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Cytokine storms in severe influenza-related pneumonia

Research Project

Project/Area Number 23591151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionOsaka University

Principal Investigator

SEKI Masafumi  大阪大学, 医学部附属病院, 講師 (80432970)

Co-Investigator(Kenkyū-buntansha) TOMONO Kazunori  大阪大学, 医学部附属病院, 教授 (40202204)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肺炎 / インフルエンザ / 好中球 / NETs / 次世代シークエンサー / NETs / MRSA / NHCAP / iインフルエンザ / 乳酸菌
Research Abstract

In the basic research field, we analyzed the excessive immune responses, including apoptosis and NETs: neutrophil extracelluar traps, in both human pneuminia cases and mice models.
In clinical research field, NHCAP: the nurshing and healthcare-associated pneumonia, cases were analyzed, and published the paper about therapeutic regimen and infection control for aspiration pneumonia in elderly persons and nosocomial pneumonia due to drug resistant pathogens, including MRSA.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (58 results)

All 2013 2012 2011 Other

All Journal Article (36 results) (of which Peer Reviewed: 13 results) Presentation (12 results) (of which Invited: 4 results) Book (6 results) Remarks (4 results)

  • [Journal Article] Fatal sepsis caused by an unusual Klebsiella species that was misidentified by an automated identification system2013

    • Author(s)
      Seki M, Tomono K, et al
    • Journal Title

      J Med Microbiol

      Volume: 62 Pages: 801-3

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mechanisms of increased severity of influenza-related pneumonia (invited review)2013

    • Author(s)
      Seki M
    • Journal Title

      General Medicine

      Volume: 1 Issue: 02 Pages: 121-122

    • DOI

      10.4172/2327-5146.1000121

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nosocomial outbreak of multidrug-resistant Pseudomonas aeruginosa caused by damaged transesophageal echocardiogram probe used in cardiovascular surgical operations2013

    • Author(s)
      Seki M, Tomono K, et al
    • Journal Title

      J Infect Chemother

      Volume: 19 Pages: 677-82

    • NAID

      10031194396

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prediction of requirement for mechanical ventilation in community-acquired pneumonia with acute respiratory failure : a multicenter prospective study2013

    • Author(s)
      Kohno S, Seki M, et al
    • Journal Title

      Respiration

      Volume: 85 Pages: 27-35

    • Related Report
      2013 Final Research Report
  • [Journal Article] Safety and tolerance of high dose/ short interval daptomycin regimen in three patients with chronic renal failure2013

    • Author(s)
      Yabuno K, Seki M, Tomono K, et al
    • Journal Title

      Clinical Pharmacology : Advances and Applications

      Volume: 5 Pages: 161-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Pneumorachis associated with multiorgan infection due to Citrobacter koseri infection2013

    • Author(s)
      Yamamoto N, Takegawa R, Seki M, Tomono K, et al
    • Journal Title

      Diag Microbiol Infect Dis

      Volume: 77 Pages: 370-2

    • Related Report
      2013 Final Research Report
  • [Journal Article] TLR4 agonistic antibody promotes innate immunity against severe pneumonia induced by co-infection with influenza virus and Streptococcus pneumoniae2013

    • Author(s)
      Tanaka A, Nakamura S, Seki M, et al
    • Journal Title

      Clinical and Vaccine Immunology

      Volume: 20 Pages: 977-85

    • Related Report
      2013 Final Research Report
  • [Journal Article] Practice guidelines for therapeutic drug monitoring of voriconazole : a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring2013

    • Author(s)
      Hamada Y, Tokimatsu I, Mikamo H, Kimura M, Seki M, et al
    • Journal Title

      J Infect Chemother

      Volume: 19 Pages: 381-21

    • NAID

      10031183309

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical Practice Guidelines for Nursing-and Healthcare-associate Pneumonia (NHCAP)2013

    • Author(s)
      Kohno S, Imamura Y, Shindo Y, Seki M, Tomono K, et al
    • Journal Title

      Resp Invest

      Volume: 51 Pages: 103-26

    • Related Report
      2013 Final Research Report
  • [Journal Article] Practice guidelines for therapeutic drug monitoring of vancomycin : a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring2013

    • Author(s)
      Matsumoto K, Takesue Y, Ohmagari T, Mocjizuki T, Mikamo H, Seki M, et al
    • Journal Title

