Identification of causative fungi for interstitial pneumonias due to home/work environments

• Project/Area Number: 23591140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MIYAZAKI Yasunari 東京医科歯科大学, 学生支援・保健管理機構, 教授 (30396999)
• Co-Investigator(Kenkyū-buntansha): SUGITA Takashi 明治薬科大学, 薬学部, 准教授 (10312076) ; EISHI Yoshinobu 東京医科歯科大学, 医歯学総合研究科, 教授 (70151959)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 過敏性肺炎 / 真菌 / 住居関連過敏性肺炎

Research Abstract

Home-related hypersensitivity pneumonitis (HRHP) is an interstitial pneumonia mainly caused by fungi in the environment, including home and working place. In the present study, we have evaluated fungus DNA of the bronchoalveolar lavage fluid (BALF) and titer of antibodies of fungi. Trichosporon asahii or T. mucoides have been thought to be most frequent antigens of HP, however various fungi were causative in HRHP. We have shown that analyses of fungus DNA in BALF and measurement of fungus antibodies are useful in diagnosis of HRHP. These results should be helpful to perform antigen avoidance and leading to improve prognosis of the disease.

Research Products

• [Journal Article] Serodiagnosis of Mycobacterium avium complex pulmonary disease in rheumatoid arthritis. (2014)
  • Author(s): Komazaki Y, Miyazaki Y, Fujie T, Sakashita H, Tsuchiya K, Tamaoka M, Sumi Y, Maruyama Y, Nanki T, Inase N.
  • Journal Title: Respiration Volume: 87 Issue: 2 Pages: 129-135
  • DOI: 10.1159/000354791
  • Peer Reviewed
• [Journal Article] 気腫を伴う慢性過敏性肺炎の臨床的検討 (2014)
  • Author(s): 尾形朋之 土屋公威 石塚聖洋 岡本師 白井剛 増尾昌宏 筒井俊晴 坂下博之 宮崎泰成 稲瀬直彦
  • Journal Title: 日呼吸誌 Volume: 3 Pages: 214-220
  • Peer Reviewed
• [Journal Article] Penicilliosis marneffei complicated with interstitial pneumonia. (2014)
  • Author(s): Furusawa H, Miyazaki Y, Sonoda S, Tsuchiya K, Yaguchi T, Kamei K. Inase N.
  • Journal Title: Intern Med Volume: 53 Pages: 321-323
  • NAID: 130003392652
  • Peer Reviewed
• [Journal Article] Higher serum CCL17 may be a promising predictor of acute exacerbations in chronic hypersensitivity pneumonitis (2013)
  • Author(s): Y Miyazaki, K Unoura, T Tateishi, T Akashi, T Takemura, M Tomita, N Inase, Y Yoshizawa
  • Journal Title: Respir Res Volume: Vol.14 Pages: 57-67
  • Peer Reviewed
• [Journal Article] A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan (2013)
  • Author(s): T Okamoto, Y Miyazaki, T Ogura, K Chida, N Kohno, S Kohno, H Taniguchi, S Akagawa, Y Mochizuki, K Yamauchi, H Takahashi, T Johkoh, S Homma, K Kishi, S Ikushima, S Konno, M Mishima, K Ohta, Y Nishioka, N Yoshimura, M Munakata, K Watanabe, Y Miyashita, N Inase
  • Journal Title: Respir Investig Volume: Vol.51 Pages: 191-199
  • Peer Reviewed
• [Journal Article] A familial history of pulmonary fibrosis in patients with chronic hypersensitivity pneumonitis (2013)
  • Author(s): T Okamoto T, Y Miyazaki, M Tomita, M Tamaoka, N Inase
  • Journal Title: Respiration Volume: Vol.85 Pages: 384-390
  • Peer Reviewed
• [Journal Article] 免疫学的機序からみた呼吸器疾患、3.過敏性肺炎の免疫反応2)慢性過敏性肺炎 (2013)
  • Author(s): 宮崎泰成
  • Journal Title: 日胸 Volume: Vol.72 Pages: 1328-1335
• [Journal Article] 抗トリコスポロン・アサヒ抗体 (2013)
  • Author(s): 宮崎泰成、稲瀬直彦
  • Journal Title: モダンメディア Volume: Vol.59 Pages: 11-17
• [Journal Article] Higher serum CCL17 may be a promising predictor of acute exacerbations in chronic hypersensitivity pneumonitis. (2013)
  • Author(s): Miyazaki Y, Unoura K, Tateishi T, Akashi T, Takemura T, Tomita M, Inase N, Yoshizawa Y.
