| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Research Abstract |
MicroRNA-127 (miR-127) is located in 14q32 region and the deletion in this region has been reported in lung cancer as well as gastric cancer and hepatocellular carcinoma. The reduced expressions of miR-127 were observed in most of lung cancer cell lines, compared the immortalized normal human bronchial epithelial cell by real time PCR method with Taqman microRNA assay. The overexpression of miR-127 in two lung cancer cell lines, leaded to tumor growth inhibition. Moreover, mRNA microarray analysis of H1975 cancer cell lines after transfection of miR-127 mimic indicated the candidate target genes of miR-127. These results suggested that miR-127 have tumor suppressive effect in non-small-cell lung cancer.
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