| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
The prevalence of depression and sleep disorder in patients with COPD was significantly higher than in the controls, and the relative risk of depression and sleep disorder in COPD was 7.6 and 1.8-folds, respectively. The COPD patients with depression had significantly more frequent exacerbations and hospitalizations than those without depression or sleep disorder.
The plasma 5-hydroxyindole acetic acid (5-HIAA), metabolite of serotonin, level in depressed COPD patients was significantly higher than in non-depressed COPD patients and non-smokers, but not smokers. The plasma 5-HIAA level was significantly associated with the severity of depression in patients with COPD.
The management for depression and sleep disorder is necessary in patients with COPD, and the measurement of plasma 5-HIAA levels may be helpful to detect the depression in patients with COPD.
|