  • Journal Title: Respir Res Volume: 14 Issue: 1 Pages: 57-67
  • DOI: 10.1186/1465-9921-14-57
  • Peer Reviewed
• [Journal Article] A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. (2013)
  • Author(s): Okamoto T, Miyazaki Y, Ogura T, Chida K, Kohno N, Kohno S, Taniguchi H, Akagawa S, Mochizuki Y, Yamauchi K, Takahashi H, Johkoh T, Homma S, Kishi K, Ikushima S, Konno S, Mishima M, Ohta K, Nishioka Y, Yoshimura N, Munakata M, Watanabe K, Miyashita Y, Inase N.
  • Journal Title: Respir Investig Volume: 51 Issue: 3 Pages: 191-199
  • DOI: 10.1016/j.resinv.2013.03.004
  • Peer Reviewed
• [Journal Article] 過敏性肺炎と肺サルコイドーシスの合併が疑われた３例 (2013)
  • Author(s): 古澤春彦 宮崎泰成 土屋公威 稲瀬直彦
  • Journal Title: 日サ会誌 Volume: 33 Pages: 127-132
  • NAID: 130004709420
  • Peer Reviewed
• [Journal Article] A familial history of pulmonary fibrosis in patients with chronic hypersensitivity pneumonitis. (2013)
  • Author(s): Okamoto T, Miyazaki Y, Tomita M, Tamaoka M, Inase N.
  • Journal Title: Respiration Volume: 85 Issue: 5 Pages: 384-390
  • DOI: 10.1159/000338123
  • Peer Reviewed
• [Journal Article] 特集真菌とアレルギー・炎症真菌と過敏性肺炎 (2012)
  • Author(s): 宮崎泰成、筒井俊晴、鵜浦康司、稲瀬直彦
  • Journal Title: 免疫・アレルギー Volume: Vol.72 Pages: 30-40
• [Journal Article] 総説過敏性肺炎の病態と治療 (2012)
  • Author(s): 宮崎泰成、岸雅人、見高恵子、安井牧人、仁多寅彦、稲瀬直彦
  • Journal Title: 呼吸 Volume: Vol.31 Pages: 101-115
• [Journal Article] 特集間質性肺疾患Up-To-Date過敏性肺炎:原因,病型,疾患進行の多様性 (2012)
  • Author(s): 宮崎泰成
  • Journal Title: THE LUNG perspectives Volume: Vol.20 Pages: 295-300
• [Journal Article] 特集/難治性びまん性肺疾患克服への取り組み慢性過敏性肺炎、呼吸と循環 (2012)
  • Author(s): 宮崎泰成、稲瀬直彦
  • Journal Title: 医学書院 Volume: Vol.60 Pages: 397-404
• [Journal Article] Proteome Analysis of Bronchoalveolar Lavage Fluid in Chronic Hypersensitivity Pneumonitis (2012)
  • Author(s): Okamoto T, Miyazaki Y, Shirahama R, Tamaoka M, Inase N.
  • Journal Title: Allergology International Volume: 61 Issue: 1 Pages: 83-92
  • DOI: 10.2332/allergolint.11-OA-0315
  • NAID: 130004873047
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Th1 and Th17 immune responses to viable Propionibacterium acnes in patients with sarcoidosis. (2012)
  • Author(s): Furusawa H
  • Journal Title: Respiratory investigation Volume: 50 Issue: 3 Pages: 104-109
  • DOI: 10.1016/j.resinv.2012.07.001
  • Peer Reviewed
• [Journal Article] Epithelial-Mesenchymal Transition in Chronic Hypersensitivity Pneumonitis. (2012)
  • Author(s): Yasui M, Miyazaki Y, Ishizuka M, Mitaka K, Unoura K, Tamaoka M, Sumi Y, Inase N.