      J Infect Chemother

      Volume: 19 Pages: 365-80

    • NAID

      10031183308

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of neutrophil extracellular traps in the blood of patients with systemic inflammatory response syndrome2013

    • Author(s)
      Hamaguchi S, Hirose T, Akeda Y, Matsumoto N, Irisawa T, Seki M, Tomono K, et al
    • Journal Title

      J Int Med Res

      Volume: 41 Pages: 162-168

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fatal sepsis caused by an unusual Klebsiella species that was misidentified by an automated identification system.2013

    • Author(s)
      Seki M, Gotoh K, Nakamura S, Akeda Y, Yoshii T, Miyaguchi S, Inohara H, Horii T, Oishi K, Iida T, Tomono K,
    • Journal Title

      J Med Microbiol

      Volume: 62 Pages: 801-803

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of requirement for mechanical ventilation in community-acquired pneumonia with acute respiratory failure: a multicenter prospective study.2013

    • Author(s)
      4) Kohno S, Seki M, Takehara K, Yamada Y, Kubo K, Ishizaka A, Soma K.
    • Journal Title

      Respiration

      Volume: 85 Pages: 27-35

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and tolerance of high dose/ short interval daptomycin regimen in three patients with chronic renal failure.2013

    • Author(s)
      Yabuno K, Seki M, Miyawaki K, Miwa Y, Tomono K.
    • Journal Title

      Clinical Pharmacology: Advances and Applications

      Volume: 5 Pages: 161-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TLR4 agonistic antibody promotes innate immunity against severe pneumonia induced by co-infection with influenza virus and Streptococcus pneumoniae2013

    • Author(s)
      7) Tanaka A, Nakamura S, Seki M, Fukudome K, Iwanaga N, Imamura Y, Miyazaki T, Izumikawa K, Kakeya H, Yanagihara K, and Kohno S.
    • Journal Title

      Clinical and Vaccine Immunology

      Volume: 20 Pages: 977-985

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loading regimen required to rapidly achieve therapeutic trough plasma concentration of teicoplanin and evaluation of clinical features2012

    • Author(s)
      Seki M, Tomono K, et al
    • Journal Title

      Clinical Pharmacology : Advances and Applications

      Volume: 4 Pages: 71-5

    • Related Report
      2013 Final Research Report
  • [Journal Article] A case of invasive non-typable Haemophilus influenzae respiratory infection with neutrophil extracellular traps rich sputum2012

    • Author(s)
      Hamaguchi S, Seki M, Tomono K. et al
    • Journal Title

      J Inflamm Res

      Volume: 5 Pages: 137-140

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Methicillin-resistant Staphylococcus aureus bacteremia at a university hospital in Japan2012

    • Author(s)
      Isobe M, Uejima E, Seki M, Tomono K, et al
    • Journal Title

      J Infect Chemother

      Volume: 18 Pages: 841-847

    • NAID

      10031143884

    • Related Report
      2013 Final Research Report
  • [Journal Article] Correlation between the consumption of meropenem or doripenem and meropenem susceptibility of Pseudomonas aeruginosa in a university hospital in Japan2012

    • Author(s)
      Miyawaki K, Miwa M, Seki M, Tomono K, et al
    • Journal Title

      Biol Pharm Bull

      Volume: 35 Pages: 946-9

    • NAID

      130001872178

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dynamic changes in Neutrophil Extracelluar Traps in acute respiratory infection2012

    • Author(s)
      Hirose T, Hamaguchi S, Matsumoto N, Irisawa T, Seki M, , Tomono K, et al
    • Journal Title

      Am J Resp Crit Care Med

      Volume: 185 Pages: 1130-1

    • Related Report
      2013 Final Research Report
  • [Journal Article] Loading regimen required to rapidly achieve therapeutic trough plasma concentration of teicoplanin and evaluation of clinical features.2012

    • Author(s)
      Seki M, Yabuno K, Miyawaki K, Miwa Y, Tomono K.
    • Journal Title

      Clinical Pharmacology: Advances and Applications

      Volume: 4 Pages: 71-75

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Methicillin-resistant Staphylococcus aureus bacteremia at a university hospital in Japan.2012

    • Author(s)
      Isobe M, Uejima E, Seki M, Yamagishi Y, Miyawaki K, Yabuno K, Masaoka M, Hamaguchi S, Yoshioka N, Tomono K.
    • Journal Title

