^<th> European Respiratory Society Annual Congress
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2011-09-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Increase of 25-hydroxycholesterol in the lungs of chronic obstructive pulmonary disease2011

    • Author(s)
      H. Sugiura, A. Koarai, et al.
    • Organizer
      106^<th> American Thoracic Society International Conference
    • Place of Presentation
      Denver, USA
    • Year and Date
      2011-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] COPD患者における25-OH cholesterolの産生について2011

    • Author(s)
      杉浦久敏,市川朋宏,小荒井晃,一ノ瀬正和
    • Organizer
      第51回日本呼吸器学会総会
    • Place of Presentation
      東京(一般演題)
    • Year and Date
      2011-04-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 難治性喘息の病態バイオマーカー2011

    • Author(s)
      杉浦久敏
    • Organizer
      第51回日本呼吸器学会総会
    • Place of Presentation
      東京(シンポジウム)
    • Year and Date
      2011-04-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性閉塞性肺疾患における窒素化ストレスの役割の研究2011

    • Author(s)
      杉浦久敏,一ノ瀬正和
    • Organizer
      第1回分子水素状シンポジウム
    • Place of Presentation
      名古屋(シンポジウム)
    • Year and Date
      2011-02-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Increase of 25-hydroxycholesterol in the lungs...2011

    • Author(s)
      Sugiura H et al.
    • Organizer
      2011 ATS International Conference
    • Place of Presentation
      米国デンバー
    • Related Report
      2011 Research-status Report
  • [Presentation] Increase of 25-hydroxycholesterol in the lungs...2011

    • Author(s)
      Sugiura H et al.
    • Organizer
      2011 ERS Annual Congress
    • Place of Presentation
      オランダアムステルダム
    • Related Report
      2011 Research-status Report
  • [Presentation] Nitrative stress in refractory asthma.2011

    • Author(s)
      Sugiura H et al.
    • Organizer
      2011 AAAS and AP Airway Disease Summit
    • Place of Presentation
      台湾台北
    • Related Report
      2011 Research-status Report
  • [Presentation] 難治性喘息の病態. バイオマーカー2011

    • Author(s)
      杉浦久敏
    • Organizer
      第51回日本呼吸器学会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 喘息コントロール向上のための課題と対策2011

    • Author(s)
      杉浦久敏
    • Organizer
      第61回日本アレルギー学会秋季学術大会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] COPD患者における25-OH cholesterolの産生について2011

    • Author(s)
      杉浦久敏
    • Organizer
      第51回日本呼吸器学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 活性窒素種によるリモデリングに対するテオフィリンの効果について2011

    • Author(s)
      杉浦久敏
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] Nitric oxide in health and disease. Respiratory System. In Nitric Oxide Synthase Inhibitors : From Animal Studies to Clinical Implications. B. Tunctan, S. Cuzzocrea, M. Yokoyama Edit2012

    • Author(s)
      H. Sugiura, M. Ichinose
    • Publisher
      Transworld Research Network Inc
    • Related Report
      2013 Final Research Report
  • [Book] Annual Review呼吸器2012

    • Author(s)
      杉浦久敏
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] 実験医学増刊2012

    • Author(s)
      杉浦久敏, 一ノ瀬正和
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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