  • Journal Title: J Med Dent Sci Volume: 59 Pages: 29-41
  • NAID: 130006943992
  • Peer Reviewed
• [Journal Article] A familial history of pulmonary fibrosis in patients with chronic hypersensitivity pneumonitis. (2012)
  • Author(s): Okamoto T, Miyazaki Y, Tomita M, Tamaoka M, Inase N.
  • Journal Title: Respiration Volume: in press
  • Peer Reviewed
• [Journal Article] Identification of fungal DNA in BALF from patients with home-related hypersensitivity pneumonitis (2011)
  • Author(s): K Unoura, Y Miyazaki, Y Sumi, M Tamaoka, T Sugita, N Inase
  • Journal Title: Respir Med Volume: Vol.105 Pages: 1696-1703
  • Peer Reviewed
• [Journal Article] Identification of fungal DNA in BALF from patients with home-related hypersensitivity pneumonitis. (2011)
  • Author(s): Unoura K, Miyazaki Y, Sumi Y, Tamaoka M, Sugita T, Inase N.
  • Journal Title: Respir Med Volume: 105 Issue: 11 Pages: 1696-1703
  • DOI: 10.1016/j.rmed.2011.07.009
  • Peer Reviewed
• [Presentation] シンポジウム１１ IPF治療におけるステロイド、免疫抑制薬の適否 特別発言 (2014)
  • Author(s): 宮崎泰成
  • Organizer: 第５４回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪（大阪国際会議場）
• [Presentation] Higher serum CCL17 may be a promising predictor of acute exacerbations in chronic hypersensitivity pneumonitis (2013)
  • Author(s): Y Miyazaki
  • Organizer: APSR Conference
  • Year and Date: 2013-11-13
• [Presentation] Serum Levels Of KL-6 And SP-D In Chronic Hypersensitivity Pneumonitis (2013)
  • Author(s): T Okamoto, Y Miyazaki, M Fujii, H Furusawa, T Tateishi, K Tsuchiya, T Fujie, M Tamaoka, H Sakashita, Yu Sumi, N Inase
  • Organizer: ATS 2013 International Conference
  • Place of Presentation: Philadelphia, USA
  • Year and Date: 2013-05-20
• [Presentation] 住居関連過敏性肺炎の検討 (2013)
  • Author(s): 駒崎義利、宮崎泰成、藤江俊秀、坂下博之、土屋公威、玉岡明洋、角勇樹、稲瀬直彦
  • Organizer: 第53回日本呼吸器学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-19
• [Presentation] シンポジウム８ 特発性肺線維症-治療を巡る新展開 1. ステロイド薬と免疫抑制薬 (2013)
  • Author(s): 宮崎泰成
  • Organizer: 第５３回日本呼吸器学会学術講演会
  • Place of Presentation: 東京（東京国際フォーラム）
• [Presentation] Proteomics Analysis Of BALF In Rheumatoid Arthritis Associated Interstitial Lung Disease With Usual Interstitial Pneumonia Pattern. (2013)
  • Author(s): Kozo Suhara, Yasunari Miyazaki, Tsukasa Okamoto, Tomoya Tateishi, Haruhiko Furusawa, Kimitake Tsuchiya, Toshihide Fujie, Meiyo Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
  • Organizer: American Thoracic Society
  • Place of Presentation: Philadelphia, USA
• [Presentation] Serum Levels Of KL-6 And SP-D In Chronic Hypersensitivity Pneumonitis. (2013)
  • Author(s): Tsukasa Okamoto, Yasunari Miyazaki, Mayumi Fujii, Haruhiko Furusawa, Tomoya Tateishi, Kimitake Tsuchiya, Toshihide Fujie, Meiyo Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
  • Organizer: American Thoracic Society
  • Place of Presentation: Philadelphia, USA
• [Presentation] Basophil Plays Anti-Fibrotic Role In Bleomycin Induced Lung Fibrosis. (2013)
  • Author(s): Tomoya Tateishi, Yasunari Miyazaki, Hajime Karasuyama, Naohiko Inase.