      J Infect Chemother

      Volume: 18 Pages: 841-847

    • NAID

      10031143884

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correlation between the consumption of meropenem or doripenem and meropenem susceptibility of Pseudomonas aeruginosa in a university hospital in Japan2012

    • Author(s)
      Miyawaki K, Miwa M, Seki M, Asari S, Tomono K, Kurokawa N.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Pages: 946-949

    • NAID

      130001872178

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamic changes in Neutrophil Extracelluar Traps in acute respiratory infection.2012

    • Author(s)
      Hirose T, Hamaguchi S, Matsumoto N, Irisawa T, Seki M, Tasaki O, Hosotsubo H, Tomono K, Shimazu T
    • Journal Title

      Am J Resp Crit Care Med.

      Volume: 185 Pages: 1130-1131

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 感染症:診断と治療 1特殊環境における感染症 2 医療・介護関連肺炎(NHCAP)ガイドラインが提起する問題2012

    • Author(s)
      関 雅文、朝野和典
    • Journal Title

      日本内科学会雑誌

      Volume: 11 Pages: 3097-3102

    • Related Report
      2012 Research-status Report
  • [Journal Article] 感染症とアレルギーの新しい視点-Neutrophil extracelluar traps (NETs)-2012

    • Author(s)
      濱口重人、関 雅文、朝野和典
    • Journal Title

      アレルギー学会雑誌

      Volume: 61 Pages: 1729-1735

    • Related Report
      2012 Research-status Report
  • [Journal Article] 術後のMRSA感染症2012

    • Author(s)
      関 雅文、朝野和典
    • Journal Title

      日本外科感染症学会雑誌

      Volume: 9 Pages: 165-169

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] テイコプラニンにおける血中トラフ濃度20ug/mL以上の臨床的効果、安全性2012

    • Author(s)
      高倉俊二、竹末芳生、大曲貴夫、笠原 敬、関 雅文、高橋佳子、時松一成、松元一明、三鴨廣繁
    • Journal Title

      日本化学療法学会雑誌

      Volume: 60 Pages: 501-504

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyusyu, Japan2011

    • Author(s)
      Seki M, et al
    • Journal Title

      J Infect Chemother

      Volume: 17 Pages: 363-369

    • Related Report
      2013 Final Research Report
  • [Journal Article] Time course analysis of apoptosis in a murine model of severe pneumococcal pneumonia during influenza A virus infection2011

    • Author(s)
      Kosai K, Seki M, et al
    • Journal Title

      Jpn J Infect Dis

      Volume: 64 Pages: 451-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Lactobacillus pentosus strain b240 suppresses pneumonia induced by Streptococcus pneumoniae in mice2011

    • Author(s)
      Tanaka A, Seki M, et al
    • Journal Title

      App. Let. Microbial

      Volume: 53 Pages: 35-43

    • NAID

      120006985060

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Evaluation of an Assessment System for the JRS 2005: A-DROP for the Management of CAP in Adults2011

    • Author(s)
      Kohno S, Seki M, et al
    • Journal Title

      Intern Med

      Volume: 50 Pages: 1183-91

    • NAID

      130000770470

    • Related Report
      2013 Final Research Report
  • [Journal Article] High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells2011

    • Author(s)
      Nakamura S, Yanagihara K, Araki N, Yamada K, Morinaga Y, Izumikawa K, Seki M, et al
    • Journal Title

      Eur J Pharmacol

      Volume: (Epub ahead of print)

    • NAID

      120006985129

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyusyu, Japan.2011

    • Author(s)
      Seki M, Hashiguchi K, Tanaka A, Kosai K, Kakugawa T, Awaya K, Kurihara S, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Tashiro T, Kohno S.
    • Journal Title

      J Infect Chemother.

      Volume: 17 Pages: 363-369

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Time course analysis of apoptosis in a murine model of severe pneumococcal pneumonia during influenza A virus infection.2011

    • Author(s)
      Kosai K, Seki M, Tanaka A, Morinaga Y, Kurihara S, Miyazaki T, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tomono K, Tashiro T, Kohno S.
    • Journal Title

      Jpn J Infect Dis.

