Molecular biological influence of sleep apnea syndrome on circadian clock system
| Project/Area Number |
23591147
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
CHIKUMI Hiroki 鳥取大学, 医学部付属病院, 教授 (90283994)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 睡眠時無呼吸症候群 / 時計遺伝子 / 概日時計 / 時計被制御遺伝子 / 分子時計 / 気管支喘息 / 睡眠時無呼吸 / 睡眠関連呼吸障害 / 低酸素血症 / 交感神経活動亢進 |
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| Outline of Final Research Achievements |
Sleep apnea syndrome is one of the important diseases, which causes many physiological impacts to human. Obstructive sleep apnea causes the repeated apnea and hypopnea during sleep, which affects the circadian clock that is composed of clock genes and molecular biological mechanism. We found several clock-controlled genes with cis-elements of E-box, D-box or RRE (REV-ERBα/ROR response element). Further studies are needed to reveal the relationship between dysfunction of circadian clock and sleep apnea syndrome.
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Report
(5 results)
Research Products
(17 results)