  • Organizer: American Thoracic Society
  • Place of Presentation: Philadelphia, USA
• [Presentation] Measurement Of Avian Antigen From The Environment Of Patients With Bird-Related Hypersensitivity Pneumonitis. (2013)
  • Author(s): Toshiharu Tsutsui, Yasunari Miyazaki, Tomoya Tateishi, Haruhiko Furusawa, Kimitake Tuchiya, Toshihide Fujie, Meiyou Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
  • Organizer: American Thoracic Society
  • Place of Presentation: Philadelphia, USA
• [Presentation] Basophils In A Murine Model Of Bird-Related Hypersensitivity Pneumonitis. (2013)
  • Author(s): Masahiro Ishizuka, Yasunari Miyazaki, Tomoya Tateishi, Haruhiko Furusawa, Kimitake Tsuchiya, Toshihide Fujie, Meiyo Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
  • Organizer: American Thoracic Society
  • Place of Presentation: Philadelphia, USA
• [Presentation] 過敏性肺炎における慢性・線維化病態に関する研究 (2013)
  • Author(s): 宮崎泰成
  • Organizer: 第33回日本サルコイドーシス／肉芽腫性疾患学会総会
  • Place of Presentation: 東京（東京医科歯科大学）
• [Presentation] Higher serum CCL17 may be a promising predictor of acute exacerbations in chronic hypersensitivity pneumonitis. (2013)
  • Author(s): Yasunari Miyazaki
  • Organizer: Asian Pacific Society of Respirology
  • Place of Presentation: 横浜（パシフィコ横浜）
• [Presentation] 住居関連過敏性肺炎(HRHP : home-related hypersensitivity pneumonitis)の検討 (2012)
  • Author(s): 駒崎義利、宮崎泰成、藤江俊秀、土屋公威、玉岡明洋、坂下博之、角勇樹、稲瀬直彦
  • Organizer: 第62回日本アレルギー学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-29
• [Presentation] 日常診療で過敏性肺炎を疑うポイント (2012)
  • Author(s): 宮崎泰成
  • Organizer: 第187回東京内科医会臨床研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-23
• [Presentation] A randomized, double-blind, multi-centered controlled trial of cyclosporine A vs. cyclophosphamide with corticosteroid in patients with idiopathic pulmonary fibrosis in Japan (2011)
  • Author(s): Y Miyazaki, A Azuma, N Inase, T Ogura, H Taniguchi, Y Yoshizawa, Y Sugiyama, S Kudoh
  • Organizer: ATS 2011 International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-16
• [Presentation] 住居関連過敏性肺炎におけるトリコスポロン特異抗体の検討 (2011)
  • Author(s): 鵜浦康司、宮崎泰成、藤井ゆみ、土屋公威、玉岡明洋、坂下博之、角勇樹、稲瀬直彦
  • Organizer: 第51回日本呼吸器学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-23
• [Presentation] A randomized, double-blind, multi-centered controlled trial of cyclosporine A vs. cyclophosphamide with corticosteroid in patients with idiopathic pulmonary fibrosis in Japan. (2011)
  • Author(s): Miyazaki Y, Azuma A, Inase N, Ogura T, Taniguchi H, Yoshizawa Y, Sugiyama Y, Kudoh S.
  • Organizer: American Thoracic Society
  • Place of Presentation: Denver, USA
• [Presentation] 過敏性肺炎における線維化機序
  • Author(s): 宮崎泰成
  • Organizer: アレルギー疾患先端治療研究会
  • Place of Presentation: 東京（ガーデンパレス）
• [Presentation] Inhalation Provocation Tests In Bird-Related Hypersensitivity Pneumonitis.