      Volume: 64 Pages: 451-457

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肺炎の診療-ガイドラインの進歩:血液検査~CRPの重要性~2011

    • Author(s)
      関 雅文、朝野和典
    • Journal Title

      日本内科学会雑誌

      Volume: 100 Pages: 3522-3526

    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of the mechanisms of increased severity of influenza-related pneumonia in mice2013

    • Author(s)
      Seki M
    • Organizer
      ISC (国際化学療法学会)
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム18感染症診療18ベーシックコース市中感染、医療関連感染の基礎肺炎(CAP, HAP, NHCAP)2013

    • Author(s)
      関雅文
    • Organizer
      感染症学会・化学療法学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis of the mechanisms of increased severity of influenza-related pneumonia in mice.2013

    • Author(s)
      Masafumi Seki
    • Organizer
      International Society of Chemotherapy
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] 感染症診療18 ベーシックコース2013

    • Author(s)
      関 雅文
    • Organizer
      日本感染症学会・化学療法学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 医療・介護関連肺炎(NHCAP)の現状と今後~医師の立場から~2013

    • Author(s)
      関 雅文
    • Organizer
      日本呼吸ケア・リハビリテーション学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Neutrophil Extracellular Traps In Acute Respiratory Infection: A Quantitative Analysis In Sputum2013

    • Author(s)
      Hamaguchi S, Hirose T, Seki M, et al
    • Organizer
      日本呼吸器学会総会 English Sympoisum
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neutrophil extracellular traps were found in the sputum of the patients of nontypeable Haemophilus influenza pneumonia2013

    • Author(s)
      Yamamoto N, Seki M, et al.
    • Organizer
      日本呼吸器学会総会 English Sympoisum
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Meet the Expertインフルエンザと関連する肺炎の病態とマネージメントについて2012

    • Author(s)
      関雅文
    • Organizer
      日本感染症学会
    • Related Report
      2013 Final Research Report
  • [Presentation] First prospective, Randomized, Clinical Study, Evaluating combination of Osertamivir phosphonate andazithromycin extended formation for influenza2012

    • Author(s)
      Kakeya K, Seki M, et al
    • Organizer
      ICCAC
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] インフルエンザと関連する肺炎の病態とマネージメントについて2012

    • Author(s)
      関 雅文
    • Organizer
      感染症学会総会
    • Place of Presentation
      長崎
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] シンポジウム2 感染症学の実践現場の現状を考えるー医師の教育はどう考えるべきかー専攻医から感染症専門医になるまでにやっておきたいこと2012

    • Author(s)
      関 雅文
    • Organizer
      中・西日本感染症/西日本化学療法学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] インフルエンザ肺炎の重症化と新しい抗インフルエンザ薬2011

    • Author(s)
      関 雅文
    • Organizer
      第20回学会賞受賞者特別講演会(北里柴三郎賞) (招待講演)
    • Place of Presentation
      東京(北里研究所)
    • Related Report
      2011 Research-status Report
  • [Book] 日本内科学会雑誌2013

    • Author(s)
      関 雅文、朝野和典
    • Total Pages
      5
    • Publisher
      日本内科学会
    • Related Report
      2013 Annual Research Report
  • [Book] 内科医のための薬の禁忌2013

    • Author(s)
      関 雅文、朝野和典、河野 茂
    • Total Pages
      3
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 大阪府内科医会誌2013

    • Author(s)
      関 雅文
    • Total Pages
      4
    • Publisher
      大阪府内科医会
    • Related Report
      2013 Annual Research Report
  • [Book] 感染と抗菌薬2013

    • Author(s)
      関 雅文
    • Total Pages
      4
    • Publisher
      ヴァンメデイカル
    • Related Report
      2013 Annual Research Report
  • [Book] 日本医事新報2013

    • Author(s)
      関 雅文、朝野和典
    • Total Pages
      2
    • Publisher
      日本医事新報社
    • Related Report
      2013 Annual Research Report
  • [Book] ガイドラインサポートハンドブック 呼吸器感染症 医療・介護関連肺炎 (NHCAP) 1. 定義2011

    • Author(s)
      関 雅文、河野 茂、朝野和典
    • Total Pages
      6
    • Publisher
      医薬ジャーナル社(大阪)
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/hp-infect/

    • Related Report
      2013 Final Research Report
  • [Remarks] 大阪大学医学部附属病院 感染制御部

    • URL

      http://www.med.osaka-u.ac.jp/pub/hp-infect/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 大阪大学医学部附属病院感染制御部website

    • URL

      http://www.med.osaka-u.ac.jp/pub/hp-infect/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/hp-infect/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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