Identification of causative fungi for interstitial pneumonias due to home/work environments
| Project/Area Number |
23591140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIYAZAKI Yasunari 東京医科歯科大学, 学生支援・保健管理機構, 教授 (30396999)
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| Co-Investigator(Kenkyū-buntansha) |
SUGITA Takashi 明治薬科大学, 薬学部, 准教授 (10312076)
EISHI Yoshinobu 東京医科歯科大学, 医歯学総合研究科, 教授 (70151959)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 過敏性肺炎 / 真菌 / 住居関連過敏性肺炎 |
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| Research Abstract |
Home-related hypersensitivity pneumonitis (HRHP) is an interstitial pneumonia mainly caused by fungi in the environment, including home and working place. In the present study, we have evaluated fungus DNA of the bronchoalveolar lavage fluid (BALF) and titer of antibodies of fungi. Trichosporon asahii or T. mucoides have been thought to be most frequent antigens of HP, however various fungi were causative in HRHP. We have shown that analyses of fungus DNA in BALF and measurement of fungus antibodies are useful in diagnosis of HRHP. These results should be helpful to perform antigen avoidance and leading to improve prognosis of the disease.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan2013
Author(s)
T Okamoto, Y Miyazaki, T Ogura, K Chida, N Kohno, S Kohno, H Taniguchi, S Akagawa, Y Mochizuki, K Yamauchi, H Takahashi, T Johkoh, S Homma, K Kishi, S Ikushima, S Konno, M Mishima, K Ohta, Y Nishioka, N Yoshimura, M Munakata, K Watanabe, Y Miyashita, N Inase
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Journal Title
Respir Investig
Volume: Vol.51
Pages: 191-199
Related Report
Peer Reviewed
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[Journal Article] A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan.2013
Author(s)
Okamoto T, Miyazaki Y, Ogura T, Chida K, Kohno N, Kohno S, Taniguchi H, Akagawa S, Mochizuki Y, Yamauchi K, Takahashi H, Johkoh T, Homma S, Kishi K, Ikushima S, Konno S, Mishima M, Ohta K, Nishioka Y, Yoshimura N, Munakata M, Watanabe K, Miyashita Y, Inase N.
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Journal Title
Respir Investig
Volume: 51
Issue: 3
Pages: 191-199
DOI
Related Report
Peer Reviewed
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[Presentation] Serum Levels Of KL-6 And SP-D In Chronic Hypersensitivity Pneumonitis2013
Author(s)
T Okamoto, Y Miyazaki, M Fujii, H Furusawa, T Tateishi, K Tsuchiya, T Fujie, M Tamaoka, H Sakashita, Yu Sumi, N Inase
Organizer
ATS 2013 International Conference
Place of Presentation
Philadelphia, USA
Year and Date
2013-05-20
Related Report
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[Presentation] Proteomics Analysis Of BALF In Rheumatoid Arthritis Associated Interstitial Lung Disease With Usual Interstitial Pneumonia Pattern.2013
Author(s)
Kozo Suhara, Yasunari Miyazaki, Tsukasa Okamoto, Tomoya Tateishi, Haruhiko Furusawa, Kimitake Tsuchiya, Toshihide Fujie, Meiyo Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
Organizer
American Thoracic Society
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] Serum Levels Of KL-6 And SP-D In Chronic Hypersensitivity Pneumonitis.2013
Author(s)
Tsukasa Okamoto, Yasunari Miyazaki, Mayumi Fujii, Haruhiko Furusawa, Tomoya Tateishi, Kimitake Tsuchiya, Toshihide Fujie, Meiyo Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
Organizer
American Thoracic Society
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] Measurement Of Avian Antigen From The Environment Of Patients With Bird-Related Hypersensitivity Pneumonitis.2013
Author(s)
Toshiharu Tsutsui, Yasunari Miyazaki, Tomoya Tateishi, Haruhiko Furusawa, Kimitake Tuchiya, Toshihide Fujie, Meiyou Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
Organizer
American Thoracic Society
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] Basophils In A Murine Model Of Bird-Related Hypersensitivity Pneumonitis.2013
Author(s)
Masahiro Ishizuka, Yasunari Miyazaki, Tomoya Tateishi, Haruhiko Furusawa, Kimitake Tsuchiya, Toshihide Fujie, Meiyo Tamaoka, Hiroyuki Sakashita, Yuki Sumi, Naohiko Inase.
Organizer
American Thoracic Society
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] A randomized, double-blind, multi-centered controlled trial of cyclosporine A vs. cyclophosphamide with corticosteroid in patients with idiopathic pulmonary fibrosis in Japan2011
Author(s)
Y Miyazaki, A Azuma, N Inase, T Ogura, H Taniguchi, Y Yoshizawa, Y Sugiyama, S Kudoh
Organizer
ATS 2011 International Conference
Place of Presentation
Denver, USA
Year and Date
2011-05-16
Related Report
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[Presentation] A randomized, double-blind, multi-centered controlled trial of cyclosporine A vs. cyclophosphamide with corticosteroid in patients with idiopathic pulmonary fibrosis in Japan.2011
Author(s)
Miyazaki Y, Azuma A, Inase N, Ogura T, Taniguchi H, Yoshizawa Y, Sugiyama Y, Kudoh S.
Organizer
American Thoracic Society
Place of Presentation
Denver, USA
Related Report
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