  • Author(s): Miyazaki Y, Tateishi T, Suhara K, Okamoto T, Unoura K, Inase N.
  • Organizer: American Thoracic Society Annual meeting
  • Place of Presentation: San Francisco
• [Book] Clinical focus series : Hypersensitivity pneumonitis, 9. Summer-type Hypersensitivity Pneumonitis (2013)
  • Author(s): Y Miyazaki, Y Yoshizawa, T Yamaguchi. Editor Om Sharma
  • Publisher: Jaypee Brothers Medical Publishers
• [Book] 免疫・アレルギー性疾患イラストレイテッドアレルギー性疾患過敏性肺炎 (2013)
  • Author(s): 宮崎泰成、稲瀬直彦
  • Publisher: 羊土社
• [Book] 過敏性肺炎今日の臨床サポート(電子書籍) (2013)
  • Author(s): 宮崎泰成
  • Publisher: エルゼビア・ジャパン
• [Book] 今日の臨床サポート（電子書籍） (2013)
  • Author(s): 宮崎泰成
  • Total Pages: 5
  • Publisher: エルゼビア・ジャパン
• [Book] 特発性間質性肺炎の治療と管理 (2013)
  • Author(s): 宮崎泰成 稲瀬直彦
  • Total Pages: 11
  • Publisher: 克誠堂出版
• [Book] 特発性肺線維症（IPF） (2013)
  • Author(s): 宮崎泰成 稲瀬直彦
  • Total Pages: 11
  • Publisher: 医療ジャーナル社
• [Book] 特発性間質性肺炎―この１０年の進歩と今後の展望－ (2013)
  • Author(s): 宮崎泰成 吉澤靖之
  • Total Pages: 8
  • Publisher: 克誠堂出版
• [Book] 免疫・アレルギー性疾患イラストレイテッド (2013)
  • Author(s): 宮崎泰成 稲瀬直彦
  • Total Pages: 2
  • Publisher: 羊土社
• [Book] 特集 肺線維症治療薬の現状 (2013)
  • Author(s): 宮崎泰成 稲瀬直彦
  • Total Pages: 10
  • Publisher: 克誠堂出版
• [Book] Clinical focus series: Hypersensitivity pneumonitis, 9. Summer-type Hypersensitivity Pneumonitis (2013)
  • Author(s): Yasunari Miyazaki, Yasuyuki Yoshizawa, Tetsuo Yamaguchi.
  • Total Pages: 177
  • Publisher: aypee Brothers Medical Publishers
• [Book] 間質性肺炎を究めるIII.特発性間質性肺炎以外の間質性肺炎過敏性肺炎 (2012)
  • Author(s): 宮崎泰成
  • Publisher: Medical View
• [Book] 特集 真菌とアレルギー・炎症 真菌と過敏性肺炎 (2012)
  • Author(s): 宮崎泰成 筒井俊晴 鵜浦康司 稲瀬直彦
  • Total Pages: 152
  • Publisher: 免疫・アレルギー
• [Book] 間質性肺炎を究める III. 特発性間質性肺炎以外の間質性肺炎 過敏性肺炎 (2012)
  • Author(s): 宮崎泰成
  • Total Pages: 303
  • Publisher: Medical View
• [Book] 疾患が読める！ 胸部X線画像診断アトラス 胸部X線読影の勘どころ 4．間質性肺疾患 (2012)
  • Author(s): 宮崎泰成
  • Total Pages: 252
  • Publisher: 中山書店
• [Book] ケアに役立つ呼吸器疾患ナーシング間質性肺炎/過敏性肺炎 (2011)
  • Author(s): 宮崎泰成
  • Publisher: 総合医学社
• [Book] 呼吸器研修医ノート第10章各疾患のみかたと対応F免疫が深く関与する肺疾患1.過敏性肺炎 (2011)
  • Author(s): 宮崎泰成
  • Publisher: 診断と治療社